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Chemistry

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Also known as: 4651-67-6, 7-ketolithocholic acid, Nutriacholic acid, 7-oxolithocholic acid, 3a-hydroxy-7-oxo-5b-cholanic acid, 3.alpha.-hydroxy-7-oxo-5.beta.-cholanic acid
Molecular Formula
C24H38O4
Molecular Weight
390.6  g/mol
InChI Key
DXOCDBGWDZAYRQ-AURDAFMXSA-N
FDA UNII
Y1357H1A28

7-Ketolithocholic acid
1 2D Structure

7-Ketolithocholic acid

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(4R)-4-[(3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
2.1.2 InChI
InChI=1S/C24H38O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-19,22,25H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,22+,23+,24-/m1/s1
2.1.3 InChI Key
DXOCDBGWDZAYRQ-AURDAFMXSA-N
2.1.4 Canonical SMILES
CC(CCC(=O)O)C1CCC2C1(CCC3C2C(=O)CC4C3(CCC(C4)O)C)C
2.1.5 Isomeric SMILES
C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C(=O)C[C@H]4[C@@]3(CC[C@H](C4)O)C)C
2.2 Other Identifiers
2.2.1 UNII
Y1357H1A28
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3 Alpha-hydroxy-7-keto-5 Beta-cholanoate

2. 3 Alpha-ol-7-one-5 Beta-cholanoic Acid

3. 7-ketolithocholic Acid

4. 7-ketolithocholic Acid, (3beta,5alpha)-isomer

5. 7-oxolithocholic Acid

2.3.2 Depositor-Supplied Synonyms

1. 4651-67-6

2. 7-ketolithocholic Acid

3. Nutriacholic Acid

4. 7-oxolithocholic Acid

5. 3a-hydroxy-7-oxo-5b-cholanic Acid

6. 3.alpha.-hydroxy-7-oxo-5.beta.-cholanic Acid

7. 3alpha-hydroxy-7-oxo-5beta-cholan-24-oic Acid

8. 3alpha-hydroxy-7-oxo-5beta-cholanoic Acid

9. Chebi:82679

10. Cholan-24-oic Acid, 3-hydroxy-7-oxo-, (3a,5b)-

11. Y1357h1a28

12. (r)-4-((3r,5s,8r,9s,10s,13r,14s,17r)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic Acid

13. Cholan-24-oic Acid, 3-hydroxy-7-oxo-, (3.alpha.,5.beta.)-

14. 3alpha-hydroxy-7-keto-5beta-cholanic Acid

15. (4r)-4-[(3r,5s,8r,9s,10s,13r,14s,17r)-3-hydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic Acid

