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1. 7 Ethyl 10 Hydroxycamptothecin
2. Camptosar
3. Camptothecin 11
4. Camptothecin-11
5. Cpt 11
6. Cpt-11
7. Cpt11
8. Irinotecan
9. Irinotecan Hydrochloride
10. Irrinotecan
11. Nk012 Compound
12. Sn 38
13. Sn 38 11
14. Sn-38
15. Sn-38-11
16. Sn3811
1. 86639-52-3
2. Sn-38
3. Sn 38
4. Sn 38 Lactone
5. (s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
6. 10-hydroxy-7-ethylcamptothecin
7. Nk 012
8. Sn38
9. 7-ethyl-10-hydroxy-20(s)-camptothecin
10. Nk012
11. Nk-012
12. Irinotecan Related Compound B
13. Chebi:8988
14. 113015-38-6
15. It-141
16. Nsc673596
17. 0h43101t0j
18. (4s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
19. (+)-7-ethyl-10-hydroxycamptothecin
20. (19s)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
21. (4s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione
22. 7-ethyl-10-hydroxy-20(s)-campthothecin
23. Le-sn38
24. Captothecin, 7-ethyl-10-hydroxy-
25. Mfcd00871873
26. Unii-0h43101t0j
27. 110714-48-2
28. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (4s)-
29. 1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (4s)-
30. Avachem1025
31. Diethyl(dihydroxy)[?]dione
32. Sn 38- Bio-x
33. Schembl34018
34. Gtpl6925
35. Sn 38 [who-dd]
36. Dtxsid4040399
37. 10-hydroxy-7-ethyl Camptothecin
38. 10-hydroxy-7-ethyl-camptothecin
39. 7-ethyl-10-hydroxy Campthotecin
40. Ex-a989
41. Hms3413b12
42. Hms3652p12
43. Hms3677b12
44. Bcp01386
45. Zinc4099013
46. 7-ethyl-10-hydroxy-20(s)-cpt
47. Bdbm50418088
48. S4908
49. Akos015920433
50. Sn-38(nk-012)
51. Ac-1357
52. Bcp9000200
53. Ccg-264764
54. Cs-1579
55. Db05482
56. Nsc-673596
57. Ncgc00167831-01
58. Ncgc00167831-05
59. (4s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)dione
60. As-13533
61. Be164132
62. Bp-24513
63. Hy-13704
64. Nci60_026056
65. Camptothecin, 7-ethyl-10-hydroxy-
66. E0748
67. N2133
68. Sw219948-1
69. S-(+)-7-ethyl-10-hydroxycampothecin
70. Irinotecan Related Compound B [usp-rs]
71. 439e812
72. A857464
73. Q-100871
74. Q1750127
75. 7-ethyl-10-hydroxycamptothecin, >=98% (hplc), Powder
76. Irinotecan Related Compound B, United States Pharmacopeia (usp) Reference Standard
77. (19s)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
78. (4s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)dione, Aldrichcpr
79. (4s)-4,9-dihydroxy-4,11-diethyl-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione;sn-38
80. (s)-4,11-diethyl-4,9-di-oh-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
81. 1h-pyrano[3',7]indolizino[1,2-b]quinoline- 3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (4s)-
82. 7-ethyl-10-hydroxycamptothecin ((s)-4,11-diethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione)
83. H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4,11-diethyl-4,9-dihydroxy-, (s)-
84. Rs4
1. Sn-38 Glucuronide
2. Sn-38g
3. Sn38 Glucuronide
| Molecular Weight | 392.4 g/mol |
|---|---|
| Molecular Formula | C22H20N2O5 |
| XLogP3 | 1.4 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 2 |
| Exact Mass | 392.13722174 g/mol |
| Monoisotopic Mass | 392.13722174 g/mol |
| Topological Polar Surface Area | 100 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 820 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Investigated for use/treatment in colorectal cancer.
