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    Chemistry

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    Also known as: Paracetamol, 4-acetamidophenol, 103-90-2, Tylenol, N-(4-hydroxyphenyl)acetamide, Apap
    Molecular Formula
    C8H9NO2
    Molecular Weight
    151.16  g/mol
    InChI Key
    RZVAJINKPMORJF-UHFFFAOYSA-N
    FDA UNII
    362O9ITL9D
    Paracetamol
    Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
    1 2D Structure

    Paracetamol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-(4-hydroxyphenyl)acetamide
    2.1.2 InChI
    InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
    2.1.3 InChI Key
    RZVAJINKPMORJF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(=O)NC1=CC=C(C=C1)O
    2.2 Other Identifiers
    2.2.1 UNII
    362O9ITL9D
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acamol

    2. Acephen

    3. Acetaco

    4. Acetamidophenol

    5. Acetominophen

    6. Algotropyl

    7. Anacin 3

    8. Anacin-3

    9. Anacin3

    10. Apap

    11. Datril

    12. Hydroxyacetanilide

    13. N-(4-hydroxyphenyl)acetanilide

    14. N-acetyl-p-aminophenol

    15. P-acetamidophenol

    16. P-hydroxyacetanilide

    17. Panadol

    18. Paracetamol

    19. Tylenol

    2.3.2 Depositor-Supplied Synonyms

    1. Paracetamol

    2. 4-acetamidophenol

    3. 103-90-2

    4. Tylenol

    5. N-(4-hydroxyphenyl)acetamide

    6. Apap

    7. Panadol

    8. N-acetyl-p-aminophenol

    9. 4'-hydroxyacetanilide

    10. Acetaminofen

    11. Datril

    12. P-hydroxyacetanilide

    13. P-acetamidophenol

    14. Algotropyl

    15. Lonarid

    16. Naprinol

    17. Doliprane

    18. Injectapap

    19. Acamol

    20. Acenol

    21. Anelix

    22. Multin

    23. P-acetaminophenol

    24. Abensanil

    25. Acetagesic

    26. Acetalgin

    27. Biocetamol

    28. Clixodyne

    29. Gelocatil

    30. Liquagesic

    31. Pyrinazine

    32. Servigesic

    33. Acephen

    34. Alvedon

    35. Anaflon

    36. Apamide

    37. Dymadon

    38. Febridol

    39. Febrilix

    40. Febrolin

    41. Finimal

    42. Homoolan

    43. Lestemp

    44. Paracet

    45. Tabalgin

    46. Tralgon

    47. Tussapap

    48. Valadol

    49. Valgesic

    50. Vermidon

    51. Alpiny

    52. Amadil

    53. Anhiba

    54. Calpol

    55. Dirox

    56. Eneril

    57. Fendon

    58. Hedex

    59. Lyteca

    60. Neopap

    61. Pacemo

    62. Panets

    63. Parmol

    64. Tapar

    65. Tempra

    66. Acetamide, N-(4-hydroxyphenyl)-

    67. Paracetamolo

    68. Dafalgan

    69. Dolprone

    70. Momentum

    71. Ortensan

    72. Paldesic

    73. Banesin

    74. Captin

    75. Disprol

    76. Enelfa

    77. Salzone

    78. Exdol

    79. P-acetylaminophenol

    80. Febro-gesic

    81. Nebs

    82. Paracetamolum

    83. Dolgesic

    84. Elixodyne

    85. Febrectal

    86. Phenaphen

    87. Tempanal

    88. Abenol

    89. Apacet

    90. Apadon

    91. Cetadol

    92. Fensum

    93. Janupap

    94. Minoset

    95. Napafen

    96. Neodol

    97. Nobedon

    98. Pacemol

    99. Panodil

    100. Parapan

    101. Pedric

    102. Phendon

    103. Rounox

    104. Suppap

    105. Korum

    106. Pinex

    107. Temlo

    108. 4-(acetylamino)phenol

    109. Ben-u-ron

    110. Dial-a-gesic

    111. Anacin-3

    112. Calmanticold

    113. Codoliprane

    114. Demogripal

    115. Dolegrippin

    116. Doloreduct

    117. Dristancito

    118. Duracetamol

    119. Eu-med

    120. Grippostad

    121. Gynospasmine

    122. Medocodene

    123. Paedialgon

    124. Paracetanol

    125. Parakapton

    126. Pediapirin

    127. Phenipirin

    128. Phogoglandin

    129. Predualito

    130. Sanicopyrine

    131. Scentalgyl

    132. Sunetheton

    133. Tachiprina

    134. Termalgine

    135. Treuphadol

    136. Abrolet

    137. Acertol

    138. Acetamol

    139. Acetofen

    140. Afebrin

    141. Afebryl

    142. Aferadol

    143. Algesidal

    144. Algomol

    145. Alpinyl

    146. Analter

    147. Antidol

    148. Apitrelal

    149. Atralidon

    150. Babikan

    151. Bacetamol

    152. Cadafen

    153. Calapol

    154. Causalon

    155. Cefalex

    156. Codabrol

    157. Codalgin

    158. Codapane

    159. Codicet

    160. Codisal

    161. Cofamol

    162. Cosutone

    163. Cuponol

    164. Curadon

    165. Custodial

    166. Darocet

    167. Daygrip

    168. Deminofen

    169. Democyl

    170. Desfebre

    171. Dimindol

    172. Dolefin

    173. Dolofugin

    174. Dolorfug

    175. Dolorstop

    176. Dolotec

    177. Dorocoff

    178. Dularin

    179. Durapan

    180. Ecosetol

    181. Excipain

    182. Fanalgic

    183. Farmadol

    184. Febranine

    185. Febrectol

    186. Febricet

    187. Febrinol

    188. Fepanil

    189. Finiweh

    190. Fluparmol

    191. Geluprane

    192. Ildamol

    193. Inalgex

    194. Infadrops

    195. Kataprin

    196. Labamol

    197. Lekadol

    198. Lemgrip

    199. Lupocet

    200. Magnidol

    201. Malidens

    202. Maxadol

    203. Mexalen

    204. Minafen

    205. Miralgin

    206. Nealgyl

    207. Neodolito

    208. Neotrend

    209. Neuridon

    210. Nodolex

    211. Ofirmev

    212. Oralgan

    213. Oxycocet

    214. Pacimol

    215. Panacete

    216. Panadeine

    217. Panadiene

    218. Panaleve

    219. Panamax

    220. Panasorbe

    221. Panofen

    222. Pantalgin

    223. Paracemol

    224. Paracenol

    225. Paracetol

    226. Paracin

    227. Paracod

    228. Paracodol

    229. Parador

    230. Paradrops

    231. Paralen

    232. Paralief

    233. Paralink

    234. Paralyoc

    235. Paramol

    236. Paramolan

    237. Paranox

    238. Parasedol

    239. Parasin

    240. Paraspen

    241. Parcetol

    242. Parogal

    243. Pediatrix

    244. Perfalgan

    245. Piramin

    246. Pirinasol

    247. Polmofen

    248. Predimol

    249. Prontina

    250. Puernol

    251. Pulmofen

    252. Pyrigesic

    253. Pyromed

    254. Remedol

    255. Rivalgyl

    256. Rubophen

    257. Rupemol

    258. Sanicet

    259. Schmerzex

    260. Sedalito

    261. Semolacin

    262. Seskamol

    263. Setakop

    264. Setamol

    265. Sifenol

    266. Sinaspril

    267. Sinedol

    268. Stanback

    269. Stopain

    270. Supofen

    271. Tazamol

    272. Termacet

    273. Termalgin

    274. Termofren

    275. Titralgan

    276. Tricoton

    277. Upsanol

    278. Utragin

    279. Veralgina

    280. Viruflu

    281. Vivimed

    282. Zatinol

    283. Abrol

    284. Algina

    285. Anapap

    286. Andox

    287. Asetam

    288. Asomal

    289. Aspac

