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Chemistry

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Also known as: 6559-91-7, 4'-dmep, 4-demethylepipodophyllotoxin, (-)-4'-demethylepipodophyllotoxin, 4'-o-demethylepipodophyllotoxin, Dmep
Molecular Formula
C21H20O8
Molecular Weight
400.4  g/mol
InChI Key
YVCVYCSAAZQOJI-JHQYFNNDSA-N
FDA UNII
X0S6I23X6L

4-Demethyl-Epipodophyllotoxin
1 2D Structure

4-Demethyl-Epipodophyllotoxin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(5S,5aR,8aR,9R)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one
2.1.2 InChI
InChI=1S/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19+/m0/s1
2.1.3 InChI Key
YVCVYCSAAZQOJI-JHQYFNNDSA-N
2.1.4 Canonical SMILES
COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
2.1.5 Isomeric SMILES
COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O
2.2 Other Identifiers
2.2.1 UNII
X0S6I23X6L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4'-demethyl Epipodophyllotoxin

2.3.2 Depositor-Supplied Synonyms

1. 6559-91-7

2. 4'-dmep

3. 4-demethylepipodophyllotoxin

4. (-)-4'-demethylepipodophyllotoxin

5. 4'-o-demethylepipodophyllotoxin

6. Dmep

7. X0s6i23x6l

8. Chebi:74422

9. (10r,11r,15r,16s)-16-hydroxy-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1,3(7),8-trien-12-one

10. (5r,5ar,8ar,9s)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-one

11. (5s,5ar,8ar,9r)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

12. (5r-(5alpha,5abeta,8aalpha,9beta))-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one

13. (5s,5ar,8ar,9r)-9-(3,5-dimethoxy-4-oxidanyl-phenyl)-5-oxidanyl-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

14. Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r,5ar,8ar,9s)-

15. Teniposide Related Compound A

16. Brn 1358259

17. Unii-x0s6i23x6l

18. 4'-demethyl-epipodophyllotoxin

19. Etoposide Aglycone

20. Ncgc00161927-01

21. Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r,5ar,8ar,9s)-

22. Dsstox_cid_28668

23. Dsstox_rid_82938

24. Dsstox_gsid_48742

25. Demethylpodophyllotoxin, 4'-

26. Chembl31929

27. Epi-4'-demethylpodophyllotoxin

28. Schembl9885196

29. Dtxsid7048742

30. 4'-demethyl-9-epipodophyllotoxin

31. Epipodophyllotoxin, 4'-demethyl-

32. 4'-o-demethyl-4-epipodophyllotoxin

33. Ex-a1205

34. Zinc5670074

35. (-)-4'-demethyl-epipodophyllotoxin

36. Tox21_113196

37. Mfcd00189421

38. S2254

39. Akos015896348

40. Ac-7468

41. Ccg-208563

42. Cs-1426

43. 4'-demethyl Epi-podophyllotoxin (dmep)

44. As-18736

45. Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5ah)-one, 5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5r-(5-alpha,5a-beta,8a-alpha,9-beta))-

46. Hy-17435

47. Cas-6559-91-7

48. D5653

49. C21185

50. Teniposide Related Compound A [usp-rs]

51. A935071

52. Sr-05000002194

53. Q-100747

54. Sr-05000002194-2

55. Teniposide Related Compound A [usp Impurity]

56. Q27144659

57. (10r,11r,15r,16s)-16-hydroxy-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-12-one

58. (5r,5ar,8ar,9s)-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one

59. (5r,5ar,8ar,9s)-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5ah)-one

60. (5r,5ar,8ar,9s)-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5ah)-on

61. (5s,5ar,8ar,9r)-5-hydroxy-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5a,6,8a,9-tetrahydro-5h-isobenzofuro[6,5-f][1,3]benzodioxol-8-one

62. 89o

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 400.4 g/mol
Molecular Formula C21H20O8
XLogP31.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass400.11581759 g/mol
Monoisotopic Mass400.11581759 g/mol
Topological Polar Surface Area104 Ų
Heavy Atom Count29
Formal Charge0
Complexity614
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

4-Demethyl-Epipodophyllotoxin Manufacturers

A 4-Demethyl-Epipodophyllotoxin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 4-Demethyl-Epipodophyllotoxin, including repackagers and relabelers. The FDA regulates 4-Demethyl-Epipodophyllotoxin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 4-Demethyl-Epipodophyllotoxin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

4-Demethyl-Epipodophyllotoxin Suppliers

A 4-Demethyl-Epipodophyllotoxin supplier is an individual or a company that provides 4-Demethyl-Epipodophyllotoxin active pharmaceutical ingredient (API) or 4-Demethyl-Epipodophyllotoxin finished formulations upon request. The 4-Demethyl-Epipodophyllotoxin suppliers may include 4-Demethyl-Epipodophyllotoxin API manufacturers, exporters, distributors and traders.

4-Demethyl-Epipodophyllotoxin GMP

4-Demethyl-Epipodophyllotoxin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 4-Demethyl-Epipodophyllotoxin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 4-Demethyl-Epipodophyllotoxin GMP manufacturer or 4-Demethyl-Epipodophyllotoxin GMP API supplier for your needs.

4-Demethyl-Epipodophyllotoxin CoA

A 4-Demethyl-Epipodophyllotoxin CoA (Certificate of Analysis) is a formal document that attests to 4-Demethyl-Epipodophyllotoxin's compliance with 4-Demethyl-Epipodophyllotoxin specifications and serves as a tool for batch-level quality control.

4-Demethyl-Epipodophyllotoxin CoA mostly includes findings from lab analyses of a specific batch. For each 4-Demethyl-Epipodophyllotoxin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

4-Demethyl-Epipodophyllotoxin may be tested according to a variety of international standards, such as European Pharmacopoeia (4-Demethyl-Epipodophyllotoxin EP), 4-Demethyl-Epipodophyllotoxin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (4-Demethyl-Epipodophyllotoxin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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