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Chemistry

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Also known as: 91421-43-1, Aminocamptothecin, 9-amino-camptothecin, 9-amino-cpt, 9-amino-20(s)-camptothecin, 9-amino-20-(s)-camptothecin
Molecular Formula
C20H17N3O4
Molecular Weight
363.4  g/mol
InChI Key
FUXVKZWTXQUGMW-FQEVSTJZSA-N
FDA UNII
5MB77ICE2Q

9-Aminocamptothecin
Aminocamptothecin is a water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)
1 2D Structure

9-Aminocamptothecin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
2.1.2 InChI
InChI=1S/C20H17N3O4/c1-2-20(26)13-7-16-17-10(6-11-14(21)4-3-5-15(11)22-17)8-23(16)18(24)12(13)9-27-19(20)25/h3-7,26H,2,8-9,21H2,1H3/t20-/m0/s1
2.1.3 InChI Key
FUXVKZWTXQUGMW-FQEVSTJZSA-N
2.1.4 Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O
2.1.5 Isomeric SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O
2.2 Other Identifiers
2.2.1 UNII
5MB77ICE2Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 9-amino-20(s)-camptothecin

2. 9-amino-20-camptothecin, (+-)-isomer

3. 9-amino-20-camptothecin, (r,s)-isomer

4. 9-amino-cpt

5. Nsc 603071

2.3.2 Depositor-Supplied Synonyms

1. 91421-43-1

2. Aminocamptothecin

3. 9-amino-camptothecin

4. 9-amino-cpt

5. 9-amino-20(s)-camptothecin

6. 9-amino-20-(s)-camptothecin

7. Nsc-603071

8. Nsc603071

9. 5mb77ice2q

10. Chembl274070

11. (s)-10-amino-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

12. Chebi:80755

13. (s)-10-amino-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

14. Camptothecin, 9-amino-

15. (19s)-8-amino-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

16. (s)-10-amino-4-ethyl-4-hydroxy-1,12-dihydro-14h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h)-dione

17. 10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione

18. 10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

19. Mls002702905

20. Unii-5mb77ice2q

21. Nsc 603071

22. Idec-132

23. Nsc-629971

24. 9-aminocamptothecan

25. 9-amino Camptothecin

26. 9-nh2-camptothecin

27. 9-amino-2(s)-camptothecin

28. Schembl26578

29. (s)-10-amino-4-ethyl-4-hydroxy-1h-pyrano(3;,4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione

30. Cid_72402

31. Mls000728575

32. 9-aminocamptothecin [mi]

33. Dtxsid10873202

34. Hms2220k11

35. Hms3339h11

36. Hms3749c03

37. 10-amino-4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

38. Bcp09002

39. Ex-a4335

40. 9-amino-cpt (9-aminocamptothecin)

41. Bdbm50008936

42. Mfcd00909855

43. S2653

44. Zinc37866089

45. 9-aminocamptothecin [who-dd]

46. Akos015896595

47. Cs-7784

48. Db12515

49. Ncgc00247552-01

50. 1h-pyrano(3;,4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 10-amino-4-ethyl-4-hydroxy-, (s)-

51. Ac-33991

52. As-14292

53. Nci60_004578

54. Smr000445687

55. Hy-100309

56. F11420

57. 421a431

58. A843867

59. J-504140

60. Brd-k09291936-001-07-5

61. Q27149808

62. (s)-10-amino-4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione

63. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 10-amino-4-ethyl-4-hydroxy-, (4s)-

64. 1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione,4-ethyl-4-hydroxy-9-nitro-

65. 1h-pyrano[3',7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione, 10-amino-4-ethyl-4-hydroxy-, (s)-

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 363.4 g/mol
Molecular Formula C20H17N3O4
XLogP30.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass363.12190603 g/mol
Monoisotopic Mass363.12190603 g/mol
Topological Polar Surface Area106 Ų
Heavy Atom Count27
Formal Charge0
Complexity775
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


ABOUT THIS PAGE

9-Aminocamptothecin Manufacturers

A 9-Aminocamptothecin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 9-Aminocamptothecin, including repackagers and relabelers. The FDA regulates 9-Aminocamptothecin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 9-Aminocamptothecin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

9-Aminocamptothecin Suppliers

A 9-Aminocamptothecin supplier is an individual or a company that provides 9-Aminocamptothecin active pharmaceutical ingredient (API) or 9-Aminocamptothecin finished formulations upon request. The 9-Aminocamptothecin suppliers may include 9-Aminocamptothecin API manufacturers, exporters, distributors and traders.

click here to find a list of 9-Aminocamptothecin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

9-Aminocamptothecin USDMF

A 9-Aminocamptothecin DMF (Drug Master File) is a document detailing the whole manufacturing process of 9-Aminocamptothecin active pharmaceutical ingredient (API) in detail. Different forms of 9-Aminocamptothecin DMFs exist exist since differing nations have different regulations, such as 9-Aminocamptothecin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A 9-Aminocamptothecin DMF submitted to regulatory agencies in the US is known as a USDMF. 9-Aminocamptothecin USDMF includes data on 9-Aminocamptothecin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 9-Aminocamptothecin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of 9-Aminocamptothecin suppliers with USDMF on PharmaCompass.

9-Aminocamptothecin GMP

9-Aminocamptothecin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of 9-Aminocamptothecin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 9-Aminocamptothecin GMP manufacturer or 9-Aminocamptothecin GMP API supplier for your needs.

9-Aminocamptothecin CoA

A 9-Aminocamptothecin CoA (Certificate of Analysis) is a formal document that attests to 9-Aminocamptothecin's compliance with 9-Aminocamptothecin specifications and serves as a tool for batch-level quality control.

9-Aminocamptothecin CoA mostly includes findings from lab analyses of a specific batch. For each 9-Aminocamptothecin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

9-Aminocamptothecin may be tested according to a variety of international standards, such as European Pharmacopoeia (9-Aminocamptothecin EP), 9-Aminocamptothecin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (9-Aminocamptothecin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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