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    Chemistry

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    Also known as: (2s,3s,4r,5r,6r)-6-{[(2s,3s,4s,5r,6s)-6-{[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-(sulfooxy)oxan-3-yl]oxy}-2-hydroxy-4-(sulfomethyl)-5-(sulfooxy)oxan-3-yl]oxy}-3-{[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-[(sulfooxy)methyl]oxan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid, Hepflush, Chembl526514, Gtpl4214, S01xa14, Bdbm50480251
    Molecular Formula
    C26H41NO34S4
    Molecular Weight
    1039.9  g/mol
    InChI Key
    ZFGMDIBRIDKWMY-PASTXAENSA-N
    Heparin Sodium
    A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
    1 2D Structure

    Heparin Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S,3S,4R,5R,6R)-3-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(sulfooxymethyl)oxan-2-yl]oxy-6-[(2S,3S,4S,5R,6S)-6-[(2R,3S,4S,5R)-2-carboxy-4,6-dihydroxy-5-sulfooxyoxan-3-yl]oxy-2-hydroxy-4-(sulfomethyl)-5-sulfooxyoxan-3-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid
    2.1.2 InChI
    InChI=1S/C26H41NO34S4/c1-4(28)27-7-9(30)8(29)6(2-52-63(43,44)45)53-24(7)56-15-10(31)11(32)25(58-19(15)21(36)37)55-13-5(3-62(40,41)42)14(60-64(46,47)48)26(59-22(13)38)57-16-12(33)17(61-65(49,50)51)23(39)54-18(16)20(34)35/h5-19,22-26,29-33,38-39H,2-3H2,1H3,(H,27,28)(H,34,35)(H,36,37)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)/t5-,6+,7+,8+,9+,10+,11+,12-,13-,14+,15-,16-,17+,18+,19-,22-,23?,24+,25+,26-/m0/s1
    2.1.3 InChI Key
    ZFGMDIBRIDKWMY-PASTXAENSA-N
    2.1.4 Canonical SMILES
    CC(=O)NC1C(C(C(OC1OC2C(C(C(OC2C(=O)O)OC3C(C(C(OC3O)OC4C(C(C(OC4C(=O)O)O)OS(=O)(=O)O)O)OS(=O)(=O)O)CS(=O)(=O)O)O)O)COS(=O)(=O)O)O)O
    2.1.5 Isomeric SMILES
    CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O[C@H]2[C@@H]([C@H]([C@@H](O[C@@H]2C(=O)O)O[C@H]3[C@@H]([C@H]([C@H](O[C@@H]3O)O[C@H]4[C@@H]([C@H](C(O[C@H]4C(=O)O)O)OS(=O)(=O)O)O)OS(=O)(=O)O)CS(=O)(=O)O)O)O)COS(=O)(=O)O)O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Alpha Heparin

    2. Alpha-heparin

    3. Heparin

    4. Heparin Sodium

    5. Heparin, Sodium

    6. Heparin, Unfractionated

    7. Heparinic Acid

    8. Liquaemin

    9. Unfractionated Heparin

    2.2.2 Depositor-Supplied Synonyms

    1. (2s,3s,4r,5r,6r)-6-{[(2s,3s,4s,5r,6s)-6-{[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-(sulfooxy)oxan-3-yl]oxy}-2-hydroxy-4-(sulfomethyl)-5-(sulfooxy)oxan-3-yl]oxy}-3-{[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-[(sulfooxy)methyl]oxan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic Acid

    2. Hepflush

    3. Chembl526514

    4. Gtpl4214

    5. S01xa14

    6. Bdbm50480251

    7. (2s,3s,4r,5r,6r)-3-[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-(sulfooxymethyl)oxan-2-yl]oxy-6-[(2s,3s,4s,5r,6s)-6-[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-sulfooxyoxan-3-yl]oxy-2-hydroxy-4-(sulfomethyl)-5-sulfooxyoxan-3-yl]oxy-4,5-dihydroxyoxane-2-carboxylic Acid

