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    Chemistry

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    Also known as: 61-73-4, Basic blue 9, Methylthioninium chloride, Solvent blue 8, Swiss blue, Chromosmon
    Molecular Formula
    C16H18ClN3S
    Molecular Weight
    319.9  g/mol
    InChI Key
    CXKWCBBOMKCUKX-UHFFFAOYSA-M
    FDA UNII
    8NAP7826UB
    Methylene Blue
    A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
    1 2D Structure

    Methylene Blue

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
    2.1.2 InChI
    InChI=1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1
    2.1.3 InChI Key
    CXKWCBBOMKCUKX-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
    2.2 Other Identifiers
    2.2.1 UNII
    8NAP7826UB
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Basic Blue 9

    2. Blue 9, Basic

    3. Blue N, Methylene

    4. Blue, Methylene

    5. Blue, Swiss

    6. Blue, Urolene

    7. Chromosmon

    8. Methylene Blue N

    9. Methylthionine Chloride

    10. Methylthioninium Chloride

    11. Swiss Blue

    12. Urolene Blue

    2.3.2 Depositor-Supplied Synonyms

    1. 61-73-4

    2. Basic Blue 9

    3. Methylthioninium Chloride

    4. Solvent Blue 8

    5. Swiss Blue

    6. Chromosmon

    7. Methylene Blue Anhydrous

    8. 3,7-bis(dimethylamino)phenothiazin-5-ium Chloride

    9. Methylene Blue N

    10. Methylene Blue Bb

    11. C.i. Basic Blue 9

    12. Methylenium Ceruleum

    13. Tetramethylthionine Chloride

    14. Bleu De Methylene

    15. Methylene Blue Chloride

    16. Methylthionine Chloride

    17. External Blue 1

    18. Methylene Blue A

    19. Methylene Blue B

    20. Methylene Blue D

    21. Methylene Blue G

    22. Calcozine Blue Zf

    23. Methylene Blue Bd

    24. Methylene Blue Bp

    25. Methylene Blue Bx

    26. Methylene Blue Bz

    27. Methylene Blue Fz

    28. Methylene Blue Gz

    29. Methylene Blue Nz

    30. Methylene Blue Sg

    31. Methylene Blue Sp

    32. Methylene Blue Zf

    33. Methylene Blue Zx

    34. Tetramethylene Blue

    35. Methylene Blue 2b

    36. Methylene Blue Bba

    37. Methylene Blue Bpc

    38. Methylene Blue Hgg

    39. Methylene Blue Iad

    40. Methylene Blue Jfa

    41. Sandocryl Blue Brl

    42. Methylenblau

    43. Methylene Blue 2bf

    44. Methylene Blue 2bn

    45. Methylene Blue 2bp

    46. M-b Tabs

    47. Rember

    48. Mitsui Methylene Blue

    49. Methylthionium Chloride

    50. Leather Pure Blue Hb

    51. Modr Methylenova

    52. Schultz No. 1038

    53. Aizen Methylene Blue Bh

    54. Aizen Methylene Blue Fz

    55. Methylene Blue Polychrome

    56. Methylene Blue Zinc Free

    57. C.i. 52015

    58. Yamamoto Methylene Blue B

    59. D And C Blue Number 1

    60. Methylene Blue (medicinal)

    61. Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, Chloride

    62. Yamamoto Methylene Blue Zf

    63. Ext D And C Blue No. 1

    64. Methylene Blue I (medicinal)

    65. Cloruro De Metiltioninio

    66. Methylene Blue Nf (medicinal)

    67. Methylthioninii Chloridum

    68. Hidaco Methylene Blue Salt Free

    69. Methylene Blue Bb (zinc Free)

    70. Methylene Blue Usp (medicinal)

    71. Lowacryl Blue 9

    72. Chlorure De Methylthioninium

    73. Methylene Blue Usp Xii (medicinal)

    74. 3,7-bis(dimethylamino)phenazathionium Chloride

    75. Methylene Blue Chloride (biological Stain)

    76. X 138

    77. Mfcd00012111

    78. 12262-49-6

    79. Ci 52015

    80. Ci-52015

    81. 8nap7826ub

    82. Chebi:6872

    83. 105504-42-5

    84. Methylthioninium Chloride [inn]

    85. [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride

    86. Urolene Blue

    87. Provayblue

    88. Nsc-215213

    89. Nsc-617593

    90. Azul De Metileno

    91. Dsstox_cid_3296

    92. N-[7-(dimethylamino)-3h-phenothiazin-3-ylidene]-n-methylmethanaminium Chloride

    93. Ceruleum Methylenum

    94. Dsstox_rid_76963

    95. Dsstox_gsid_23296

    96. Methylenum Coeruleum

    97. Ci Basic Blue 9

    98. Zinc Free Methylene Blue

    99. Caswell No. 567

    100. Methylenblau [german]

    101. Methylthionini Chloridum

    102. 3h-phenothiazine, 3-methochloride

    103. Trx0014

    104. Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, Chloride (1:1)

