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1-Hydroxyethane 1,1-Diphosphonic Acid Disodium Salt

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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 2 USDMF, 3 Listed Suppliers

5 API Suppliers
2 USDMF
3 Listed Suppliers

FINISHED DOSAGE FORMULATIONS

9 FDF Dossiers, 5 FDA Orange Book, 4 Canada

9 FDF Dossiers
5 FDA Orange Book
4 Canada

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Faran Shimi Pharmaceutical, 9 Gangwal Healthcare, 3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 DFE Pharma, 3 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 4 Kerry, 7 Microlex e.U, 1 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 13 Roquette, 1 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 8 Sigachi Industries, 2 Vasa Pharmachem

relatedExcipients
4 SPI Pharma
2 Faran Shimi Pharmaceutical
9 Gangwal Healthcare
3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
2 DFE Pharma
3 Gangwal Chemicals
1 Ideal Cures Pvt Ltd
2 Ingredion Pharma Solutions
4 Kerry
7 Microlex e.U
1 Pharmatrans-Sanaq
2 Pluviaendo
2 Prachin Chemical
13 Roquette
1 Seppic
3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
8 Sigachi Industries
2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

33 Fillers, Diluents & Binders, 19 Direct Compression, 11 Co-Processed Excipients, 11 Thickeners and Stabilizers, 10 Lubricants & Glidants, 9 Disintegrants & Superdisintegrants, 6 Granulation, 5 Controlled & Modified Release, 5 Chewable & Orodispersible Aids, 5 Taste Masking, 3 Coating Systems & Additives, 1 Rheology Modifiers, 1 Emulsifying Agents, 1 Film Formers & Plasticizers

excipientsByApplications
33 Fillers, Diluents & Binders
19 Direct Compression
11 Co-Processed Excipients
11 Thickeners and Stabilizers
10 Lubricants & Glidants
9 Disintegrants & Superdisintegrants
6 Granulation
5 Controlled & Modified Release
5 Chewable & Orodispersible Aids
5 Taste Masking
3 Coating Systems & Additives
1 Rheology Modifiers
1 Emulsifying Agents
1 Film Formers & Plasticizers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

PATENTS & EXCLUSIVITIES

1 Health Canada Patents

patents
1 Health Canada Patents

REF. STANDARDS & IMPURITIES

1 EDQM , 2 USP , 2 Others

otherSolutions
1 EDQM
2 USP
2 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

69 RELATED EXCIPIENT COMPANIES

120EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 7414-83-7, Didronel, Disodium etidronate, Sodium etidronate, Sodium ethidronate, Sodium ethydronate

Molecular Formula

C₂H₆Na₂O₇P₂

Molecular Weight

249.99 g/mol

InChI Key

GWBBVOVXJZATQQ-UHFFFAOYSA-L

FDA UNII

M16PXG993G

A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.

1 2D Structure

Etidronate Disodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

2.1.2 InChI

InChI=1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

2.1.3 InChI Key

GWBBVOVXJZATQQ-UHFFFAOYSA-L

2.1.4 Canonical SMILES

CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

M16PXG993G

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (1-hydroxyethylene)diphosphonic Acid

