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    Chemistry

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    Also known as: 69-09-0, Chlorpromazine hcl, Sonazine, Chloractil, Klorproman, Klorpromex
    Molecular Formula
    C17H20Cl2N2S
    Molecular Weight
    355.3  g/mol
    InChI Key
    FBSMERQALIEGJT-UHFFFAOYSA-N
    FDA UNII
    9WP59609J6
    Chlorpromazine Hydrochloride
    The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
    1 2D Structure

    Chlorpromazine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine;hydrochloride
    2.1.2 InChI
    InChI=1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H
    2.1.3 InChI Key
    FBSMERQALIEGJT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    9WP59609J6
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aminazine

    2. Chlorazine

    3. Chlordelazine

    4. Chlorpromazine

    5. Contomin

    6. Fenactil

    7. Hydrochloride, Chlorpromazine

    8. Largactil

    9. Propaphenin

    10. Thorazine

    2.3.2 Depositor-Supplied Synonyms

    1. 69-09-0

    2. Chlorpromazine Hcl

    3. Sonazine

    4. Chloractil

    5. Klorproman

    6. Klorpromex

    7. Marazine

    8. Norcozine

    9. Promacid

    10. Hebanil

    11. Promapar

    12. Hybernal

    13. Lomazine

    14. Neurazine

    15. Plegomazin

    16. Promachel

    17. Promexin

    18. Taroctyl

    19. Tranzine

    20. Hibernal

    21. Unitensen

    22. Nci-c05210

    23. Chlorpromazine (hydrochloride)

    24. Aminazin Monohydrochloride

    25. Fenactil Monohydrochloride

    26. Chloropromazine Monohydrochloride

    27. Ampliactil Monohydrochloride

    28. Hibanil

    29. Chlorpromazinium Chloride

    30. Chlorpromazine Monohydrochloride

    31. [3-(2-chloro-10h-phenothiazin-10-yl)propyl]-dimethylamine Hydrochloride

    32. Chloropromazine Hydrochloride

    33. Propaphen

    34. 10-(3-dimethylaminopropyl)-2-chlorophenothiazine Monohydrochloride

    35. Thorazine Hydrochloride

    36. 3-(2-chlorophenothiazin-10-yl)-n,n-dimethylpropan-1-amine;hydrochloride

    37. 3-(2-chloro-10h-phenothiazin-10-yl)-n,n-dimethylpropan-1-amine Hydrochloride

    38. Mls000069401

    39. Chebi:3649

    40. 2-chloro-10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride

    41. 10h-phenothiazine-10-propanamine, 2-chloro-n,n-dimethyl-, Monohydrochloride

    42. Nsc-17479

    43. 9wp59609j6

    44. 69-09-0 (hcl)