    105. Modr Methylenova [czech]

    106. Chembl405110

    107. Modr Zasadita 9

    108. Modr Zasadita 9 [czech]

    109. Cas-61-73-4

    110. N-(7-(dimethylamino)-3h-phenothiazin-3-ylidene)-n-methylmethanaminium Chloride

    111. Nsc3089

    112. 152071-32-4

    113. Ccris 833

    114. Metiltioninio Cloruro [dcit]

    115. Metiltioninio Cloruro

    116. Modr Rozpoustedlova 8 [czech]

    117. 3h-phenothiazine, 7-(dimethylamino)-3-(methylimino)-, 3-methochloride

    118. Modr Rozpoustedlova 8

    119. Nsc215213

    120. Nsc617593

    121. C.i. 52 015

    122. Hsdb 1405

    123. Ncgc00167496-01

    124. Ncgc00167496-03

    125. Phenothiazin-5-ium,7-bis(dimethylamino)-, Chloride

    126. Einecs 200-515-2

    127. Methylthioninii Chloridum [inn-latin]

    128. Epa Pesticide Chemical Code 039505

    129. Nsc 215213

    130. Cloruro De Metiltioninio [inn-spanish]

    131. Unii-8nap7826ub

    132. Wln: T C666 Bs Ey Inj Euk1&1 Mn1&1 &g &421

    133. Chlorure De Methylthioninium [inn-french]

    134. Methylene Blue Usp

    135. Methylene Azure Ii

    136. Prestwick_326

    137. Methylene Blue (inhibitor)

    138. Schembl1351

    139. Methylene Blue [mi]

    140. Mls000719838

    141. Methylene Blue [hsdb]

    142. Basic Blue 9 [inci]

    143. Dog (couch) Grass Powder

    144. Dtxsid0023296

    145. Hms2598o03

    146. Pharmakon1600-01505444

    147. Ci No 52015

    148. Nsc-3089

    149. Trx-0014

    150. Tox21_112497

    151. Tox21_302087

    152. Nsc759135

    153. S4535

    154. Stk018918

    155. Akos000486124

    156. Akos015916406

    157. Tox21_112497_1

    158. Ccg-267696

    159. Db09241

    160. 4-(1-hydroxy-ethyl)-benzoicacid

    161. Methylthioninium Chloride [mart.]

    162. Ncgc00255351-01

    163. Ac-15225

    164. As-35256

    165. Basic Blue 9;tetramethylthionine Chloride

    166. Hy-14536

    167. Methylene Blue, 1% W/v Aqueous Solution

    168. Methylthioninium Chloride [who-dd]

    169. Methylthioninium Chloride Proveblue

    170. Smr000304367

    171. Sy076497

    172. Methylthioninium Chloride (methylene Blue)

    173. Methylene Blue (c.i. 52015) Biochemica

    174. Methylthioninium Chloride [ema Epar]

    175. A0574

    176. Ft-0622580

    177. M0501

    178. M2392

    179. C00220

    180. M-3598

    181. Methylthioninium Chloride [ep Impurity]

    182. 3,7-bis(dimethylamino)-5-phenothiazinium Chloride

    183. Q422134

    184. Methylthioninium Chloride Anhydrous [who-ip]

    185. 3,7-bis(dimethylamino)-phenothiazin-5-ium Chloride Salt

    186. Methylthioninii Chloridum Anhydrous [who-ip Latin]

    187. Methylene Blue Solution (methanol Solution) [for Cell Staining]

    188. 3-n,3-n,7-n,7-n-tetramethylphenothiazin-5-ium-3,7-diamine;chloride

    189. N-(7-(dimethylamino)-3h-phenothiazin-3-ylidene)-n-methylmethanaminiumchloride

    190. 1341-90-8

    191. 6476-03-5

    192. 97130-83-1

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 319.9 g/mol
    Molecular Formula C16H18ClN3S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count1
    Exact Mass319.0909965 g/mol
    Monoisotopic Mass319.0909965 g/mol
    Topological Polar Surface Area43.9 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity483
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Enzyme Inhibitors

    National Library of Medicine's Medical Subject Headings. Methylene Blue. Online file (MeSH, 2018). Available from, as of August 29, 2018: https://meshb.nlm.nih.gov/search

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Methylene blue is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of August 29, 2018: https://clinicaltrials.gov/

    Drug-induced methemoglobinemia. /Included in US product label/

    NIH; DailyMed. Current Medication Information for Methylene blue injection (Updated: November 20, 2017). Available from, as of September 5, 2018: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fde64824-2be5-4d85-8d57-5098ca6890bb

    Methylene blue posses weak urinary antiseptic properties. Methylene blue directly inhibits calcium binding by oxalate and by organic stone matrix. The drug also acts as a crystal poison at the interface, reducing the tendency of calcium oxalate particles to aggregate. In addition, it reverses intracellular acidosis (such as that in renal tubule acidosis), apparently by competing with diphosphopyridine nucleotide as a hydrogen receptor.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    For more Therapeutic Uses (Complete) data for Methylene blue (32 total), please visit the HSDB record page.

    4.2 Drug Warning

    /BOXED WARNING/ WARNING: SEROTONIN SYNDROME WITH CONCOMITANT USE OF SEROTONERGIC DRUGS. Methylene Blue Injection may cause serious or fatal serotonergic syndrome when used in combination with serotonergic drugs. Avoid concomitant use of Methylene blue injection with selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors.

    NIH; DailyMed. Current Medication Information for Methylene blue injection (Updated: November 20, 2017). Available from, as of September 5, 2018: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fde64824-2be5-4d85-8d57-5098ca6890bb

    Large IV doses of methylene blue may produce nausea, vomiting, abdominal pain, precordial pain, dizziness, headache, profuse sweating, dyspnea, hypertension, and mental confusion. Urinary tract irritation may occur. High IV dosage or high local concentrations of methylene blue may cause formation of methemoglobin and cyanosis.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    Hemolysis and hemolytic anemia may occur, especially in young infants and patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    Hypersensitivity, manifested as wheal and flare reactions at the injection site, has been reported. Severe hypersensitivity reactions, including anaphylaxis, generalized urticaria, and hypotension, tachycardia, and bronchospasm, have been reported following local instillation or injection of methylene blue.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    For more Drug Warnings (Complete) data for Methylene blue (20 total), please visit the HSDB record page.