    290. Asplin

    291. Benmyo

    292. Curpol

    293. Dhamol

    294. Dolcor

    295. Dolko

    296. Dresan

    297. Dypap

    298. Febrex

    299. Febrin

    300. Lemsip

    301. Malgis

    302. Oltyl

    303. Paceco

    304. Pacet

    305. Paedol

    306. Painex

    307. Pamol

    308. Panex

    309. Parake

    310. Paroma

    311. Plicet

    312. Prodol

    313. Reliv

    314. Scanol

    315. Setol

    316. Sinmol

    317. Tiffy

    318. Tylex

    319. Tylol

    320. Tymol

    321. Verpol

    322. Volpan

    323. Zolben

    324. Neocitran

    325. Nilnocen

    326. Nina

    327. Rubiemol

    328. Vips

    329. Supadol Mono

    330. Treupel Mon

    331. Bickie-mol

    332. Fortalidon P

    333. Gattaphen T

    334. Gripin Bebe

    335. Influbene N

    336. Lonarid Mono

    337. Lyteca Syrup

    338. Panadeine Co

    339. Dymadon Co

    340. Toximer P

    341. Treupel N

    342. Accu-tap

    343. 4-acetaminophenol

    344. Helon N

    345. Malex N

    346. Spalt N

    347. Tylex Cd

    348. N-acetyl-4-aminophenol

    349. Sk-apap

    350. Paracetamole

    351. Conacetol

    352. Darvocet

    353. Empracet

    354. Panasorb

    355. A-per

    356. Apamid

    357. Parelan

    358. Prompt

    359. Vicodin

    360. Fevor

    361. Freka-cetamol

    362. Codisal Forte

    363. Croix Blanche

    364. Dolorol Forte

    365. Dymadon Forte

    366. Junior Disprol

    367. Kinder Finimal

    368. Liquigesic Co

    369. Mono Praecimed

    370. Percocet-demi

    371. Perdolan Mono

    372. Rockamol Plus

    373. Viclor Richet

    374. Actifed Plus

    375. Kratofin Simplex

    376. Neo-fepramol

    377. Paracetamol Al

    378. Paracetamol Bc

    379. Paracetamol Pb

    380. Acetanilide, 4'-hydroxy-

    381. Claradol Codeine

    382. Geralgine-p

    383. Melabon Infantil

    384. Migraleve Yellow

    385. Paracetamol Saar

    386. Pyregesic-c

    387. Anti-algos

    388. Para-suppo

    389. Pasolind N

    390. Supramol-m

    391. No-febril

    392. Panado-co

    393. Para-tabs

    394. Paracetamol Hexal

    395. Paracetamol Raffo

    396. Paracetamol Rosch

    397. Paracetamol Stada

    398. Dol-stop

    399. Anadin Dla Dzieci

    400. P-hydroxyphenolacetamide

    401. Percocet-5

    402. Cod-acamol Forte

    403. Contra-schmerz P

    404. Hy-phen

    405. Medinol Paediatric

    406. Paracetamol Basics

    407. Panado-co Caplets

    408. Paracetamol Von Ct

    409. Pe-tam

    410. Paracetamol Fecofar

    411. Paracetamol Harkley

    412. Paracetamol Heumann

    413. Paracetamol Nycomed

    414. Codral Pain Relief

    415. Paracetamol Hanseler

    416. Paracetamol Winthrop

    417. 4-hydroxyacetanilide

    418. Phenaphen W/codeine

    419. Spalt Fur Die Nacht

    420. A.f. Anacin

    421. Capital With Codeine

    422. Paracetamol Genericon

    423. Anexsia

    424. Demilets

    425. Efferalgan

    426. Endecon

    427. Intensin

    428. Naldegesic

    429. Propacet

    430. Resfenol

    431. Theraflu

    432. Wygesic

    433. Paracetamol Ratiopharm

    434. Coricidin Sinus

    435. Paracetamol Italfarmaco

    436. Sudafed Sinus

    437. Coricidin D

    438. Paracetamol Dc

    439. Quiet World

    440. Paracetamol Antipanin P

    441. St Joseph Aspirin-free

    442. New Cortal For Children

    443. Infants' Feverall

    444. St. Joseph Fever Reducer

    445. Midol Teen Formula

    446. Paracetamol Dr. Schmidgall

    447. Acetamide, N-(p-hydroxyphenyl)-

    448. P-hydroxy-acetanilid

    449. Aspirin-free Anacin

    450. Children's Tylenol Chewable

    451. Nci-c55801

    452. Pcm Paracetamol Lichtenstein

    453. Tylenol Allergy Sinus

    454. P-(acetylamino)phenol

    455. Rhinex D-lay Tablets

    456. Acetaminophene

    457. Midol Regular Strength

    458. Paracetamol Smithkline Beecham

    459. Scherzatabletten Rezeptur 534

    460. Percogesic With Codeine

    461. 4-hydroxyanilid Kyseliny Octove

    462. Bayer Select Head Cold

    463. Bayer Select Allergy-sinus

    464. Bayer Select Headache Pain

    465. Dristan Cold No Drowsiness

    466. Prestwick_13

    467. St Joseph Aspirin-free For Children

    468. 4-acetylaminophenol

    469. Children's Acetaminophen Elixir Drops

    470. Mfcd00002328

    471. Children's Acetaminophen Oral Solution

    472. Midol Pm Night Time Formula

    473. Triaminic Sore Throat Formula

    474. N-(4-hydroxyphenyl)ethanamide

    475. Bayer Select Sinus Pain Relief

    476. Phenol, P-acetamido-

    477. Sine-off Sinus Medicine Caplets

    478. Chebi:46195

    479. Roxicet 5/500

    480. Tocris-1706

    481. Nsc-3991

    482. N-acetyl-para-aminophenol

    483. 4-(n-acetylamino)phenol

    484. Acetaminophen (4-hydroxyacetanilide)

    485. Bayer Select Menstrual Multi-symptom

    486. Acetaco

    487. N-acetyl-4-hydroxyaniline

    488. St. Joseph Cold Tablets For Children

    489. Chembl112

    490. Nsc-109028

    491. N-(4-hydroxyphenyl)acetamide (tylenol)

    492. N-(4-hydroxyphenyl)-acetamide

    493. 362o9itl9d

    494. Aminofen

    495. Dtxsid2020006

    496. Atasol

    497. Duaneo

    498. Duorol

    499. Component Of Dialog

    500. Component Of Dilone

    501. Fever All

    502. Paracetamol (inn)

    503. Component Of Endecon

    504. Component Of Percocet

    505. Component Of Phenaphen

    506. Tyl

    507. Component Of Percogesic

    508. Dsstox_cid_6

    509. Ncgc00016361-07

    510. Acetominophen

    511. Actamin

    512. Cas-103-90-2

    513. Pasolind

    514. Redutemp

    515. Robigesic

    516. Valorin

    517. Aceta Elixir

    518. Paracetamol [inn]

    519. Dafalgan Codeine

    520. Jin Gang

    521. Wln: Qr Dmv1

    522. Dsstox_rid_75318

    523. Dsstox_gsid_20006

    524. Component Of Hycomine Compound

    525. Acetavance

    526. Paracetamolo [italian]

    527. Calonal

    528. Flexsure

    529. Acenol (pharmaceutical)

    530. N-(4-hydroxyphenyl)acetanilide

    531. Drixoral Sinus

    532. Aceta Tablets

    533. Paracetamol [inn:ban]

    534. Valorin Extra

    535. Ccris 3

    536. Snaplets-fr

    537. Oraphen-pd

    538. Phenaphen Caplets

    539. Paracetamolum [inn-latin]

    540. Tylenol (caplet)

    541. Tylenol (geltab)

    542. Tylenol 8-hour

    543. Smr000112065

    544. Tavist Allergy/sinus/headache

    545. Dapa X-s

    546. Drixoral Cold & Flu

    547. Hsdb 3001

    548. Sr-01000597517

    549. Einecs 203-157-5

    550. 222 Af

    551. Acetaminophen [usp:jan]

    552. Paracetamol (acetaminophen)

    553. Nsc 109028

    554. Acetominophene

    555. Unii-362o9itl9d

    556. 4-hydroxyanilid Kyseliny Octove [czech]

