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Chemistry

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Also known as: 111indium trichloride, Indium chloride in-111, Indium chloride (111incl3), Indium in-111 chloride, 50800-85-6, Unii-58td96h03i
Molecular Formula
Cl3In
Molecular Weight
217.26  g/mol
InChI Key
PSCMQHVBLHHWTO-FZTWWWDYSA-K

111Indium Trichloride
Indium In-111 Chloride is a radioactive salt that is used as a reagent in the preparation of indium 111-labeled radiopharmaceuticals. Indium 111-labeled radioconjugates are used as radioactive tracers in nuclear medicine that detect malignant lesions and inflammatory tissues probably due to an increased capillary permeability. Indium-111 chloride is particularly used in the radiolabeling of the monoclonal antibodies satumomab pendetide, 7E11-C5.3 (CYT-356), and ibritumomab tiuxetan. (NCI05)
1 2D Structure

111Indium Trichloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
trichloro(111In)indigane
2.1.2 InChI
InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
2.1.3 InChI Key
PSCMQHVBLHHWTO-FZTWWWDYSA-K
2.1.4 Canonical SMILES
Cl[In](Cl)Cl
2.1.5 Isomeric SMILES
Cl[111In](Cl)Cl
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. 111indium Trichloride

2. Indium Chloride In-111

3. Indium Chloride (111incl3)

4. Indium In-111 Chloride

5. 50800-85-6

6. Unii-58td96h03i

7. Dtxsid90965038

8. Db09490

9. Q27098008

2.3 Create Date
2010-12-22
3 Chemical and Physical Properties
Molecular Weight 217.26 g/mol
Molecular Formula Cl3In
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass215.81167 g/mol
Monoisotopic Mass215.81167 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count4
Formal Charge0
Complexity8
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure


5 Pharmacology and Biochemistry
5.1 Pharmacology

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone


5.2 Absorption, Distribution and Excretion

Absorption

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone


Route of Elimination

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone


Volume of Distribution

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone


Clearance

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone


5.3 Metabolism/Metabolites

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone


5.4 Biological Half-Life

2.8 days


5.5 Mechanism of Action

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone


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