    4.3 Drug Indication

    Indicated for the treatment of pediatric and adult patients with acquired methemoglobinemia. Other clinical applications of methylene blue include improvement of hypotension associated with various clinical states, an antiseptic in urinary tract infections, treatment of hypoxia and hyperdynamic circulation in cirrhosis of liver and severe hepatopulmonary syndrome, and treatment of ifofosamide induced neurotoxicity.

    Acute symptomatic treatment of medicinal and chemical products- induced methaemoglobinaemia.

    Methylthioninium chloride Proveblue is indicated in adults, children and adolescents (aged 0 to 17 years old).

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Enzyme Inhibitors

    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Oxidation-Reduction Agent [EPC]; Oxidation-Reduction Activity [MoA]
    5.3 ATC Code

    V03AB17

    V - Various

    V03 - All other therapeutic products

    V03A - All other therapeutic products

    V03AB - Antidotes

    V03AB17 - Methylthioninium chloride

    V - Various

    V04 - Diagnostic agents

    V04C - Other diagnostic agents

    V04CG - Tests for gastric secretion

    V04CG05 - Methylthioninium chloride

    5.4 Absorption, Distribution and Excretion

    Route of Elimination

    Excreted in urine and bile. About 75% of an oral dose excreted in urine, primarily as stabilized colorless leukomethylene blue.

    Volume of Distribution

    10 mg/kg (in rats).

    Clearance

    3.00.7 L/min.

    ... The concentration of methylene blue in whole blood was measured using high-performance liquid chromatography in seven volunteers after IV and oral administration of 100 mg methylene blue with and without mesna. The distribution of methylene blue in different tissues was measured in rats after intraduodenal and IV application. The time course of methylene blue in whole blood after IV administration showed a multiphasic time course with an estimated terminal half-life of 5.25 hr. Following oral administration, the area under the concentration-time curve was much lower (9 nmol/min/mL vs 137 nmol/min/mL). Co-administration of mesna, which could influence distribution by ion-pairing, did not alter the pharmacokinetics. The urinary excretion of methylene blue and its leukoform was only moderately higher after IV administration (18% vs 28% dose). Intraduodenal administration to rats resulted in higher concentrations in intestinal wall and liver but lower concentrations in whole blood and brain than IV methylene blue. Differences in organ distribution of methylene blue are mainly responsible for the different pharmacokinetics after oral and IV administration. ...

    PMID:10952480 Peter C et al; Eur J Clin Pharmacol 56 (3): 247-50 (2000)

    Methylene blue is well absorbed from the GI tract, and peak plasma concentrations occur approximately 1-2 hours after an oral dose. ... Following distribution into tissues, methylene blue is rapidly reduced to leukomethylene blue (leucomethylthioninium chloride). Metabolism to leucomethylene blue may be less efficient in neonates than in older individuals. Methylene blue is excreted in urine and bile. About 75% of an oral dose of methylene blue is excreted in urine, mostly as stabilized colorless leukomethylene blue. On exposure to air, the urine turns green or blue, due to the presence of the oxidation product methylene azure (methylene blue sulfone). Some unchanged drug is also excreted in urine.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    BACKGROUND: Although blue dye is routinely used for lymphatic mapping, it is not used for lymphatic mapping in pregnancy-associated breast cancer, because of concern of fetal risk. METHODS: To investigate the safety of blue dye for lymphatic mapping in pregnant women, the pharmacokinetics of methylene blue dye were examined in 10 nonpregnant women, and the results were extrapolated to estimate maximal fetal exposure to the dye. RESULTS: Plasma and urine measurements indicated that the dye quickly distributed from the breast injection site to the circulation, with 32% of the total dose excreted in urine within 48 hours. Combined with existing data on organ distribution of methylene blue, the estimated maximal dose to the fetus is 0.25 mg (5% of the administered dose), likely further reduced by other physiologic factors related to pregnancy. CONCLUSIONS: The analysis suggests that methylene blue dye can be used for lymphatic mapping in pregnancy-associated breast cancer with minimal fetal risk.

    PMID:21167367 Pruthi S et al; Am J Surg 201 (1): 70-5 (2011)

    The disposition and urinary excretion pharmacokinetics of methylene blue were determined after its intravenous administration at 15 mg/kg to mature female sheep. Comparisons were made between methylene blue administered alone or subsequent to 50 mg/kg sodium nitrite. The overall elimination rate constant (beta) of methylene blue, 0.0076 +/- 0.0016 min-1, was not influenced by prior administration of sodium nitrite. However, the distribution rate was significantly altered by sodium nitrite. Very little of the methylene blue was eliminated in the urine either intact or as leukomethylene blue in spite of its relatively short half life. ...

    PMID:6492250 Burrows GE; J Vet Pharmacol Ther 7 (3): 225-31(1984)

    5.5 Metabolism/Metabolites

    Following distribution into tissues, rapidly reduced to leukomethylene blue (leucomethylthioninium chloride). Metabolism to leucomethylene blue may be less efficient in neonates than in older individuals.