    557. Children's Acetaminophen Elixir Solution

    558. Claratal

    559. Daphalgan

    560. Resprin

    561. Apacet Capsules

    562. Atasol Caplets

    563. Atasol Tablets

    564. Tempra Caplets

    565. Tylenol Caplets

    566. Tylenol Elixir

    567. Tylenol Gelcaps

    568. Tylenol Tablets

    569. Actamin Extra

    570. Actamin Super

    571. Aminofen Max

    572. Anexsia 10/660

    573. Apacet Elixir

    574. Atasol Drops

    575. Exdol Strong

    576. P-acetoaminophen

    577. Tempra Drops

    578. Tempra Syrup

    579. Tylenol Drops

    580. Alpha-per

    581. Citramon P

    582. Excedrin Caplets

    583. Dial-alpha-gesic

    584. Apo-acetaminophen

    585. 4-acetominophenol

    586. Genebs X-tra

    587. Paracetamol;tylenol

    588. 4-acetamido Phenol

    589. 4-acetamido-phenol

    590. Tempra D.s

    591. Apap, Paracetamol

    592. P-hydroxyacetoanilide

    593. Tylenol (tn)

    594. Supac (salt/mix)

    595. Tylox (salt/mix)

    596. Zydone (salt/mix)

    597. Atasol Forte Caplets

    598. Atasol Forte Tablets

    599. Atasol Oral Solution

    600. Para-acetylaminophenol

    601. Anexsia (salt/mix)

    602. Endecon (salt/mix)

    603. Sinubid (salt/mix)

    604. Talacen (salt/mix)

    605. Vicodin (salt/mix)

    606. Wygesic (salt/mix)

    607. Acetaminophen Uniserts

    608. Datril Extra-strength

    609. Tylenol Infants Drops

    610. Demilets (salt/mix)

    611. Empracet (salt/mix)

    612. Intensin (salt/mix)

    613. Propacet (salt/mix)

    614. Suppap-120

    615. Suppap-325

    616. Suppap-650

    617. Panadol Extra Strength

    618. Theraflu (salt/mix)

    619. Coricidin (salt/mix)

    620. Liquiprin (salt/mix)

    621. Hy-phen (salt/mix)

    622. Iv-apap

    623. Phenol Derivative, 11

    624. Spectrum_000016

    625. Tempra Chewable Tablets

    626. Naldegesic (salt/mix)

    627. Actimol Chewable Tablets

    628. Feverall Junior Strength

    629. Darvocet-n (salt/mix)

    630. Anacin-3 Extra Strength

    631. Liquiprin Infants" Drops

    632. N-acetyl Para Aminophenol

    633. Prestwick0_000868

    634. Prestwick1_000868

    635. Prestwick2_000868

    636. Prestwick3_000868

    637. Spectrum2_000085

    638. Spectrum3_000283

    639. Spectrum4_000140

    640. Spectrum5_000736

    641. Coricidin D (salt/mix)

    642. Quiet World (salt/mix)

    643. Genapap Children's Elixir

    644. Tylenol Children's Elixir

    645. 4-acetamidophenol, 98%

    646. Actifed Plus (salt/mix)

    647. Acetaminophen [mi]

    648. Paracetamol [iarc]

    649. Epitope Id:117710

    650. Genapap Children's Tablets

    651. Sudafed Sinus (salt/mix)

    652. Acetaminophen [jan]

    653. Ec 203-157-5

    654. Actimol Infants' Suspension

    655. Drixoral Sinus (salt/mix)

    656. Liquiprin Children's Elixir

    657. Schembl3480

    658. Acetaminophen (jp17/usp)

    659. Acetaminophen [hsdb]

    660. Acetaminophen [inci]

    661. Coricidin Sinus (salt/mix)

    662. N-(4-hydroxyfenyl)ethanamid

    663. Paracetamol [mart.]

    664. Acetaminophen [vandf]

    665. Bspbio_000915

    666. Bspbio_001786

    667. Dds-06a

    668. Kbiogr_000560

    669. Kbioss_000356

    670. Paracetamol [who-dd]

    671. Paracetamol [who-ip]

    672. 4-13-00-01091 (beilstein Handbook Reference)

