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    Chemistry

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    Also known as: 88-12-0, 1-vinylpyrrolidin-2-one, N-vinylpyrrolidone, 1-vinyl-2-pyrrolidone, N-vinyl-2-pyrrolidinone, Polyvinylpyrrolidone
    Molecular Formula
    C6H9NO
    Molecular Weight
    111.14  g/mol
    InChI Key
    WHNWPMSKXPGLAX-UHFFFAOYSA-N
    FDA UNII
    76H9G81541
    Povidone API
    A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander. See [povidone] for full details.
    1 2D Structure

    Povidone API

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-ethenylpyrrolidin-2-one
    2.1.2 InChI
    InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
    2.1.3 InChI Key
    WHNWPMSKXPGLAX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C=CN1CCCC1=O
    2.2 Other Identifiers
    2.2.1 UNII
    76H9G81541
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-vinyl-2-pyrrolidone

    2. N- Vinyl Pyrrolidone

    3. N-vinyl-2-pyrrolidinone

    4. N-vinylpyrrolidone

    2.3.2 Depositor-Supplied Synonyms

    1. 88-12-0

    2. 1-vinylpyrrolidin-2-one

    3. N-vinylpyrrolidone

    4. 1-vinyl-2-pyrrolidone

    5. N-vinyl-2-pyrrolidinone

    6. Polyvinylpyrrolidone

    7. Vinylpyrrolidone

    8. 9003-39-8

    9. 1-vinyl-2-pyrrolidinone

    10. Povidone

    11. 2-pyrrolidinone, 1-ethenyl-

    12. 1-ethenylpyrrolidin-2-one

    13. N-vinylpyrrolidinone

    14. Polyvidone

    15. 1-vinylpyrrolidone

    16. Vinylbutyrolactam

    17. Plasdone

    18. Vinylpyrrolidinone

    19. V-pyrol

    20. Luviskol

    21. 1-vinylpyrrolidinone

    22. Vinyl-2-pyrrolidone

    23. 25249-54-1

    24. Polyclar At

    25. N-vinyl Pyrrolidone

    26. 1-ethenyl-2-pyrrolidinone

    27. N-vinylpyrrolidone-2

    28. 2-pyrrolidinone, 1-vinyl-

    29. Poly(n-vinylpyrrolidone)

    30. 1-vinyl-2-pyrrolidinone, Monomer

    31. Poly(1-vinyl-2-pyrrolidone)

    32. Pvp 40

    33. Pvp

    34. Nsc 10222

    35. Mpk 90

    36. 143 Rp

    37. At 717

    38. 1-vinyl-pyrrolidin-2-one

    39. K 15

    40. K 90

    41. Pvp-40

    42. Dtxsid2021440

    43. Chebi:82551

    44. Poly[1-(2-oxo-1-pyrrolidinyl)-1,2-ethanediyl]

    45. Mfcd00003197

    46. Nsc-10222

    47. 2-pyrrolidinone, 1-ethenyl-, Trimer

    48. 2-pyrrolidinone, Polymers

    49. 76h9g81541

    50. Dsstox_cid_1440

    51. Dsstox_rid_76160

    52. Dsstox_gsid_21440

    53. Wln: /t5nvtj Ay*1*/

    54. Mfcd01076626

    55. Cas-88-12-0

    56. Polyvinylpyrrolidine

    57. 109412-11-5

    58. K 25

    59. K 115

    60. Hsdb 7231

    61. Einecs 201-800-4

    62. Polyvinylpyrrolidone K 90

    63. Polyvinylpyrrolidone K-30

    64. 2-pyrrolidinone, Polymers, Compd. With Aluminum Acetate

    65. Brn 0110513

    66. Ccris 8581

    67. Povidonepvp

    68. Vinyl Pyrrolidone

    69. Polyvinylpyrrolidon

    70. Poly[1-(2-oxo-1-pyrrolidinyl)-1, .alpha.-hydro-.omega.-[[4-(iodo-131i)phenyl]methyl]-

    71. Unii-76h9g81541

    72. N-vinyl-pyrrolidone

    73. N -vinylpyrrolidinone

    74. 1-vinyl-2-pyrrolidon

    75. Povidone Monomer

    76. Vinylbutylolactam

    77. N-vinylpyrrolidin-2-one

    78. N-vinyl Pyrrolidin-2-one

    79. N-vinyl-pyrrolidin-2-one

    80. Pvp K3o

    81. Crospovidone ~40,000

    82. Ec 201-800-4

    83. Poly (n-vinyl Pyrrolidone)

    84. Schembl10869

    85. Wln: T5nvtj A1u1

    86. Pvp K15

    87. Pvp K30

    88. Pvp-k30

    89. Polyvinylpyrrolidone Pvp K30

    90. Povidone Monomer [mi]