    Methylene blue can be reduced to a colorless form, leukomethylene blue; together, these compounds form a reversible oxidation-reduction system. In low concentrations, methylene blue accelerates conversion of methemoglobin to hemoglobin. In patients with methemoglobinemia, methylene blue is reduced to leukomethylene blue by methemoglobin reductases in erythrocytes; leukomethylene blue then reduces methemoglobin to hemoglobin. In high concentrations, methylene blue oxidizes the ferrous iron of reduced hemoglobin to the ferric state, thereby changing hemoglobin to methemoglobin.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    Following distribution into tissues, methylene blue is rapidly reduced to leukomethylene blue (leucomethylthioninium chloride). Metabolism to leucomethylene blue may be less efficient in neonates than in older individuals.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    5.6 Biological Half-Life

    56.5 hours (after IV dose).

    Following IV administration, the estimated half-life of methylene blue is 5-6.5 hours.

    American Society of Health-System Pharmacists; Drug Information 2018. Bethesda, MD. 2018

    ... The concentration of methylene blue in whole blood was measured using high-performance liquid chromatography in seven volunteers after IV and oral administration of 100 mg methylene blue with and without mesna. The distribution of methylene blue in different tissues was measured in rats after intraduodenal and IV application. The time course of methylene blue in whole blood after IV administration showed a multiphasic time course with an estimated terminal half-life of 5.25 hr. ...

    PMID:10952480 Peter C et al; Eur J Clin Pharmacol 56 (3): 247-50 (2000)

    5.7 Mechanism of Action

    * Main mechanism of action involves inhibition of nitric oxide synthase and guanylate cyclase. * In Alzheimers Disease: a mechanistic study found that methylene blue oxidizes cysteine sulfhydryl groups on tau to keep tau monomeric. One preclinical treatment study in tauopathy mice reported anti-inflammatory or neuroprotective effects mediated by the Nrf2/antioxidant response element (ARE); another reported insoluble tau reduction and a learning and memory benefit when given early. * In Methemoglobinemia: Methylene Blue acts by reacting within RBC to form leukomethylene blue, which is a reducing agent of oxidized hemoglobin converting the ferric ion (fe+++) back to its oxygen-carrying ferrous state(fe++). * As antimalarial agent: Methylene Blue, a specific inhibitor of P.falciparum glutathione reductase has the potential to reverse CQ resistance and it prevents the polymerization of haem into haemozoin similar to 4-amino-quinoline antimalarials. * For ifosfamide induced neurotoxicity: Methylene blue functions as an alternate electron acceptor. It acts to reverse the NADH inhibition caused by gluconeogenesis in the liver while blocking the transformation of chloroethylamine into chloroacetaldehyde. In addition, it inhibits various amine oxidase activities, which also prevents the formation of chloroacetaldehyde.

    The mechanism of modulation of cyclic guanosine monophosphate accumulation by methylene blue, a putative inhibitor of soluble guanylate cyclase, was investigated in cultured rabbit pulmonary arterial smooth muscle cells. Control or methylene blue pretreated rabbit pulmonary arterial smooth muscle were stimulated with sodium nitroprusside, nitrosothiols or endothelium derived relaxing factor released basally from bovine pulmonary arterial endothelial cells, in short term cocultures. The putative endothelium-derived relaxing factor, S-nitroso-L-cysteine, a stab1e deaminated analog of S-nitroso-L-cysteine, S-nitroso-3-mercaptoproprionic acid and sodium nitroprusside produced concentration-dependent (1-100 uM) increase (1.5- to 12-fold) in rabbit pulmonary arterial smooth muscle cells cyclic guanosine monophospate levels. Methylene blue pretreatment inhibited S-nitroso-L-cysteine and sodium nitroprusside induced cyclic guanosine monophosphate accumulation by 51% to 100%, but S-nitroso-3-mercaptoproprionic acid mediated responses were not altered by methylene blue. The inhibition profile of methylene blue on nitrovasodilator induced cyclic guanosine monophosphate accumulation was quantitatively reproduced by extracellular generation of superoxide anion with xanthine (100 uM) and xanthine oxidase (5 mU). Similarly to methylene blue pretreatment, superoxide anion generation had no effects on base-line cyclic guanosine phosphate levels or cyclic guanosine phosphate responses elicited by S-nitroso-3-mercaptoproprionic acid. Furthermore, methylene blue induced a dose and time dependent generation of superoxide anion from rabbit pulmonary arterial smooth muscle cells, as evidenced from spectrophotometric determination of cytochrome c reduction. Inhibition of cyclic guanosine monophosphate accumulation in response to S-nitroso-L-cysteine and sodium nitroprusside by methylene blue was completely prevented by superoxide dismutase but not catalase. Selective pretreatment of endothelial cells with methylene blue before co-culture with untreated rabbit pulmonary arterial smooth muscle produced a reduction in rabbit pulmonary arterial smooth muscle cyclic guanosine monophosphate levels of a magnitude comparable with that seen in cocultures of methylene blue pretreated rabbit pulmonary arterial smooth muscle with untreated endothelial cells, and which was partially prevented by superoxide dismutase.

    PMID:1328604 Marczin N et al; J Pharmacol Exp Ther 263 (1): 170-9 (1992)

    API SUPPLIERS

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    01

    Axplora

    Germany

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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    World ADC- San Diego
    Attending
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    Virtual BoothAxplora- The partner of choice for complex APIs.

