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Acecainida

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ANALYTICAL

1 Analytical Methods

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1 Analytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

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NDC API

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API REF. PRICE (USD/KG)

$ 0

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Chemistry

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Also known as: N-acetylprocainamide, 32795-44-1, Napa, Acekainid, Acecainida, Acecainidum

Molecular Formula

C₁₅H₂₃N₃O₂

Molecular Weight

277.36 g/mol

InChI Key

KEECCEWTUVWFCV-UHFFFAOYSA-N

FDA UNII

910Q707V6F

A major metabolite of PROCAINAMIDE. Its anti-arrhythmic action may cause cardiac toxicity in kidney failure.

1 2D Structure

Acecainida

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-acetamido-N-[2-(diethylamino)ethyl]benzamide

2.1.2 InChI

InChI=1S/C15H23N3O2/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19)

2.1.3 InChI Key

KEECCEWTUVWFCV-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCN(CC)CCNC(=O)C1=CC=C(C=C1)NC(=O)C

2.2 Other Identifiers

2.2.1 UNII

910Q707V6F

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Acecainide Hydrochloride

2. Acecainide Monohydrochloride

3. Acetylprocainamide

4. Hydrochloride, Acecainide

5. Monohydrochloride, Acecainide

6. N Acetylprocainamide

7. N-acetylprocainamide

2.3.2 Depositor-Supplied Synonyms

1. N-acetylprocainamide

2. 32795-44-1

3. Napa

4. Acekainid

5. Acecainida

6. Acecainidum

7. N-acetyloprokainamid

8. Acetylprocainamide

9. Acecainide [inn]

10. 4'-((2-(diethylamino)ethyl)carbamoyl)acetanilide

11. N-acetylprocaine Amide

12. 4-acetamido-n-[2-(diethylamino)ethyl]benzamide

13. Acecainide;napa

14. Benzamide, 4-(acetylamino)-n-(2-(diethylamino)ethyl)-

15. N-acetylnovocainamide

16. N-acetyl-procainamide

17. Chebi:60728

18. Acetylprocainamide, N-

19. N-[2-(diethylamino)ethyl]-4-acetamidobenzamide

20. Chembl1097

21. Mls000069490

22. 910q707v6f

23. Acetanilide, 4'-((2-(diethylamino)ethyl)carbamoyl)-

24. Smr000059070

25. Acekainid [polish]

26. Acecainidum [inn-latin]

27. Acecainida [inn-spanish]

28. N-acetyloprokainamid [polish]

29. 4-acetamido-n-(2-(diethylamino)ethyl)benzamide

30. Brn 2868559

31. Unii-910q707v6f

32. Procainamide-n-acetyl

33. N-acetyl Procainamide

34. Acecainide [mi]

35. Opera_id_1541

36. Spectrum3_001843

37. Lopac-a-5909

38. Epitope Id:140121

39. Acecainide [who-dd]

40. Lopac0_000009

41. Bspbio_003226

42. Mls001146871

43. Schembl156943

44. N-acetylprocainamide, >=99%

45. Dtxsid6048414

46. Kbio3_002726

47. Hms2232g18

48. Hms3372e09

49. Bcp26213

50. Hy-b1109

51. Zinc1999404

52. Bdbm50151860

53. Akos016614968

54. N-acetyl Procainamide(<30%)

55. Ccg-204105

56. Cs-4707

57. Sdccgsbi-0049998.p003

58. Ncgc00015072-01

59. Ncgc00015072-02

60. Ncgc00015072-03

61. Ncgc00015072-04

62. Ncgc00015072-05

63. Ncgc00015072-06

64. Ncgc00015072-07

65. Ncgc00015072-13

66. Ncgc00023226-03

67. Ncgc00023226-04

68. As-57414

69. Sbi-0049998.p002

70. Db-048268

71. N-acetylprocainamide 1.0 Mg/ml In Methanol

72. Ft-0639052

73. Ab00384286_20

74. 4-acetylamino-n-(2-diethylamino-ethyl)-benzamide

75. A905428

76. J-018880

77. Q4726688

78. 4-(acetylamino)-n-[2-(diethylamino)ethyl]benzamide #

79. Brd-k07753030-003-01-0

80. Brd-k07753030-003-11-9

81. Z26393212

82. N-(4-{[2-(diethylamino)ethyl]carbamoyl}phenyl)ethanimidic Acid

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₃N₃O₂
Molecular Weight	277.36 g/mol
XLogP3	0.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	7
Exact Mass	277.17902698 g/mol
Monoisotopic Mass	277.17902698 g/mol
Topological Polar Surface Area	61.4 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	308
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

4.2 Metabolism/Metabolites

Acecainide is a known human metabolite of Procainamide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

ANALYTICAL

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Analytical Methods

ABOUT THIS PAGE

Acecainida Manufacturers

A Acecainida manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acecainida, including repackagers and relabelers. The FDA regulates Acecainida manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acecainida API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Acecainida Suppliers

A Acecainida supplier is an individual or a company that provides Acecainida active pharmaceutical ingredient (API) or Acecainida finished formulations upon request. The Acecainida suppliers may include Acecainida API manufacturers, exporters, distributors and traders.

Acecainida GMP

Acecainida Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Acecainida GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Acecainida GMP manufacturer or Acecainida GMP API supplier for your needs.

Acecainida CoA

A Acecainida CoA (Certificate of Analysis) is a formal document that attests to Acecainida's compliance with Acecainida specifications and serves as a tool for batch-level quality control.

Acecainida CoA mostly includes findings from lab analyses of a specific batch. For each Acecainida CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Acecainida may be tested according to a variety of international standards, such as European Pharmacopoeia (Acecainida EP), Acecainida JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acecainida USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.