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1. 2,4-pentanedione
2. Indium-111-acetylacetone
1. 2,4-pentanedione
2. Pentane-2,4-dione
3. 123-54-6
4. Acetoacetone
5. 2,4-pentadione
6. Diacetylmethane
7. Acac
8. 2,4-dioxopentane
9. Acetyl Acetone
10. Pentanedione
11. Pentan-2,4-dione
12. Pentanedione-2,4
13. Acetyl 2-propanone
14. Acetone, Acetyl-
15. Hacac
16. 2-propanone, Acetyl-
17. 2,4-pentandione
18. Acetylaceton
19. Acetyl-acetone
20. Nsc 5575
21. Ch3coch2coch3
22. Benzil-related Compound, 44
23. Ch3-co-ch2-co-ch3
24. Chebi:14750
25. 46r950bp4j
26. Nsc-5575
27. Ccris 3466
28. Hsdb 2064
29. 14024-62-5
30. Einecs 204-634-0
31. Un2310
32. Brn 0741937
33. Unii-46r950bp4j
34. Ai3-02266
35. Pentane-2
36. Pentan-2
37. 2,4 Pentanedione
38. 2.4-pentanedione
39. Pentane2,4-dione
40. 2,4-diketopentane
41. Acetyl-2-propanone
42. 2, 4-pentanedione
43. 2,4-pentane Dione
44. 2,4-pentane-dione
45. Mfcd00008787
46. Acetylacetone Enol
47. Dsstox_cid_1979
48. Acetylacetone [mi]
49. 1-methylbutane-1,3-dione
50. Ec 204-634-0
51. Schembl1608
52. Dsstox_rid_76439
53. Nciopen2_000702
54. Dsstox_gsid_21979
55. 4-01-00-03662 (beilstein Handbook Reference)
56. 81235-32-7
57. Pentane-2,4-dione [un2310] [flammable Liquid]
58. Acetyl Acetone [hsdb]
59. Chembl191625
60. Wln: 1v1v1
61. Dtxsid4021979
62. Acetylacetone;pentane-2,4-dione
63. Bdbm22766
64. Nsc5575
65. Acetylacetone, Analytical Standard
66. Bcp31333
67. Str00020
68. Zinc4720638
69. Tox21_200414
70. Lmfa12000075
71. 2,4-pentadione, Acac, Acetylacetone
72. Akos000118994
73. Un 2310
74. Acetylacetone, Reagentplus(r), >=99%
75. Ncgc00248599-01
76. Ncgc00257968-01
77. Bp-30252
78. Cas-123-54-6
79. Acetylacetone, Jis Special Grade, >=99%
80. Db-020012
81. Ds-002710
82. Ft-0610237
83. Ft-0622988
84. P0052
85. Q413447
86. J-507260
87. Pentane-2,4-dione [un2310] [flammable Liquid]
88. F1908-0168
89. Acetylacetone, Produced By Wacker Chemie Ag, Burghausen, Germany, >=99.5% (gc)
| Molecular Weight | 100.12 g/mol |
|---|---|
| Molecular Formula | C5H8O2 |
| XLogP3 | 0.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Exact Mass | 100.052429494 g/mol |
| Monoisotopic Mass | 100.052429494 g/mol |
| Topological Polar Surface Area | 34.1 Ų |
| Heavy Atom Count | 7 |
| Formal Charge | 0 |
| Complexity | 82.3 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
2,4-Pentanedione (2,4-PD; CAS No. 123-54-6) ... was investigated for its comparative pharmacokinetics in male Fischer 344 rats by a single intravenous (i.v.) injection of (4.3, 43, 148.5, and 430 mg/kg), or a 6-hr nose-only inhalation exposure (400 ppm) to (14)C-2,4-PD. For the i.v. route, the plasma concentration of (14)C-2,4-PD-derived radioactivity declined in a biexponential fashion. The overall form of the (14)C plasma concentration-time curves and derived pharmacokinetic parameters indicated that dose-linear kinetics occurred in the i.v. dose range 4.3-148.5 mg/kg, but not with 430 mg/kg. Metabolism of 2,4-PD was rapid to undetectable after 8 hr. (14)C-2,4-PD derived radioactivity was eliminated mainly as (14)CO2 and in urine. For the 4.3, 43 and 148.5 mg/kg doses (14)CO2 elimination was relatively constant (36.8, 38.8 and 42.3% in 48 hr samples respectively) and greater than urinary excretion (17.9, 14.3 and 29.6%; 48 hr specimens). At 430 mg/kg i.v. there was a reversal of the excretion pattern, with urine (14)C excretion (54.7%) becoming greater than that for (14)CO2 (27.3%). Excretion in expired volatiles and feces was small. Radiochromatograms of urine showed