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Chemistry

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Also known as: Invanz, 153773-82-1, Ertapenem sodium salt, Mk-826, Chebi:60070, Mk-0826
Molecular Formula
C22H24N3NaO7S
Molecular Weight
497.5  g/mol
InChI Key
ZXNAQFZBWUNWJM-HRXMHBOMSA-M

153773-82-1
A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of Gram-positive and Gram-negative bacterial infections including intra-abdominal infections, acute gynecological infections, complicated urinary tract infections, skin infections, and respiratory tract infections. It is also used to prevent infection in colorectal surgery.
1 2D Structure

153773-82-1

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;3-[[(2S,4S)-4-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl]pyrrolidine-2-carbonyl]amino]benzoate
2.1.2 InChI
InChI=1S/C22H25N3O7S.Na/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30;/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32);/q;+1/p-1/t9-,10-,13+,14+,15-,16-;/m1./s1
2.1.3 InChI Key
ZXNAQFZBWUNWJM-HRXMHBOMSA-M
2.1.4 Canonical SMILES
CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)NC4=CC=CC(=C4)C(=O)[O-])C(=O)O)C(C)O.[Na+]
2.1.5 Isomeric SMILES
C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)NC4=CC=CC(=C4)C(=O)[O-])C(=O)O)[C@@H](C)O.[Na+]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Ertapenem

2. Invanoz

3. Invanz

2.2.2 Depositor-Supplied Synonyms

1. Invanz

2. 153773-82-1

3. Ertapenem Sodium Salt

4. Mk-826

5. Chebi:60070

6. Mk-0826

7. L-749345

8. Invanz (tn)

9. Ertapenem Sodium (usan)

10. Chembl1232

11. Schembl102761

12. Bdbm50248009

13. Mfcd09475566

14. Cs-8020

15. Zd-4433

16. As-84039

17. Hy-13625

18. D04049

19. Sodium 3-((2s,4s)-4-(((4r,5s,6s)-2-carboxy-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)pyrrolidine-2-carboxamido)benzoate

20. Sodium 3-[(2s,4s)-4-{[(4r,5s,6s)-2-carboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl}pyrrolidine-2-amido]benzoate

21. Sodium;3-[[(2s,4s)-4-[[(4r,5s,6s)-2-carboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl]pyrrolidine-2-carbonyl]amino]benzoate

2.3 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 497.5 g/mol
Molecular Formula C22H24N3NaO7S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass497.12326557 g/mol
Monoisotopic Mass497.12326557 g/mol
Topological Polar Surface Area184 Ų
Heavy Atom Count34
Formal Charge0
Complexity900
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

* Treatment:

Treatment of the following infections when caused by bacteria known or very likely to be susceptible to ertapenem and when parenteral therapy is required:

- intra-abdominal infections;

- community-acquired pneumonia;

- acute gynaecological infections;

- diabetic foot infections of the skin and soft tissue.

* Prevention:

Invanz is indicated in adults for the prophylaxis of surgical site infection following elective colorectal surgery.

Consideration should be given to official guidance on the appropriate use of antibacterial agents.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Penem Antibacterial [EPC]; Carbapenems [CS]
5.3 ATC Code

J01DH03


ABOUT THIS PAGE

153773-82-1 Manufacturers

A 153773-82-1 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 153773-82-1, including repackagers and relabelers. The FDA regulates 153773-82-1 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 153773-82-1 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

153773-82-1 Suppliers

A 153773-82-1 supplier is an individual or a company that provides 153773-82-1 active pharmaceutical ingredient (API) or 153773-82-1 finished formulations upon request. The 153773-82-1 suppliers may include 153773-82-1 API manufacturers, exporters, distributors and traders.

153773-82-1 GMP

153773-82-1 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 153773-82-1 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 153773-82-1 GMP manufacturer or 153773-82-1 GMP API supplier for your needs.

153773-82-1 CoA

A 153773-82-1 CoA (Certificate of Analysis) is a formal document that attests to 153773-82-1's compliance with 153773-82-1 specifications and serves as a tool for batch-level quality control.

153773-82-1 CoA mostly includes findings from lab analyses of a specific batch. For each 153773-82-1 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

153773-82-1 may be tested according to a variety of international standards, such as European Pharmacopoeia (153773-82-1 EP), 153773-82-1 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (153773-82-1 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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