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Chemistry

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Also known as: 185106-16-5, Acotiamide [inn], Unii-d42owk5383, N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide, Chembl2107723, Chebi:34523
Molecular Formula
C21H30N4O5S
Molecular Weight
450.6  g/mol
InChI Key
TWHZNAUBXFZMCA-UHFFFAOYSA-N
FDA UNII
D42OWK5383

AC1NQZWJ
Acotiamide is a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
1 2D Structure

AC1NQZWJ

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide
2.1.2 InChI
InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27)
2.1.3 InChI Key
TWHZNAUBXFZMCA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C
2.2 Other Identifiers
2.2.1 UNII
D42OWK5383
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Acotiamide Hydrochloride

2. N-(2-(diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxamide

3. N-(n',n'-diisopropylaminoethyl)-(2-(2-hydroxy-4,5-dimethoxybenzoylamino)-1,3-thiazole-4-yl)carboxyamide

4. Ym 443

5. Ym-443

6. Ym443 Cpd

7. Z 338

8. Z-338

2.3.2 Depositor-Supplied Synonyms

1. 185106-16-5

2. Acotiamide [inn]

3. Unii-d42owk5383

4. N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide

5. Chembl2107723

6. Chebi:34523

7. Ym 443

8. C14127

9. D42owk5383

10. Ac1nqzwj

11. Acotiamide [mi]

12. Acotiamide [who-dd]

13. Schembl1043131

14. Dtxsid40870163

15. Hms3886o11

16. Bcp21087

17. Zinc2002237

18. Mfcd00953661

19. Mz-338

20. S5075

21. Akos025401963

22. Ccg-269239

23. Db12482

24. Sb19646

25. Ncgc00506872-01

26. Ac-27642

27. N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxy-benzoyl)amino]thiazole-4-carboxamide

28. Hy-121467

29. Cs-0082145

30. Acotiamide; Mz-338; Unii-d42owk5383;

31. F14756

32. A899477

33. Q4674598

34. Ym443; Ym-443; Ym 443; Z338; Z-338; Z 338

35. N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide

36. 4-thiazolecarboxamide, N-(2-(bis(1-methylethyl)amino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-

37. N-(2-(bis(1-methylethyl)amino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)thiazol-4-carboxamide

38. N-(2-(bis(1-methylethyl)amino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)thiazole-4-carboxamide

39. N-{2-[bis(propan-2-yl)amino]ethyl}-2-(2-hydroxy-4,5-dimethoxybenzamido)-1,3-thiazole-4-carboxamide

2.4 Create Date
2005-10-11
3 Chemical and Physical Properties
Molecular Weight 450.6 g/mol
Molecular Formula C21H30N4O5S
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count10
Exact Mass450.19369124 g/mol
Monoisotopic Mass450.19369124 g/mol
Topological Polar Surface Area141 Ų
Heavy Atom Count31
Formal Charge0
Complexity586
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of functional dyspepsia


Treatment of functional dyspepsia


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)


Gastrointestinal Agents

Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion. (See all compounds classified as Gastrointestinal Agents.)


ABOUT THIS PAGE

Looking for 185106-16-5 / AC1NQZWJ API manufacturers, exporters & distributors?

AC1NQZWJ manufacturers, exporters & distributors 1

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PharmaCompass offers a list of AC1NQZWJ API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right AC1NQZWJ manufacturer or AC1NQZWJ supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred AC1NQZWJ manufacturer or AC1NQZWJ supplier.

PharmaCompass also assists you with knowing the AC1NQZWJ API Price utilized in the formulation of products. AC1NQZWJ API Price is not always fixed or binding as the AC1NQZWJ Price is obtained through a variety of data sources. The AC1NQZWJ Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

AC1NQZWJ

Synonyms

185106-16-5, Acotiamide [inn], Unii-d42owk5383, N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide, Chembl2107723, Chebi:34523

Cas Number

185106-16-5

Unique Ingredient Identifier (UNII)

D42OWK5383

About AC1NQZWJ

Acotiamide is a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.

AC1NQZWJ Manufacturers

A AC1NQZWJ manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AC1NQZWJ, including repackagers and relabelers. The FDA regulates AC1NQZWJ manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AC1NQZWJ API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

AC1NQZWJ Suppliers

A AC1NQZWJ supplier is an individual or a company that provides AC1NQZWJ active pharmaceutical ingredient (API) or AC1NQZWJ finished formulations upon request. The AC1NQZWJ suppliers may include AC1NQZWJ API manufacturers, exporters, distributors and traders.

AC1NQZWJ GMP

AC1NQZWJ Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of AC1NQZWJ GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AC1NQZWJ GMP manufacturer or AC1NQZWJ GMP API supplier for your needs.

AC1NQZWJ CoA

A AC1NQZWJ CoA (Certificate of Analysis) is a formal document that attests to AC1NQZWJ's compliance with AC1NQZWJ specifications and serves as a tool for batch-level quality control.

AC1NQZWJ CoA mostly includes findings from lab analyses of a specific batch. For each AC1NQZWJ CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

AC1NQZWJ may be tested according to a variety of international standards, such as European Pharmacopoeia (AC1NQZWJ EP), AC1NQZWJ JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AC1NQZWJ USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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