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    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2023-12-26

    Pay. Date : 2023-09-26

    DMF Number : 32900

    Submission : 2023-09-21

    Status : Active

    Type : II

     CEP/COS JDMF EU-WCarrow-down
    ✖

    Date of Issue : 2022-03-18

    Valid Till : 2025-05-28

    Written Confirmation Number : WC-0019

    Address of the Firm :

    NDC arrow-down
    ✖

    NDC Package Code : 12598-9541

    Start Marketing Date : 2018-01-08

    End Marketing Date : 2025-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING

     KDMF VMF EU arrow-down
    ✖
    Available Reg Filing : EU
    AUDIT
    Axplora CB

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    02

    ChemWerth Inc

    U.S.A

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

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    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2022-06-28

    Pay. Date : 2022-05-10

    DMF Number : 36603

    Submission : 2022-06-01

    Status : Active

    Type : II

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
    Chemwerth Compnay Banner

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    Digital Content

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    03

    Biophore India Pharmaceuticals Pvt...

    India

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    CPhI India 2024
    Booth #1.A01
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothBiophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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    Flag India
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    Digital Content Digital Content
    USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
    Biophore

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

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    Corporate PDF

    04

    Jai Radhe Sales

    India

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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    CPhI India 2024
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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    Flag India
    Virtual Booth Virtual Booth
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    USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
    Jai Radhe Sales

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    Virtual Booth

    Digital Content

    Website

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    05

    Macsen Labs

    India

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    CPhI India 2024
    Booth #IP-81
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

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    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2023-10-18

    Pay. Date : 2023-08-28

    DMF Number : 35095

    Submission : 2020-08-17

    Status : Active

    Type : II

     CEP/COS JDMF EU-WCarrow-down
    ✖

    Date of Issue : 2022-03-28

    Valid Till : 2025-02-17

    Written Confirmation Number : WC-0438

    Address of the Firm :

    NDC arrow-down
    ✖

    NDC Package Code : 73379-101

    Start Marketing Date : 2020-11-25

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT

     KDMF VMF Others AUDIT
    Macsen Company Banner

    Portfolio PDF

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    Digital Content

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    06

    Macsen Labs

    India

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    CPhI India 2024
    Booth #IP-81
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

    Contact Supplier Contact Supplier
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 35482

    Submission : 2020-12-22

    Status : Active

    Type : IV

     CEP/COS JDMF EU-WC NDC arrow-down
    ✖

    NDC Package Code : 73379-101

    Start Marketing Date : 2020-11-25

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT

     KDMF VMF Others AUDIT
    Macsen Company Banner

    Portfolio PDF

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    Digital Content

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    07

    Sichuan Qingmu Pharmaceutical

    China

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    SupplySide West 2024
    Not Confirmed
    arrow

    Sichuan Qingmu Pharmaceutical

    China

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    SupplySide West 2024
    Not Confirmed
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2024-05-01

    Pay. Date : 2024-04-19

    DMF Number : 39341

    Submission : 2024-04-15

    Status : Active

    Type : II

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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    08

    Provepharm Life Solutions

    France

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    SupplySide West 2024
    Not Confirmed
    arrow

    Provepharm Life Solutions

    France

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    SupplySide West 2024
    Not Confirmed
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 26735

    Submission : 2013-01-09

    Status : Active

    Type : II

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    09

    Mikrochem

    Slovakia

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    SupplySide West 2024
    Not Confirmed
    arrow

    Mikrochem

    Slovakia

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    SupplySide West 2024
    Not Confirmed
    USDMF arrow-down
    ✖

    GDUFA

    DMF Review : Reviewed

    Rev. Date : 2023-02-23

    Pay. Date : 2023-02-21

    DMF Number : 31694

    Submission : 2017-07-05

    Status : Active

    Type : II

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

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    10

    ISO TEX DIAGNOSTICS INC

    U.S.A

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    SupplySide West 2024
    Not Confirmed
    arrow

    ISO TEX DIAGNOSTICS INC

    U.S.A

    USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

    arrow
    SupplySide West 2024
    Not Confirmed
    USDMF Inactive-api
    ✖

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 17684

    Submission : 2004-09-09

    Status : Inactive

    Type : II

     CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
    blank

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    USDMF

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    01

    Pharmazell Gmbh

    Germany
    arrow
    World ADC- San Diego
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothAxplora- The partner of choice for complex APIs.

    Contact Supplier Contact Supplier
    Flag Germany
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    GDUFA

    DMF Review : Complete

    Rev. Date : 2023-12-26

    Pay. Date : 2023-09-26

    DMF Number : 32900

    Submission : 2023-09-21

    Status : Active

    Type : II

    Axplora CB

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    02

    Chemwerth Inc

    U.S.A
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

    Contact Supplier Contact Supplier
    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    GDUFA

    DMF Review : Complete

    Rev. Date : 2022-06-28

    Pay. Date : 2022-05-10

    DMF Number : 36603

    Submission : 2022-06-01

    Status : Active

    Type : II

    Chemwerth Compnay Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

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    03

    Macsen Drugs

    India
    arrow
    CPhI India 2024
    Booth #IP-81
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

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    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 35482

    Submission : 2020-12-22

    Status : Active

    Type : IV

    Macsen Company Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    04

    Macsen Drugs

    India
    arrow
    CPhI India 2024
    Booth #IP-81
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

    Contact Supplier Contact Supplier
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    GDUFA

