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    Also known as: Tripotassium citrate, 866-84-2, Kaliksir, 7778-49-6, Potassium citrate anhydrous, Litocit
    Molecular Formula
    C6H5K3O7
    Molecular Weight
    306.39  g/mol
    InChI Key
    QEEAPRPFLLJWCF-UHFFFAOYSA-K
    FDA UNII
    86R1NVR0HW
    Potassium Citrate
    A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
    Potassium citrate anhydrous is a Metabolic Alkalinizer. The mechanism of action of potassium citrate anhydrous is as an Alkalinizing Activity.
    1 2D Structure

    Potassium Citrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    tripotassium;2-hydroxypropane-1,2,3-tricarboxylate
    2.1.2 InChI
    InChI=1S/C6H8O7.3K/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    2.1.3 InChI Key
    QEEAPRPFLLJWCF-UHFFFAOYSA-K
    2.1.4 Canonical SMILES
    C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+]
    2.2 Other Identifiers
    2.2.1 UNII
    86R1NVR0HW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anhydrous, Potassium Citrate

    2. Citrate, Potassium

    3. Potassium Citrate Anhydrous

    2.3.2 Depositor-Supplied Synonyms

    1. Tripotassium Citrate

    2. 866-84-2

    3. Kaliksir

    4. 7778-49-6

    5. Potassium Citrate Anhydrous

    6. Litocit

    7. Potassiumcitrate

    8. Citric Acid, Tripotassium Salt

    9. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Tripotassium Salt

    10. Potassium Citrate Tribasic Solution

    11. Tripotassium;2-hydroxypropane-1,2,3-tricarboxylate

    12. 86r1nvr0hw

    13. Chebi:64733

    14. Tripotassium 2-hydroxypropane-1,2,3-tricarboxylate

    15. Kalii Citras

    16. Porekal

    17. Kajos

    18. Polycitra K

    19. Urocit K

    20. Seltz-k

    21. K Citrate

    22. Potassium Tribasic Citrate

    23. Ins No.332(ii)

    24. Ins-332(ii)

    25. Tripotassium Citrate Anhydrous

    26. Acalka

    27. Ccris 6566

    28. E-332(ii)

    29. Hsdb 1248

    30. Nsc-760107

    31. Einecs 212-755-5

    32. Unii-86r1nvr0hw

    33. Potassium Citrate (anhydrous)

    34. Einecs 231-905-0

    35. Tri Potassium Citrate

    36. Potassium Citrate (anh.)

    37. Anhydrous Potassium Citrate

    38. Ec 212-755-5

    39. Tripotassium Citrate (anh.)

    40. Anhydrous Tripotassium Citrate

    41. Potassium Citrate [mi]

    42. Chembl1200458

    43. Dtxsid8027325

    44. Tripotassium Citrate (anhydrous)

    45. Potassium Citrate [who-dd]

    46. Citric Acid Tripotassium Salt (anh.)

    47. Akos015918285

    48. Db09125

    49. Citric Acid Tripotassium Salt (anhydrous)

    50. E332

    51. Potassium Citrate Anhydrous [hsdb]

    52. Potassium Citrate Anhydrous [mart.]

    53. Ft-0653076

    54. Potassium 2-hydroxypropane-1,2,3-tricarboxylate

    55. A841790

    56. Q419921

    57. Tripotassium 2-oxidanylpropane-1,2,3-tricarboxylate

    58. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Potassium Salt (1:?)

    59. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Potassium Salt (1:3)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 306.39 g/mol
    Molecular Formula C6H5K3O7
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count2
    Exact Mass305.8946469 g/mol
    Monoisotopic Mass305.8946469 g/mol
    Topological Polar Surface Area141 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity211
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NamePotassium citrate
    PubMed HealthPotassium Citrate (By mouth)
    Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
    Drug LabelPotassium citrate USP is a citrate salt of potassium and has the chemical name 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate. Its molecular formula is K3C6H 5O7.H2O , and its structural formula is: M.W. 324.41Potassium c...
    Active IngredientPotassium citrate
    Dosage FormTablet, extended release
    RouteOral
    Strength5meq; 15meq; 10meq
    Market StatusPrescription
    CompanyCorepharma; Zydus Pharms Usa

