DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 157-03-9, Diazooxonorleucine, L-don, L-norleucine, 6-diazo-5-oxo-, 6-diazo-5-oxo-l-nor-leucine, L-6-diazo-5-oxonorleucine

Molecular Formula

C₆H₉N₃O₃

Molecular Weight

171.15 g/mol

InChI Key

YCWQAMGASJSUIP-YFKPBYRVSA-N

FDA UNII

03J0H273KZ

An amino acid that inhibits phosphate-activated glutaminase and interferes with glutamine metabolism. It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil. (From Merck Index, 11th ed)

1 2D Structure

6-Diazo-5-oxo-L-norleucine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-2-amino-6-diazo-5-oxohexanoic acid

2.1.2 InChI

InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1

2.1.3 InChI Key

YCWQAMGASJSUIP-YFKPBYRVSA-N

2.1.4 Canonical SMILES

C(CC(=O)C=[N+]=[N-])C(C(=O)O)N

2.1.5 Isomeric SMILES

C(CC(=O)C=[N+]=[N-])[C@@H](C(=O)O)N

2.2 Other Identifiers

2.2.1 UNII

03J0H273KZ

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 6 Diazo 5 Oxo L Norleucine

2. Diazooxonorleucine

2.3.2 Depositor-Supplied Synonyms

1. 157-03-9

2. Diazooxonorleucine

3. L-don

4. L-norleucine, 6-diazo-5-oxo-

5. 6-diazo-5-oxo-l-nor-leucine

6. L-6-diazo-5-oxonorleucine

7. L-norleucine,6-diazo-5-oxo-

8. Don

9. Nsc-7365

10. 03j0h273kz

11. Don (pharmaceutical)

12. Mfcd00037218

13. Nsc 7365

14. Brn 1725815

15. Norleucine,6-diazo-5-oxo-

16. Nsc7365

17. (s)-2-amino-6-diazo-5-oxocaproic Acid

18. Unii-03j0h273kz

19. Ai3-26441

20. Norleucine, 6-diazo-5-oxo, L-

21. Ncimech_000302

22. Ncistruc1_000220

23. Ncistruc2_000175

24. (l)-don

25. 4-04-00-03278 (beilstein Handbook Reference)

26. Chembl97485

27. Chembl4303391

28. Diazo-5-oxo-l-norleucine, 6-

29. Schembl15349013

30. Schembl15349015

31. Kmx-010

32. Nci7365

33. Chebi:138889

34. Dtxsid501028846

35. Ex-a1965

36. Zinc3953825

37. Ccg-35449

38. Ccg-37571

39. Ncgc00013078

40. Akos030213039

41. Ncgc00013078-02

42. Ncgc00096202-01

43. 6-diazo-5-oxo-l-norleucine, Crystalline

44. 6-diazo-5-oxo-l-norleucine [mi]

45. (2s)-2-amino-6-diazo-5-oxohexanoic Acid

46. Hy-108357

47. (2s)-2-amino-6-diazo-5-oxo-hexanoic Acid

48. Cs-0028442

49. A936514

50. Q245487

51. J-009370

2.4 Create Date

2005-08-01

3 Chemical and Physical Properties

Molecular Formula	C₆H₉N₃O₃
Molecular Weight	171.15 g/mol
XLogP3	-3.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	171.06439116 g/mol
Monoisotopic Mass	171.06439116 g/mol
Topological Polar Surface Area	82.4 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	232
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	1
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antimetabolites, Antineoplastic

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)

Antibiotics, Antineoplastic

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)

Drugs in Development