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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 8 USDMF, 6 CEP/COS, 1 JDMF, 1 EU WC, 18 NDC API, 1 VMF, 11 Listed Suppliers, $ API Reference Price

15 API Suppliers
8 USDMF
6 CEP/COS
1 JDMF
1 EU WC
18 NDC API
1 VMF
11 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

123 Drugs in Development

123 Drugs in Development

FINISHED DOSAGE FORMULATIONS

63 FDF Dossiers, 18 FDA Orange Book, 11 Europe, 8 Canada, 6 South Africa, 20 Listed Dossiers

63 FDF Dossiers
18 FDA Orange Book
11 Europe
8 Canada
6 South Africa
20 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - EQ 100MG BASE/ML, INJECTABLE;INJECTION - EQ 10MG BASE/ML, INJECTABLE;INJECTION - EQ 50MG BASE/ML

drugProductComposition
INJECTABLE;INJECTION - EQ 100MG BASE/ML
INJECTABLE;INJECTION - EQ 10MG BASE/ML
INJECTABLE;INJECTION - EQ 50MG BASE/ML

RELATED EXCIPIENT COMPANIES

2 Nanjing Well Pharmaceutical, 3 Actylis, 1 BASF, 1 Finar, 1 Kerry, 1 Valens Pharmachem

relatedExcipients
2 Nanjing Well Pharmaceutical
3 Actylis
1 BASF
1 Finar
1 Kerry
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

4 Parenteral, 4 Solubilizers, 3 Topical, 2 Film Formers & Plasticizers, 2 Emulsifying Agents, 1 Coating Systems & Additives, 1 Controlled & Modified Release, 1 Thickeners and Stabilizers

excipientsByApplications
4 Parenteral
4 Solubilizers
3 Topical
2 Film Formers & Plasticizers
2 Emulsifying Agents
1 Coating Systems & Additives
1 Controlled & Modified Release
1 Thickeners and Stabilizers

DIGITAL CONTENT

100 NEWS #PharmaBuzz

media
100 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

7 Finished Drug Prices

globalSalesInformation
7 Finished Drug Prices

MARKET PLACE

11 APIs, 7 FDF Dossiers

marketPlace
11 APIs
7 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM , 2 USP , 2 Others

otherSolutions
2 EDQM
2 USP
2 Others

ANALYTICAL

1 Analytical Methods

otherMethods
1 Analytical Methods

Seqens Ketamine Hydrochloride

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

100

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

18EXCIPIENTS BY APPLICATIONS

Chemistry

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Click the button for full data set

Also known as: 1867-66-9, Vetalar, Ketaset, Ketalar, Ketamine hcl, Ketanest

Molecular Formula

C₁₃H₁₇Cl₂NO

Molecular Weight

274.18 g/mol

InChI Key

VCMGMSHEPQENPE-UHFFFAOYSA-N

FDA UNII

O18YUO0I83

A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.

1 2D Structure

Ketamine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C13H16ClNO.ClH/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14;/h2-3,6-7,15H,4-5,8-9H2,1H3;1H

2.1.3 InChI Key

VCMGMSHEPQENPE-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CNC1(CCCCC1=O)C2=CC=CC=C2Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