    45. Aminazinum

    46. Megatil

    47. Smr000058254

    48. 2-chloro-10-(3-dimethylaminopropyl)phenothiazine Hydrochloride

    49. 4560 Rp Hydrochloride

    50. Chlorpromazine, Hydrochloride

    51. Contomin Hydrochloride

    52. Megaphen Hydrochloride

    53. Phenothiazine Hydrochloride

    54. Largactil Monohydrochloride

    55. Cpz (van)

    56. Nsc17479

    57. Ccris 6221

    58. [3-(2-chloro-10h-phenothiazin-10-yl)propyl]dimethylamine Hydrochloride

    59. Cas-69-09-0

    60. Sr-01000000012

    61. Einecs 200-701-3

    62. Nsc 17479

    63. Chloropromazin Hydrochloride

    64. Largaktyl

    65. Ai3-28023

    66. Unii-9wp59609j6

    67. Prestwick_58

    68. Sonazine (tn)

    69. Chlorpromazine Hydrochloride Intensol

    70. Mfcd00012654

    71. Chlorpromazine Chloride

    72. Ac1lcwf1

    73. Chlorpromazine Hydrochloride [usp:ban:jan]

    74. Opera_id_1294

    75. Dsstox_cid_4827

    76. Chlorpromazini Hydrochloridum

    77. Chembl1713

    78. Dsstox_rid_77545

    79. Dsstox_gsid_24827

    80. Schembl41771

    81. Mls001148603

    82. Mls002222157

    83. Chlorpromazin-d6 Hydrochloride

    84. Dtxsid7024827

    85. Hy-b0407a

    86. Chlorpromazine Hydrochloride, 98%

    87. Hms1568m09

    88. Bcp30284

    89. Tox21_300517

    90. Tox21_500249

    91. Nsc226514

    92. S2456

    93. Akos005111082

    94. Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, Monohydrochloride

    95. Ccg-220064

    96. Ccg-221553

    97. Chlorpromazine-[13c,d3] Hydrochloride

    98. Lp00249

    99. Nc00552

    100. 7-[diethylamino]coumarin-3-carbonylazide

    101. Chlorpromazine Hydrochloride (jp17/usp)

    102. Chlorpromazine Hydrochloride [mi]

    103. Ncgc00024409-09

    104. Ncgc00093711-01

    105. Ncgc00093711-02

    106. Ncgc00180973-01

    107. Ncgc00254272-01

    108. Ncgc00260934-01

    109. Ac-10573

    110. Chlorpromazine Hydrochloride [jan]

    111. Ls-14587

    112. Chlorpromazine Hydrochloride [mart.]

    113. Chlorpromazine Hydrochloride [vandf]

    114. C-165

    115. Chlorpromazine Hydrochloride [usp-rs]

    116. Chlorpromazine Hydrochloride [who-dd]

    117. Chlorpromazine Hydrochloride [who-ip]

    118. Chlorpromazine Hydrochloride, >=98% (tlc)

    119. Eu-0100249

    120. Ft-0623715

    121. Ft-0665009

    122. Sw196373-5

    123. C 8138

    124. C07952

    125. Chlorpromazine, Hydrochloride - Cas 69-09-0

    126. D00789

    127. D89519

    128. Mls-0090820.0001

    129. Chlorpromazine Hydrochloride [green Book]

    130. Wln: T C666 Bn Isj B3n1&1 Eg &gh

    131. 012c654

    132. Chlorpromazine Hydrochloride [ep Impurity]

    133. Chlorpromazine Hydrochloride [ep Monograph]

    134. Chlorpromazine Hydrochloride [orange Book]

    135. Chlorpromazine Hydrochloride [usp Monograph]

    136. Chlorpromazini Hydrochloridum [who-ip Latin]

    137. Q-200842

    138. Sr-01000000012-2

    139. Sr-01000000012-9

    140. Chlorpromazine Hydrochloride 100 Microg/ml In Methanol

    141. Q27106159

    142. Z1259155914

    143. 2-chloro-10-(3-dimethylaminopropyl) Phenothiazine Hydrochloride

    144. Chlorpromazine Hydrochloride, Meets Usp Testing Specifications

    145. Chlorpromazine Hydrochloride, Vetranal(tm), Analytical Standard

    146. 2-chloro-10-(3-dimethylaminopropyl)phenothiazine Monohydrochloride

    147. 2-chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride

    148. Chlorpromazine Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    149. 10h-phenothiazine-10-propanamine Hydrochloride, 2-chloro-n,n-dimethyl-

    150. 3-(2-chlorophenothiazin-10-yl)-n,n-dimethylpropan-1-amine;hydrochloride.

    151. Chlorpromazine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    152. 10h-phenothiazine-10-propanamine, 2-chloro-n,n-dimethyl-, Hydrochloride (1:1)

    153. Chlorpromazine Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    154. Chlorpromazine Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.3.3 Other Synonyms

    1. 2-chlorophenothiazine

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 355.3 g/mol
    Molecular Formula C17H20Cl2N2S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass354.0724252 g/mol
    Monoisotopic Mass354.0724252 g/mol
    Topological Polar Surface Area31.8 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity339
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameChlorpromazine hydrochloride
    Drug LabelDESCRIPTION Chlorpromazine hydrochloride, a dimethylamine derivative of phenothiazine, has a chemical formula of 2-chloro-10-[3(-dimethylamino) propyl] phenothiazine monohydochloride. It is available in tablets for oral administration. It has the fol...
    Active IngredientChlorpromazine hydrochloride
    Dosage FormInjectable; Tablet
    RouteInjection; Oral
    Strength25mg/ml; 200mg; 100mg; 25mg; 50mg; 10mg
    Market StatusPrescription
    CompanyHikma Maple; Usl Pharma; Sandoz

    2 of 2  
    Drug NameChlorpromazine hydrochloride
    Drug LabelDESCRIPTION Chlorpromazine hydrochloride, a dimethylamine derivative of phenothiazine, has a chemical formula of 2-chloro-10-[3(-dimethylamino) propyl] phenothiazine monohydochloride. It is available in tablets for oral administration. It has the fol...
    Active IngredientChlorpromazine hydrochloride
    Dosage FormInjectable; Tablet
    RouteInjection; Oral
    Strength25mg/ml; 200mg; 100mg; 25mg; 50mg; 10mg
    Market StatusPrescription
    CompanyHikma Maple; Usl Pharma; Sandoz

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Antiemetics

    Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phenothiazines [CS]; Phenothiazine [EPC]

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    06-Jan-2021
    20-Dec-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - INJECTABLE;INJECTION - 25MG/ML

    USFDA APPLICATION NUMBER - 83329

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    DOSAGE - TABLET;ORAL - 10MG

    USFDA APPLICATION NUMBER - 83386

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    DOSAGE - TABLET;ORAL - 25MG

    USFDA APPLICATION NUMBER - 84112

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    USFDA APPLICATION NUMBER - 84113

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    DOSAGE - TABLET;ORAL - 100MG

    USFDA APPLICATION NUMBER - 84114

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    DOSAGE - TABLET;ORAL - 200MG

    USFDA APPLICATION NUMBER - 84115

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    ABOUT THIS PAGE

    Looking for 69-09-0 / Chlorpromazine Hydrochloride API manufacturers, exporters & distributors?