    2.2.3 Other Synonyms

    1. 9005-49-6

    2.3 Create Date
    2007-12-05
    3 Chemical and Physical Properties
    Molecular Weight 1039.9 g/mol
    Molecular Formula C26H41NO34S4
    XLogP3-10.4
    Hydrogen Bond Donor Count14
    Hydrogen Bond Acceptor Count34
    Rotatable Bond Count18
    Exact Mass1039.0392821 g/mol
    Monoisotopic Mass1039.0392821 g/mol
    Topological Polar Surface Area589 Ų
    Heavy Atom Count65
    Formal Charge0
    Complexity2140
    Isotope Atom Count0
    Defined Atom Stereocenter Count19
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameHeparin sodium
    Drug LabelIntravenous solutions with heparin sodium (derived from porcine intestinal mucosa) are sterile, nonpyrogenic fluids for intravenous administration. They contain no bacteriostat or antimicrobial agent or added buffer. Edetate disodium, anhydrous is ad...
    Active IngredientHeparin sodium
    Dosage FormInjectable
    RouteInjection
    Strength5,000 units/ml; 10,000 units/ml; 20,000 units/ml; 1,000 units/ml
    Market StatusPrescription
    CompanyHospira; Shenzhen Techdow; Sandoz; Pfizer; Fresenius Kabi Usa; Hikma Maple; Sagent Pharms

    2 of 2  
    Drug NameHeparin sodium
    Drug LabelIntravenous solutions with heparin sodium (derived from porcine intestinal mucosa) are sterile, nonpyrogenic fluids for intravenous administration. They contain no bacteriostat or antimicrobial agent or added buffer. Edetate disodium, anhydrous is ad...
    Active IngredientHeparin sodium
    Dosage FormInjectable
    RouteInjection
    Strength5,000 units/ml; 10,000 units/ml; 20,000 units/ml; 1,000 units/ml
    Market StatusPrescription
    CompanyHospira; Shenzhen Techdow; Sandoz; Pfizer; Fresenius Kabi Usa; Hikma Maple; Sagent Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anticoagulants

    Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)

    Fibrinolytic Agents

    Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)

    API Reference Price

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    DOSAGE - INJECTABLE;INJECTION - 1,000 UNITS/M...DOSAGE - INJECTABLE;INJECTION - 1,000 UNITS/ML

    USFDA APPLICATION NUMBER - 17029

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    USFDA APPLICATION NUMBER - 201370

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    ABOUT THIS PAGE

    Looking for / Heparin Sodium API manufacturers, exporters & distributors?

    Heparin Sodium manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Heparin Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Heparin Sodium manufacturer or Heparin Sodium supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Heparin Sodium manufacturer or Heparin Sodium supplier.

    PharmaCompass also assists you with knowing the Heparin Sodium API Price utilized in the formulation of products. Heparin Sodium API Price is not always fixed or binding as the Heparin Sodium Price is obtained through a variety of data sources. The Heparin Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Heparin Sodium

    Synonyms

    (2s,3s,4r,5r,6r)-6-{[(2s,3s,4s,5r,6s)-6-{[(2r,3s,4s,5r)-2-carboxy-4,6-dihydroxy-5-(sulfooxy)oxan-3-yl]oxy}-2-hydroxy-4-(sulfomethyl)-5-(sulfooxy)oxan-3-yl]oxy}-3-{[(2r,3r,4r,5s,6r)-3-acetamido-4,5-dihydroxy-6-[(sulfooxy)methyl]oxan-2-yl]oxy}-4,5-dihydroxyoxane-2-carboxylic acid, Hepflush, Chembl526514, Gtpl4214, S01xa14, Bdbm50480251

    About Heparin Sodium

    A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.

