Find 5-Aza-t-dcyd manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 5-aza-t-dcyd, U2ptn0rzf6, 169514-76-5, 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-1,3,5-triazin-2-one, Unii-u2ptn0rzf6, Schembl19244084
Molecular Formula
C8H12N4O3S
Molecular Weight
244.27  g/mol
InChI Key
HOOZQNOZVFCJNL-KVQBGUIXSA-N
FDA UNII
U2PTN0RZF6

5-Aza-t-dcyd
5-Aza-4'-thio-2'-deoxycytidine is an orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor, with potential DNA hypomethylating and antineoplastic activities. Upon administration, 5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds to the active site of DNMT1, a maintenance methyltransferase that contributes to the hypermethylation and silencing of tumor suppressor genes. The formation of covalent DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes CpG demethylation, and results in the re-expression and re-activation of silenced tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated in tumor cells, plays a key role in tumor cell proliferation.
1 2D Structure

5-Aza-t-dcyd

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-1,3,5-triazin-2-one
2.1.2 InChI
InChI=1S/C8H12N4O3S/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
2.1.3 InChI Key
HOOZQNOZVFCJNL-KVQBGUIXSA-N
2.1.4 Canonical SMILES
C1C(C(SC1N2C=NC(=NC2=O)N)CO)O
2.1.5 Isomeric SMILES
C1[C@@H]([C@H](S[C@H]1N2C=NC(=NC2=O)N)CO)O
2.2 Other Identifiers
2.2.1 UNII
U2PTN0RZF6
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 5-aza-t-dcyd

2. U2ptn0rzf6

3. 169514-76-5

4. 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-1,3,5-triazin-2-one

5. Unii-u2ptn0rzf6

6. Schembl19244084

7. 4-amino-1(2'-deoxy-4-thio-.beta.-d-erythropentofuranosyl)-1,3,5-triazin-2(1h)-one

8. 1-[4alpha-hydroxy-5beta-(hydroxymethyl)tetrahydrothiophene-2beta-yl]-4-amino-1,3,5-triazine-2(1h)-one

9. 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-1,3,5-triazin-2-one

2.4 Create Date
2005-10-07
3 Chemical and Physical Properties
Molecular Weight 244.27 g/mol
Molecular Formula C8H12N4O3S
XLogP3-0.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass244.06301143 g/mol
Monoisotopic Mass244.06301143 g/mol
Topological Polar Surface Area137 Ų
Heavy Atom Count16
Formal Charge0
Complexity359
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

5-Aza-t-dcyd Manufacturers

A 5-Aza-t-dcyd manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 5-Aza-t-dcyd, including repackagers and relabelers. The FDA regulates 5-Aza-t-dcyd manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 5-Aza-t-dcyd API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

5-Aza-t-dcyd Suppliers

A 5-Aza-t-dcyd supplier is an individual or a company that provides 5-Aza-t-dcyd active pharmaceutical ingredient (API) or 5-Aza-t-dcyd finished formulations upon request. The 5-Aza-t-dcyd suppliers may include 5-Aza-t-dcyd API manufacturers, exporters, distributors and traders.

click here to find a list of 5-Aza-t-dcyd suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

5-Aza-t-dcyd USDMF

A 5-Aza-t-dcyd DMF (Drug Master File) is a document detailing the whole manufacturing process of 5-Aza-t-dcyd active pharmaceutical ingredient (API) in detail. Different forms of 5-Aza-t-dcyd DMFs exist exist since differing nations have different regulations, such as 5-Aza-t-dcyd USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A 5-Aza-t-dcyd DMF submitted to regulatory agencies in the US is known as a USDMF. 5-Aza-t-dcyd USDMF includes data on 5-Aza-t-dcyd's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 5-Aza-t-dcyd USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of 5-Aza-t-dcyd suppliers with USDMF on PharmaCompass.

5-Aza-t-dcyd GMP

5-Aza-t-dcyd Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 5-Aza-t-dcyd GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 5-Aza-t-dcyd GMP manufacturer or 5-Aza-t-dcyd GMP API supplier for your needs.

5-Aza-t-dcyd CoA

A 5-Aza-t-dcyd CoA (Certificate of Analysis) is a formal document that attests to 5-Aza-t-dcyd's compliance with 5-Aza-t-dcyd specifications and serves as a tool for batch-level quality control.

5-Aza-t-dcyd CoA mostly includes findings from lab analyses of a specific batch. For each 5-Aza-t-dcyd CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

5-Aza-t-dcyd may be tested according to a variety of international standards, such as European Pharmacopoeia (5-Aza-t-dcyd EP), 5-Aza-t-dcyd JP (Japanese Pharmacopeia) and the US Pharmacopoeia (5-Aza-t-dcyd USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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