O18YUO0I83

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone

2. Calipsol

3. Calypsol

4. Ci 581

5. Ci-581

6. Ci581

7. Kalipsol

8. Ketalar

9. Ketamine

10. Ketanest

11. Ketaset

2.3.2 Depositor-Supplied Synonyms

1. 1867-66-9

2. Vetalar

3. Ketaset

4. Ketalar

5. Ketamine Hcl

6. Ketanest

7. Ketolar

8. 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

9. Cl 369

10. Cn-52,372-2

11. (+-)-ketamine Hydrochloride

12. Ci-581

13. Ketamine Hydrochloride Ciii

14. Ketamine (as Hydrochloride)

15. O18yuo0i83

16. Calipsol

17. Kalipsol

18. Ketavet

19. (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

20. Cl-369

21. Dea No. 7285

22. Cn-523722

23. 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one;hydrochloride

24. Cn-52372-2

25. Ketamine Chloride

26. Ketavet 100

27. Ketavet (veterinary)

28. Ci 581

29. Chebi:650657

30. Einecs 217-484-6

31. Unii-o18yuo0i83

32. Ketalar (tn)

33. Ketamini Hydrochloridum

34. Ketamine Hydrochloride [usan:usp:jan]

35. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride

36. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+-)-

37. Ec 217-484-6

38. Chembl1714

39. Schembl26999

40. Dtxsid4040137

41. Ketamine Hydrochloride [mi]

42. 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one Hydrochloride

43. Bcp25943

44. Ketamine Hydrochloride (jp17/usp)

45. Ketamine Hydrochloride [jan]

46. (+/-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone Hydrochloride

47. Ketamine Hydrochloride [usan]

48. Nsc116131

49. (+/-)-ketamine Hydrochloride, Solid

50. Ketamine Hydrochloride [vandf]

51. Akos005287313

52. Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+-)-

53. Ketamine Hydrochloride [mart.]

54. Ab02117

55. Ketamine Hydrochloride [who-dd]

56. Ketamine Hydrochloride [who-ip]

57. Nsc-116131

58. Ketamine Hydrochloride [green Book]

59. Db-044614

60. Db-048467

61. Ketamine Hydrochloride [ep Impurity]

62. Ketamine Hydrochloride [orange Book]

63. Ketamine Hydrochloride [ep Monograph]

64. Ketamine Hydrochloride Ciii [usp-rs]

65. Ketamine Hydrochloride [usp Monograph]

66. Ketamini Hydrochloridum [who-ip Latin]

67. C07843

68. D00711

69. 867k669

70. A813079

71. Q-201266

72. Q27105184

73. Ketamine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

74. 2-(2-chlorophenyl)-2-(methylamino)-1-cyclohexanone Hydrochloride

75. Ketamine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

76. Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, Hydrochloride (1:1)

77. Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, Hydrochloride, (+/-)-

78. Ketamine (+-)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanonehydrochloride

79. Ketamine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₁₇Cl₂NO
Molecular Weight	274.18 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	273.0687196 g/mol
Monoisotopic Mass	273.0687196 g/mol
Topological Polar Surface Area	29.1 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	269
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Ketalar
Drug Label	Ketalar is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrat...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Par Sterile Products

2 of 4
Drug Name	Ketamine hydrochloride
PubMed Health	Ketamine (Injection)
Drug Label	Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injectio...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Hospira; Mylan Institutional; Eurohlth Intl

3 of 4
Drug Name	Ketalar
Drug Label	Ketalar is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injection in concentrat...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Par Sterile Products

4 of 4
Drug Name	Ketamine hydrochloride
PubMed Health	Ketamine (Injection)
Drug Label	Ketamine hydrochloride is a nonbarbiturate anesthetic chemically designated dl 2-(0-chlorophenyl)-2-(methylamino) cyclohexanone hydrochloride. It is formulated as a slightly acid (pH 3.5-5.5) sterile solution for intravenous or intramuscular injectio...
Active Ingredient	Ketamine hydrochloride
Dosage Form	Injectable
Route	Injection
Strength	eq 10mg base/ml; eq 50mg base/ml; eq 100mg base/ml
Market Status	Prescription
Company	Hospira; Mylan Institutional; Eurohlth Intl

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anesthetics, Dissociative

Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) (See all compounds classified as Anesthetics, Dissociative.)

Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)

Excitatory Amino Acid Antagonists

Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

General Anesthetic [EPC]; General Anesthesia [PE]

API SUPPLIERS

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USDMF

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JDMF

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EU WC

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NDC API

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VMF

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Listed Suppliers

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API Reference Price

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