    DMF Review : Complete

    Rev. Date : 2023-10-18

    Pay. Date : 2023-08-28

    DMF Number : 35095

    Submission : 2020-08-17

    Status : Active

    Type : II

    Macsen Company Banner

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

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    05

    Chemcon Gmbh

    Germany

    USDMF

    arrow
    SupplySide West 2024
    Not Confirmed

    05

    Chemcon Gmbh

    Germany
    arrow
    SupplySide West 2024
    Not Confirmed

    GDUFA

    DMF Review : Complete

    Rev. Date : 2022-10-25

    Pay. Date : 2022-07-01

    DMF Number : 36353

    Submission : 2022-07-14

    Status : Active

    Type : II

    blank

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    06

    Icrom Srl

    Italy

    USDMF

    arrow
    SupplySide West 2024
    Not Confirmed

    06

    Icrom Srl

    Italy
    arrow
    SupplySide West 2024
    Not Confirmed

    GDUFA

    DMF Review : Complete

    Rev. Date : 2022-01-25

    Pay. Date : 2021-12-16

    DMF Number : 36307

    Submission : 2021-12-02

    Status : Active

    Type : II

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    07

    SupplySide West 2024
    Not Confirmed

    07

    Iso Tex Diagnostics Inc

    U.S.A
    arrow
    SupplySide West 2024
    Not Confirmed

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 17684

    Submission : 2004-09-09

    Status : Inactive

    Type : II

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    08

    SupplySide West 2024
    Not Confirmed

    08

    Luitpold Pharmaceuticals Inc

    U.S.A
    arrow
    SupplySide West 2024
    Not Confirmed

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 15237

    Submission : 2000-12-28

    Status : Inactive

    Type : II

    blank

    Portfolio PDF

    Product Web Link

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    Digital Content

    Website

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    09

    Mikrochem Spol Sro

    Slovakia

    USDMF

    arrow
    SupplySide West 2024
    Not Confirmed

    09

    Mikrochem Spol Sro

    Slovakia
    arrow
    SupplySide West 2024
    Not Confirmed

    GDUFA

    DMF Review : Complete

    Rev. Date : 2023-02-23

    Pay. Date : 2023-02-21

    DMF Number : 31694

    Submission : 2017-07-05

    Status : Active

    Type : II

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    10

    Provepharm Sas

    France

    USDMF

    arrow
    SupplySide West 2024
    Not Confirmed

    10

    Provepharm Sas

    France
    arrow
    SupplySide West 2024
    Not Confirmed

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 26735

    Submission : 2013-01-09

    Status : Active

    Type : II

    blank

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    NDC API

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    01

    PharmaZell GmbH

    Germany
    arrow
    World ADC- San Diego
    Attending
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothAxplora- The partner of choice for complex APIs.

    Contact Supplier Contact Supplier
    Flag Germany
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 12598-9541

    Start Marketing Date : 2018-01-08

    End Marketing Date : 2025-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT FOR HUMAN P...

    Axplora CB

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    02

    MACSEN DRUGS

    India
    arrow
    CPhI India 2024
    Booth #IP-81
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

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    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 73379-102

    Start Marketing Date : 2023-01-12

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT FOR HUMAN P...

    Macsen Company Banner

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    03

    MACSEN DRUGS

    India
    arrow
    CPhI India 2024
    Booth #IP-81
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothMacsen Labs, a leader in Chemistry since 1952, specializing in APIs, specialty and fine chemicals, and dyes.

    Contact Supplier Contact Supplier
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 73379-101

    Start Marketing Date : 2020-11-25

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT

    Macsen Company Banner

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    04

    Azico Biophore India Private Limite...

    India
    SupplySide West 2024
    Not Confirmed
    arrow

    Azico Biophore India Private Limite...

    India
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    METHYLENE BLUE

    NDC Package Code : 69575-4026

    Start Marketing Date : 2017-11-20

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (25kg/25kg)

    Marketing Category : BULK INGREDIENT

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    05

    DARMERICA, LLC

    U.S.A
    SupplySide West 2024
    Not Confirmed
    arrow

    DARMERICA, LLC

    U.S.A
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 71052-652

    Start Marketing Date : 2022-11-04

    End Marketing Date : 2025-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

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    Digital Content

    Website

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    06

    KALCHEM INTERNATIONAL INC

    U.S.A
    SupplySide West 2024
    Not Confirmed
    arrow

    KALCHEM INTERNATIONAL INC

    U.S.A
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag U.S.A
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 60592-923

    Start Marketing Date : 2023-10-16

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT

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    07

    LETCO MEDICAL, LLC

    U.S.A
    SupplySide West 2024
    Not Confirmed
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    LETCO MEDICAL, LLC

    U.S.A
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 62991-3203

    Start Marketing Date : 2024-02-22

    End Marketing Date : 2025-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT FOR HUMAN P...

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    08

    Medisca Inc.

    U.S.A
    SupplySide West 2024
    Not Confirmed
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    Medisca Inc.

    U.S.A
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 38779-3297

    Start Marketing Date : 2023-11-24

    End Marketing Date : 2024-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT

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    09

    Professional Compounding Centers of...

    United Kingdom
    SupplySide West 2024
    Not Confirmed
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    Professional Compounding Centers of...

    United Kingdom
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 51927-1115

    Start Marketing Date : 2022-11-21

    End Marketing Date : 2025-12-31

    Dosage Form (Strength) : POWDER (1g/g)

    Marketing Category : BULK INGREDIENT FOR HUMAN P...

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    10

    Shandong Keyuan Pharmaceutical Co.,...

    China
    SupplySide West 2024
    Not Confirmed
    arrow

    Shandong Keyuan Pharmaceutical Co.,...