    673. Actimol Children's Suspension

    674. Apacet Extra Strength Caplets

    675. Apacet Extra Strength Tablets

    676. Aspirin-free Excedrin Caplets

    677. Genebs Extra Strength Caplets

    678. Mls001146925

    679. Mls001331684

    680. Mls002154041

    681. Bidd:gt0005

    682. Divk1c_000660

    683. Spectrum1500101

    684. Genapap Extra Strength Caplets

    685. Genapap Extra Strength Tablets

    686. Spbio_000010

    687. Spbio_002836

    688. Tapanol Extra Strength Caplets

    689. Tapanol Extra Strength Tablets

    690. Tylenol Extra Strength Caplets

    691. Tylenol Extra Strength Gelcaps

    692. Tylenol Extra Strength Tablets

    693. Acetaminophen [usp-rs]

    694. Actimol Junior Strength Caplets

    695. Apacet Regular Strength Tablets

    696. Bpbio1_001007

    697. Excedrin Extra Strength Caplets

    698. Genebs Regular Strength Tablets

    699. Gtpl5239

    700. Panadol Junior Strength Caplets

    701. Sgcut00014

    702. Tylenol Junior Strength Caplets

    703. Midol Teen Formula (salt/mix)

    704. Genapap Regular Strength Tablets

    705. Panadol Maximum Strength Caplets

    706. Panadol Maximum Strength Tablets

    707. Schembl19474893

    708. Tylenol Regular Strength Caplets

    709. Tylenol Regular Strength Tablets

    710. Aspirin-free Anacin (salt/mix)

    711. Bdbm26197

    712. Hms502a22

    713. Kbio1_000660

    714. Kbio2_000356

    715. Kbio2_002924

    716. Kbio2_005492

    717. Kbio3_001286

    718. Nsc3991

    719. Tylenol Arthritis Extended Relief

    720. Acetaminophen, Analytical Standard

    721. Ninds_000660

    722. Tylenol Infants" Suspension Drops

    723. Bcpp000441

    724. Drixoral Cold & Flu (salt/mix)

    725. Hms1570n17

    726. Hms1920a03

    727. Hms2091g03

    728. Hms2097n17

    729. Hms2269g20

    730. Hms3268a10

    731. Hms3412d16

    732. Hms3676d16

    733. Hms3714n17

    734. Paracetamol [ep Monograph]

    735. Pharmakon1600-01500101

    736. Tylenol Allergy Sinus (salt/mix)

    737. Acetaminophen [orange Book]

    738. Midol Regular Strength (salt/mix)

    739. Act06727

    740. Allay Component Acetaminophen

    741. Amy39958

    742. Bcp23431

    743. Bucet Component Acetaminophen

    744. Esgic Component Acetaminophen

    745. Norco Component Acetaminophen

    746. Nsc 3991

    747. Str00901

    748. To_000023

    749. Triad Component Acetaminophen

    750. Tylenol Children's Chewable Tablets

    751. Tylox Component Acetaminophen

    752. Acetaminophen [usp Impurity]

    753. Acetaminophen, Bioxtra, >=99.0%

    754. Bayer Select Head Cold (salt/mix)

    755. Robitussin Night Relief (salt/mix)

    756. Tox21_110397

    757. Tox21_201930

    758. Tox21_300100

    759. Ac8790

    760. Acetaminophen [usp Monograph]

    761. Bancap Component Acetaminophen

    762. Bbl005229

    763. Ccg-38901

    764. Codrix Component Acetaminophen

    765. Femcet Component Acetaminophen

    766. Lortab Component Acetaminophen

    767. Norcet Component Acetaminophen

    768. Nsc109028

    769. Nsc755853

    770. Oxycet Component Acetaminophen

    771. Paracetamolum [who-ip Latin]

    772. Stl140694

    773. Tencon Component Acetaminophen

    774. Trezix Component Acetaminophen

    775. Tylenol Children's Suspension Liquid

    776. Zinc13550868

    777. Zydone Component Acetaminophen

    778. Anexsia Component Acetaminophen

    779. Anoquan Component Acetaminophen

    780. Butapap Component Acetaminophen

    781. Roxicet Component Acetaminophen

    782. Roxilox Component Acetaminophen

    783. Sedapap Component Acetaminophen

    784. Talacen Component Acetaminophen

    785. Tycolet Component Acetaminophen

    786. Vicodin Component Acetaminophen

    787. Wygesic Component Acetaminophen

    788. Akos000121004

    789. Darvocet Component Acetaminophen

    790. Excedrin Component Acetaminophen

    791. Feverall Sprinkle Caps Junior Strength

    792. Fioricet Component Acetaminophen

    793. Hy-phen Component Acetaminophen

    794. Ornex Severe Cold Formula (salt/mix)

    795. Percocet Component Acetaminophen

    796. Tox21_110397_1

    797. Triaprin Component Acetaminophen

    798. Ultracet Component Acetaminophen

    799. Xartemis Component Acetaminophen

    800. Acetaminophen Component Of Allay

    801. Acetaminophen Component Of Bucet

    802. Acetaminophen Component Of Esgic

    803. Acetaminophen Component Of Norco

    804. Acetaminophen Component Of Triad

    805. Acetaminophen Component Of Tylox

    806. Bayer Select Allergy-sinus (salt/mix)

    807. Bcp9000225

    808. Co-gesic Component Acetaminophen

    809. Db00316

    810. Dhc Plus Component Acetaminophen

    811. Nsc-755853

    812. Paracetamol 100 Microg/ml In Methanol

    813. Acetaminophen Component Of Bancap

    814. Acetaminophen Component Of Codrix

    815. Acetaminophen Component Of Femcet

    816. Acetaminophen Component Of Lortab

    817. Acetaminophen Component Of Norcet

    818. Acetaminophen Component Of Oxycet

    819. Acetaminophen Component Of Tencon

    820. Acetaminophen Component Of Zydone

    821. Bancap Hc Component Acetaminophen

    822. Idi1_000660

    823. Lorcet-hd Component Acetaminophen

    824. Phrenilin Component Acetaminophen

    825. Sine-aid, Maximum Strength (salt/mix)

    826. Sudafed Severe Cold Formula (salt/mix)

    827. Acetaminophen Component Of Anexsia

    828. Acetaminophen Component Of Anoquan

    829. Acetaminophen Component Of Butapap

    830. Acetaminophen Component Of Roxicet

    831. Acetaminophen Component Of Roxilox

    832. Acetaminophen Component Of Sedapap

    833. Acetaminophen Component Of Talacen

    834. Acetaminophen Component Of Tycolet

    835. Acetaminophen Component Of Vicodin

    836. Acetaminophen Component Of Wygesic

    837. Ncgc00016361-01

    838. Ncgc00016361-02

    839. Ncgc00016361-03

    840. Ncgc00016361-04

    841. Ncgc00016361-05

    842. Ncgc00016361-06

    843. Ncgc00016361-08

    844. Ncgc00016361-09

    845. Ncgc00016361-10

    846. Ncgc00016361-12

    847. Ncgc00016361-13

    848. Ncgc00016361-20

    849. Ncgc00025267-01

    850. Ncgc00025267-02

    851. Ncgc00025267-03

    852. Ncgc00025267-04

    853. Ncgc00025267-05

    854. Ncgc00253912-01

    855. Ncgc00259479-01

    856. Tylenol Junior Strength Chewable Tablets

    857. Ac-23969

    858. Acetaminophen Component Of Darvocet

    859. Acetaminophen Component Of Excedrin

    860. Acetaminophen Component Of Fioricet

    861. Acetaminophen Component Of Hy-phen

    862. Acetaminophen Component Of Percocet

    863. Acetaminophen Component Of Triaprin

    864. Acetaminophen Component Of Ultracet

    865. Acetaminophen Component Of Xartemis

    866. Hy-66005

    867. Midol Pm Night Time Formula (salt/mix)

    868. Sy001162

    869. Triaminic Sore Throat Formula (salt/mix)

    870. Acetaminophen Component Of Co-gesic

    871. Acetaminophen Component Of Dhc Plus

    872. Acetaminophen Component Of Phrenilin

    873. Bcp0726000305

    874. Duradyne Dhc Component Acetaminophen

    875. Sbi-0051269.p003

    876. Acetaminophen Component Of Bancap Hc

    877. Acetaminophen Component Of Lorcet-hd

    878. Bayer Select Sinus Pain Relief (salt/mix)

    879. Drixoral Plus Component Acetaminophen

    880. Ab00051905

    881. Aspirin Free Anacin Maximum Strength Caplets

    882. Aspirin Free Anacin Maximum Strength Tablets

    883. Dolene Ap-65 Component Acetaminophen

    884. Ft-0658035

    885. Ft-0661041

    886. Ft-0661042

    887. H0190

    888. Medigesic Plus Component Acetaminophen

    889. Sine-off Sinus Medicine Caplets (salt/mix)

    890. Synalgos-dc-a Component Acetaminophen

    891. Acetaminophen Component Of Duradyne Dhc

    892. N-(4-hydroxyphenyl)-acetamide-[13c2,15n]

