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Chemistry

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Also known as: L-histidine, 71-00-1, H-his-oh, Glyoxaline-5-alanine, L-(-)-histidine, Anti-rheuma
Molecular Formula
C6H9N3O2
Molecular Weight
155.15  g/mol
InChI Key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
FDA UNII
4QD397987E

L-Histidine
An essential amino acid that is required for the production of HISTAMINE.
1 2D Structure

L-Histidine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid
2.1.2 InChI
InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
2.1.3 InChI Key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
2.1.4 Canonical SMILES
C1=C(NC=N1)CC(C(=O)O)N
2.1.5 Isomeric SMILES
C1=C(NC=N1)C[C@@H](C(=O)O)N
2.2 Other Identifiers
2.2.1 UNII
4QD397987E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Histidine, L Isomer

2. Histidine, L-isomer

3. L-histidine

4. L-isomer Histidine

2.3.2 Depositor-Supplied Synonyms

1. L-histidine

2. 71-00-1

3. H-his-oh

4. Glyoxaline-5-alanine

5. L-(-)-histidine

6. Anti-rheuma

7. Istidina

8. S-histidine

9. (l)-histidine

10. Histidine (van)

11. Histidine, L-

12. Histidina

13. (s)-4-(2-amino-2-carboxyethyl)imidazole

14. (2s)-2-amino-3-(1h-imidazol-4-yl)propanoic Acid

15. L-histidin

16. (s)-alpha-amino-1h-imidazole-4-propanoic Acid

17. Fema No. 3694

18. Histidine [usan:inn]

19. Histidinum [inn-latin]

20. (s)-histidine

21. Histidina [inn-spanish]

22. L-beta-(4-imidazolyl)alanin

23. 4-(2-amino-2-carboxyethyl)imidazole

24. His

25. L-hystidine

26. 1h-imidazole-4-alanine, (s)-

27. L-hisidine

28. (s)-2-amino-3-(4-imidazolyl)propionsaeure

29. L-beta-(4-imidazolyl)-alpha-alanin

30. (s)-alpha-amino-1h-imidazole-4-propionic Acid

31. L-his

32. L-alanine, 3-(1h-imidazol-4-yl)-

33. Ai3-26558

34. Alpha-amino-4(or 5)-imidazolepropionic Acid

35. Histidine (l-histidine)

36. Alpha-amino-1h-imidazole-4-propionic Acid, (s)-

37. 1h-imidazole-4-propanoic Acid, Alpha-amino-, (s)-

38. (s)-a-amino-1h-imidazole-4-propanoic Acid

39. (s)-2-amino-3-(4-imidazolyl)propionic Acid

40. Chebi:15971

41. 4qd397987e

42. Nsc-137773

43. 7006-35-1

44. Histidinum

45. Mfcd00064315

46. (2s)-2-amino-3-(imidazol-4-yl)propanoic Acid

47. Histidine, Monohydrochloride

48. Hsdb 1810

49. Einecs 200-745-3

50. Nsc 137773

51. Unii-4qd397987e

52. 1hsl

53. 1lag

54. [3h]histidine

55. Histidine,(s)

56. [3h]-histidine

57. (2s)-2-amino-3-(1h-imidazol-4-yl)propanoic Acid Hydrochloride

58. Histidine (usp/inn)

59. Histidine [inn]

60. Histidine [ii]

61. Histidine [mi]

62. L-histidine (jp17)

63. L-2-amino-3-(4-imidazolyl)propionic Acid

64. Histidine [hsdb]

65. Histidine [inci]

66. Histidine [usan]

67. Histidine [vandf]

68. Lopac-h-8125

69. Bmse000039

70. Bmse000976

71. Bmse001015

72. Histidine [mart.]

73. L-histidine [fcc]

74. L-histidine [jan]

75. L-histidine (h-his-oh)

76. Amino-4-imidazoleproprionate

77. Histidine [who-dd]

78. L-histidine [fhfi]

79. Schembl3259

80. Lopac0_000566

81. Us9138393, Histidine

82. Us9144538, Histidine

83. (s)1h-imidazole-4-alanine

84. Chembl17962

85. L-histidine [usp-rs]

86. (2s)-2-amino-3-(1h-imidazol-5-yl)propanoic Acid

87. (s)-1h-imidazole-4-alanine

88. Bdbm7953

89. Gtpl3310

90. Gtpl4670

91. L-histidine, Non-animal Source

92. Imidazole C-4(5) Deriv. 5

93. Amino-4-imidazoleproprionic Acid

94. Dtxsid9023126

95. Histidine [ep Monograph]

96. Amino-1h-imidazole-4-propanoate

97. Histidine [usp Monograph]

98. L-histidine, P.a., 98.5%

99. Bdbm181118

100. L-histidine, Cell Culture Reagent

101. 3-(1h-imidazol-4-yl)-l-alanine

102. Hy-n0832

103. Zinc6661227

104. Amino-1h-imidazole-4-propanoic Acid

105. Akos015854051

106. Akos026676613

107. Am81801

108. Ccg-204656

109. Cs-7781

110. Db00117

111. Sdccgsbi-0050549.p002

112. Serine Impurity C [ep Impurity]

113. (s)-a-amino-1h-imidazole-4-propanoate

114. Ncgc00015518-01

115. Ncgc00162189-01

116. Ncgc00162189-02

117. Ncgc00162189-05

118. Ac-35086

119. As-14171

120. (s)-alpha-amino-1h-imidazole-4-propanoate

121. (s)-alpha-amino-1h-imidazole-4-propionate

122. L-histidine, Bioultra, >=99.5% (nt)

123. H0149

124. L-histidine, Saj Special Grade, >=98.5%

125. S3989

126. C00135

127. D00032

128. D70843

129. H-2310

130. L-histidine, Reagentplus(r), >=99% (tlc)

131. M02982

132. L-histidine, Vetec(tm) Reagent Grade, >=99%

