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4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine; Phosphoric Acid

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ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 4 USDMF, 1 CEP/COS, 3 EU WC, 4 NDC API, 4 Listed Suppliers, $ API Reference Price

8 API Suppliers
4 USDMF
1 CEP/COS
3 EU WC
4 NDC API
4 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers, 5 FDA Orange Book, 2 Europe, 1 Canada, 4 Listed Dossiers

12 FDF Dossiers
5 FDA Orange Book
2 Europe
1 Canada
4 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma, 2 Seqens, 3 DKSH, 1 Jai Radhe Sales, 3 Faran Shimi Pharmaceutical, 10 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 5 Actylis, 1 Aeon Procare, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 12 BASF, 1 Clariant, 10 Corel Pharma Chem, 4 DFE Pharma, 1 Finar, 9 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 30 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 10 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 15 Roquette, 13 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 2 The Dow Chemical Company, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

55 Fillers, Diluents & Binders, 44 Coating Systems & Additives, 27 Direct Compression, 25 Controlled & Modified Release, 20 Thickeners and Stabilizers, 15 Co-Processed Excipients, 15 Solubilizers, 14 Granulation, 13 Lubricants & Glidants, 11 Film Formers & Plasticizers, 11 Topical, 10 Disintegrants & Superdisintegrants, 9 Parenteral, 7 Taste Masking, 7 Emulsifying Agents, 6 Chewable & Orodispersible Aids, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 4 Coloring Agents, 4 Rheology Modifiers, 3 Surfactant & Foaming Agents

DIGITAL CONTENT

3 NEWS #PharmaBuzz

media
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

globalSalesInformation
1 US Medicaid Prescriptions

MARKET PLACE

1 APIs, 2 FDF Dossiers

marketPlace
1 APIs
2 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 USP , 2 Others

otherSolutions
1 USP
2 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 388

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

18,535

Annual Reports (USD Million)

Finished Drug Prices

189 RELATED EXCIPIENT COMPANIES

314EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Primaquine diphosphate, 63-45-6, Primaquine bisphosphate, Primaquine (diphosphate), Malquine, 1,4-pentanediamine, n4-(6-methoxy-8-quinolinyl)-, phosphate (1:2)

Molecular Formula

C₁₅H₂₇N₃O₉P₂

Molecular Weight

455.34 g/mol

InChI Key

GJOHLWZHWQUKAU-UHFFFAOYSA-N

FDA UNII

H0982HF78B

An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)

1 2D Structure

Primaquine Diphosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid

2.1.2 InChI

InChI=1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)

2.1.3 InChI Key

GJOHLWZHWQUKAU-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(CCCN)NC1=C2C(=CC(=C1)OC)C=CC=N2.OP(=O)(O)O.OP(=O)(O)O

2.2 Other Identifiers

2.2.1 UNII

H0982HF78B

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Diphosphate, Primaquine

2. Phosphate, Primaquine

3. Primacin

4. Primaquine

5. Primaquine Diphosphate

2.3.2 Depositor-Supplied Synonyms

1. Primaquine Diphosphate

2. 63-45-6

3. Primaquine Bisphosphate

4. Primaquine (diphosphate)

5. Malquine

6. 1,4-pentanediamine, N4-(6-methoxy-8-quinolinyl)-, Phosphate (1:2)

7. Primaquine Phosphate;primaquine Bisphosphate

8. N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine Bis(phosphate)

9. H0982hf78b

10. Nsc-149765

11. N-(5-aminopentan-2-yl)-6-methoxyquinolin-8-amine; Bis(phosphoric Acid)

12. Primaquine Bis(phosphate)

13. Wr 2975

14. Dsstox_cid_25248

15. Dsstox_rid_80773

16. Dsstox_gsid_45248

17. Ccris 1946

18. Sr-05000001864

19. Ncgc00178754-06

20. Einecs 200-560-8

21. Nsc 149765

22. Primaquine Phosphate [usp]

23. Unii-h0982hf78b

24. Primaquine (tn)

25. Prestwick_406

26. Primaquini Diphosphas

27. Camden

28. Sn13272 Diphosphate

29. 8-((4-amino-1-methylbutyl)amino)-6-methoxyquinoline Diphosphate

30. Cas-63-45-6

31. Ncgc00016284-01

32. 8-((4-amino-1-methylbutyl)amino)-6-methoxyquinoline Phosphate (1:2)

33. Primachine Phosphate

34. Schembl41096

35. Chembl43128

36. Primaquine Bisphosphate, 98%

37. Spectrum1500500

38. Dtxsid6045248

39. Hms502i08

40. Primaquine Phosphate (jan/usp)

41. 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline Diphosphate

42. 8-(4-amino-1-methylbutylamino)-6-methoxyquinolinediphosphate

43. Hms1569o14

44. Hms1920j18

45. Hms2092a19

46. Hms2096o14

47. Hms3652b19

48. Hms3713o14

49. Primaquine Phosphate [jan]

50. Primaquine Diphosphate [mi]

51. Ibscreen-bb Bb_sc-03079

52. Primaquine Phosphate [vandf]

53. Tox21_110350

54. Ccg-40283

55. Mfcd00013166

56. Primaquine Phosphate [mart.]

57. S4237

58. Primaquine Phosphate [usp-rs]

59. Primaquine Phosphate [who-dd]

60. (+-)-8-((4-amino-1-methylbutyl)amino)-6-methoxyquinoline Phosphate (1:2)