    893. Acetaminophen Component Of Dolene Ap-65

    894. Acetaminophen Component Of Drixoral Plus

    895. Acetaminophen Component Of Synalgos-dc-a

    896. C06804

    897. D00217

    898. Q57055

    899. Ab00051905-09

    900. Ab00051905_10

    901. Acetaminophen Component Of Medigesic Plus

    902. Aspirin Free Anacin Maximum Strength Gel Caplets

    903. Bayer Select Menstrual Multi-symptom (salt/mix)

    904. Contac Cough & Sore Throat Formula (salt/mix)

    905. L024125

    906. St. Joseph Cold Tablets For Children (salt/mix)

    907. Tylenol Extra Strength Adult Liquid Pain Reliever

    908. J-001064

    909. J-514275

    910. Paracetamol (acetaminophen) 1.0 Mg/ml In Methanol

    911. Sr-01000597517-1

    912. Sr-01000597517-2

    913. Sr-01000597517-4

    914. Acetaminophenol 4-acetamino Phenol Paracetamol Somedon

    915. Brd-k41524689-001-08-6

    916. F3096-1731

    917. F48b493f-b1fd-410c-aa0a-f40ec71a0689

    918. Bayer Select Maximum Strength Headache Pain Relief Formula

    919. Paracetamol, British Pharmacopoeia (bp) Reference Standard

    920. Paracetamol, European Pharmacopoeia (ep) Reference Standard

    921. Acetaminophen Solution, Drug Standard, 1.0 Mg/ml In Methanol

    922. Acetaminophen, United States Pharmacopeia (usp) Reference Standard

    923. Acetaminophen, Meets Usp Testing Specifications, 98.0-102.0%, Powder

    924. Acetaminophen Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material

    925. Acetaminophen, Pharmaceutical Secondary Standard; Certified Reference Material

    926. Paracetamol For Equipment Qualification, Europepharmacopoeia (ep) Reference Standard

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 151.16 g/mol
    Molecular Formula C8H9NO2
    XLogP30.5
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count1
    Exact Mass151.063328530 g/mol
    Monoisotopic Mass151.063328530 g/mol
    Topological Polar Surface Area49.3 Ų
    Heavy Atom Count11
    Formal Charge0
    Complexity139
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 20  
    Drug NameAcephen
    PubMed HealthAcetaminophen
    Drug ClassesAcetaminophen Combination, Analgesic, Antipyretic
    Active IngredientAcetaminophen
    Dosage FormSuppository
    RouteRectal
    Strength650mg; 120mg; 325mg
    Market StatusOver the Counter
    CompanyG And W Labs

    2 of 20  
    Drug NameAcetaminophen
    PubMed HealthHydrocodone/Acetaminophen (By mouth)
    Drug ClassesAnalgesic, Opioid/Acetaminophen Combination
    Drug LabelAcetaminophen and codeine phosphate is supplied in tablet form for oral administration.Acetaminophen, 4'-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the
    Active IngredientAcetaminophen
    Dosage FormTablet, extended release; Suppository
    RouteRectal; Oral
    Strength650mg; 120mg; 325mg
    Market StatusOver the Counter
    CompanyOhm Labs; Perrigo; Perrigo New York; Ranbaxy Labs; Taro Pharms North

    3 of 20  
    Drug NameButapap
    PubMed HealthAcetaminophen
    Drug ClassesAcetaminophen Combination, Analgesic, Antipyretic
    Active Ingredientbutalbital; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength50mg; 325mg
    Market StatusPrescription
    CompanyMikart

    4 of 20  
    Drug NameInfants' feverall
    PubMed HealthAcetaminophen and Codeine
    Drug ClassesAnalgesic, Codeine, Opioid/Acetaminophen Combination
    Active IngredientAcetaminophen
    Dosage FormSuppository
    RouteRectal
    Strength80mg
    Market StatusOver the Counter
    CompanyTaro Pharms North

    5 of 20  
    Drug NameNeopap
    Active IngredientAcetaminophen
    Dosage FormSuppository
    RouteRectal
    Strength120mg
    Market StatusOver the Counter
    CompanyPolymedica

    6 of 20  
    Drug NameNorco
    Drug LabelAcetaminophen is a non-salicylate antipyretic and non-opioid analgesic agent. Its chemical name is N-acetyl-p-aminophenol. Acetaminophen has a molecular weight of 151.16. Its structural formula is: OFIRMEV injection is a sterile, clear, colorless, no...
    Active Ingredienthydrocodone bitartrate; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength7.5mg; 5mg; 10mg; 325mg
    Market StatusPrescription
    CompanyActavis Labs Fl; Watson Labs

    7 of 20  
    Drug NameOfirmev
    Active IngredientAcetaminophen
    Dosage FormSolution
    RouteIv (infusion)
    Strength1000mg/100ml (10mg/ml)
    Market StatusPrescription
    CompanyCadence Pharms

    8 of 20  
    Drug NameOxycet
    Active Ingredientoxycodone hydrochloride; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength5mg; 325mg
    Market StatusPrescription
    CompanyMallinckrodt

    9 of 20  
    Drug NamePercocet
    Active Ingredientoxycodone hydrochloride; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 7.5mg; 5mg; 10mg; 325mg
    Market StatusPrescription
    CompanyVintage Pharms

    10 of 20  
    Drug NameTylenol
    Active IngredientAcetaminophen
    Dosage FormTablet, extended release
    RouteOral
    Strength650mg
    Market StatusOver the Counter
    CompanyMcneil Cons

    11 of 20  
    Drug NameAcephen
    PubMed HealthAcetaminophen
    Drug ClassesAcetaminophen Combination, Analgesic, Antipyretic
    Active IngredientAcetaminophen
    Dosage FormSuppository
    RouteRectal
    Strength650mg; 120mg; 325mg
    Market StatusOver the Counter
    CompanyG And W Labs

    12 of 20  
    Drug NameAcetaminophen
    PubMed HealthHydrocodone/Acetaminophen (By mouth)
    Drug ClassesAnalgesic, Opioid/Acetaminophen Combination
    Drug LabelAcetaminophen and codeine phosphate is supplied in tablet form for oral administration.Acetaminophen, 4'-hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the
    Active IngredientAcetaminophen
    Dosage FormTablet, extended release; Suppository
    RouteRectal; Oral
    Strength650mg; 120mg; 325mg
    Market StatusOver the Counter
    CompanyOhm Labs; Perrigo; Perrigo New York; Ranbaxy Labs; Taro Pharms North

    13 of 20  
    Drug NameButapap
    PubMed HealthAcetaminophen
    Drug ClassesAcetaminophen Combination, Analgesic, Antipyretic
    Active Ingredientbutalbital; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength50mg; 325mg
    Market StatusPrescription
    CompanyMikart

    14 of 20  
    Drug NameInfants' feverall
    PubMed HealthAcetaminophen and Codeine
    Drug ClassesAnalgesic, Codeine, Opioid/Acetaminophen Combination
    Active IngredientAcetaminophen
    Dosage FormSuppository
    RouteRectal
    Strength80mg
    Market StatusOver the Counter
    CompanyTaro Pharms North

    15 of 20  
    Drug NameNeopap
    Active IngredientAcetaminophen
    Dosage FormSuppository
    RouteRectal
    Strength120mg
    Market StatusOver the Counter
    CompanyPolymedica

    16 of 20  
    Drug NameNorco
    Drug LabelAcetaminophen is a non-salicylate antipyretic and non-opioid analgesic agent. Its chemical name is N-acetyl-p-aminophenol. Acetaminophen has a molecular weight of 151.16. Its structural formula is: OFIRMEV injection is a sterile, clear, colorless, no...
    Active Ingredienthydrocodone bitartrate; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength7.5mg; 5mg; 10mg; 325mg
    Market StatusPrescription
    CompanyActavis Labs Fl; Watson Labs

    17 of 20  
    Drug NameOfirmev
    Active IngredientAcetaminophen
    Dosage FormSolution
    RouteIv (infusion)
    Strength1000mg/100ml (10mg/ml)
    Market StatusPrescription
    CompanyCadence Pharms

    18 of 20  
    Drug NameOxycet
    Active Ingredientoxycodone hydrochloride; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength5mg; 325mg
    Market StatusPrescription
    CompanyMallinckrodt

    19 of 20  
    Drug NamePercocet
    Active Ingredientoxycodone hydrochloride; Acetaminophen
    Dosage FormTablet
    RouteOral
    Strength2.5mg; 7.5mg; 5mg; 10mg; 325mg
    Market StatusPrescription
    CompanyVintage Pharms