    91. Vinyl Pyrrolidone (vp)

    92. Poly(1-vinylpyrrolidin-2-one)

    93. Chembl1878943

    94. Pvp - K-30 (pharm Grade)

    95. Polyvinylpyrrolidone, Cross Linked

    96. N-vinyl Pyrrolidone [inci]

    97. 1-vinyl-2-pyrrolidone(stabilized With 200ppm Ammonium Hydroxide)

    98. Nsc10222

    99. Zinc3590964

    100. Polyvinylpyrrolidone, M.w. 8,000

    101. Tox21_202462

    102. Tox21_300073

    103. Nsc114022

    104. Nsc142693

    105. Nsc683040

    106. N-vinyl-2-pyrrolidone, Optical Grade

    107. Polyvinylpyrrolidone (mw ~40,000)

    108. Polyvinylpyrrolidone, M.w. 10.000

    109. Polyvinylpyrrolidone, M.w. 40.000

    110. Polyvinylpyrrolidone, M.w. 58,000

    111. Akos000119985

    112. N-vinyl-2-pyrrolidone [iarc]

    113. At18510

    114. Cs-w020981

    115. Fg-0420

    116. Nsc-114022

    117. Nsc-142693

    118. Nsc-683040

    119. Polyvinylpyrrolidone, M.w. 360.000

    120. Ncgc00166252-01

    121. Ncgc00166252-02

    122. Ncgc00166252-03

    123. Ncgc00254200-01

    124. Ncgc00260011-01

    125. Polyvinylpyrrolidone, M.w. 1,300,000

    126. 2-pyrrolidinone, 1-ethenyl-[hsdb]

    127. Ft-0608329

    128. Ft-0645144

    129. Ft-0655284

    130. V0026

    131. C19548

    132. A817742

    133. A843417

    134. Poly(n-vinyl-2-pyrrolidone) (low M.wt.)

    135. Q420628

    136. Sr-01000944531

    137. J-015891

    138. Sr-01000944531-1

    139. W-100417

    140. 1-vinyl-2-pyrrolidinone, Saj First Grade, >=99.0%

    141. F8881-5579

    142. 3-chloro-5,6-difluoro-1-benzothiophene-2-carbonylchloride

    143. 1-vinyl-2-pyrrolidinone, Contains Sodium Hydroxide As Inhibitor, >=99%

    144. 1-vinyl-2-pyrrolidinone, Pharmaceutical Secondary Standard; Certified Reference Material

    145. 1-vinyl-2-pyrrolidone (stabilized With N,n'-di-sec-butyl-p-phenylenediamine)

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 111.14 g/mol
    Molecular Formula C6H9NO
    XLogP30.4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count1
    Exact Mass111.068413911 g/mol
    Monoisotopic Mass111.068413911 g/mol
    Topological Polar Surface Area20.3 Ų
    Heavy Atom Count8
    Formal Charge0
    Complexity120
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Pharmaceutic Aids; Plasma Substitutes

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    CLINICAL INDICATIONS: ...FOR ALL PATHOLOGICAL CONDITIONS WHERE THERE IS DECR IN MASS OF LIQ BLOOD: SHOCK STATE... HEMORRHAGE...SERIOUS BURNS. ANTHREPSIA & NEURO-TOXICOSES OF INFANTS.

    Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 292

    ...HAS BEEN USED IN A...SERIES OF PATIENTS TO REPLACE THE AQ HUMOR AFTER EXTRACTION OF CATARACTS, CORNEAL TRANSPLANTS, & ANTIGLAUCOMA OPERATIONS.

    Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 758

    4.2 Minimum/Potential Fatal Human Dose

    1. 1= PRACTICALLY NONTOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QUART (2.2 LB) FOR 70 KG PERSON (150 LB).

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-245

    4.3 Drug Indication

    When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.

    When in complex with iodine, indicated for inducing antisepsis for prevention of infection in minor cuts, scrapes, and burns.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Povidone itself has no microbicidal activity. [DB06812] exhibits rapid, potent, broad-spectrum antimicrobial properties. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application.