    Chlorpromazine Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Chlorpromazine Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Chlorpromazine Hydrochloride manufacturer or Chlorpromazine Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Chlorpromazine Hydrochloride manufacturer or Chlorpromazine Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Chlorpromazine Hydrochloride API Price utilized in the formulation of products. Chlorpromazine Hydrochloride API Price is not always fixed or binding as the Chlorpromazine Hydrochloride Price is obtained through a variety of data sources. The Chlorpromazine Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Chlorpromazine Hydrochloride

    Synonyms

    69-09-0, Chlorpromazine hcl, Sonazine, Chloractil, Klorproman, Klorpromex

    Cas Number

    69-09-0

    Unique Ingredient Identifier (UNII)

    9WP59609J6

    About Chlorpromazine Hydrochloride

    The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

    2-Chlorophenothiazine Manufacturers

    A 2-Chlorophenothiazine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 2-Chlorophenothiazine, including repackagers and relabelers. The FDA regulates 2-Chlorophenothiazine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 2-Chlorophenothiazine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of 2-Chlorophenothiazine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    2-Chlorophenothiazine Suppliers

    A 2-Chlorophenothiazine supplier is an individual or a company that provides 2-Chlorophenothiazine active pharmaceutical ingredient (API) or 2-Chlorophenothiazine finished formulations upon request. The 2-Chlorophenothiazine suppliers may include 2-Chlorophenothiazine API manufacturers, exporters, distributors and traders.

    click here to find a list of 2-Chlorophenothiazine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    2-Chlorophenothiazine USDMF

    A 2-Chlorophenothiazine DMF (Drug Master File) is a document detailing the whole manufacturing process of 2-Chlorophenothiazine active pharmaceutical ingredient (API) in detail. Different forms of 2-Chlorophenothiazine DMFs exist exist since differing nations have different regulations, such as 2-Chlorophenothiazine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A 2-Chlorophenothiazine DMF submitted to regulatory agencies in the US is known as a USDMF. 2-Chlorophenothiazine USDMF includes data on 2-Chlorophenothiazine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 2-Chlorophenothiazine USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of 2-Chlorophenothiazine suppliers with USDMF on PharmaCompass.

    2-Chlorophenothiazine JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The 2-Chlorophenothiazine Drug Master File in Japan (2-Chlorophenothiazine JDMF) empowers 2-Chlorophenothiazine API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the 2-Chlorophenothiazine JDMF during the approval evaluation for pharmaceutical products. At the time of 2-Chlorophenothiazine JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of 2-Chlorophenothiazine suppliers with JDMF on PharmaCompass.

    2-Chlorophenothiazine CEP

    A 2-Chlorophenothiazine CEP of the European Pharmacopoeia monograph is often referred to as a 2-Chlorophenothiazine Certificate of Suitability (COS). The purpose of a 2-Chlorophenothiazine CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of 2-Chlorophenothiazine EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of 2-Chlorophenothiazine to their clients by showing that a 2-Chlorophenothiazine CEP has been issued for it. The manufacturer submits a 2-Chlorophenothiazine CEP (COS) as part of the market authorization procedure, and it takes on the role of a 2-Chlorophenothiazine CEP holder for the record. Additionally, the data presented in the 2-Chlorophenothiazine CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the 2-Chlorophenothiazine DMF.

    A 2-Chlorophenothiazine CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. 2-Chlorophenothiazine CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of 2-Chlorophenothiazine suppliers with CEP (COS) on PharmaCompass.

    2-Chlorophenothiazine WC

    A 2-Chlorophenothiazine written confirmation (2-Chlorophenothiazine WC) is an official document issued by a regulatory agency to a 2-Chlorophenothiazine manufacturer, verifying that the manufacturing facility of a 2-Chlorophenothiazine active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting 2-Chlorophenothiazine APIs or 2-Chlorophenothiazine finished pharmaceutical products to another nation, regulatory agencies frequently require a 2-Chlorophenothiazine WC (written confirmation) as part of the regulatory process.

    click here to find a list of 2-Chlorophenothiazine suppliers with Written Confirmation (WC) on PharmaCompass.

    2-Chlorophenothiazine NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing 2-Chlorophenothiazine as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for 2-Chlorophenothiazine API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture 2-Chlorophenothiazine as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain 2-Chlorophenothiazine and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a 2-Chlorophenothiazine NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of 2-Chlorophenothiazine suppliers with NDC on PharmaCompass.

    2-Chlorophenothiazine GMP

    2-Chlorophenothiazine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of 2-Chlorophenothiazine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 2-Chlorophenothiazine GMP manufacturer or 2-Chlorophenothiazine GMP API supplier for your needs.

    2-Chlorophenothiazine CoA

    A 2-Chlorophenothiazine CoA (Certificate of Analysis) is a formal document that attests to 2-Chlorophenothiazine's compliance with 2-Chlorophenothiazine specifications and serves as a tool for batch-level quality control.

    2-Chlorophenothiazine CoA mostly includes findings from lab analyses of a specific batch. For each 2-Chlorophenothiazine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    2-Chlorophenothiazine may be tested according to a variety of international standards, such as European Pharmacopoeia (2-Chlorophenothiazine EP), 2-Chlorophenothiazine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (2-Chlorophenothiazine USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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