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Chemistry

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Also known as: Copper(ii) chloride, Copper chloride, 7447-39-4, Cupric chloride anhydrous, Copper dichloride, Copper bichloride
Molecular Formula
Cl2Cu
Molecular Weight
134.45  g/mol
InChI Key
ORTQZVOHEJQUHG-UHFFFAOYSA-L

Copper Chloride
Cupric chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
1 2D Structure

Copper Chloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
dichlorocopper
2.1.2 InChI
InChI=1S/2ClH.Cu/h2*1H;/q;;+2/p-2
2.1.3 InChI Key
ORTQZVOHEJQUHG-UHFFFAOYSA-L
2.1.4 Canonical SMILES
Cl[Cu]Cl
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Copper(ii) Chloride

2. Cucl2

3. Cupric Chloride Anhydrous

4. Cupric Chloride Dihydrate

5. Cupric Chloride Eriochalcite (cucl2.2h2o)

6. Cupric Chloride, 64cu-labeled Cpd

7. Cupric Chloride, Dihydrate 2h-labeled Cpd

2.2.2 Depositor-Supplied Synonyms

1. Copper(ii) Chloride

2. Copper Chloride

3. 7447-39-4

4. Cupric Chloride Anhydrous

5. Copper Dichloride

6. Copper Bichloride

7. Cupric Dichloride

8. Copper(2+) Chloride

9. Cucl2

10. Copper Chloride (cucl2)

11. Dichlorocopper

12. Copper(2+)chloride

13. Copper (ii) Chloride

14. Copper(ii) Chloride (1:2)

15. Coclor

16. Copper(ii)chloride

17. Copper(ii) Chloride, Anhydrous

18. Chebi:49553

19. Mfcd00010972

20. Nsc165706

21. Copper Chloride (van)

22. Ccris 6883

23. Hsdb 259

24. Cupric Chloride In Plastic Container

25. Einecs 231-210-2

26. Copper (ii)chloride

27. Copper(ii)-chloride

28. Copper (ii) Cloride

29. Nsc 165706

30. Copper (ii)-chloride

31. Ai3-01658

32. Epitope Id:156811

33. Copper(ii) Chloride, 97%

34. Copper (ii) Chloride, 95%

35. Copper(ii) Chloride, Ultra Dry

36. Unii-p484053j2y

37. Copper(ii) Chloride, Powder, 99%

38. Copper(ii) Chloride, P.a., 97%

39. Copper(ii) Chloride, Lr, >=98%

40. Akos015902778

41. Db09131

42. Bp-13443

43. Nci60_001274

44. Copper (ii) Chloride, Trace Metals Grade

45. Ft-0624119

46. Ec 231-210-2

47. Copper(ii) Chloride, Saj First Grade, >=98.0%

48. Q421781

49. Copper(ii) Chloride, 99.999% Trace Metals Basis

50. Copper(ii) Chloride, Anhydrous, Powder, >=99.995% Trace Metals Basis

51. Copper (ii) Chloride, Ultra Dry, Powder, Ampoule, 99.995% Trace Metals Grade

52. Copper Atomic Spectroscopy Standard Concentrate 1.00 G Cu, 1.00 G/l, For 1l Standard Solution, Analytical Standard

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 134.45 g/mol
Molecular Formula Cl2Cu
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass132.867303 g/mol
Monoisotopic Mass132.867303 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count3
Formal Charge0
Complexity2.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameCupric chloride in plastic container
Active IngredientCupric chloride
Dosage FormInjectable
RouteInjection
Strengtheq 0.4mg copper/ml
Market StatusPrescription
CompanyHospira

2 of 2  
Drug NameCupric chloride in plastic container
Active IngredientCupric chloride
Dosage FormInjectable
RouteInjection
Strengtheq 0.4mg copper/ml
Market StatusPrescription
CompanyHospira

4.2 Drug Indication

For use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).


5 Pharmacology and Biochemistry
5.1 Pharmacology

Copper is an essential nutrient which serves as a co factor for serum ceruloplasmin, an oxidase necessary for proper formation of the iron carrier protein, transferrin. Copper also helps maintain normal rates of red and white blood cell formation. Providing copper during Total Parenteral Nutrition helps prevent development of the following deficiency symptoms: Leukopenia, neutropenia, anemia, depressed ceruloplasmin levels, impaired transferrin formation, secondary iron deficiency and osteoporosis.


5.2 Absorption, Distribution and Excretion

Absorption

Mean copper absorption of 57 percent (range 40 to 70 per cent) following oral administration of 0.4 - 4.5 mg copper (as copper acetate) to four volunteers. An early human study suggested a maximum blood copper concentration was reached some two hours after oral copper chloride administration (1.5 - 12 mg copper)


Route of Elimination

Renal


Volume of Distribution

Copper is distributed to all tissues with the highest concentrations in liver, heart, brain, kidneys and muscle. Intracellular copper is predominantly metallothionein-bound. Reported copper in the lungs, liver, kidney, blood, bile and stomach (33.7, 35.1, 41.4, 13.8, 2.8, and 2988 g/g wet weight respectively)


ICR male mice aged 5 weeks were injected subcutaneously with cadmium chloride, lead acetate, silver nitrate, cupric chloride, a combination of cadmium and silver compounds, or a combination of copper and silver compounds. These injections were carried out 3 times. Twenty four hours after the last injection, they were sacrificed. Cadmium injection significantly stimulated serum ceruloplasmin activity and copper concentration, accompanied by an increase in hepatic copper. Lead injection also slightly increased the serum ceruloplasmin level. In contrast, silver injection markedly decreased both serum ceruloplasmin activity and copper concentration in the serum. Hepatic copper increased slightly after silver injection. The copper injection stimulated copper binding to metallothionein and bile excretion of copper, but not serum ceruloplasmin release. With a copper and silver combination, the effect of silver on serum ceruloplasmin was lost, with a concomitant disappearance of silver from the serum ceruloplasmin fraction in the serum. In the mouse, cadmium and silver, copper antagonistic metals, influence different sites of serum ceruloplasmin metabolism. Excess hepatic copper is partly eliminated by excretion of bile and is partly detoxified by metallothionein induction.

PMID:3606389 Sugawara N, Sugaware C; Arch Toxicol 59 (6): 432-36 (1987)


5.3 Mechanism of Action

The in vitro interaction of organic copper compounds with rat liver glutathione S-transferases was studied with reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Both organic and inorganic copper are spontaneously conjugated with glutathione, but interact with glutathione S-transferase by direct binding to these proteins.


The in vitro interaction of organic copper compounds with rat liver glutathione S-transferases was studied with reduced glutathione and 1-chloro-2,4-dinitrobenzene as substrates. Both organic and inorganic copper are spontaneously conjugated with glutathione, but interact with glutathione S-transferase by direct binding to these proteins.

PMID:3008276 Dierickx PJ; Res Commun Chem Pathol Pharmacol 51 (2): 285-88 (1986)


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