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Chemistry

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Also known as: Propyleneimine, Propylenimine, Aziridine, 2-methyl-, 75-55-8, Methylaziridine, 1,2-propylenimine
Molecular Formula
C3H7N
Molecular Weight
57.09  g/mol
InChI Key
OZDGMOYKSFPLSE-UHFFFAOYSA-N
FDA UNII
ULC972Q7TZ

2-Methylaziridine
Propylenimine is a synthetic, flammable, volatile, colorless oily liquid that is soluble in water, ethanol and most organic solvents. Propylenimine is used in the United States exclusively as an intermediate, and its derivatives are used in the paper, textile, rubber and pharmaceutical industries. Due to its volatility, potential exposure could occur during production, packaging, or use of substances made with this liquid. The primary routes of potential human exposure to propylenimine are inhalation, ingestion and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
1 2D Structure

2-Methylaziridine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-methylaziridine
2.1.2 InChI
InChI=1S/C3H7N/c1-3-2-4-3/h3-4H,2H2,1H3
2.1.3 InChI Key
OZDGMOYKSFPLSE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1CN1
2.2 Other Identifiers
2.2.1 UNII
ULC972Q7TZ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Propylene Imine

2. Propyleneimine

2.3.2 Depositor-Supplied Synonyms

1. Propyleneimine

2. Propylenimine

3. Aziridine, 2-methyl-

4. 75-55-8

5. Methylaziridine

6. 1,2-propylenimine

7. 2-methylethylenimine

8. Methylethylenimine

9. 1,2-propyleneimine

10. 2-methylazacyclopropane

11. 2-methyl Aziridine

12. Rcra Waste Number P067

13. Nsc 20655

14. Propyleneimine, Inhibited

15. Ulc972q7tz

16. Chebi:82340

17. Propylene Imine

18. 2-methylaziridine (propylenimine)

19. Nsc-20655

20. Propilenimina

21. Propilenimina [spanish]

22. S-2-methylaziridine

23. Ccris 539

24. Hsdb 739

25. Dl-2-methylaziridine

26. Einecs 200-878-7

27. Un1921

28. Rcra Waste No. P067

29. Unii-ulc972q7tz

30. Brn 0102386

31. Ai3-50325

32. Dsstox_cid_4286

33. Ec 200-878-7

34. Wln: T3mtj B1

35. Dsstox_rid_77355

36. Dsstox_gsid_24286

37. Propyleneimine [hsdb]

38. 5-20-01-00150 (beilstein Handbook Reference)

39. Un 1921 (salt/mix)

40. Chembl3183775

41. Dtxsid8024286

42. Ozdgmoyksfplse-uhfffaoysa-

43. 2-methylaziridine [iarc]

44. 2-?methylaziridine (propylenimine)

45. Nsc20655

46. Tox21_202944

47. Stl168051

48. 2-methylaziridine, (+/-)-

49. Akos005366679

50. Cas-75-55-8

51. Ncgc00260490-01

52. 2-methylaziridine, Technical Grade, 90%

53. Db-016804

54. Ft-0649217

55. C19257

56. Q7250470

57. Propyleneimine, Inhibited [un1921] [flammable Liquid]

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 57.09 g/mol
Molecular Formula C3H7N
XLogP30
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass57.057849228 g/mol
Monoisotopic Mass57.057849228 g/mol
Topological Polar Surface Area21.9 Ų
Heavy Atom Count4
Formal Charge0
Complexity26.5
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Mechanism of Action

The application of (1)H nuclear magnetic resonance (NMR) spectroscopy to the study of the biochemical effects of six nephrotoxic compounds, including mercury-chloride (HgCl2), was investigated in the male Fischer-344-rat. The rats were treated with nephrotoxic doses of sodium-chromate, cisplatin, hexachlorobutadiene, HgCl2, propylene-imine, and bromoethanamine. 1H-NMR spectroscopy and conventional biochemical methods were used to provide biochemical fingerprints of urine collected up to 48 hours after dosing. Severe glycosuria and transient enzymuria were produced by hexachlorobutadiene and HgCl2. Aminoaciduria, glycosuria, and lactic aciduria were noted after exposure to all proximal tubular toxins with the exception of cisplatin. Papillary insult resulted in early elevations in urinary trimethylamine-N-oxide and dimethylamine, together with later elevations in urinary acetate, succinate, and N,N-dimethylglycine /after propylene-imine/.

Gartland KP et al; Mol Pharmcol 35 (2): 242-250 (1989)


ABOUT THIS PAGE

2-Methylaziridine Manufacturers

A 2-Methylaziridine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 2-Methylaziridine, including repackagers and relabelers. The FDA regulates 2-Methylaziridine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 2-Methylaziridine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

2-Methylaziridine Suppliers

A 2-Methylaziridine supplier is an individual or a company that provides 2-Methylaziridine active pharmaceutical ingredient (API) or 2-Methylaziridine finished formulations upon request. The 2-Methylaziridine suppliers may include 2-Methylaziridine API manufacturers, exporters, distributors and traders.

2-Methylaziridine GMP

2-Methylaziridine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 2-Methylaziridine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 2-Methylaziridine GMP manufacturer or 2-Methylaziridine GMP API supplier for your needs.

2-Methylaziridine CoA

A 2-Methylaziridine CoA (Certificate of Analysis) is a formal document that attests to 2-Methylaziridine's compliance with 2-Methylaziridine specifications and serves as a tool for batch-level quality control.

2-Methylaziridine CoA mostly includes findings from lab analyses of a specific batch. For each 2-Methylaziridine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

2-Methylaziridine may be tested according to a variety of international standards, such as European Pharmacopoeia (2-Methylaziridine EP), 2-Methylaziridine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (2-Methylaziridine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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