61. 1,4-pentanediamine, N(sup 4)-(6-methoxy-8-quinolinyl)-, Phosphate (1:2)

62. Akos026749962

63. Quinoline, 8-((4-amino-1-methylbutyl)amino)-6-methoxy-, Phosphate (1:2)

64. Tox21_110350_1

65. Cs-3875

66. Primaquine Diphosphate [who-ip]

67. 1,4-pentanediamine, N(sup 4)-(6-methoxy-8-quinolinyl)-, (+-)-, Phosphate (1:2)

68. Ncgc00094767-01

69. Ncgc00094767-02

70. As-13148

71. Hy-12651

72. Primaquine Phosphate [orange Book]

73. Db-054488

74. Primaquine Phosphate [usp Monograph]

75. Primaquine Diphosphate [ep Monograph]

76. Primaquini Diphosphas [who-ip Latin]

77. Sw196647-3

78. D02126

79. E75742

80. 013p166

81. Sr-05000001864-1

82. Sr-05000001864-3

83. Sr-05000001864-7

84. Q27279400

85. N4-(6-methoxyquinolin-8-yl)pentane-1,4-diaminebis(phosphate)

86. 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline Diphosphate Salt

87. 1,4-pentanediamine, N^4-(6-methoxy-8-quinolinyl)-, Phosphate (1:2)

88. 8-?(4-?amino-?1-?methylbutylamino)?-?6-?methoxyquinoline Diphosphate Salt

89. Primaquine Diphosphate, European Pharmacopoeia (ep) Reference Standard

90. Primaquine Phosphate, United States Pharmacopeia (usp) Reference Standard

91. Quinoline, 8-((4-amino-1-methylbutyl)amino)-6-methoxy-, Diphosphate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₇N₃O₉P₂
Molecular Weight	455.34 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	6
Exact Mass	455.12225344 g/mol
Monoisotopic Mass	455.12225344 g/mol
Topological Polar Surface Area	216 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	312
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Primaquine phosphate
Drug Label	Primaquine phosphate is 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline phosphate, a synthetic compound with potent antimalarial activity. Each tablet contains 26.3 mg of Primaquine phosphate (equivalent to 15 mg of primaquine base). The dosage i...
Active Ingredient	Primaquine phosphate
Dosage Form	Tablet
Route	Oral
Strength	eq 15mg base
Market Status	Prescription
Company	Bayshore Pharms; Alvogen

2 of 2
Drug Name	Primaquine phosphate
Drug Label	Primaquine phosphate is 8-[(4-Amino-1-methylbutyl)amino]-6-methoxyquinoline phosphate, a synthetic compound with potent antimalarial activity. Each tablet contains 26.3 mg of Primaquine phosphate (equivalent to 15 mg of primaquine base). The dosage i...
Active Ingredient	Primaquine phosphate
Dosage Form	Tablet
Route	Oral
Strength	eq 15mg base
Market Status	Prescription
Company	Bayshore Pharms; Alvogen

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antimalarials

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Antimalarial [EPC]

API SUPPLIERS

01

Viatris

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

02

Ipca Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

03

Country

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

04

Country

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

05

BOC Sciences

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

06

Sibbiotech

Russia

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

07

Mangalam Drugs & Organics Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

08

Mangalam Drugs & Organics Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

PPS Boston

Not Confirmed

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USDMF

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CEP/COS

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ACTIVE PHARMA INGREDIENTS

8 API Suppliers

4 USDMF

1 CEP/COS

3 EU WC

4 NDC API

4 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

12 FDF Dossiers

5 FDA Orange Book

2 Europe

1 Canada

4 Listed Dossiers

RELATED EXCIPIENT COMPANIES

4 SPI Pharma

2 Seqens

3 DKSH

1 Jai Radhe Sales

3 Faran Shimi Pharmaceutical

10 Gangwal Healthcare

3 Nanjing Well Pharmaceutical

1 ACG Worldwide

5 Actylis

1 Aeon Procare

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

12 BASF

1 Clariant

10 Corel Pharma Chem

4 DFE Pharma

1 Finar

9 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

2 Ingredion Pharma Solutions

30 Kerry

3 Kima Chemical

6 Lonza Capsugel

10 Microlex e.U

1 Nanjing Bold Chemical

2 Nomisma Healthcare

1 Novo Excipients

1 Pharmatrans-Sanaq

3 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

15 Roquette

13 Seppic

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

10 Sigachi Industries

2 The Dow Chemical Company

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

55 Fillers, Diluents & Binders

44 Coating Systems & Additives

27 Direct Compression

25 Controlled & Modified Release

20 Thickeners and Stabilizers

15 Co-Processed Excipients

15 Solubilizers

14 Granulation

13 Lubricants & Glidants

11 Film Formers & Plasticizers

11 Topical

10 Disintegrants & Superdisintegrants

9 Parenteral

7 Taste Masking

7 Emulsifying Agents

6 Chewable & Orodispersible Aids

5 Empty Capsules

5 API Stability Enhancers

4 Vegetarian Capsules

4 Coloring Agents

4 Rheology Modifiers

3 Surfactant & Foaming Agents