    China
    arrow
    SupplySide West 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Digital Content Digital Content

    METHYLENE BLUE

    NDC Package Code : 43263-0101

    Start Marketing Date : 2024-05-02

    End Marketing Date : 2025-12-31

    Dosage Form (Strength) : POWDER (1kg/kg)

    Marketing Category : BULK INGREDIENT

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    API Reference Price

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    [{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1625077800,"product":"METHYLTHIONINIUM CHLORIDE EP 10 (METHYLE N BLUE) BATCH NO. 250221 MFG. DATE FEBRU ARY 2021 EXP DATE JANUARY 2024","address":"VILLAGE TITERDI, TEHSIL GIRVANEAR MUNCIPAL TRENCHING GROUND","city":"DIST. UDAIPUR. ,RAJASTHAN","supplier":"MACSEN LABS","supplierCountry":"INDIA","foreign_port":"HO CHI MINH C","customer":"BV PHARMA PHARMACEUTICAL ","customerCountry":"VIETNAM","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"868.3","totalValueFC":"839.5","currency":"USD","unitRateINR":62563.779999999999,"date":"01-Jul-2021","totalValueINR":"62563.78","totalValueInUsd":"839.5","indian_port":"DELHI AIR","hs_no":"29343000","bill_no":"2823605","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"VIETNAM, DEMOCRATIC REP. OF","selfForZScoreResived":"Pharma Grade","supplierPort":"DELHI AIR","supplierAddress":"VILLAGE TITERDI, TEHSIL GIRVANEAR MUNCIPAL TRENCHING GROUND, DIST. UDAIPUR. ,RAJASTHAN","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1662402600,"product":"METHYLENE BLUE","address":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,","city":"HYDERABAD,TELANGANA","supplier":"AZICO BIOPHORE INDIA PVT. LTD","supplierCountry":"INDIA","foreign_port":"NEW YORK - JOHN F. K","customer":"M\/S.","customerCountry":"UNITED STATES","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"2000","totalValueFC":"19490.6","currency":"USD","unitRateINR":156200,"date":"06-Sep-2022","totalValueINR":"1562000","totalValueInUsd":"19490.6","indian_port":"HYDERABAD AIR","hs_no":"29239000","bill_no":"3997961","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1662921000,"product":"METHYLENE BLUE","address":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,","city":"HYDERABAD,TELANGANA","supplier":"AZICO BIOPHORE INDIA PVT. LTD","supplierCountry":"INDIA","foreign_port":"CINCINNATI, OH","customer":"M\/S.","customerCountry":"UNITED STATES","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"2000","totalValueFC":"38694.3","currency":"USD","unitRateINR":155050,"date":"12-Sep-2022","totalValueINR":"3101000","totalValueInUsd":"38694.3","indian_port":"HYDERABAD AIR","hs_no":"29239000","bill_no":"4108807","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683657000,"product":"NON HAZARDOUS ACTIIVE PHARMACEUTICAL INGREDIENT METHYLENE BLUE","address":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,","city":"HYDERABAD,TELANGANA","supplier":"AZICO BIOPHORE INDIA PVT. LTD","supplierCountry":"INDIA","foreign_port":"NEW YORK JOHN F K","customer":"TO THE ORDER","customerCountry":"UNITED STATES","quantity":"16.47","actualQuantity":"16.47","unit":"KGS","unitRateFc":"2000","totalValueFC":"32254.1","currency":"USD","unitRateINR":161141.46933819065,"date":"10-May-2023","totalValueINR":"2654000","totalValueInUsd":"32254.1","indian_port":"HYDERABAD AIR","hs_no":"29239000","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1689532200,"product":"METHYLENE BLUE","address":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,","city":"HYDERABAD,TELANGANA","supplier":"AZICO BIOPHORE INDIA PVT. LTD","supplierCountry":"INDIA","foreign_port":"NEW YORK - JOHN F. K","customer":"TO THE ORDER","customerCountry":"UNITED STATES","quantity":"33.33","actualQuantity":"33.332","unit":"KGS","unitRateFc":"2000","totalValueFC":"65835.6","currency":"USD","unitRateINR":162336.50312012481,"date":"17-Jul-2023","totalValueINR":"5411000.322","totalValueInUsd":"65835.6","indian_port":"HYDERABAD AIR","hs_no":"29239000","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"425\/3RT, D.NO.7-1-621\/328,,SANJEEV AREDDY NAGAR,, HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"METHYLENE BLUE","year":"2021","qtr":"Q2","strtotime":1621449000,"product":"METHYLENE BLUE - 43834SF60-11111","address":"","city":"","supplier":"MIKROCCHEM SPOL S.R.O","supplierCountry":"SLOVAKIA","foreign_port":"BRATISLAVA","customer":"STERISCIENCE SPECIALTIES PRIVATE ","customerCountry":"INDIA","quantity":"0.23","actualQuantity":"0.2335","unit":"KGS","unitRateFc":"15000","totalValueFC":"6434.6","currency":"EUR","unitRateINR":"2018546.6","date":"20-May-2021","totalValueINR":"471330.63","totalValueInUsd":"6434.6","indian_port":"BANGALORE AIR","hs_no":"29349990","bill_no":"4014112","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVAK REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"BRATISLAVA","supplierAddress":"","customerAddress":""}]
    20-May-2021
    17-Jul-2023
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    FDA Orange Book

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    01

    PROVEPHARM SAS

    France
    World Vaccine Congress
    Not Confirmed
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    PROVEPHARM SAS

    France
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    RLD : Yes

    TE Code : AP

    METHYLENE BLUE

    Brand Name : PROVAYBLUE

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 50MG/10ML (5MG/ML)

    Approval Date : 2016-04-08

    Application Number : 204630

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code : AP

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    PROVEPHARM SAS

    France
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    RLD : Yes

    TE Code : AP

    METHYLENE BLUE

    Brand Name : PROVAYBLUE

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 10MG/2ML (5MG/ML)

