Find 8-Chlorotheophylline manufacturers, exporters & distributors on PharmaCompass

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Virtual Booth

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 Listed Suppliers

2 API Suppliers
2 Listed Suppliers

MARKET PLACE

1 APIs

marketPlace
1 APIs

REF. STANDARDS & IMPURITIES

1 Others

otherSolutions
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 85-18-7, 1,3-dimethyl-8-chloroxanthine, 8-chloro-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione, 8-chloro-1,3-dimethyl-7h-purine-2,6-dione, Chlortheophylline, Theophylline, 8-chloro-

Molecular Formula

C₇H₇ClN₄O₂

Molecular Weight

214.61 g/mol

InChI Key

RYIGNEOBDRVTHA-UHFFFAOYSA-N

FDA UNII

GE2UA340FM

8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Its main use is in combination with [Diphenhydramine] as the antiemetic drug [Dimenhydrinate]. The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's anti-histamine activity in the central nervous system. 8-chlorotheophylline produces a number of effects including nervousness, restlessness, insomnia, headache, and nausea, which are primarily attributed to its ability to block the adenosine receptor. Because adenosine causes a decrease in neuronal firing, blockade of the adenosine receptor causes the reverse effect resulting in excitation.

1 2D Structure

8-Chlorotheophylline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

8-chloro-1,3-dimethyl-7H-purine-2,6-dione

2.1.2 InChI

InChI=1S/C7H7ClN4O2/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h1-2H3,(H,9,10)

2.1.3 InChI Key

RYIGNEOBDRVTHA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Cl

2.2 Other Identifiers

2.2.1 UNII

GE2UA340FM

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 8-chlorotheophylline, Sodium Salt

2. S8ct

3. Sodium-8-chlorotheophylline

2.3.2 Depositor-Supplied Synonyms

1. 85-18-7

2. 1,3-dimethyl-8-chloroxanthine

3. 8-chloro-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione

4. 8-chloro-1,3-dimethyl-7h-purine-2,6-dione

5. Chlortheophylline

6. Theophylline, 8-chloro-

7. 8-chloro-theophylline

8. 1h-purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-

9. 8-chloro-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione

10. Chlorotheophylline

11. Nsc 6113

12. 8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione

13. Ge2ua340fm

14. Chembl88611

15. Chebi:59771

16. 8-chloro-1,3-dimethyl-2,6(1h,3h)-purinedione

17. Nsc-6113

18. 8-chloro-1,3-dimethyl-3,7-dihydro-purine-2,6-dione

19. 8-chlortheophyllin

20. 8-chloro-1,3-dimethyl-2,6-purinedione

21. Einecs 201-590-4

22. Unii-ge2ua340fm

23. 8-chloro-1,3-dimethyl-3,9-dihydro-1h-purine-2,6-dione

24. 8-chorotheophylline

25. 8-chlorotheophyline

26. Mfcd00005581

27. 2uy3

28. 8-chloro-1,3-dimethyl-2,3,6,7-tetrahydro-1h-purine-2,6-dione

29. 8-chlortheophylline

30. Ec 201-590-4

31. Oprea1_038673

32. Oprea1_741931

33. Schembl411139

34. Amy493

35. Dtxsid5043764

36. 1,3-dimethyl 8-chloro Xanthine

37. Nsc6113

38. Bbl009700

39. Bdbm50331852

40. Stk701164

41. 8-chlortheophylline [who-dd]

42. 8-chlorotheophylline [usp-rs]

43. Akos000119705

44. Akos005521865

45. Zinc100018165

46. Db14132

47. As-67718

48. Db-056856

49. Ft-0631394

50. Pamabrom Related Compound A [usp-rs]

51. D97697

52. Ab01563382_01

53. A841253

54. Sr-01000479303

55. Q4644272

56. Sr-01000479303-1

57. W-104090

58. 1h-purine-2, 8-chloro-3,7-dihydro-1,3-dimethyl-

59. 8-chloro-1,3-dimethyl-3,7-dihydropurine-2,6-dione

60. 8-chloro-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione #

61. 8-chloro-1,3-dimethyl-3,9-dihydro-1h-purine-2,6-dione, Aldrichcpr

62. H33

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₇H₇ClN₄O₂
Molecular Weight	214.61 g/mol
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	214.0257532 g/mol
Monoisotopic Mass	214.0257532 g/mol
Topological Polar Surface Area	69.3 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	297
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

When used in combination with [DB01075] as the antiemetic [DB00985], 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

8-chlorotheophylline produces a number of effects including nervousness, restlessness, insomnia, headache, and nausea, which are primarily attributed to its ability to block the adenosine receptor. Because adenosine causes a decrease in neuronal firing, blockade of the adenosine receptor causes the reverse effect resulting in excitation.

API SUPPLIERS