133. (s)-2-amino-3-(1h-imidazol-4-yl)propanoic Acid

134. 064h315

135. Q485277

136. B81aedb0-eaca-4296-9bab-52d60f137ffb

137. 1h-imidazole-4-propanoic Acid, .alpha.-amino-, (s)-

138. F8881-8926

139. F8889-0575

140. L-histidine, Certified Reference Material, Tracecert(r)

141. Z955123622

142. Histidine, European Pharmacopoeia (ep) Reference Standard

143. L-histidine, United States Pharmacopeia (usp) Reference Standard

144. L-histidine, Pharmaceutical Secondary Standard; Certified Reference Material

145. L-histidine, Cell Culture Tested, Meets Ep, Usp Testing Specifications, From Non-animal Source

146. L-histidine, Pharmagrade, Ajinomoto, Ep, Usp, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production, Suitable For Cell Culture

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 155.15 g/mol
Molecular Formula C6H9N3O2
XLogP3-3.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass155.069476538 g/mol
Monoisotopic Mass155.069476538 g/mol
Topological Polar Surface Area92 Ų
Heavy Atom Count11
Formal Charge0
Complexity151
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia. A deficiency can cause poor hearing.


5.2 Absorption, Distribution and Excretion

Absorption

Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.


ESSENTIAL AMINO ACIDS ARE TRANSFERRED TO FETUS AGAINST A CONCN GRADIENT &, IN THE CASE OF HISTIDINE, NATURAL L-ISOMER HAS BEEN SHOWN TO CROSS SEVERAL TIMES AS FAST AS THE D-ISOMER.

LaDu, B.N., H.G. Mandel, and E.L. Way. Fundamentals of Drug Metabolism and Disposition. Baltimore: Williams and Wilkins, 1971., p. 89


5.3 Metabolism/Metabolites

PRODUCT OF OXIDATIVE DEAMINATION OR TRANSAMINATION OF L-HISTIDINE IS BETA-IMIDAZOLEPYRUVIC ACID; & PRODUCT OF DECARBOXYLATION IS HISTAMINE. HISTAMINE ENTERS OTHER PATHWAYS TO YIELD FURTHER METABOLIC PRODUCTS. /FROM TABLE/

Fenaroli's Handbook of Flavor Ingredients. Volume 2. Edited, translated, and revised by T.E. Furia and N. Bellanca. 2nd ed. Cleveland: The Chemical Rubber Co., 1975., p. 830


5.4 Mechanism of Action

Since the actions of supplemental L-histidine are unclear, any postulated mechanism is entirely speculative. However, some facts are known about L-histidine and some of its metabolites, such as histamine and trans-urocanic acid, which suggest that supplemental L-histidine may one day be shown to have immunomodulatory and/or antioxidant activities. Low free histidine has been found in the serum of some rheumatoid arthritis patients. Serum concentrations of other amino acids have been found to be normal in these patients. L-histidine is an excellent chelating agent for such metals as copper, iron and zinc. Copper and iron participate in a reaction (Fenton reaction) that generates potent reactive oxygen species that could be destructive to tissues, including joints.
L-histidine is the obligate precursor of histamine, which is produced via the decarboxylation of the amino acid. In experimental animals, tissue histamine levels increase as the amount of dietary L-histidine increases. It is likely that this would be the case in humans as well. Histamine is known to possess immunomodulatory and antioxidant activity. Suppressor T cells have H2 receptors, and histamine activates them. Promotion of suppressor T cell activity could be beneficial in rheumatoid arthritis. Further, histamine has been shown to down-regulate the production of reactive oxygen species in phagocytic cells, such as monocytes, by binding to the H2 receptors on these cells. Decreased reactive oxygen species production by phagocytes could play antioxidant, anti-inflammatory and immunomodulatory roles in such diseases as rheumatoid arthritis.
This latter mechanism is the rationale for the use of histamine itself in several clinical trials studying histamine for the treatment of certain types of cancer and viral diseases. In these trials, down-regulation by histamine of reactive oxygen species formation appears to inhibit the suppression of natural killer (NK) cells and cytotoxic T lymphocytes, allowing these cells to be more effective in attacking cancer cells and virally infected cells.


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06-Jan-2021
19-Feb-2025
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ABOUT THIS PAGE

Looking for 71-00-1 / L-Histidine API manufacturers, exporters & distributors?