free 2,4-PD in the 12 hr sample, together with 7 other metabolites. Free 2,4-PD and 6 of the metabolites decreased or were not detectable in a 24 or 48 hr urine sample, but one peak (retention 7.9 min) increased progressively to become the major fraction (97%). Nose-only exposure to 400 ppm (14)C-2, 4-PD produced a mean decrease in breathing rate of 20.1%, which was constant and sustained throughout exposure, due to a lengthening of the expiratory phase of the respiratory cycle. (14)C-2,4-PD was rapidly absorbed during the first 3 hr of exposure, then began to plateau, but did not reach a steady state. Postexposure elimination of (14)C from plasma followed a biexponential form with a t1/2 for the terminal disposition phase of 30.72 hr. ... Postexposure, plasma unmetabolized 2,4-PD declined rapidly to undetectable concentrations by 12 hr. Radiolabel excretion was approximately equivalent in urine (37.6%) and expired (14)CO2 (36.3%). Urine radiochromatograms showed a minor 2,4-PD contaminant (0.6-5.9% over 48 hr), along with 7 other peaks probably representing metabolites. The major metabolite peak was at 7.8 min retention, increasing from 41.1% (12 hr) to 62.8% (48 hr). Immediately postexposure, radioactivity was present in all tissues examined, but on a concentration basis (microgram equiv/g) there was no preferential accumulation of (14)C in any tissue or organ. ...
PMID:9569447 Frantz SW et al; Toxicol Ind health 14 (3): 413-28 (1998)
About 10.75 hours in rats; [ACGIH]
ACGIH - Documentation of the TLVs and BEIs, 7th Ed. Cincinnati: ACGIH Worldwide, 2020.
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PharmaCompass offers a list of Acetylacetone API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Acetylacetone manufacturer or Acetylacetone supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Acetylacetone manufacturer or Acetylacetone supplier.
PharmaCompass also assists you with knowing the Acetylacetone API Price utilized in the formulation of products. Acetylacetone API Price is not always fixed or binding as the Acetylacetone Price is obtained through a variety of data sources. The Acetylacetone Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Acetoacetone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acetoacetone, including repackagers and relabelers. The FDA regulates Acetoacetone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acetoacetone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Acetoacetone supplier is an individual or a company that provides Acetoacetone active pharmaceutical ingredient (API) or Acetoacetone finished formulations upon request. The Acetoacetone suppliers may include Acetoacetone API manufacturers, exporters, distributors and traders.
Acetoacetone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Acetoacetone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Acetoacetone GMP manufacturer or Acetoacetone GMP API supplier for your needs.
A Acetoacetone CoA (Certificate of Analysis) is a formal document that attests to Acetoacetone's compliance with Acetoacetone specifications and serves as a tool for batch-level quality control.
Acetoacetone CoA mostly includes findings from lab analyses of a specific batch. For each Acetoacetone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Acetoacetone may be tested according to a variety of international standards, such as European Pharmacopoeia (Acetoacetone EP), Acetoacetone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acetoacetone USP).