    9005-49-6 Manufacturers

    A 9005-49-6 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of 9005-49-6, including repackagers and relabelers. The FDA regulates 9005-49-6 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. 9005-49-6 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of 9005-49-6 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    9005-49-6 Suppliers

    A 9005-49-6 supplier is an individual or a company that provides 9005-49-6 active pharmaceutical ingredient (API) or 9005-49-6 finished formulations upon request. The 9005-49-6 suppliers may include 9005-49-6 API manufacturers, exporters, distributors and traders.

    click here to find a list of 9005-49-6 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    9005-49-6 USDMF

    A 9005-49-6 DMF (Drug Master File) is a document detailing the whole manufacturing process of 9005-49-6 active pharmaceutical ingredient (API) in detail. Different forms of 9005-49-6 DMFs exist exist since differing nations have different regulations, such as 9005-49-6 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A 9005-49-6 DMF submitted to regulatory agencies in the US is known as a USDMF. 9005-49-6 USDMF includes data on 9005-49-6's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The 9005-49-6 USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of 9005-49-6 suppliers with USDMF on PharmaCompass.

    9005-49-6 JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The 9005-49-6 Drug Master File in Japan (9005-49-6 JDMF) empowers 9005-49-6 API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the 9005-49-6 JDMF during the approval evaluation for pharmaceutical products. At the time of 9005-49-6 JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of 9005-49-6 suppliers with JDMF on PharmaCompass.

    9005-49-6 KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a 9005-49-6 Drug Master File in Korea (9005-49-6 KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of 9005-49-6. The MFDS reviews the 9005-49-6 KDMF as part of the drug registration process and uses the information provided in the 9005-49-6 KDMF to evaluate the safety and efficacy of the drug.

    After submitting a 9005-49-6 KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their 9005-49-6 API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of 9005-49-6 suppliers with KDMF on PharmaCompass.

    9005-49-6 CEP

    A 9005-49-6 CEP of the European Pharmacopoeia monograph is often referred to as a 9005-49-6 Certificate of Suitability (COS). The purpose of a 9005-49-6 CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of 9005-49-6 EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of 9005-49-6 to their clients by showing that a 9005-49-6 CEP has been issued for it. The manufacturer submits a 9005-49-6 CEP (COS) as part of the market authorization procedure, and it takes on the role of a 9005-49-6 CEP holder for the record. Additionally, the data presented in the 9005-49-6 CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the 9005-49-6 DMF.

    A 9005-49-6 CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. 9005-49-6 CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of 9005-49-6 suppliers with CEP (COS) on PharmaCompass.

    9005-49-6 WC

    A 9005-49-6 written confirmation (9005-49-6 WC) is an official document issued by a regulatory agency to a 9005-49-6 manufacturer, verifying that the manufacturing facility of a 9005-49-6 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting 9005-49-6 APIs or 9005-49-6 finished pharmaceutical products to another nation, regulatory agencies frequently require a 9005-49-6 WC (written confirmation) as part of the regulatory process.

    click here to find a list of 9005-49-6 suppliers with Written Confirmation (WC) on PharmaCompass.

    9005-49-6 NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing 9005-49-6 as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for 9005-49-6 API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture 9005-49-6 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain 9005-49-6 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a 9005-49-6 NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of 9005-49-6 suppliers with NDC on PharmaCompass.

    9005-49-6 GMP

    9005-49-6 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of 9005-49-6 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right 9005-49-6 GMP manufacturer or 9005-49-6 GMP API supplier for your needs.

    9005-49-6 CoA

    A 9005-49-6 CoA (Certificate of Analysis) is a formal document that attests to 9005-49-6's compliance with 9005-49-6 specifications and serves as a tool for batch-level quality control.

    9005-49-6 CoA mostly includes findings from lab analyses of a specific batch. For each 9005-49-6 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    9005-49-6 may be tested according to a variety of international standards, such as European Pharmacopoeia (9005-49-6 EP), 9005-49-6 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (9005-49-6 USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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