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Chemistry

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Also known as: Asenapine maleate, 85650-56-2, Asenapine (maleate), Sycrest, Asenapine maleate [usan], Org 5222
Molecular Formula
C21H20ClNO5
Molecular Weight
401.8  g/mol
InChI Key
GMDCDXMAFMEDAG-CHHFXETESA-N
FDA UNII
CU9463U2E2

Asenapine Maleate
1 2D Structure

Asenapine Maleate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(Z)-but-2-enedioic acid;(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene
2.1.2 InChI
InChI=1S/C17H16ClNO.C4H4O4/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;5-3(6)1-2-4(7)8/h2-8,14-15H,9-10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1
2.1.3 InChI Key
GMDCDXMAFMEDAG-CHHFXETESA-N
2.1.4 Canonical SMILES
CN1CC2C(C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
CU9463U2E2
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz(2,3-6,7)oxepino(4,5-c)pyrrole

2. Asenapine

3. Asenapine Maleate

4. Org 5222

5. Org-5222

6. Secuado

7. Trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole

2.3.2 Depositor-Supplied Synonyms

1. Asenapine Maleate

2. 85650-56-2

3. Asenapine (maleate)

4. Sycrest

5. Asenapine Maleate [usan]

6. Org 5222

7. Org-5222

8. Cu9463u2e2

9. (z)-but-2-enedioic Acid;(2s,6s)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.02,6.07,12]octadeca-1(18),7(12),8,10,14,16-hexaene

10. 1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, Trans-, (z)-2-butenedioate (1:1)

11. Trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole Maleate

12. Asenapine (as Maleate)

13. (3ars,12brs)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzo(2,3:6,7)oxepino(4,5-c)pyrrole (2z)-2-butenedioate (1:1)

14. 1h-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3ar,12br)-rel-, (2z)-2-butenedioate (1:1)

15. Trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole Maleate

16. Unii-cu9463u2e2

17. Einecs 288-064-8

18. Saphris (tn)

19. Org 5222 Maleate

20. Asenapine Maleate Solution

21. (s,s)-asenapine Maleate

22. Schembl175228

23. Asenapine Maleate [mi]

24. Asenapine Maleate (jan/usan)

25. Asenapine Maleate [jan]

26. Chebi:71248

27. Asenapine Maleate [mart.]

28. Dtxsid301017360

29. Hms3884e09

30. Asenapine Maleate [who-dd]

31. Asenapine Maleate [ema Epar]

32. Asenapine Maleate, >=98% (hplc)

33. Mfcd00900588

34. S1283

35. Akos015951084

36. Asenapine Maleate [orange Book]

37. Ccg-268667

38. Cs-0859

39. Mk-8274

40. Sch-900274

41. Ac-24116

42. Hy-11100

43. Sw219879-1

44. D02995

45. 650a562

46. Q27139467

47. 65576-45-6, 135883-08-8 (maleic Acid)

48. Asenapine Maleate 1.0 Mg/ml In Methanol (as Free Base)

49. (3as,12bs)-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole Maleate

50. 1h-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-,(3ar,12br)-rel-, (2z)-2-butenedioate (1:1)

51. Trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenzo[2,3;6,7]-oxepino[4,5-c]pyrrole Maleate

52. Trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrolemaleate

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 401.8 g/mol
Molecular Formula C21H20ClNO5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass401.1030004 g/mol
Monoisotopic Mass401.1030004 g/mol
Topological Polar Surface Area87.1 Ų
Heavy Atom Count28
Formal Charge0
Complexity482
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameSaphris
PubMed HealthAsenapine (By mouth)
Drug ClassesAntipsychotic
Drug LabelSAPHRIS is a psychotropic agent that is available for sublingual administration. Asenapine belongs to the class dibenzo-oxepino pyrroles. The chemical designation is (3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c...
Active IngredientAsenapine maleate
Dosage FormTablet
RouteSublingual
Strengtheq 5mg base; eq 10mg base
Market StatusPrescription
CompanyForest Labs

2 of 2  
Drug NameSaphris
PubMed HealthAsenapine (By mouth)
Drug ClassesAntipsychotic
Drug LabelSAPHRIS is a psychotropic agent that is available for sublingual administration. Asenapine belongs to the class dibenzo-oxepino pyrroles. The chemical designation is (3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1Hdibenzo[2,3:6,7]oxepino[4,5-c...
Active IngredientAsenapine maleate
Dosage FormTablet
RouteSublingual
Strengtheq 5mg base; eq 10mg base
Market StatusPrescription
CompanyForest Labs

4.2 Drug Indication

Sycrest is indicated for the treatment of moderate to severe manic episodes associated with bipolar I disorder in adults.


Treatment of bipolar I disorder


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Atypical Antipsychotic [EPC]
5.3 ATC Code

N05AH05


API Reference Price

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19-Apr-2021
15-Feb-2022
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INTERMEDIATES SUPPLIERS

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2024 ACI Convention
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2024 ACI Convention
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CAS Number : 129385-59-7

End Use API : Asenapine Maleate

About The Company : We specialize in the supply of API and API related intermediates and services. A significant part of our business comes from the process/production development ...

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02

2024 ACI Convention
Not Confirmed
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2024 ACI Convention
Not Confirmed
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CAS Number : 1012884-46-6

End Use API : Asenapine Maleate

About The Company : We specialize in the supply of API and API related intermediates and services. A significant part of our business comes from the process/production development ...

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DOSAGE - TABLET;SUBLINGUAL - EQ 10MG BASE

USFDA APPLICATION NUMBER - 22117

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DOSAGE - TABLET;SUBLINGUAL - EQ 2.5MG BASE

USFDA APPLICATION NUMBER - 22117

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DOSAGE - TABLET;SUBLINGUAL - EQ 5MG BASE

USFDA APPLICATION NUMBER - 22117

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