2. (1-hydroxyethylene)diphosphonic Acid, Tetrapotassium Salt

3. 1 Hydroxyethane 1,1 Diphosphonate

4. 1 Hydroxyethylidene 1,1 Bisphosphonate

5. 1,1 Hydroxyethylenediphosphonate

6. 1,1-hydroxyethylenediphosphonate

7. 1-hydroxyethane-1,1-diphosphonate

8. 1-hydroxyethylene Diphosphonate, Disodium

9. 1-hydroxyethylidene-1,1-bisphosphonate

10. Dicalcium Ehdp

11. Dicalcium Etidronate

12. Didronel

13. Diphosphonate, Disodium 1-hydroxyethylene

14. Diphosphonic Acid, Hydroxyethylidene

15. Disodium 1 Hydroxyethylene Diphosphonate

16. Disodium 1-hydroxyethylene Diphosphonate

17. Disodium Etidronate

18. Ehdp

19. Ehdp, Dicalcium

20. Ethanehydroxydiphosphonate

21. Ethanehydroxyphosphate

22. Etidronate

23. Etidronate, Dicalcium

24. Etidronate, Disodium

25. Etidronate, Sodium

26. Etidronate, Tetrapotassium Salt

27. Etidronic Acid

28. Hedp

29. Hedspa

30. Hydroxyethanediphosphonate

31. Hydroxyethylidene Diphosphonic Acid

32. Phosphonic Acid, (1-hydroxyethylidene)bis-, Disodium Salt

33. Salt Etidronate, Tetrapotassium

34. Sodium Etidronate

35. Tetrapotassium Salt Etidronate

36. Xidifon

37. Xidiphon

38. Xydiphone

2.3.2 Depositor-Supplied Synonyms

1. 7414-83-7

2. Didronel

3. Disodium Etidronate

4. Sodium Etidronate

5. Sodium Ethidronate

6. Sodium Ethydronate

7. Disodium Ethydronate

8. Turpinal 2nz

9. Disodium Ethanol-1,1-diphosphonate

10. Etidronic Acid Disodium Salt

11. Etidronatedisodium

12. Disodium (1-hydroxyethylidene)diphosphonate

13. Phosphonic Acid, (1-hydroxyethylidene)bis-, Disodium Salt

14. Disodium 1-hydroxyethylidene Phosphonate

15. Chebi:4906

16. Hedpa;hedp

17. Disodium Dihydrogen (1-hydroxyethylidene)diphosphonate

18. Disodium Ethane-1-hydroxy-1,1-diphosphonate

19. (1-hydroxyethylidene)diphosphonic Acid, Disodium Salt

20. Etidronic Acid, Disodium Salt

21. 1-hydroxyethylidene-1,1-diphosphonic Acid Disodium Salt

22. (1-hydroxyethane-1,1-diyl)diphosphonic Acid Disodium Salt

23. M16pxg993g

24. Didronel R

25. 1-hydroxyethane-1,1-diphosphonic Acid Disodium Salt

26. Nsc-759157

27. Cas-7414-83-7

28. Dsstox_cid_9671

29. Disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

30. Dsstox_rid_78804

31. Dsstox_gsid_29671

32. Disodium (1-hydroxyethane-1,1-diyl)bis[hydrogen (phosphonate)]

33. Etidronsaeure Dinatriumsalz

34. Etidronate Disodium Hydrate

35. Etidronic Acid Disodium

36. Ncgc00159352-02

37. 29329-71-3

38. Einecs 231-025-7

39. Sm-5600

40. Unii-m16pxg993g

41. Didronel Iv

42. Didronel Pmo

43. Phosphonic Acid, (1-hydroxyethylidene)bis-, Sodium Salt

44. Didronel (tn)

45. Ethane-1-hydroxy-1,1-diphosphonate, Disodium Salt

46. Etidronate Disodium [usan:usp:jan]

47. Mfcd00152567

48. Prestwick_1061

49. Disodium Dihydrogen (1-hydroxyethylidene)bisphosphonate

50. Ethane-1-hydroxy-1,1-diphosphonic Acid, Disodium Salt

51. Phosphonic Acid, (1-hydroxyethylidene)di-, Disodium Salt

52. Disodium Hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

53. Chembl1201042

54. Dtxsid1029671

55. Etidronate Disodium [jan]

56. Etidronate Disodium (jp17/usp)

57. Disodium Etidronate [inci]

58. Etidronate Disodium [usan]

59. Hms1570n07

60. Hms2093p03

61. Hms2097n07

62. Etidronate Disodium [vandf]

63. Bcp22743

64. Etidronate Disodium [mart.]

65. Tox21_111596

66. Bdbm50247999

67. Etidronate Disodium [usp-rs]

68. Etidronate Disodium [who-dd]

69. Phosphonic Acid, P,p'-(1-hydroxyethylidene)bis-, Sodium Salt (1:2)

70. Akos015961949

71. Tox21_111596_1

72. Ac-2078

73. Ccg-213569

74. Ks-1297

75. Nsc 759157

76. Etidronate Disodium [orange Book]

77. Ncgc00017072-01

78. Ncgc00179380-04

79. Be164429

80. Etidronate Disodium [ep Monograph]

81. Etidronic Acid Disodium Salt [mi]

82. Etidronate Disodium [usp Monograph]

83. Disodium 1-hydroxyethane-1,1-diphosphonate

84. D4159

85. Ft-0630369

86. D00314

87. H11387

88. Etidronate Disodium;hedpa Disodium;hedp Disodium

89. A838033

90. Etidronate Disodium Hydrate, >=97% (nmr), Solid

91. W-104431

92. 1-hydroxyethane 1,1-diphosphonic Acid Disodium Salt

93. Disodium Etidronate;sm-5600; Sm-5600; Sm-5600

94. Q27106537

95. Sodium 1-hydroxyethane-1,1-diylbis(hydrogenphosphonate)

96. Disodium [1-[oxidanidyl(oxidanyl)phosphoryl]-1-oxidanyl-ethyl]-oxidanyl-phosphinate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂H₆Na₂O₇P₂
Molecular Weight	249.99 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	249.93841509 g/mol
Monoisotopic Mass	249.93841509 g/mol
Topological Polar Surface Area	141 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	206
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Didronel
Active Ingredient	Etidronate disodium
Dosage Form	Tablet
Route	Oral
Strength	200mg; 400mg
Market Status	Prescription
Company	Procter And Gamble

2 of 4
Drug Name	Etidronate disodium
PubMed Health	Etidronate (By mouth)
Drug Classes	Calcium Regulator
Drug Label	Etidronate disodium tablets, USP contain either 200 mg or 400 mg of etidronate disodium, the disodium salt of (1-hydroxyethylidene) diphosphonic acid, for oral administration. This compound, also known as EHDP, regulates bone metabolism. Etidronate d...
Active Ingredient	Etidronate disodium
Dosage Form	Tablet
Route	Oral
Strength	200mg; 400mg
Market Status	Prescription
Company	Mylan

3 of 4
Drug Name	Didronel
Active Ingredient	Etidronate disodium
Dosage Form	Tablet
Route	Oral
Strength	200mg; 400mg
Market Status	Prescription
Company	Procter And Gamble

4 of 4
Drug Name	Etidronate disodium
PubMed Health	Etidronate (By mouth)
Drug Classes	Calcium Regulator
Drug Label	Etidronate disodium tablets, USP contain either 200 mg or 400 mg of etidronate disodium, the disodium salt of (1-hydroxyethylidene) diphosphonic acid, for oral administration. This compound, also known as EHDP, regulates bone metabolism. Etidronate d...
Active Ingredient	Etidronate disodium
Dosage Form	Tablet
Route	Oral
Strength	200mg; 400mg
Market Status	Prescription
Company	Mylan

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Bone Density Conservation Agents

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)

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