    20 of 20  
    Drug NameTylenol
    Active IngredientAcetaminophen
    Dosage FormTablet, extended release
    RouteOral
    Strength650mg
    Market StatusOver the Counter
    CompanyMcneil Cons

    4.2 Therapeutic Uses

    Analgesics, Non-Narcotic; Antipyretics

    National Library of Medicine's Medical Subject Headings. Acetaminophen. Online file (MeSH, 2014). Available from, as of January 30, 2014: https://www.nlm.nih.gov/mesh/2014/mesh_browser/MBrowser.html

    Ofirmev (acetaminophen) injection is indicated for the management of mild to moderate pain the management of moderate to severe pain with adjunctive opioid analgesics the reduction of fever. /Included in US product label/

    US Natl Inst Health; DailyMed. Current Medication Information for OFIRMEV (acetaminophen) injection, solution (October 2013). Available from, as of March 6, 2014: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c5177abd-9465-40d8-861d-3904496d82b7

    Acetaminophen is used to provide temporary analgesia in the treatment of mild to moderate pain. Acetaminophen also is used in fixed combination with other agents (e.g., chlorpheniramine, dextromethorphan, diphenhydramine, doxylamine, guaifenesin, phenylephrine, pseudoephedrine) for short-term relief of minor aches and pain, headache, and/or other symptoms (e.g., rhinorrhea, sneezing, lacrimation, itching eyes, oronasopharyngeal itching, nasal congestion, cough) associated with seasonal allergic rhinitis (e.g., hay fever), other upper respiratory allergies, or the common cold.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2206

    Acetaminophen has been used in the treatment of pain in various combinations with aspirin, caffeine, opiates, and/or other agents. Acetaminophen ... in combination with oral doses of an opiate (e.g., codeine, oxycodone) produces greater analgesic effect than that produced by either acetaminophen or higher doses of the opiate alone.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2206

    For more Therapeutic Uses (Complete) data for ACETAMINOPHEN (11 total), please visit the HSDB record page.

    4.3 Drug Warning

    The U.S. Food and Drug Administration (FDA) is informing the public that acetaminophen has been associated with a risk of rare but serious skin reactions. These skin reactions, known as Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP), can be fatal. Acetaminophen is a common active ingredient to treat pain and reduce fever; it is included in many prescription and over-the-counter (OTC) products. Reddening of the skin, rash, blisters, and detachment of the upper surface of the skin can occur with the use of drug products that contain acetaminophen. These reactions can occur with first-time use of acetaminophen or at any time while it is being taken. ... Anyone who develops a skin rash or reaction while using acetaminophen or any other pain reliever/fever reducer should stop the drug and seek medical attention right away. Anyone who has experienced a serious skin reaction with acetaminophen should not take the drug again and should contact their health care professional to discuss alternative pain relievers/fever reducers. Health care professionals should be aware of this rare risk and consider acetaminophen, along with other drugs already known to have such an association, when assessing patients with potentially drug-induced skin reactions.

    US FDA; FDA Drug Safety Communication: FDA Warns of Rare but Serious Skin Reactions with the Pain Reliever/Fever Reducer Acetaminophen (8/1/2013). Available from, as of March 6, 2014: https://www.fda.gov/drugs/drugsafety/ucm363041.htm

    FDA is recommending health care professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 milligrams (mg) of acetaminophen1 per tablet, capsule, or other dosage unit. There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury. Further, limiting the amount of acetaminophen per dosage unit will reduce the risk of severe liver injury from inadvertent acetaminophen overdose, which can lead to liver failure, liver transplant, and death.

    US FDA; FDA Drug Safety and Availability: FDA recommends health care professionals discontinue prescribing and dispensing prescription combination drug products with more than 325 mg of acetaminophen to protect consumers (1/14/2014). Available from, as of March 9, 2014: https://www.fda.gov/Drugs/DrugSafety/ucm381644.htm

    /BOXED WARNING/ WARNING: RISK OF MEDICATION ERRORS AND HEPATOTOXICITY. Take care when prescribing, preparing, and administering Ofirmev Injection to avoid dosing errors which could result in accidental overdose and death. In particular, be careful to ensure that: the dose in milligrams (mg) and milliliters (mL) is not confused; the dosing is based on weight for patients under 50 kg; infusion pumps are properly programmed; and the total daily dose of acetaminophen from all sources does not exceed maximum daily limits. Ofirmev contains acetaminophen. Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed the maximum daily limits, and often involve more than one acetaminophen-containing product.

    US Natl Inst Health; DailyMed. Current Medication Information for OFIRMEV (acetaminophen) injection, solution (October 2013). Available from, as of March 6, 2014: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c5177abd-9465-40d8-861d-3904496d82b7

    Use caution when administering acetaminophen in patients with the following conditions: hepatic impairment or active hepatic disease, alcoholism, chronic malnutrition, severe hypovolemia (e.g., due to dehydration or blood loss), or severe renal impairment (creatinine clearance = 30 mL/min).

    US Natl Inst Health; DailyMed. Current Medication Information for OFIRMEV (acetaminophen) injection, solution (October 2013). Available from, as of March 6, 2014: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c5177abd-9465-40d8-861d-3904496d82b7

    For more Drug Warnings (Complete) data for ACETAMINOPHEN (23 total), please visit the HSDB record page.

    4.4 Minimum/Potential Fatal Human Dose

    In adults, hepatic toxicity rarely has occurred with acute overdoses of less than 10 g, although hepatotoxicity has been reported in fasting patients ingesting 4-10 g of acetaminophen. Fatalities are rare with less than 15 g.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2210

    4.5 Drug Indication

    In general, acetaminophen is used for the treatment of mild to moderate pain and reduction of fever. It is available over the counter in various forms, the most common being oral forms. Acetaminophen _injection_ is indicated for the management of mild to moderate pain, the management of moderate to severe pain with adjunctive opioid analgesics, and the reduction of fever. Because of its low risk of causing allergic reactions, this drug can be administered in patients who are intolerant to salicylates and those with allergic tendencies, including bronchial asthmatics. Specific dosing guidelines should be followed when administering acetaminophen to children.

    FDA Label

    Moderate pain and fever

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Animal and clinical studies have determined that acetaminophen has both antipyretic and analgesic effects. This drug has been shown to lack anti-inflammatory effects. As opposed to the _salicylate_ drug class, acetaminophen does not disrupt tubular secretion of uric acid and does not affect acid-base balance if taken at the recommended doses. Acetaminophen does not disrupt hemostasis and does not have inhibitory activities against platelet aggregation. Allergic reactions are rare occurrences following acetaminophen use.

    5.2 MeSH Pharmacological Classification

    Analgesics, Non-Narcotic

    A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

    Antipyretics

    Drugs that are used to reduce body temperature in fever. (See all compounds classified as Antipyretics.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]; Cyclooxygenase Inhibitors [MoA]; Decreased Platelet Aggregation [PE]; Decreased Prostaglandin Production [PE]; Histamine Receptor Antagonists [MoA]; Histamine-1 Receptor Antagonist [EPC]; Methylxanthine [EPC]; Nonsteroidal Anti-inflammatory Drug [EPC]; Platelet Aggregation Inhibitor [EPC]; Sigma-1 Agonist [EPC]; Sigma-1 Receptor Agonists [MoA]; Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC]; Uncompetitive NMDA Receptor Antagonists [MoA]; Xanthines [CS]; Anti-Inflammatory Agents, Non-Steroidal [CS]; Antihistamine [EPC]; Histamine H1 Receptor Antagonists [MoA]
    5.4 ATC Code

    N02BE01

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N02 - Analgesics

    N02B - Other analgesics and antipyretics

    N02BE - Anilides

    N02BE01 - Paracetamol

    5.5 Absorption, Distribution and Excretion

    Absorption

    Acetaminophen has 88% oral bioavailability and reaches its highest plasma concentration 90 minutes after ingestion. Peak blood levels of free acetaminophen are not reached until 3 hours after rectal administration of the suppository form of acetaminophen and the peak blood concentration is approximately 50% of the observed concentration after the ingestion of an equivalent oral dose (10-20 mcg/mL). The percentage of a systemically absorbed rectal dose of acetaminophen is inconsistent, demonstrated by major differences in the bioavailability of acetaminophen after a dose administered rectally. Higher rectal doses or an increased frequency of administration may be used to attain blood concentrations of acetaminophen similar to those attained after oral acetaminophen administration.

