DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

10 Drugs in Development

10 Drugs in Development

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

10DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 177lu-tetraxetan-hh1, 177lu-dota-hh1, Unii-054zp16k2q, 054zp16k2q, Who 10078, Lutetium (lu177) lilotomab satetraxetan

Molecular Formula

C₃₀H₄₄LuN₇O₁₀S

Molecular Weight

871.7 g/mol

InChI Key

JKXKGIYHPWESMW-NARNYJRYSA-K

Lutetium Lu 177 Lilotomab-satetraxetan is a radioconjugate consisting of lilotomab, a murine immunoglobulin G1 (IgG1) antibody directed against the CD37 antigen, conjugated via the chelating agent 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-tetraacetic acid (p-SCN-Bn-DOTA) with potential antineoplastic activities. Upon administration of lutetium Lu 177 lilotomab-satetraxetan, the lilotomab moiety binds to CD37 expressed on certain tumor cells. Upon binding, lutetium Lu 177 lilotomab-satetraxetan delivers a cytotoxic dose of beta radiation to CD37-expressing cells. CD37 is a transmembrane glycoprotein expressed at high-levels on B-cells and to a lesser extent on T-cells and myeloid cells, and is frequently overexpressed in certain B-cell lymphomas.

1 2D Structure

177Lu Lilotomab Satetraxetan

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-2-amino-6-[[4-[[(2R)-1,4,7,10-tetrakis(carboxylatomethyl)-1,4,7,10-tetrazacyclododec-2-yl]methyl]phenyl]carbamothioylamino]hexanoate;hydron;lutetium-177(3+)

2.1.2 InChI

InChI=1S/C30H47N7O10S.Lu/c31-24(29(46)47)3-1-2-8-32-30(48)33-22-6-4-21(5-7-22)15-23-16-36(19-27(42)43)12-11-34(17-25(38)39)9-10-35(18-26(40)41)13-14-37(23)20-28(44)45;/h4-7,23-24H,1-3,8-20,31H2,(H,38,39)(H,40,41)(H,42,43)(H,44,45)(H,46,47)(H2,32,33,48);/q;+3/p-3/t23-,24+;/m1./s1/i;1+2

2.1.3 InChI Key

JKXKGIYHPWESMW-NARNYJRYSA-K

2.1.4 Canonical SMILES

[H+].[H+].C1CN(CCN(C(CN(CCN1CC(=O)[O-])CC(=O)[O-])CC2=CC=C(C=C2)NC(=S)NCCCCC(C(=O)[O-])N)CC(=O)[O-])CC(=O)[O-].[Lu+3]

2.1.5 Isomeric SMILES

[H+].[H+].C1CN(CCN([C@@H](CN(CCN1CC(=O)[O-])CC(=O)[O-])CC2=CC=C(C=C2)NC(=S)NCCCC[C@@H](C(=O)[O-])N)CC(=O)[O-])CC(=O)[O-].[177Lu+3]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 177lu-dota-hh1

2. 177lu-tetraxetan-tetulomab

3. 177lu-tetulomab

4. Betalutin

5. Tetulomab Tetraxetan Lu-177

2.2.2 Depositor-Supplied Synonyms

1. 177lu-tetraxetan-hh1

2. 177lu-dota-hh1

3. Unii-054zp16k2q

4. 054zp16k2q

5. Who 10078

6. Lutetium (lu177) Lilotomab Satetraxetan

7. Lutetium (177lu) Lilotomab Satetraxetan [inn]

8. Lutetium (lu177) Lilotomab Satetraxetan [usan]

9. 1453362-90-7

10. Immunoglobulin G1-kappa, Anti-(homo Sapiens Cd37 (tspan26, Tetraspanin-26)), Mus Musculus Monoclonal Antibody, Lutetium (lu 177) Radiolabelled Satetraxetan (dota Derivative) Conjugate

2.3 Create Date

2018-05-07

3 Chemical and Physical Properties

Molecular Formula	C₃₀H₄₄LuN₇O₁₀S
Molecular Weight	871.7 g/mol
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	12
Exact Mass	871.23080 g/mol
Monoisotopic Mass	871.23080 g/mol
Topological Polar Surface Area	296 Å²
Heavy Atom Count	49
Formal Charge	0
Complexity	1050
Isotope Atom Count	1
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4