    Approval Date : 2019-07-18

    Application Number : 204630

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code : AP

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    India
    World Vaccine Congress
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    RLD : No

    TE Code : AP

    METHYLENE BLUE

    Brand Name : METHYLENE BLUE

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 10MG/2ML (5MG/ML)

    Approval Date : 2023-12-05

    Application Number : 215636

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    ZYDUS LIFESCIENCES

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    India
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    RLD : No

    TE Code : AP

    METHYLENE BLUE

    Brand Name : METHYLENE BLUE

    Dosage Form : SOLUTION;INTRAVENOUS

    Dosage Strength : 50MG/10ML (5MG/ML)

    Approval Date : 2023-12-05

    Application Number : 215636

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    01

    MONICO SpA

    Country
    AusBiotech 2024
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    Regulatory Info :

    Registration Country : Italy

    Methylene Blue

    Brand Name : Methylene Blue

    Dosage Form :

    Dosage Strength : 5 Vials 50 Mg 5 Ml

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    Registration Country : Italy

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    Methylene Blue

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    Registration Country : Italy

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    MONICO SpA

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    AusBiotech 2024
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    Methylene Blue

    Brand Name : Methylene Blue

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    Dosage Strength : 5 Ampoule 100 Mg 10 Ml

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    Regulatory Info :

    Registration Country : Italy

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    SALF SpA

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    AusBiotech 2024
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    Methylene Blue

    Brand Name : Metiltioninio

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    Dosage Strength : 5 Ampoule 100 Mg 10 Ml

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    Approval Date :

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    Regulatory Info :

    Registration Country : Italy

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    RAMINI SpA

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    AusBiotech 2024
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    Methylene Blue

    Brand Name : Metiltioninio

    Dosage Form :

    Dosage Strength : Skin Soluz 25 Ml 100 Mg/10 Ml  

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    Approval Date :

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    Registration Country : Italy

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    Provepharm SAS

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    AusBiotech 2024
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    Regulatory Info :

    Registration Country : Norway

    Methylene Blue

    Brand Name : Methylthioninium chloride Prov Blue

    Dosage Form : Injection fluid, resolution

    Dosage Strength : 5 mg/ml

    Packaging : Ampoule

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Norway

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    Methylene Blue

    Brand Name : Methylthioninium chloride Prov Blue

    Dosage Form : Injection fluid, resolution

    Dosage Strength : 5 mg/ml

    Packaging : Ampoule

    Approval Date :

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    Regulatory Info :

    Registration Country : Norway

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    01

    FRILAB SA

    Switzerland
    AusBiotech 2024
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    Regulatory Info : OTC

    Registration Country : Canada

    METHYLENE BLUE

    Brand Name : COLLYRE BLEU LAITER

    Dosage Form : DROPS

    Dosage Strength : 0.2MG/ML

    Packaging : 10ML

    Approval Date :

    Application Number : 674354

    Regulatory Info : OTC

    Registration Country : Canada

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    LABORATOIRE ATLAS INC

    Canada
    AusBiotech 2024
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    Regulatory Info : OTC

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    METHYLENE BLUE

    Brand Name : METHYLENE BLEU LIQ 1%

    Dosage Form : LIQUID

    Dosage Strength : 1%

    Packaging : 25ML

    Approval Date :

    Application Number : 50466

    Regulatory Info : OTC

    Registration Country : Canada

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    LABORATOIRE ATLAS INC

    Canada
    AusBiotech 2024
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    Regulatory Info : OTC

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    METHYLENE BLUE

    Brand Name : METHYLENE BLEU LIQ 2%

    Dosage Form : LIQUID

    Dosage Strength : 2%

    Packaging : 25ML

    Approval Date :

    Application Number : 50474

    Regulatory Info : OTC

    Registration Country : Canada

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    OMEGA LABORATORIES LIMITED

    Canada
    AusBiotech 2024
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    Regulatory Info : Ethical

    Registration Country : Canada

    METHYLENE BLUE

    Brand Name : METHYLENE BLUE INJECTION USP

    Dosage Form : LIQUID

    Dosage Strength : 10MG/ML

    Packaging : 1/5 ML

    Approval Date :

    Application Number : 2230770

    Regulatory Info : Ethical

    Registration Country : Canada

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    PHEBRA PTY LTD

    Australia
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    Australia
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    METHYLENE BLUE

    Brand Name : METHYLENE BLUE INJECTION

    Dosage Form : SOLUTION

    Dosage Strength : 10MG/ML

    Packaging :

    Approval Date :

    Application Number : 2487993

    Regulatory Info : Ethical

    Registration Country : Canada

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    Listed Dossiers

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    01

    Health Biotech

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    Methylene Blue

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    Dosage Form : Ampoule

    Dosage Strength : 10MG

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    Registration Country : India

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    Health Biotech

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    Registration Country : India

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    02

    Laboratório Gross

    Brazil
    AusBiotech 2024
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    Brazil
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    Registration Country : Brazil

    Methanamine; Methylthioninium Chloride

    Brand Name : Sepurin®

    Dosage Form : Tablet

    Dosage Strength : 120MG; 20MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Brazil

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    Laboratório Gross

    Brazil
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    Methanamine; Methylthioninium Chloride

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    Dosage Strength : 120MG; 20MG

    Brand Name : Sepurin®

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    Verve Human Care Laboratories

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    Methylene Blue

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    Dosage Form : Injection

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    Packaging : 10ml Ampoule

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    Methylene Blue

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    Brand Name : VERBLUE

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    METHYLENE BLUE

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