Find 8-Chlorotheophylline manufacturers, exporters & distributors on PharmaCompass

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Chemistry

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Also known as: 85-18-7, 1,3-dimethyl-8-chloroxanthine, 8-chloro-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione, 8-chloro-1,3-dimethyl-7h-purine-2,6-dione, Chlortheophylline, Theophylline, 8-chloro-

Molecular Formula

C₇H₇ClN₄O₂

Molecular Weight

214.61 g/mol

InChI Key

RYIGNEOBDRVTHA-UHFFFAOYSA-N

FDA UNII

GE2UA340FM

8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Its main use is in combination with [Diphenhydramine] as the antiemetic drug [Dimenhydrinate]. The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's anti-histamine activity in the central nervous system. 8-chlorotheophylline produces a number of effects including nervousness, restlessness, insomnia, headache, and nausea, which are primarily attributed to its ability to block the adenosine receptor. Because adenosine causes a decrease in neuronal firing, blockade of the adenosine receptor causes the reverse effect resulting in excitation.

1 2D Structure

8-Chlorotheophylline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

8-chloro-1,3-dimethyl-7H-purine-2,6-dione

2.1.2 InChI

InChI=1S/C7H7ClN4O2/c1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h1-2H3,(H,9,10)

2.1.3 InChI Key

RYIGNEOBDRVTHA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CN1C2=C(C(=O)N(C1=O)C)NC(=N2)Cl

2.2 Other Identifiers

2.2.1 UNII

GE2UA340FM

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 8-chlorotheophylline, Sodium Salt

2. S8ct

3. Sodium-8-chlorotheophylline

2.3.2 Depositor-Supplied Synonyms

1. 85-18-7

2. 1,3-dimethyl-8-chloroxanthine

3. 8-chloro-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione

4. 8-chloro-1,3-dimethyl-7h-purine-2,6-dione

5. Chlortheophylline

6. Theophylline, 8-chloro-

7. 8-chloro-theophylline

8. 1h-purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-

9. 8-chloro-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione

10. Chlorotheophylline

11. Nsc 6113

12. 8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione

13. Ge2ua340fm

14. Chembl88611

15. Chebi:59771

16. 8-chloro-1,3-dimethyl-2,6(1h,3h)-purinedione

17. Nsc-6113

18. 8-chloro-1,3-dimethyl-3,7-dihydro-purine-2,6-dione

19. 8-chlortheophyllin

20. 8-chloro-1,3-dimethyl-2,6-purinedione

21. Einecs 201-590-4

22. Unii-ge2ua340fm

23. 8-chloro-1,3-dimethyl-3,9-dihydro-1h-purine-2,6-dione

24. 8-chorotheophylline

25. 8-chlorotheophyline

26. Mfcd00005581

27. 2uy3

28. 8-chloro-1,3-dimethyl-2,3,6,7-tetrahydro-1h-purine-2,6-dione

29. 8-chlortheophylline

30. Ec 201-590-4

31. Oprea1_038673

32. Oprea1_741931

33. Schembl411139

34. Amy493

35. Dtxsid5043764

36. 1,3-dimethyl 8-chloro Xanthine

37. Nsc6113

38. Bbl009700

39. Bdbm50331852

40. Stk701164

41. 8-chlortheophylline [who-dd]

42. 8-chlorotheophylline [usp-rs]

43. Akos000119705

44. Akos005521865

45. Zinc100018165

46. Db14132

47. As-67718

48. Db-056856

49. Ft-0631394

50. Pamabrom Related Compound A [usp-rs]

51. D97697

52. Ab01563382_01

53. A841253

54. Sr-01000479303

55. Q4644272

56. Sr-01000479303-1

57. W-104090

58. 1h-purine-2, 8-chloro-3,7-dihydro-1,3-dimethyl-

59. 8-chloro-1,3-dimethyl-3,7-dihydropurine-2,6-dione

60. 8-chloro-1,3-dimethyl-3,7-dihydro-1h-purine-2,6-dione #

61. 8-chloro-1,3-dimethyl-3,9-dihydro-1h-purine-2,6-dione, Aldrichcpr

62. H33

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₇H₇ClN₄O₂
Molecular Weight	214.61 g/mol
XLogP3	0.9
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	214.0257532 g/mol
Monoisotopic Mass	214.0257532 g/mol
Topological Polar Surface Area	69.3 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	297
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

When used in combination with [DB01075] as the antiemetic [DB00985], 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.

5 Pharmacology and Biochemistry

5.1 Mechanism of Action

8-chlorotheophylline produces a number of effects including nervousness, restlessness, insomnia, headache, and nausea, which are primarily attributed to its ability to block the adenosine receptor. Because adenosine causes a decrease in neuronal firing, blockade of the adenosine receptor causes the reverse effect resulting in excitation.

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ABOUT THIS PAGE

8-Chlorotheophylline Manufacturers

A 8-Chlorotheophylline manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 8-Chlorotheophylline, including repackagers and relabelers. The FDA regulates 8-Chlorotheophylline manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 8-Chlorotheophylline API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of 8-Chlorotheophylline manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

8-Chlorotheophylline Suppliers

A 8-Chlorotheophylline supplier is an individual or a company that provides 8-Chlorotheophylline active pharmaceutical ingredient (API) or 8-Chlorotheophylline finished formulations upon request. The 8-Chlorotheophylline suppliers may include 8-Chlorotheophylline API manufacturers, exporters, distributors and traders.

click here to find a list of 8-Chlorotheophylline suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

8-Chlorotheophylline GMP

8-Chlorotheophylline Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 8-Chlorotheophylline GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 8-Chlorotheophylline GMP manufacturer or 8-Chlorotheophylline GMP API supplier for your needs.

8-Chlorotheophylline CoA

A 8-Chlorotheophylline CoA (Certificate of Analysis) is a formal document that attests to 8-Chlorotheophylline's compliance with 8-Chlorotheophylline specifications and serves as a tool for batch-level quality control.

8-Chlorotheophylline CoA mostly includes findings from lab analyses of a specific batch. For each 8-Chlorotheophylline CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

8-Chlorotheophylline may be tested according to a variety of international standards, such as European Pharmacopoeia (8-Chlorotheophylline EP), 8-Chlorotheophylline JP (Japanese Pharmacopeia) and the US Pharmacopoeia (8-Chlorotheophylline USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.