    2 of 4  
    Drug NameUrocit-k
    PubMed HealthPotassium Citrate (By mouth)
    Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
    Drug LabelUrocit-K is a citrate salt of potassium. Its empirical formula is K3C6H5O7 H2O, and it has the following chemical structure:Urocit-K yellowish to tan, oral wax-matrix tablets, contain 5 mEq (540 mg) potassium citrate, 10 mEq (1080 mg) potassi...
    Active IngredientPotassium citrate
    Dosage FormTablet, extended release
    RouteOral
    Strength5meq; 15meq; 10meq
    Market StatusPrescription
    CompanyMission Pharma

    3 of 4  
    Drug NamePotassium citrate
    PubMed HealthPotassium Citrate (By mouth)
    Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
    Drug LabelPotassium citrate USP is a citrate salt of potassium and has the chemical name 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tripotassium salt, monohydrate. Its molecular formula is K3C6H 5O7.H2O , and its structural formula is: M.W. 324.41Potassium c...
    Active IngredientPotassium citrate
    Dosage FormTablet, extended release
    RouteOral
    Strength5meq; 15meq; 10meq
    Market StatusPrescription
    CompanyCorepharma; Zydus Pharms Usa

    4 of 4  
    Drug NameUrocit-k
    PubMed HealthPotassium Citrate (By mouth)
    Drug ClassesPotassium Supplement, Urinary Alkalinizer, Urinary Stone Agent
    Drug LabelUrocit-K is a citrate salt of potassium. Its empirical formula is K3C6H5O7 H2O, and it has the following chemical structure:Urocit-K yellowish to tan, oral wax-matrix tablets, contain 5 mEq (540 mg) potassium citrate, 10 mEq (1080 mg) potassi...
    Active IngredientPotassium citrate
    Dosage FormTablet, extended release
    RouteOral
    Strength5meq; 15meq; 10meq
    Market StatusPrescription
    CompanyMission Pharma

    4.2 Therapeutic Uses

    Diuretics; Expectorants

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    THE...CITRATE...OF POTASSIUM.../IS/ ADMIN ORALLY. ... 40 MEQ OF POTASSIUM IS PROVIDED BY APPROX...4.3 G OF POTASSIUM CITRATE.

    American Hospital Formulary Service. Volumes I and II. Washington, DC: American Society of Hospital Pharmacists, to 1984., p. 40:12

    A SYSTEMIC & URINARY ALKALIZER & FOR THE EFFECTS OF THE POTASSIUM ION. IT HAS ALSO BEEN USED AS AN EXPECTORANT & A DIURETIC. DOSE- USUAL, 1 G. ...USED IN DOSE OF 1-2 G EVERY FEW HR, DILUTED WITH AT LEAST 1/2 GLASSFUL OF WATER OR FRUIT JUICE.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 801

    COMPOSITION CONTAINS POTASSIUM CITRATE.

    GAGIU F; PREPN FOR TREATMENT OF URIC LITHIASIS; ROMANIAN PATENT NUMBER 57645 09/12/74

    MEDICATION (VET): DIURETIC AGENT

    The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 990

    4.3 Drug Indication

    For the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Potassium citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.g. calcium oxalate, calcium phosphate and uric acid. Increased citrate levels in the urine will make complexation with calcium which decrease the calcium ion activity and decrease the chance for the formation of calcium phosphate crystals. Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate.

    5.2 MeSH Pharmacological Classification

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    Expectorants

    Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here. (See all compounds classified as Expectorants.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    POTASSIUM CITRATE ANHYDROUS
    5.3.2 FDA UNII
    86R1NVR0HW
    5.3.3 Pharmacological Classes
    Anti-coagulant [EPC]; Calcium Chelating Activity [MoA]; Calculi Dissolution Agent [EPC]; Decreased Coagulation Factor Activity [PE]; Acidifying Activity [MoA]
    5.4 ATC Code

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12B - Potassium

    A12BA - Potassium

    A12BA02 - Potassium citrate

    5.5 Absorption, Distribution and Excretion

    Route of Elimination

    Urinary; less than 5% unchanged.

    5.6 Metabolism/Metabolites

    Potassium Citrate is absorbed and the citrate is metabolised to bicarbonate.

    5.7 Mechanism of Action

    After oral administration of potassium citrate, its metabolism yields alkaline load. Potassium Citrate therapy appears to increase urinary citrate mainly by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. In addition to raising urinary pH and citrate, Potassium Citrate increases urinary potassium by approximately the amount contained in the medication. In some patients, Potassium Citrate causes a transient reduction in urinary calcium.

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    05-Jan-2021
    17-Sep-2024
    KGS
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    Average Price (USD/KGS)

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 5MEQ

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