SN-38 (7-ethyl-10-hydroxycamptothecin) is the active metabolite of Irinotecan (CPT-11). Irinotecan is a topoisomerase I inhibitor commercially available as Camptosar. SN-38 has been found to be 2002000 times more cytotoxic than CPT-11, but has not been used as an anticancer drug due to its poor solubility in pharmaceutically acceptable solvents and low affinity to lipid membranes. SN-38 also undergoes a reversible conversion to an inactive open lactone ring structure at physiological pH. LE-SN-38 is a novel lipsome based formulation containing liposomes of uniform size distribution (<200 nm). Drug entrapment efficiency of the formulation is>95%.
Topoisomerase I Inhibitors
Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)
The entrapment of SN-38 in lipsomes results in a more stable and more soluble form of the drug. This allows for increased affinity of SN-38 to lipid membranes and improved delivery of the drug to tumor sites. SN-38 is a highly effective cytotoxic topoisomerase I inhibitor.
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A 7 Ethyl 10 hydroxycamptothecin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 7 Ethyl 10 hydroxycamptothecin, including repackagers and relabelers. The FDA regulates 7 Ethyl 10 hydroxycamptothecin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 7 Ethyl 10 hydroxycamptothecin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of 7 Ethyl 10 hydroxycamptothecin manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A 7 Ethyl 10 hydroxycamptothecin supplier is an individual or a company that provides 7 Ethyl 10 hydroxycamptothecin active pharmaceutical ingredient (API) or 7 Ethyl 10 hydroxycamptothecin finished formulations upon request. The 7 Ethyl 10 hydroxycamptothecin suppliers may include 7 Ethyl 10 hydroxycamptothecin API manufacturers, exporters, distributors and traders.
click here to find a list of 7 Ethyl 10 hydroxycamptothecin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A 7 Ethyl 10 hydroxycamptothecin DMF (Drug Master File) is a document detailing the whole manufacturing process of 7 Ethyl 10 hydroxycamptothecin active pharmaceutical ingredient (API) in detail. Different forms of 7 Ethyl 10 hydroxycamptothecin DMFs exist exist since differing nations have different regulations, such as 7 Ethyl 10 hydroxycamptothecin USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A 7 Ethyl 10 hydroxycamptothecin DMF submitted to regulatory agencies in the US is known as a USDMF. 7 Ethyl 10 hydroxycamptothecin USDMF includes data on 7 Ethyl 10 hydroxycamptothecin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 7 Ethyl 10 hydroxycamptothecin USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of 7 Ethyl 10 hydroxycamptothecin suppliers with USDMF on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing 7 Ethyl 10 hydroxycamptothecin as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for 7 Ethyl 10 hydroxycamptothecin API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture 7 Ethyl 10 hydroxycamptothecin as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain 7 Ethyl 10 hydroxycamptothecin and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a 7 Ethyl 10 hydroxycamptothecin NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of 7 Ethyl 10 hydroxycamptothecin suppliers with NDC on PharmaCompass.
7 Ethyl 10 hydroxycamptothecin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of 7 Ethyl 10 hydroxycamptothecin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 7 Ethyl 10 hydroxycamptothecin GMP manufacturer or 7 Ethyl 10 hydroxycamptothecin GMP API supplier for your needs.
A 7 Ethyl 10 hydroxycamptothecin CoA (Certificate of Analysis) is a formal document that attests to 7 Ethyl 10 hydroxycamptothecin's compliance with 7 Ethyl 10 hydroxycamptothecin specifications and serves as a tool for batch-level quality control.
7 Ethyl 10 hydroxycamptothecin CoA mostly includes findings from lab analyses of a specific batch. For each 7 Ethyl 10 hydroxycamptothecin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
7 Ethyl 10 hydroxycamptothecin may be tested according to a variety of international standards, such as European Pharmacopoeia (7 Ethyl 10 hydroxycamptothecin EP), 7 Ethyl 10 hydroxycamptothecin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (7 Ethyl 10 hydroxycamptothecin USP).
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