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ACTIVE PHARMA INGREDIENTS

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Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

$ 49

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Chemistry

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Also known as: 6018-19-5, Parasal sodium, Sodium 4-amino-2-hydroxybenzoate dihydrate, Sodium aminosalicylate, Pamisyl sodium, Aminosalicylate sodium

Molecular Formula

C₇H₁₀NNaO₅

Molecular Weight

211.15 g/mol

InChI Key

GMUQJDAYXZXBOT-UHFFFAOYSA-M

FDA UNII

S38B9W6AXW

An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.

1 2D Structure

6018-19-5

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;4-amino-2-hydroxybenzoate;dihydrate

2.1.2 InChI

InChI=1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1

2.1.3 InChI Key

GMUQJDAYXZXBOT-UHFFFAOYSA-M

2.1.4 Canonical SMILES

C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

S38B9W6AXW

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4 Aminosalicylic Acid

2. 4-aminosalicylic Acid

3. Acid, Aminosalicylic

4. Alumino 4 Aminosalicylic Acid

5. Alumino-4-aminosalicylic Acid

6. Aminosalicylic Acid

7. P Aminosalicylic Acid

8. P Aminosalicylic Acid Monolithium Salt

9. P Aminosalicylic Acid Monopotassium Salt

10. P Aminosalicylic Acid Monosodium Salt

11. P-aminosalicylic Acid

12. P-aminosalicylic Acid Monolithium Salt

13. P-aminosalicylic Acid Monopotassium Salt

14. P-aminosalicylic Acid Monosodium Salt

15. P-aminosalicylic Acid, Aluminum (2:1) Salt

16. P-aminosalicylic Acid, Calcium (2:1) Salt

17. P-aminosalicylic Acid, Monosodium Salt, Dihydrate

18. Pamisyl

19. Para Aminosalicylic Acid

20. Para-aminosalicylic Acid

21. Rezipas

2.3.2 Depositor-Supplied Synonyms

1. 6018-19-5

2. Parasal Sodium

3. Sodium 4-amino-2-hydroxybenzoate Dihydrate

4. Sodium Aminosalicylate

5. Pamisyl Sodium

6. Aminosalicylate Sodium

7. Teebacin

8. 4-aminosalicylic Acid Sodium Salt Dihydrate

9. Benzoic Acid, 4-amino-2-hydroxy-, Monosodium Salt, Dihydrate

10. Aminacyl

11. Nemasol Sodium

12. Paramisan Sodium

13. Sodium 4-aminosalicylate (dihydrate)

14. Sodium Aminosalicylate Dihydrate

15. 4-amino-salicylic Acid Sodium Salt

16. Para-aminosodium Salicylate

17. Monosodium 4-aminosalicylate Dihydrate

18. S38b9w6axw

19. Aminosalicylate Sodium [usp]

20. P-aminosalicylic Acid Sodium Salt Dihydrate

21. Nsc-755862

22. Sodium;4-amino-2-hydroxybenzoate;dihydrate

23. 4-aminosalicylic Acid (sodium Salt Dihydrate)

24. Aminosalicylate Sodium (usp)

25. Sodium P.a.s.

26. P.a.s. Sodium

27. Unii-s38b9w6axw

28. Mfcd00151044

29. Parasal Sodium (tn)

30. Aminosalyle Sodium

31. Aminosalicylate Sodium Dihydrate

32. Natrium-p-aminosalicylatdihydrat

33. Sodium4-aminosalicylatedihydrate

34. Chembl2096646

35. Dtxsid5036638

36. Hy-i0447a

37. Sodium P Aminosalicylate Dihydrate

38. Sodium P-aminosalicylate Dihydrate

39. Cs-m3079

40. Aminosalicylate Sodium [vandf]

41. P-aminosalicylic Acid Monosodium Salt

42. Akos024258376

43. Nsc 755862

44. As-11771

45. Para-aminosodium Salicylate [vandf]

46. Aminosalicylate Sodium [orange Book]

47. P-aminosalicylate Acid Sodium Salt Dihydrate

48. Aminosalicylate Sodium [usp Impurity]

49. Ft-0617611

50. Sodium 4-azanyl-2-oxidanyl-benzoate Dihydrate

51. D00875

52. D78312

53. Sodium Aminosalicylate Dihydrate [vandf]

54. Beta-d-ribopyranose1,2,3,4-tetraacetate

55. Sodium Aminosalicylate Dihydrate [mart.]

56. Sodium Aminosalicylate Dihydrate [who-dd]

57. A832630

58. Neopasalate Component Aminosalicylate Sodium

59. Sodium 4-aminosalicylate Dihydrate, >=97.0% (t)

60. Aminosalicylate Sodium Component Of Neopasalate

61. Q27288525

62. Sodium Aminosalicylate Dihydrate [ep Monograph]

63. F1905-7110

64. P-aminosalicylic Acid Sodium Salt Dihydrate [mi]

65. Sodium Aminosalicylate Dihydrate For Equipment Qualification

66. Benzoic Acid, 4-amino-2-hydroxy-, Sodium Salt, Hydrate (1:1:2)

67. Sodium Aminosalicylate Dihydrate, European Pharmacopoeia (ep) Reference Standard

68. Sodium Aminosalicylate Dihydrate For Equipment Qualification, European Pharmacopoeia (ep) Reference Standard

69. Sodium Aminosalicylate Dihydrate, Pharmaceutical Secondary Standard; Certified Reference Material

2.4 Create Date

2007-07-12

3 Chemical and Physical Properties

Molecular Formula	C₇H₁₀NNaO₅
Molecular Weight	211.15 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	1
Exact Mass	211.04566670 g/mol
Monoisotopic Mass	211.04566670 g/mol
Topological Polar Surface Area	88.4 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	165
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antitubercular Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)

4.2 ATC Code

J - Antiinfectives for systemic use

J04 - Antimycobacterials

J04A - Drugs for treatment of tuberculosis

J04AA - Aminosalicylic acid and derivatives

J04AA02 - Sodium aminosalicylate

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ABOUT THIS PAGE

6018-19-5 Manufacturers

A 6018-19-5 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 6018-19-5, including repackagers and relabelers. The FDA regulates 6018-19-5 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 6018-19-5 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

6018-19-5 Suppliers

A 6018-19-5 supplier is an individual or a company that provides 6018-19-5 active pharmaceutical ingredient (API) or 6018-19-5 finished formulations upon request. The 6018-19-5 suppliers may include 6018-19-5 API manufacturers, exporters, distributors and traders.

6018-19-5 GMP

6018-19-5 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 6018-19-5 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 6018-19-5 GMP manufacturer or 6018-19-5 GMP API supplier for your needs.

6018-19-5 CoA

A 6018-19-5 CoA (Certificate of Analysis) is a formal document that attests to 6018-19-5's compliance with 6018-19-5 specifications and serves as a tool for batch-level quality control.

6018-19-5 CoA mostly includes findings from lab analyses of a specific batch. For each 6018-19-5 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

6018-19-5 may be tested according to a variety of international standards, such as European Pharmacopoeia (6018-19-5 EP), 6018-19-5 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (6018-19-5 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.