    Route of Elimination

    Acetaminophen metabolites are mainly excreted in the urine. Less than 5% is excreted in the urine as free (unconjugated) acetaminophen and at least 90% of the administered dose is excreted within 24 hours.

    Volume of Distribution

    Volume of distribution is about 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Acetaminophen appears to be widely distributed throughout most body tissues except in fat.

    Clearance

    Adults: 0.27 L/h/kg following a 15 mg/kg intravenous (IV) dose. Children: 0.34 L/h/kg following a 15 mg/kg intravenous (IV dose).

    Acetaminophen is rapidly and almost completely absorbed from the GI tract following oral administration. In healthy men, steady-state oral bioavailability of 1.3-g doses of extended-release tablets of acetaminophen administered every 8 hours for a total of 7 doses was equal to 1-g doses of conventional tablets of acetaminophen given every 6 hours for a total of 7 doses. Food may delay slightly absorption of extended-release tablets of acetaminophen. Following oral administration of immediate- or extended-release acetaminophen preparations, peak plasma concentrations are attained within 10-60 or 60-120 minutes, respectively. Following oral administration of a single 500-mg conventional tablet or a single 650-mg extended-release tablet, average plasma acetaminophen concentrations of 2.1 or 1.8 ug/mL, respectively, occur at 6 or 8 hours, respectively. In addition, dissolution of the extended-release tablets may depend slightly on the gastric or intestinal pH. Dissolution appears to be slightly faster in the alkaline pH of the intestines compared with the acidic pH of the stomach; however, this is of no clinical importance. Following administration of conventional preparations of acetaminophen, only small amounts of the drug are detectable in plasma after 8 hours. The extended-release tablets of acetaminophen release the drug for up to 8 hours, but in vitro data indicate that at least 95% of the dose is released within 5 hours.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2212

    Following rectal administration of acetaminophen, there is considerable variation in peak plasma concentrations attained, and time to reach peak plasma concentrations is substantially longer than after oral administration.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2212

    In 12 nursing mothers (nursing 2-22 months) given a single oral dose of 650 mg, peak levels of acetaminophen occurred at 1-2 hours in the range of 10-15 ug/mL. Assuming 90 mL of milk were ingested at 3-, 6-, and 9-hour intervals after ingestion, the amount of drug available to the infant was estimated to range from 0.04% to 0.23% of the maternal dose.

    Briggs, G.G., Freeman, R.K., Yaffee, S.J.; Drugs in Pregancy and Lactation Nineth Edition. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia, PA. 2011, p. 11

    Acetaminophen is rapidly and uniformly distributed into most body tissues. About 25% of acetaminophen in blood is bound to plasma proteins.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2212

    For more Absorption, Distribution and Excretion (Complete) data for ACETAMINOPHEN (11 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Acetaminophen is the major metabolite of _phenacetin_ and _acetanilid_. Acetaminophen is mainly metabolized in the liver by first-order kinetics and its metabolism of comprised of 3 pathways: conjugation with glucuronide, conjugation with sulfate, and oxidation through the cytochrome P450 enzyme pathway, mainly CYP2E1, to produce a reactive metabolite (N-acetyl-p-benzoquinone imine or NAPQI). At normal therapeutic doses, NAPQI undergoes fast conjugation with glutathione and is subsequently metabolized to produce both cysteine and mercapturic acid conjugates. High doses of acetaminophen (overdoses) can lead to hepatic necrosis due to the depletion of glutathione and of binding of high levels of reactive metabolite (NAPQI) to important parts of liver cells. The abovementioned damage to the liver can be prevented by the early administration of sulfhydryl compounds, for example, methionine and N-acetylcysteine.

    About 80-85% of the acetaminophen in the body undergoes conjugation principally with glucuronic acid and to a lesser extent with sulfuric acid. Acetaminophen also is metabolized by microsomal enzyme systems in the liver.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2212

    In vitro and animal data indicate that small quantities of acetaminophen are metabolized by a cytochrome P-450 microsomal enzyme to a reactive intermediate metabolite (N-acetyl-p-benzoquinoneimine, N-acetylimidoquinone, NAPQI) which is further metabolized via conjugation with glutathione and ultimately excreted in urine as a mercapturic acid. It has been suggested that this intermediate metabolite is responsible for acetaminophen-induced liver necrosis and that high doses of acetaminophen may deplete glutathione so that inactivation of this toxic metabolite is decreased. At high doses, the capacity of metabolic pathways for conjugation with glucuronic acid and sulfuric acid may be exceeded, resulting in increased metabolism of acetaminophen by alternative pathways. In addition, it also has been suggested that in fasting individuals conjugation of high doses of acetaminophen with glucuronic acid may be reduced, secondary to decreased hepatic carbohydrate reserves and microsomal oxidation may be increased, resulting in increased risk of hepatotoxicity.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2212

    Yields 4-acetamidocatechol in rat; yields s-(5-acetamido-2-hydroxyphenyl)-l-cysteine probably in man. Yields p-acetamidophenyl-beta-d-glucuronide in rabbit; yields p-acetamidophenyl-beta-d-glucuronide in rat, in guinea pig, & in ferret; yields p-acetamidophenyl-beta-d-glucuronide in man & in dog; yields p-acetamidophenyl sulfate in rabbit, guinea pig, & ferret; yields p-acetamidophenyl sulfate in rat & in man; yields p-methoxyacetanilide in guinea pig; yields quinol probably in rat. /From table/

    Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. A-10

    Children have less capacity for glucuronidation of the drug than do adults. A small proportion of acetaminophen undgoes n-hydroxylation to form n-acetyl-benzoquinoneimine, a highly reactive intermediate. This metabolite normally reacts with sulfhydryl groups in glutathione. However, after large doses of acetaminophen the metabolite is formed in amounts sufficient to deplete hepatic glutathione; under these circumstances reaction with sulfhydryl groups in hepatic proteins is increased and hepatic necrosis can result.

    Hardman, J.G., L.E. Limbird, P.B., A.G. Gilman. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed. New York, NY: McGraw-Hill, 2001., p. 704

    For more Metabolism/Metabolites (Complete) data for ACETAMINOPHEN (7 total), please visit the HSDB record page.

    Acetaminophen has known human metabolites that include (2S,3S,4S,5R)-6-(4-Acetamidophenoxy)-3,4,5-trihydroxyoxane-2-carboxylic acid, 3-Hydroxyacetaminophen, Acetaminophen sulfate, and N-Acetyl-p-benzoquinone.

    Acetaminophen is a known human metabolite of O-isopropyl acetaminophen, acetanilide, p-Methoxyacetanilide, and phenacetin.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.7 Biological Half-Life

    The half-life for adults is 2.5 h after an intravenous dose of 15 mg/kg. After an overdose, the half-life can range from 4 to 8 hours depending on the severity of injury to the liver, as it heavily metabolizes acetaminophen.

