DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 52806-53-8, 2-hydroxyflutamide, Hydroxyniphtholide, 2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)propanamide, Hydroxy-flutamide, 2-hydroxy-2-methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Molecular Formula

C₁₁H₁₁F₃N₂O₄

Molecular Weight

292.21 g/mol

InChI Key

YPQLFJODEKMJEF-UHFFFAOYSA-N

FDA UNII

31D90UKP5Y

1 2D Structure

2-Hydroxyflutamide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

2.1.2 InChI

InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)

2.1.3 InChI Key

YPQLFJODEKMJEF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)(C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F)O

2.2 Other Identifiers

2.2.1 UNII

31D90UKP5Y

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-hydroxyflutamide

2. Oh-flutamide

3. Sch 16423

4. Sch-16423

2.3.2 Depositor-Supplied Synonyms

1. 52806-53-8

2. 2-hydroxyflutamide

3. Hydroxyniphtholide

4. 2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)propanamide

5. Hydroxy-flutamide

6. 2-hydroxy-2-methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

7. Sch 16423

8. Hydroxy Flutamide

9. 2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)-phenyl)propanamide

10. .alpha.-hydroxyflutamide

11. Chembl491

12. Propanamide, 2-hydroxy-2-methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]-

13. 31d90ukp5y

14. 2-hydroxy-flutamide

15. Oh-flutamide

16. Propanamide, 2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-

17. Dsstox_cid_13562

18. Dsstox_rid_79084

19. Dsstox_gsid_33562

20. Hft

21. Hydroxyflutamid

22. Liproca Depot

23. 2-hydroxy-2-methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]propanamide (2-hydroxyflutamide)

24. Smr001227196

25. Cas-52806-53-8

26. Unii-31d90ukp5y

27. 2-hydroxy Flutamide

28. Mfcd00563126

29. 2ax6

30. Alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide

31. 2-hof

32. Cid_91649

33. Mls001061267

34. Mls006011954

35. Bidd:er0519

36. Gtpl2862

37. Schembl3079778

38. Dtxsid8033562

39. Schembl19117358

40. Bdbm35909

41. Hms3039a05

42. Bcp12495

43. Hydroxyflutamide, >=98% (hplc)

44. Zinc4655055

45. Tox21_201204

46. Tox21_303659

47. Hydroxyflutamide (hydroxyniphtholide)

48. Akos007930906

49. Cs-w013988

50. Hy-w013272

51. Sb17029

52. S10360

53. Ncgc00091014-01

54. Ncgc00091014-02

55. Ncgc00091014-03

56. Ncgc00091014-04

57. Ncgc00091014-06

58. Ncgc00257382-01

59. Ncgc00258756-01

60. Bs-17460

61. A1728

62. Ft-0627147

63. H1600

64. A21118

65. Q15633976

66. 2-hydroxy-4'-nitro-3'-(trifluoromethyl)isobutyranilide

67. Z1617901126

68. 2-hydroxy-2-methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]propionamide

69. 2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethyl-phenyl)-propionamide (hydroxy Flutamide)

70. 2-hydroxy-2-methyl-n-(4-nitro-3-trifluoromethyl-phenyl)-propionamide(hydroxyflutamide)

71. 2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)propanamide; Hydroxyniphtholide

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₁F₃N₂O₄
Molecular Weight	292.21 g/mol
XLogP3	2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	292.06709132 g/mol
Monoisotopic Mass	292.06709132 g/mol
Topological Polar Surface Area	95.2 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	392
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Androgen Antagonists

Compounds which inhibit or antagonize the biosynthesis or actions of androgens. (See all compounds classified as Androgen Antagonists.)

4.2 Metabolism/Metabolites

2-hydroxy-flutamide is a known human metabolite of flutamide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

Drugs in Development

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

ABOUT THIS PAGE

Find 2-Hydroxyflutamide manufacturers, exporters & distributors on PharmaCompass

2-Hydroxyflutamide

ACCESS ALL DATA

Browse all information

CHEMISTRY

Discover Molecule Insights

DEVELOPMENTS

4 Drugs in Development

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

4DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

What are you looking for?