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Chemistry

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Also known as: 284490-13-7, Forodesine hcl, Forodesine (hydrochloride), Bcx-1777, Bcx-1777 hydrochloride, 6sn82y9u73
Molecular Formula
C11H15ClN4O4
Molecular Weight
302.71  g/mol
InChI Key
WEIAMZKHBCLFOG-QPAIBFMUSA-N
FDA UNII
6SN82Y9U73

284490-13-7
Forodesine Hydrochloride is the hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction.
1 2D Structure

284490-13-7

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride
2.1.2 InChI
InChI=1S/C11H14N4O4.ClH/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19;/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19);1H/t5-,7+,9-,10+;/m1./s1
2.1.3 InChI Key
WEIAMZKHBCLFOG-QPAIBFMUSA-N
2.1.4 Canonical SMILES
C1=C(C2=C(N1)C(=O)NC=N2)C3C(C(C(N3)CO)O)O.Cl
2.1.5 Isomeric SMILES
C1=C(C2=C(N1)C(=O)NC=N2)[C@H]3[C@@H]([C@@H]([C@H](N3)CO)O)O.Cl
2.2 Other Identifiers
2.2.1 UNII
6SN82Y9U73
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iminoribitol

2. Bcx-1777

3. Bcx1777

4. Forodesine

5. Immh Cpd

6. Immucillin H

7. Immucillin-h

2.3.2 Depositor-Supplied Synonyms

1. 284490-13-7

2. Forodesine Hcl

3. Forodesine (hydrochloride)

4. Bcx-1777

5. Bcx-1777 Hydrochloride

6. 6sn82y9u73

7. (-)-7-((2s,3s,4r,5r)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-1,5-dihydro-4h-pyrrolo(3,2-d)pyrimidin-4-one Monohydrochloride

8. 4h-pyrrolo(3,2-d)pyrimidin-4-one, 7-((2s,3s,4r,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl)-1,5-dihydro-, Monohydrochloride

9. 7-[(2s,3s,4r,5r)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride

10. Immucillin-h Hydrochloride

11. Unii-6sn82y9u73

12. Forodesine Hydrochloride [usan]

13. Forodesine Hydrochloride [usan:jan]

14. Forodesinehydrochloride

15. Chembl550755

16. Schembl1949526

17. Schembl15525350

18. Dtxsid90182647

19. Forodesine Hydrochloride (jan/usan)

20. Forodesine Hydrochloride [mi]

21. Forodesine Hydrochloride [jan]

22. Cs-3780

23. Forodesine Hydrochloride [mart.]

24. Forodesine Hydrochloride [who-dd]

25. Hy-16209

26. D04245

27. Q27265452

28. 7-((2s,3s,4r,5r)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3h-pyrrolo[3,2-d]pyrimidin-4-(5h)-one Hydrochloride

29. 7-[(2s,3s,4r,5r)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride

2.4 Create Date
2019-01-15
3 Chemical and Physical Properties
Molecular Weight 302.71 g/mol
Molecular Formula C11H15ClN4O4
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area130
Heavy Atom Count20
Formal Charge0
Complexity404
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Treatment of Cutaneous T-Cell Lymphoma


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ABOUT THIS PAGE

284490-13-7 Manufacturers

A 284490-13-7 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 284490-13-7, including repackagers and relabelers. The FDA regulates 284490-13-7 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 284490-13-7 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

284490-13-7 Suppliers

A 284490-13-7 supplier is an individual or a company that provides 284490-13-7 active pharmaceutical ingredient (API) or 284490-13-7 finished formulations upon request. The 284490-13-7 suppliers may include 284490-13-7 API manufacturers, exporters, distributors and traders.

284490-13-7 GMP

284490-13-7 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 284490-13-7 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 284490-13-7 GMP manufacturer or 284490-13-7 GMP API supplier for your needs.

284490-13-7 CoA

A 284490-13-7 CoA (Certificate of Analysis) is a formal document that attests to 284490-13-7's compliance with 284490-13-7 specifications and serves as a tool for batch-level quality control.

284490-13-7 CoA mostly includes findings from lab analyses of a specific batch. For each 284490-13-7 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

284490-13-7 may be tested according to a variety of international standards, such as European Pharmacopoeia (284490-13-7 EP), 284490-13-7 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (284490-13-7 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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