Find 111Indium Trichloride manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 111indium trichloride, Indium chloride in-111, Indium chloride (111incl3), Indium in-111 chloride, 50800-85-6, Unii-58td96h03i
Molecular Formula
Cl3In
Molecular Weight
217.26  g/mol
InChI Key
PSCMQHVBLHHWTO-FZTWWWDYSA-K

111Indium Trichloride
Indium In-111 Chloride is a radioactive salt that is used as a reagent in the preparation of indium 111-labeled radiopharmaceuticals. Indium 111-labeled radioconjugates are used as radioactive tracers in nuclear medicine that detect malignant lesions and inflammatory tissues probably due to an increased capillary permeability. Indium-111 chloride is particularly used in the radiolabeling of the monoclonal antibodies satumomab pendetide, 7E11-C5.3 (CYT-356), and ibritumomab tiuxetan. (NCI05)
1 2D Structure

111Indium Trichloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
trichloro(111In)indigane
2.1.2 InChI
InChI=1S/3ClH.In/h3*1H;/q;;;+3/p-3/i;;;1-4
2.1.3 InChI Key
PSCMQHVBLHHWTO-FZTWWWDYSA-K
2.1.4 Canonical SMILES
Cl[In](Cl)Cl
2.1.5 Isomeric SMILES
Cl[111In](Cl)Cl
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. 111indium Trichloride

2. Indium Chloride In-111

3. Indium Chloride (111incl3)

4. Indium In-111 Chloride

5. 50800-85-6

6. Unii-58td96h03i

7. Dtxsid90965038

8. Db09490

9. Q27098008

2.3 Create Date
2010-12-22
3 Chemical and Physical Properties
Molecular Weight 217.26 g/mol
Molecular Formula Cl3In
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass215.81167 g/mol
Monoisotopic Mass215.81167 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count4
Formal Charge0
Complexity8
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Indium In-111 Chloride is indicated for radio labeling of monoclonal antibodies in preparations used for in vivo diagnostic imaging procedures. Indiclor is also indicated for radiolabeling Zevalin in preparations used for radio immunotherapy procedure


5 Pharmacology and Biochemistry
5.1 Pharmacology

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its pharmacodynamics is related to the final product and not specific to Indium In-111 Chloride alone


5.2 Absorption, Distribution and Excretion

Absorption

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its absoption is related to the final product and not specific to Indium In-111 Chloride alone


Route of Elimination

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Itsroute of elimination is related to the final product and not specific to Indium In-111 Chloride alone


Volume of Distribution

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its volume of distribution is related to the final product and not specific to Indium In-111 Chloride alone


Clearance

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its clearance is related to the final product and not specific to Indium In-111 Chloride alone


5.3 Metabolism/Metabolites

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its metabolism is related to the final product and not specific to Indium In-111 Chloride alone


5.4 Biological Half-Life

2.8 days


5.5 Mechanism of Action

Indium In-111 Chloride is a radioactive tracer for labeling monoclonal antibodies in certain preparations such as OncoScint, ProstaScint and Zevalin. Its mechanism of action is related to the final product and not specific to Indium In-111 Chloride alone


ABOUT THIS PAGE

111Indium Trichloride Manufacturers

A 111Indium Trichloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 111Indium Trichloride, including repackagers and relabelers. The FDA regulates 111Indium Trichloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 111Indium Trichloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

111Indium Trichloride Suppliers

A 111Indium Trichloride supplier is an individual or a company that provides 111Indium Trichloride active pharmaceutical ingredient (API) or 111Indium Trichloride finished formulations upon request. The 111Indium Trichloride suppliers may include 111Indium Trichloride API manufacturers, exporters, distributors and traders.

click here to find a list of 111Indium Trichloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

111Indium Trichloride USDMF

A 111Indium Trichloride DMF (Drug Master File) is a document detailing the whole manufacturing process of 111Indium Trichloride active pharmaceutical ingredient (API) in detail. Different forms of 111Indium Trichloride DMFs exist exist since differing nations have different regulations, such as 111Indium Trichloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A 111Indium Trichloride DMF submitted to regulatory agencies in the US is known as a USDMF. 111Indium Trichloride USDMF includes data on 111Indium Trichloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 111Indium Trichloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of 111Indium Trichloride suppliers with USDMF on PharmaCompass.

111Indium Trichloride GMP

111Indium Trichloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 111Indium Trichloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 111Indium Trichloride GMP manufacturer or 111Indium Trichloride GMP API supplier for your needs.

111Indium Trichloride CoA

A 111Indium Trichloride CoA (Certificate of Analysis) is a formal document that attests to 111Indium Trichloride's compliance with 111Indium Trichloride specifications and serves as a tool for batch-level quality control.

111Indium Trichloride CoA mostly includes findings from lab analyses of a specific batch. For each 111Indium Trichloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

111Indium Trichloride may be tested according to a variety of international standards, such as European Pharmacopoeia (111Indium Trichloride EP), 111Indium Trichloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (111Indium Trichloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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