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Chemistry

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Also known as: 156223-05-1, Gts 21 dihydrochloride, Dmxba, Gts-21 (dihydrochloride), Dmxb-anabaseine, 3-[(5e)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2h-pyridin-6-yl]pyridine;dihydrochloride
Molecular Formula
C19H22Cl2N2O2
Molecular Weight
381.3  g/mol
InChI Key
BXKYFUGAAFLYJL-BXGYHSFXSA-N

3-2,4-Dimethoxybenzylidene-Anabaseine
1 2D Structure

3-2,4-Dimethoxybenzylidene-Anabaseine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(5E)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2H-pyridin-6-yl]pyridine;dihydrochloride
2.1.2 InChI
InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
2.1.3 InChI Key
BXKYFUGAAFLYJL-BXGYHSFXSA-N
2.1.4 Canonical SMILES
COC1=CC(=C(C=C1)C=C2CCCN=C2C3=CN=CC=C3)OC.Cl.Cl
2.1.5 Isomeric SMILES
COC1=CC(=C(C=C1)/C=C/2\CCCN=C2C3=CN=CC=C3)OC.Cl.Cl
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 3-(2,4-dimethoxybenzylidene)anabaseine

2. Dmxba

3. Gts 21

4. Gts-21

2.2.2 Depositor-Supplied Synonyms

1. 156223-05-1

2. Gts 21 Dihydrochloride

3. Dmxba

4. Gts-21 (dihydrochloride)

5. Dmxb-anabaseine

6. 3-[(5e)-5-[(2,4-dimethoxyphenyl)methylidene]-3,4-dihydro-2h-pyridin-6-yl]pyridine;dihydrochloride

7. Dmbx-a

8. Dmbx-anabaseine

9. (e)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine Dihydrochloride

10. 3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine Dihydrochloride

11. 156743-66-7

12. Gts-21 2hcl

13. Gts 21

14. Dmxb

15. Schembl2561893

16. Schembl12274790

17. Ex-a5724

18. Hy-14564a

19. Akos037515500

20. Cs-5486

21. (e)-3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-2,3'-bipyridine Dihydrochloride

22. 2,3'-bipyridine, 3-((2,4-dimethoxyphenyl)methylene)-3,4,5,6-tetrahydro-, Dihydrochloride, (e)-

23. Ac-31954

24. Gts-21, >=97% (hplc)

25. 3-(2,4-dimethoxybenzylidene)anabaseine Dihydrochloride

26. 3-(2,4-dimethoxybenzylidene)-anabaseine Dihydrochloride

27. 3-(3-(2,4-dimethoxybenzyl)-3,4,5,6-tetrahydropyridin-2-yl)pyridine Dihydrochloride

28. (e)-3-(3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydropyridin-2-yl)pyridine Dihydrochloride

2.3 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 381.3 g/mol
Molecular Formula C19H22Cl2N2O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass380.1058333 g/mol
Monoisotopic Mass380.1058333 g/mol
Topological Polar Surface Area43.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity447
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Nicotinic Agonists

Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission. (See all compounds classified as Nicotinic Agonists.)


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3-2,4-Dimethoxybenzylidene-Anabaseine Manufacturers

A 3-2,4-Dimethoxybenzylidene-Anabaseine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 3-2,4-Dimethoxybenzylidene-Anabaseine, including repackagers and relabelers. The FDA regulates 3-2,4-Dimethoxybenzylidene-Anabaseine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 3-2,4-Dimethoxybenzylidene-Anabaseine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

3-2,4-Dimethoxybenzylidene-Anabaseine Suppliers

A 3-2,4-Dimethoxybenzylidene-Anabaseine supplier is an individual or a company that provides 3-2,4-Dimethoxybenzylidene-Anabaseine active pharmaceutical ingredient (API) or 3-2,4-Dimethoxybenzylidene-Anabaseine finished formulations upon request. The 3-2,4-Dimethoxybenzylidene-Anabaseine suppliers may include 3-2,4-Dimethoxybenzylidene-Anabaseine API manufacturers, exporters, distributors and traders.

click here to find a list of 3-2,4-Dimethoxybenzylidene-Anabaseine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

3-2,4-Dimethoxybenzylidene-Anabaseine USDMF

A 3-2,4-Dimethoxybenzylidene-Anabaseine DMF (Drug Master File) is a document detailing the whole manufacturing process of 3-2,4-Dimethoxybenzylidene-Anabaseine active pharmaceutical ingredient (API) in detail. Different forms of 3-2,4-Dimethoxybenzylidene-Anabaseine DMFs exist exist since differing nations have different regulations, such as 3-2,4-Dimethoxybenzylidene-Anabaseine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A 3-2,4-Dimethoxybenzylidene-Anabaseine DMF submitted to regulatory agencies in the US is known as a USDMF. 3-2,4-Dimethoxybenzylidene-Anabaseine USDMF includes data on 3-2,4-Dimethoxybenzylidene-Anabaseine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 3-2,4-Dimethoxybenzylidene-Anabaseine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of 3-2,4-Dimethoxybenzylidene-Anabaseine suppliers with USDMF on PharmaCompass.

3-2,4-Dimethoxybenzylidene-Anabaseine GMP

3-2,4-Dimethoxybenzylidene-Anabaseine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 3-2,4-Dimethoxybenzylidene-Anabaseine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 3-2,4-Dimethoxybenzylidene-Anabaseine GMP manufacturer or 3-2,4-Dimethoxybenzylidene-Anabaseine GMP API supplier for your needs.

3-2,4-Dimethoxybenzylidene-Anabaseine CoA

A 3-2,4-Dimethoxybenzylidene-Anabaseine CoA (Certificate of Analysis) is a formal document that attests to 3-2,4-Dimethoxybenzylidene-Anabaseine's compliance with 3-2,4-Dimethoxybenzylidene-Anabaseine specifications and serves as a tool for batch-level quality control.

3-2,4-Dimethoxybenzylidene-Anabaseine CoA mostly includes findings from lab analyses of a specific batch. For each 3-2,4-Dimethoxybenzylidene-Anabaseine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

3-2,4-Dimethoxybenzylidene-Anabaseine may be tested according to a variety of international standards, such as European Pharmacopoeia (3-2,4-Dimethoxybenzylidene-Anabaseine EP), 3-2,4-Dimethoxybenzylidene-Anabaseine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (3-2,4-Dimethoxybenzylidene-Anabaseine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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