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Chemistry

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Also known as: 10402-53-6, Eprazinone hydrochloride, Eftapan, Resplen, 3-(4-(2-ethoxy-2-phenylethyl)piperazin-1-yl)-2-methyl-1-phenylpropan-1-one dihydrochloride, Mucitux
Molecular Formula
C24H34Cl2N2O2
Molecular Weight
453.4  g/mol
InChI Key
BPMQVOKMMQFZGV-UHFFFAOYSA-N
FDA UNII
394X1L8I9Y

10402-53-6
1 2D Structure

10402-53-6

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one;dihydrochloride
2.1.2 InChI
InChI=1S/C24H32N2O2.2ClH/c1-3-28-23(21-10-6-4-7-11-21)19-26-16-14-25(15-17-26)18-20(2)24(27)22-12-8-5-9-13-22;;/h4-13,20,23H,3,14-19H2,1-2H3;2*1H
2.1.3 InChI Key
BPMQVOKMMQFZGV-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCOC(CN1CCN(CC1)CC(C)C(=O)C2=CC=CC=C2)C3=CC=CC=C3.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
394X1L8I9Y
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(2-phenyl-2-ethoxy)ethyl-4-(2-benzyloxy)propylpiperazine

2. 1-(2-phenyl-2-ethoxy)ethyl-4-(3-phenyl-2-methyl-3-propanone)piperazine

3. 3-(4-(beta-ethoxyphenethyl)-1-piperazinyl)-2-methylpropiophenone

4. 746 Ce

5. Eftapan

6. Eprazinone

7. Eprazinone Dihydrochloride, 3-(14)c-labeled

8. Eprazinone Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 10402-53-6

2. Eprazinone Hydrochloride

3. Eftapan

4. Resplen

5. 3-(4-(2-ethoxy-2-phenylethyl)piperazin-1-yl)-2-methyl-1-phenylpropan-1-one Dihydrochloride

6. Mucitux

7. Eprazinone Hcl

8. Nsc 317935

9. Eprazinone Hydrochloride [jan]

10. Eprazinone (dihydrochloride)

11. Chebi:31551

12. 394x1l8i9y

13. 1-(2-benzoylpropyl)-2-(2-ethoxy-2-phenylethyl)piperazine Dihydrochloride

14. 1-(2-phenyl-2-ethoxy)ethyl-4-(2-benzyloxy)propylpiperazine Dihydrochloride

15. 2-(4-(beta-ethoxyphenethyl)-1-piperazinylmethyl)propiophenone Dihydrochloride

16. Dsstox_cid_26631

17. Dsstox_rid_81779

18. Dsstox_gsid_46631

19. Eprazinone Hydrochloride (jan)

20. 3-(4-(2-ethoxy-2-phenylethyl)piperazin-1-yl)-2-methyl-1-phenylpropan-1-one 2hcl

21. 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one Dihydrochloride

22. Cas-10402-53-6

23. Nsc-317935

24. Ncgc00167445-01

25. Einecs 233-872-8

26. 746 Ce

27. Unii-394x1l8i9y

28. Eprazinone Dihcl

29. Resplen (tn)

30. Eprazinonedihydrochloride

31. 1-propanone, 3-(4-(2-ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-, Dihydrochloride

32. 3-(4-(2-ethoxy-2-phenylethyl)-1-piperazinyl)-2-methyl-1-phenyl-1-propanone Dihydrochloride

33. 3-(4-(beta-ethoxyphenethyl)-1-piperazinyl)-2-methyl-1-propiophenone Dihydrochloride

34. Chembl2359721

35. Dtxsid1046631

36. Schembl21807703

37. Hy-b2078a

38. Bcp13485

39. Tox21_112449

40. Mfcd01695215

41. S4137

42. Akos016008437

43. Tox21_112449_1

44. Ac-8087

45. Ccg-269264

46. Ds-3924

47. Eprazinone Dihydrochloride [mi]

48. 3-(4-(beta-ethoxyphenethyl)-1-piperazinyl)-2-methylpropiophenone Dihydrochloride

49. Eprazinone Hydrochloride [mart.]

50. Propiophenone, 2-(4-(beta-ethoxyphenethyl)-1-piperazinyl)methyl-, Dihydrochloride

51. Eprazinone Hydrochloride [who-dd]

52. Ncgc00167445-02

53. Cs-0019683

54. D01106

55. 402e536

56. A896306

57. Q27104199

58. 1-(2-ethoxy-2-phenylethyl)-4-(2-methyl-3-oxo-3-phenylpropyl)piperazinediium Dichloride

59. 3-(4-(.beta.-ethoxyphenethyl)piperazin-1-yl)-2-methylpropiophenone Dihydrochloride

60. 1-(2-benzoylpropyl)-4-(2-ethoxy-2-phenylethyl)piperazine Dihydrochloride; 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-one Dihydrochloride;eprazinone 2hcl

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 453.4 g/mol
Molecular Formula C24H34Cl2N2O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass452.1997337 g/mol
Monoisotopic Mass452.1997337 g/mol
Topological Polar Surface Area32.8 Ų
Heavy Atom Count30
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Expectorants

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)


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10402-53-6 Manufacturers

A 10402-53-6 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 10402-53-6, including repackagers and relabelers. The FDA regulates 10402-53-6 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 10402-53-6 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

10402-53-6 Suppliers

A 10402-53-6 supplier is an individual or a company that provides 10402-53-6 active pharmaceutical ingredient (API) or 10402-53-6 finished formulations upon request. The 10402-53-6 suppliers may include 10402-53-6 API manufacturers, exporters, distributors and traders.

click here to find a list of 10402-53-6 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

10402-53-6 JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The 10402-53-6 Drug Master File in Japan (10402-53-6 JDMF) empowers 10402-53-6 API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the 10402-53-6 JDMF during the approval evaluation for pharmaceutical products. At the time of 10402-53-6 JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of 10402-53-6 suppliers with JDMF on PharmaCompass.

10402-53-6 GMP

10402-53-6 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 10402-53-6 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 10402-53-6 GMP manufacturer or 10402-53-6 GMP API supplier for your needs.

10402-53-6 CoA

A 10402-53-6 CoA (Certificate of Analysis) is a formal document that attests to 10402-53-6's compliance with 10402-53-6 specifications and serves as a tool for batch-level quality control.

10402-53-6 CoA mostly includes findings from lab analyses of a specific batch. For each 10402-53-6 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

10402-53-6 may be tested according to a variety of international standards, such as European Pharmacopoeia (10402-53-6 EP), 10402-53-6 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (10402-53-6 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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