    Povidone itself has no microbicidal activity. [Povidone-iodine] exhibits rapid, potent, broad-spectrum antimicrobial properties. The clinical effectiveness of povidon-iodine on wound healing remains somewhat controversial; in few clinical studies investigating the effects of povidone-iodine on wound healing, topical administration of the complex was associated with no significant infections, but slower healing and mild to moderate discomfort on application.

    5.2 MeSH Pharmacological Classification

    Biocompatible Materials

    Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function. (See all compounds classified as Biocompatible Materials.)

    5.3 Absorption, Distribution and Excretion

    Absorption

    This pharmacokinetic data does not apply to povidone.

    Route of Elimination

    This pharmacokinetic data does not apply to povidone.

    Volume of Distribution

    This pharmacokinetic data does not apply to povidone.

    Clearance

    This pharmacokinetic data does not apply to povidone.

    Absorption

    This pharmacokinetic data does not apply to povidone.

    Route of Elimination

    This pharmacokinetic data does not apply to povidone.

    Volume of Distribution

    This pharmacokinetic data does not apply to povidone.

    Clearance

    This pharmacokinetic data does not apply to povidone.

    WHEN GIVEN PARENTERALLY, UNEXCRETED PARTICLES ARE PHAGOCYTIZED BY CELLS OF RETICULOENDOTHELIAL SYSTEM & DEPOSITED IN STORAGE SITES IN LIVER, SPLEEN, LUNG, BONE MARROW...

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-245

    ...30-40% OF SUBTOSAN PASSES INTO THE URINE IN THE FIRST 24 HR & ABOUT 50% IN THE FIRST 2 DAYS. ...SMALLEST MOLECULES ARE...FIRST & MOST RAPIDLY EXCRETED. IT TAKES 10 DAYS AFTER PERFUSION FOR 80% OF AMT INJECTED TO BE ELIMINATED.

    Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 292

    INTERMEDIATE MOLECULR WT PARTICLES MAY BE SLOWLY EXCRETED OVER SEVERAL MONTHS TO A YR.

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-245

    IN GROUPS OF RATS FED DIETS CONTAINING 1 & 10% PVP (MOLECULAR WEIGHT 38,000) FOR 2 YEARS...THERE WAS NO EVIDENCE THAT PVP WAS ABSORBED FROM THE INTESTINAL TRACT.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V19 471

    For more Absorption, Distribution and Excretion (Complete) data for POLYVINYLPYRROLIDONE (6 total), please visit the HSDB record page.

    5.4 Metabolism/Metabolites

    This pharmacokinetic data does not apply to povidone.

    This pharmacokinetic data does not apply to povidone.

    PVP LABELLED WITH (14)C OR (131)I WAS NOT METABOLIZED TO ANY SIGNIFICANT DEGREE BY RATS, RABBITS OR DOGS FOLLOWING ITS IV INJECTION.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V19 472

    5.5 Biological Half-Life

    This pharmacokinetic data does not apply to povidone.

    This pharmacokinetic data does not apply to povidone.

    5.6 Mechanism of Action

    Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen. Please refer to the drug entry for [DB06812] for the full mechanism of action of the complex.

    Povidone-iodine is a water-soluble complex that mediates a bactericidal or virucidal action following the gradual liberation of free iodine from the complex at the application site to react with the pathogen. Please refer to the drug entry for [Povidone-iodine] for the full mechanism of action of the complex.

    ONE OF MAJOR PROPERTIES OF PVP IS ITS PHYSIO-CHEMICAL BEHAVIOR, WHICH IS... COMPARABLE TO THAT OF SERUM ALBUMEN... THUS IT FIXES & TRANSPORTS WATER AS WELL AS THE PRODUCTS FIXED BY SERUM ALBUMEN... IT CAN ALSO CARRY SUCH SUBSTANCES AS UREA, CREATININE, LACTOFLAVIN, COLORING MATTERS, HORMONES, & GLUCOSE.

    Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968., p. 290

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    ✖

    Certificate Number : R1-CEP 2014-365 - Rev 00

    Issue Date : 2021-02-16

    Type : Chemical

    Substance Number : 891

    Status : Valid

     JDMF EU-WC NDC KDMF VMF Others AUDIT
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    API Reference Price

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    [{"dataSource":"API Import","activeIngredients":"N-VINYL-2-PYRROLIDONE","year":"2021","qtr":"Q1","strtotime":1610044200,"product":"140925000 N-VINYL-2-PYRROLIDONE, STABILIZED WITH NAOH, 99%","address":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN EXPRESS","city":"HIGH WAY, SION(E) MUMBA,MAHARASHTRA","supplier":"ACROS OITOANLCS BVBA","supplierCountry":"BELGIUM","foreign_port":"BRUSSELS","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"LTR","unitRateFc":"75.9","totalValueFC":"44.3","currency":"USD","unitRateINR":"6473.4","date":"08-Jan-2021","totalValueINR":"3236.68","totalValueInUsd":"44.3","indian_port":"HYDERABAD AIR","hs_no":"29337990","bill_no":"2282224","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"","customerAddress":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN 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EXPRESS"},{"dataSource":"API Import","activeIngredients":"PYRROLIDONE","year":"2021","qtr":"Q2","strtotime":1618425000,"product":"140925000N-VINYL-2-PYRROLIDONE, STABILIZED WITH NAOH, 99%","address":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN EXPRESS","city":"HIGH WAY, SION(E) MUMBA,MAHARASHTRA","supplier":"ACROS OITOANLCS BVBA","supplierCountry":"BELGIUM","foreign_port":"BRUSSELS","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"LTR","unitRateFc":"78.2","totalValueFC":"190.3","currency":"USD","unitRateINR":"7082","date":"15-Apr-2021","totalValueINR":"14163.98","totalValueInUsd":"190.3","indian_port":"HYDERABAD AIR","hs_no":"29337990","bill_no":"3578508","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"","customerAddress":"GODREJ COLISEUM,101A-101-B,SOMAIYAHOSPITAL ROAD, OFF EASTERN 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EASTERN EXPRESS"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1671820200,"product":"140925000 N-VINYL-2-PYRROLIDONE, STABILIZED WITH NAOH, 99%","address":"403-404, B WING, DELPHI,,HIRANANDA NI BUSINESS PARK, POWAI,","city":"MUMBAI,MAHARASHTRA","supplier":"ACROS OITOANLCS BVBA","supplierCountry":"BELGIUM","foreign_port":"NA","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"LTR","unitRateFc":"86.4","totalValueFC":"107","currency":"USD","unitRateINR":"8815.5","date":"24-Dec-2022","totalValueINR":"8815.5","totalValueInUsd":"107","indian_port":"HYDERABAD AIR","hs_no":"29337990","bill_no":"3900368","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"403-404, B WING, DELPHI,,HIRANANDA NI BUSINESS PARK, POWAI,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698258600,"product":"140925000 N-VINYL-2-PYRROLIDONE, STABILIZED WITH NAOH, 99%","address":"403-404, B WING, DELPHI,,HIRANANDA","city":"MUMBAI,MAHARASHTRA","supplier":"ACROS OITOANLCS BVBA","supplierCountry":"BELGIUM","foreign_port":"BRUSSELS","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"LTR","unitRateFc":"95.4","totalValueFC":"116.4","currency":"USD","unitRateINR":"9692","date":"26-Oct-2023","totalValueINR":"9692.04","totalValueInUsd":"116.4","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"8473706","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"ENA23, ZONE 1, NR 1350 JANSSEN PHARMACEUTICALAAN 3A B-2440 GEEL BTW-BE-0451.781.854 RPR TURNHOUT Brussel Belgium","customerAddress":"403-404, B WING, DELPHI,,HIRANANDA"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702578600,"product":"140925000 N-VINYL-2-PYRROLIDONE, STABILIZED WITH NAOH, 99%","address":"403-404, B WING, DELPHI,,HIRANANDA","city":"MUMBAI,MAHARASHTRA","supplier":"ACROS OITOANLCS BVBA","supplierCountry":"BELGIUM","foreign_port":"BRUSSELS","customer":"THERMO FISHER SCIENTIFIC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"LTR","unitRateFc":"95.4","totalValueFC":"116.1","currency":"USD","unitRateINR":"9663.9","date":"15-Dec-2023","totalValueINR":"9663.88","totalValueInUsd":"116.1","indian_port":"Hyderabad Air","hs_no":"29337990","bill_no":"9240019","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"BRUSSELS","supplierAddress":"ENA23, ZONE 1, NR 1350 JANSSEN PHARMACEUTICALAAN 3A B-2440 GEEL BTW-BE-0451.781.854 RPR TURNHOUT Brussel Belgium","customerAddress":"403-404, B WING, DELPHI,,HIRANANDA"}]
    08-Jan-2021
    15-Dec-2023
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