L-Histidine manufacturers, exporters & distributors 1

80

PharmaCompass offers a list of L-Histidine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right L-Histidine manufacturer or L-Histidine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred L-Histidine manufacturer or L-Histidine supplier.

PharmaCompass also assists you with knowing the L-Histidine API Price utilized in the formulation of products. L-Histidine API Price is not always fixed or binding as the L-Histidine Price is obtained through a variety of data sources. The L-Histidine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

L-Histidine

Synonyms

71-00-1, H-his-oh, Glyoxaline-5-alanine, L-(-)-histidine, Anti-rheuma, Istidina

Cas Number

71-00-1

Unique Ingredient Identifier (UNII)

4QD397987E

About L-Histidine

An essential amino acid that is required for the production of HISTAMINE.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid Manufacturers

A (2S)-2-amino-3-(imidazol-4-yl)propanoic acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid, including repackagers and relabelers. The FDA regulates (2S)-2-amino-3-(imidazol-4-yl)propanoic acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. (2S)-2-amino-3-(imidazol-4-yl)propanoic acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid Suppliers

A (2S)-2-amino-3-(imidazol-4-yl)propanoic acid supplier is an individual or a company that provides (2S)-2-amino-3-(imidazol-4-yl)propanoic acid active pharmaceutical ingredient (API) or (2S)-2-amino-3-(imidazol-4-yl)propanoic acid finished formulations upon request. The (2S)-2-amino-3-(imidazol-4-yl)propanoic acid suppliers may include (2S)-2-amino-3-(imidazol-4-yl)propanoic acid API manufacturers, exporters, distributors and traders.

click here to find a list of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid USDMF

A (2S)-2-amino-3-(imidazol-4-yl)propanoic acid DMF (Drug Master File) is a document detailing the whole manufacturing process of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid active pharmaceutical ingredient (API) in detail. Different forms of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid DMFs exist exist since differing nations have different regulations, such as (2S)-2-amino-3-(imidazol-4-yl)propanoic acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A (2S)-2-amino-3-(imidazol-4-yl)propanoic acid DMF submitted to regulatory agencies in the US is known as a USDMF. (2S)-2-amino-3-(imidazol-4-yl)propanoic acid USDMF includes data on (2S)-2-amino-3-(imidazol-4-yl)propanoic acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The (2S)-2-amino-3-(imidazol-4-yl)propanoic acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

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(2S)-2-amino-3-(imidazol-4-yl)propanoic acid JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The (2S)-2-amino-3-(imidazol-4-yl)propanoic acid Drug Master File in Japan ((2S)-2-amino-3-(imidazol-4-yl)propanoic acid JDMF) empowers (2S)-2-amino-3-(imidazol-4-yl)propanoic acid API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the (2S)-2-amino-3-(imidazol-4-yl)propanoic acid JDMF during the approval evaluation for pharmaceutical products. At the time of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid suppliers with JDMF on PharmaCompass.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP

A (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP of the European Pharmacopoeia monograph is often referred to as a (2S)-2-amino-3-(imidazol-4-yl)propanoic acid Certificate of Suitability (COS). The purpose of a (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid to their clients by showing that a (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP has been issued for it. The manufacturer submits a (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP (COS) as part of the market authorization procedure, and it takes on the role of a (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP holder for the record. Additionally, the data presented in the (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the (2S)-2-amino-3-(imidazol-4-yl)propanoic acid DMF.

A (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid suppliers with CEP (COS) on PharmaCompass.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing (2S)-2-amino-3-(imidazol-4-yl)propanoic acid as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for (2S)-2-amino-3-(imidazol-4-yl)propanoic acid API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture (2S)-2-amino-3-(imidazol-4-yl)propanoic acid as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain (2S)-2-amino-3-(imidazol-4-yl)propanoic acid and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a (2S)-2-amino-3-(imidazol-4-yl)propanoic acid NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid suppliers with NDC on PharmaCompass.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid GMP

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of (2S)-2-amino-3-(imidazol-4-yl)propanoic acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right (2S)-2-amino-3-(imidazol-4-yl)propanoic acid GMP manufacturer or (2S)-2-amino-3-(imidazol-4-yl)propanoic acid GMP API supplier for your needs.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid CoA

A (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CoA (Certificate of Analysis) is a formal document that attests to (2S)-2-amino-3-(imidazol-4-yl)propanoic acid's compliance with (2S)-2-amino-3-(imidazol-4-yl)propanoic acid specifications and serves as a tool for batch-level quality control.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid CoA mostly includes findings from lab analyses of a specific batch. For each (2S)-2-amino-3-(imidazol-4-yl)propanoic acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

(2S)-2-amino-3-(imidazol-4-yl)propanoic acid may be tested according to a variety of international standards, such as European Pharmacopoeia ((2S)-2-amino-3-(imidazol-4-yl)propanoic acid EP), (2S)-2-amino-3-(imidazol-4-yl)propanoic acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia ((2S)-2-amino-3-(imidazol-4-yl)propanoic acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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