16. (3alpha,5beta)-3-hydroxy-7-oxocholan-24-oic Acid

17. 7-ketochenodeoxycholic Acid

18. Ccris 3987

19. Mfcd00271393

20. Unii-y1357h1a28

21. Nsc-226118

22. Einecs 225-083-2

23. 3-alpha-hydroxy-7-oxo-5beta-cholanic Acid

24. 3-alpha-hydroxy-7-oxo-5-beta-cholanic Acid

25. Nsc 226118

26. 7-keto-lca

27. 7-keto-lithocholic Acid

28. Ec 225-083-2

29. Schembl234771

30. Chembl1254169

31. Amy1798

32. Dtxsid501032263

33. 3-hydroxy-7-oxo-5-cholanic Acid

34. 3?-hydroxy-7 Ketolithocholic Acid

35. Zinc3914814

36. Lmst04010150

37. Akos015855480

38. Akos016010910

39. Cs-w019298

40. Ds-4325

41. Hy-w018512

42. 3-hydroxy-7-oxocholan-24-oic Acid #

43. 7-oxo-3alpha-hydroxycholan-24-oic Acid

44. Ac-29218

45. 3alpha--hydroxy-7-oxo-5beta-cholanic Acid

46. 3i+/--hydroxy-7-oxo-5i(2)-cholanic Acid

47. H0869

48. F11720

49. 3alpha-hydroxy-7-keto-5beta-cholan-24-oic Acid

50. (3a,5ss)-3-hydroxy-7-oxo-cholan-24-?oic Acid

51. 7-oxo-3.alpha.-hydroxycholan-24-oic Acid

52. 3.alpha.-hydroxy-7-oxo-5.beta.-cholic Acid

53. Q27156201

54. Ursodeoxycholic Acid Impurity F [ep Impurity]

55. 3.alpha.-hydroxy-7-oxo-5.beta.-cholanoic Acid

56. Cholan-24-oic Acid, 3-hydroxy-7-oxo-, (3alpha,5beta)-

57. 3.alpha.-hydroxy-7-oxo-5.beta.-cholan-24-oic Acid

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 390.6 g/mol
Molecular Formula C24H38O4
XLogP34.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass390.27700969 g/mol
Monoisotopic Mass390.27700969 g/mol
Topological Polar Surface Area74.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity645
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Cholagogues and Choleretics

Gastrointestinal agents that stimulate the flow of bile into the duodenum (cholagogues) or stimulate the production of bile by the liver (choleretic). (See all compounds classified as Cholagogues and Choleretics.)


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CO.,LTD","supplierCountry":"CHINA","foreign_port":"NA","customer":"ENERGON LABS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"113","totalValueFC":"2843.7","currency":"USD","unitRateINR":"9299.9","date":"26-Jan-2023","totalValueINR":"232497.5","totalValueInUsd":"2843.7","indian_port":"HYDERABAD AIR","hs_no":"29339990","bill_no":"4360192","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO. 10-B, H.NO. 5-36 \/1\/10B,, TSIIC IDA, KUKATPALLY VILLAGE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721932200,"product":"7-KETOLITHOCHOLIC ACID","address":"FLAT NO.302, BHANU ENCLAVE","city":"HYDERABAD.AP","supplier":"JINAN QINMU FINE CHEMICAL CO., LTD.","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"METROCHEM API PRIVATE 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16-Jan-2021
26-Jul-2024
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ABOUT THIS PAGE

7-Ketolithocholic acid Manufacturers

A 7-Ketolithocholic acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 7-Ketolithocholic acid, including repackagers and relabelers. The FDA regulates 7-Ketolithocholic acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 7-Ketolithocholic acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

7-Ketolithocholic acid Suppliers

A 7-Ketolithocholic acid supplier is an individual or a company that provides 7-Ketolithocholic acid active pharmaceutical ingredient (API) or 7-Ketolithocholic acid finished formulations upon request. The 7-Ketolithocholic acid suppliers may include 7-Ketolithocholic acid API manufacturers, exporters, distributors and traders.

click here to find a list of 7-Ketolithocholic acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

7-Ketolithocholic acid USDMF

A 7-Ketolithocholic acid DMF (Drug Master File) is a document detailing the whole manufacturing process of 7-Ketolithocholic acid active pharmaceutical ingredient (API) in detail. Different forms of 7-Ketolithocholic acid DMFs exist exist since differing nations have different regulations, such as 7-Ketolithocholic acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A 7-Ketolithocholic acid DMF submitted to regulatory agencies in the US is known as a USDMF. 7-Ketolithocholic acid USDMF includes data on 7-Ketolithocholic acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 7-Ketolithocholic acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of 7-Ketolithocholic acid suppliers with USDMF on PharmaCompass.

7-Ketolithocholic acid NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing 7-Ketolithocholic acid as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for 7-Ketolithocholic acid API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture 7-Ketolithocholic acid as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain 7-Ketolithocholic acid and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a 7-Ketolithocholic acid NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of 7-Ketolithocholic acid suppliers with NDC on PharmaCompass.

7-Ketolithocholic acid GMP

7-Ketolithocholic acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 7-Ketolithocholic acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 7-Ketolithocholic acid GMP manufacturer or 7-Ketolithocholic acid GMP API supplier for your needs.

7-Ketolithocholic acid CoA

A 7-Ketolithocholic acid CoA (Certificate of Analysis) is a formal document that attests to 7-Ketolithocholic acid's compliance with 7-Ketolithocholic acid specifications and serves as a tool for batch-level quality control.

7-Ketolithocholic acid CoA mostly includes findings from lab analyses of a specific batch. For each 7-Ketolithocholic acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

7-Ketolithocholic acid may be tested according to a variety of international standards, such as European Pharmacopoeia (7-Ketolithocholic acid EP), 7-Ketolithocholic acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (7-Ketolithocholic acid USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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