    The elimination half life is 1-3 hours after a therapeutic dose but may be greater than 12 hours after an overdose.

    OLSON, K.R. (Ed). Poisoning and Drug Overdose, Sixth Edition. McGraw-Hill, New York, NY 2012, p. 69

    5.8 Mechanism of Action

    According to its FDA labeling, acetaminophen's exact mechanism of action has not been fully established - despite this, it is often categorized alongside NSAIDs (nonsteroidal anti-inflammatory drugs) due to its ability to inhibit the cyclooxygenase (COX) pathways. It is thought to exert central actions which ultimately lead to the alleviation of pain symptoms. One theory is that acetaminophen increases the pain threshold by inhibiting two isoforms of cyclooxygenase, COX-1 and COX-2, which are involved in prostaglandin (PG) synthesis. Prostaglandins are responsible for eliciting pain sensations. Acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, therefore, has no peripheral anti-inflammatory effects. Though acetylsalicylic acid (aspirin) is an irreversible inhibitor of COX and directly blocks the active site of this enzyme, studies have shown that acetaminophen (paracetamol) blocks COX indirectly. Studies also suggest that acetaminophen selectively blocks a variant type of the COX enzyme that is unique from the known variants COX-1 and COX-2. This enzyme has been referred to as _COX-3_. The antipyretic actions of acetaminophen are likely attributed to direct action on heat-regulating centers in the brain, resulting in peripheral vasodilation, sweating, and loss of body heat. The exact mechanism of action of this drug is not fully understood at this time, but future research may contribute to deeper knowledge.

    Acetaminophen produces analgesia and antipyresis by a mechanism similar to that of salicylates. Unlike salicylates, however, acetaminophen does not have uricosuric activity. There is some evidence that acetaminophen has weak anti-inflammatory activity in some nonrheumatoid conditions (e.g., in patients who have had oral surgery). ... Acetaminophen lowers body temperature in patients with fever but rarely lowers normal body temperature. The drug acts on the hypothalamus to produce antipyresis; heat dissipation is increased as a result of vasodilation and increased peripheral blood flow.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2211

    The effects of acetaminophen on cyclooxygenase activity have not been fully determined. Acetaminophen is a weak, reversible, isoform-nonspecific cyclooxygenase inhibitor at dosages of 1 g daily. The inhibitory effect of acetaminophen on cyclooxygenase-1 is limited, and the drug does not inhibit platelet function. Therapeutic doses of acetaminophen appear to have little effect on cardiovascular and respiratory systems; however, toxic doses may cause circulatory failure and rapid, shallow breathing.

    American Society of Health-System Pharmacists 2013; Drug Information 2013. Bethesda, MD. 2013, p. 2211

    Acetaminophen (N-acetyl-p-aminophenol (APAP)) is the most common antipyretic/analgesic medicine worldwide. If APAP is overdosed, its metabolite, N-acetyl-p-benzo-quinoneimine (NAPQI), causes liver damage. However, epidemiological evidence has associated previous use of therapeutic APAP doses with the risk of chronic obstructive pulmonary disease (COPD) and asthma. The transient receptor potential ankyrin-1 (TRPA1) channel is expressed by peptidergic primary sensory neurons. Because NAPQI, like other TRPA1 activators, is an electrophilic molecule, /the researchers/ hypothesized that APAP, via NAPQI, stimulates TRPA1, thus causing airway neurogenic inflammation. NAPQI selectively excites human recombinant and native (neuroblastoma cells) TRPA1. TRPA1 activation by NAPQI releases proinflammatory neuropeptides (substance P and calcitonin gene-related peptide) from sensory nerve terminals in rodent airways, thereby causing neurogenic edema and neutrophilia. Single or repeated administration of therapeutic (15-60 mg/kg) APAP doses to mice produces detectable levels of NAPQI in the lung, and increases neutrophil numbers, myeloperoxidase activity, and cytokine and chemokine levels in the airways or skin. Inflammatory responses evoked by NAPQI and APAP are abated by TRPA1 antagonism or are absent in TRPA1-deficient mice. This novel pathway, distinguished from the tissue-damaging effect of NAPQI, may contribute to the risk of COPD and asthma associated with therapeutic APAP use.

    PMID:20720158 Nassini R et al; FASEB J 24 (12): 4904-16 (2010)

    Acetaminophen is at present one of the most commonly used analgesics and antipyretics. Recent evidence has suggested that oxidative stress is involved in the mechanism of acetaminophen intoxication. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with acetaminophen intoxication. A total of 20 patients with acetaminophen intoxication and 25 healthy controls were enrolled. Serum total antioxidant capacity (TAC), lipid hydroperoxide (LOOH) levels, and paraoxonase and arylesterase activities were measured spectrophotometrically. The serum TAC levels and the paraoxonase and arylesterase activities were significantly lower in patients with acetaminophen intoxication compared with controls (all, p < 0.001), while the serum LOOH levels were significantly higher (p < 0.001). Results suggest that decreased PON1 activity seems to be associated with increased oxidative stress in patients with acetaminophen intoxication. Measuring serum PON1 activity may be useful in assessing the development of toxicity risk in acetaminophen toxicity. It would be useful to recommend vitamins with antioxidant effects such as vitamins C and E along with medical treatments.

    PMID:24501102 Karadas S et al; Hum Exp Toxicol 33 (11): 1134-40 (2014)

    For more Mechanism of Action (Complete) data for ACETAMINOPHEN (9 total), please visit the HSDB record page.

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    01-Jan-2021
    30-Oct-2024
    MTS
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    Average Price (USD/MTS)

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    Total Quantity (MTS)

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    Quantity (MTS) & Unit rate (USD/MTS) over time

    API Imports and Exports

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - SUPPOSITORY;RECTAL - 120MG

    USFDA APPLICATION NUMBER - 18337

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    DOSAGE - SUPPOSITORY;RECTAL - 325MG

    USFDA APPLICATION NUMBER - 18337

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    DOSAGE - SUPPOSITORY;RECTAL - 650MG

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    DOSAGE - SUPPOSITORY;RECTAL - 80MG

    USFDA APPLICATION NUMBER - 18337

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    DOSAGE - CAPSULE;ORAL - 325MG;50MG;40MG;30MG

    USFDA APPLICATION NUMBER - 20232

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    DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 325M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 325MG;7.5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 204031

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    DOSAGE - TABLET;ORAL - 250MG;250MG;65MG

    USFDA APPLICATION NUMBER - 20802

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    DOSAGE - TABLET;ORAL - 325MG;37.5MG

    USFDA APPLICATION NUMBER - 21123

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    DOSAGE - SOLUTION;INTRAVENOUS - 1GM/100ML (10...DOSAGE - SOLUTION;INTRAVENOUS - 1GM/100ML (10MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 22450

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    DOSAGE - TABLET;ORAL - 300MG;15MG

    USFDA APPLICATION NUMBER - 85055

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    DOSAGE - TABLET;ORAL - 300MG;30MG

    USFDA APPLICATION NUMBER - 85055

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    DOSAGE - TABLET;ORAL - 300MG;60MG

    USFDA APPLICATION NUMBER - 85055

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    DOSAGE - TABLET;ORAL - 325MG;5MG

    USFDA APPLICATION NUMBER - 87003

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    DOSAGE - TABLET;ORAL - 325MG;50MG;40MG

    USFDA APPLICATION NUMBER - 88616

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    DOSAGE - TABLET;ORAL - 300MG;60MG

    USFDA APPLICATION NUMBER - 88629

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