Find 4-Chlorokynurenine manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 153152-32-0, L-4-chlorokynurenine, Av-101, L-4-cl-kyn, 77xlh9l40b, 4-chloro kynurenine
Molecular Formula
C10H11ClN2O3
Molecular Weight
242.66  g/mol
InChI Key
HQLHZNDJQSRKDT-QMMMGPOBSA-N
FDA UNII
77XLH9L40B

4-Chlorokynurenine
L-4-chlorokynurenine is an orally bioavailable, blood brain barrier (BBB) penetrating, chlorinated analog of the endogenous neuromodulator kynurenic acid and prodrug of 7-chlorokynurenic acid (7-Cl-KYNA), a N-methyl-D-aspartate receptor (NMDA-R) antagonist at the glycine-coagonist (GlyB) site, with potential anti-hyperalgesic, neuroprotective and anti-epileptic activities. Unlike 7-Cl-KYNA, L-4-chlorokynurenine, upon oral administration, crosses the BBB and is enzymatically converted, through transamination, within activated astrocytes located at sites of injury in the central nervous system (CNS) to its active metabolite, 7-Cl-KYNA, which allows for high levels of this active metabolite at these specific sites. In turn, 7-Cl-KYNA selectively binds to and blocks the GlyB site within the NMDA receptors. This inhibits both NMDA-R overstimulation by the excitatory neurotransmitter glutamate and NMDA-R-mediated excitotoxicity, which prevents neuronal damage and induces analgesia. In addition, another metabolite, 4-chloro-3-hydroxyanthranilic acid, inhibits the synthesis of quinolinic acid, an endogenous NMDA receptor agonist, thereby further preventing excitotoxic damage. Compared to conventional NMDA-R antagonists, NMDA-R GlyB-specific antagonists appear to have fewer side effects.
1 2D Structure

4-Chlorokynurenine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic acid
2.1.2 InChI
InChI=1S/C10H11ClN2O3/c11-5-1-2-6(7(12)3-5)9(14)4-8(13)10(15)16/h1-3,8H,4,12-13H2,(H,15,16)/t8-/m0/s1
2.1.3 InChI Key
HQLHZNDJQSRKDT-QMMMGPOBSA-N
2.1.4 Canonical SMILES
C1=CC(=C(C=C1Cl)N)C(=O)CC(C(=O)O)N
2.1.5 Isomeric SMILES
C1=CC(=C(C=C1Cl)N)C(=O)C[C@@H](C(=O)O)N
2.2 Other Identifiers
2.2.1 UNII
77XLH9L40B
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 153152-32-0

2. L-4-chlorokynurenine

3. Av-101

4. L-4-cl-kyn

5. 77xlh9l40b

6. 4-chloro Kynurenine

7. J578.071c

8. (s)-2-amino-4-(2-amino-4-chlorophenyl)-4-oxobutanoic Acid

9. 4-cl-kyn

10. (s)-4-chlorokynurenine

11. 4-chloro-l-kynurenine

12. Starbld0018860

13. Unii-77xlh9l40b

14. Schembl727370

15. 3-(4-chloroanthraniloyl)alanine

16. Zinc6092007

17. Db12878

18. Benzenebutanoic Acid, Alpha,2-diamino-4-chloro-gamma-oxo-, (s)

19. Benzenebutanoic Acid, .alpha.,2-diamino-4-chloro-.gamma.-oxo-, (s)

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 242.66 g/mol
Molecular Formula C10H11ClN2O3
XLogP3-1.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass242.0458199 g/mol
Monoisotopic Mass242.0458199 g/mol
Topological Polar Surface Area106 Ų
Heavy Atom Count16
Formal Charge0
Complexity285
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

4-Chlorokynurenine Manufacturers

A 4-Chlorokynurenine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 4-Chlorokynurenine, including repackagers and relabelers. The FDA regulates 4-Chlorokynurenine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 4-Chlorokynurenine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

4-Chlorokynurenine Suppliers

A 4-Chlorokynurenine supplier is an individual or a company that provides 4-Chlorokynurenine active pharmaceutical ingredient (API) or 4-Chlorokynurenine finished formulations upon request. The 4-Chlorokynurenine suppliers may include 4-Chlorokynurenine API manufacturers, exporters, distributors and traders.

4-Chlorokynurenine GMP

4-Chlorokynurenine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 4-Chlorokynurenine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 4-Chlorokynurenine GMP manufacturer or 4-Chlorokynurenine GMP API supplier for your needs.

4-Chlorokynurenine CoA

A 4-Chlorokynurenine CoA (Certificate of Analysis) is a formal document that attests to 4-Chlorokynurenine's compliance with 4-Chlorokynurenine specifications and serves as a tool for batch-level quality control.

4-Chlorokynurenine CoA mostly includes findings from lab analyses of a specific batch. For each 4-Chlorokynurenine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

4-Chlorokynurenine may be tested according to a variety of international standards, such as European Pharmacopoeia (4-Chlorokynurenine EP), 4-Chlorokynurenine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (4-Chlorokynurenine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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