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    Chemistry

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    Also known as: N-hydroxyacetamide, 546-88-3, Lithostat, Methylhydroxamic acid, Acetylhydroxamic acid, Acetic acid, oxime
    Molecular Formula
    C2H5NO2
    Molecular Weight
    75.07  g/mol
    InChI Key
    RRUDCFGSUDOHDG-UHFFFAOYSA-N
    FDA UNII
    4RZ82L2GY5
    Acetohydroxamic Acid
    acetohydroxamic acid is a natural product found in Chlamydomonas reinhardtii and Arabidopsis thaliana with data available.
    Acetohydroxamic acid is an Urease Inhibitor. The mechanism of action of acetohydroxamic acid is as an Urease Inhibitor.
    1 2D Structure

    Acetohydroxamic Acid

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-hydroxyacetamide
    2.1.2 InChI
    InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
    2.1.3 InChI Key
    RRUDCFGSUDOHDG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(=O)NO
    2.2 Other Identifiers
    2.2.1 UNII
    4RZ82L2GY5
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Lithostat

    2. N-hydroxyacetamide

    3. N-hydroxyacetamidine

    4. Uronefrex

    2.3.2 Depositor-Supplied Synonyms

    1. N-hydroxyacetamide

    2. 546-88-3

    3. Lithostat

    4. Methylhydroxamic Acid

    5. Acetylhydroxamic Acid

    6. Acetic Acid, Oxime

    7. N-acetylhydroxylamine

    8. Acetohydroximic Acid

    9. Acetamide, N-hydroxy-

    10. Acethydroxamsaeure

    11. N-acetyl Hydroxyacetamide

    12. Cetohyroxamic Acid

    13. Acetohydroxamate

    14. Acethydroxamsaure

    15. Acethydroxamic Acid

    16. Aha

    17. Hydroxylamine, N-acetyl-

    18. Acido Acetohidroxamico

    19. Acide Acetohydroxamique

    20. Acidum Acetohydroxamicum

    21. N-hydroxy-acetamide

    22. Nsc 176136

    23. Mfcd00009994

    24. Nsc-176136

    25. 4rz82l2gy5

    26. Acetamide, N-hydroxy- (9ci)

    27. Chebi:27777

    28. Ncgc00094576-01

    29. Dsstox_cid_2546

    30. Wln: Qmv1

    31. Acetohydroxamicacid

    32. Acetyl Hydroxyamino

    33. Dsstox_rid_76622

    34. Dsstox_gsid_22546

    35. Acethydroxamsaeure [german]

    36. Oxime

    37. Acide Acetohydroxamique [french]

    38. Acido Acetohidroxamico [spanish]

    39. Acidum Acetohydroxamicum [latin]

    40. Lithostat (tn)

    41. Cas-546-88-3

    42. Ccris 1730

    43. Hsdb 3585

    44. N-hydroxyacetimidic Acid

    45. N-hydroxyethanimidic Acid

    46. Einecs 208-913-8

    47. Unii-4rz82l2gy5

    48. Ai3-62232

    49. Acetohydroxamsaure

    50. Acetohydroxamic Acid (usp/inn)

    51. Acetic Acid

    52. Oxime

    53. N-oxylatoacetamide

    54. Acethydroximic Acid

    55. Acetohyroxamic Acid

    56. Acetyl Hydroxyamine

    57. Prestwick_38

    58. Acetohydroxamic-acid

    59. N-oxidanylethanamide

    60. Acetohydroxarnic Acid

    61. Acetohydroxamic Acid [usan:usp:inn]

    62. Methyl Hydroximic Acid

    63. Spectrum_000020

    64. Spectrum2_000109

    65. Spectrum3_000285

    66. Spectrum4_000138

    67. Spectrum5_000812

    68. Ch3c(o)nhoh

    69. Chembl734

    70. Acetohydroxamic Acid, 98%

    71. Bspbio_001790

    72. Kbiogr_000556

    73. Kbioss_000360

    74. Mls001076662

    75. Divk1c_000821

    76. Spectrum1500103

    77. Spbio_000098

    78. Dtxsid7022546

    79. Chebi:49029

    80. Hms502j03

    81. Kbio1_000821

    82. Kbio2_000360

    83. Kbio2_002928

    84. Kbio2_005496

    85. Kbio3_001290

    86. Acetohydroxamic Acid [mi]

    87. Nsc5073

    88. Ninds_000821

    89. Acetohydroxamic Acid (aha)

    90. Acetohydroxamic Acid [inn]

    91. Hms1920a07

    92. Hms2091g07

    93. Hms2231m17

    94. Pharmakon1600-01500103

    95. Acetohydroxamic Acid [hsdb]

    96. Acetohydroxamic Acid [usan]

    97. Act05768

    98. Hy-b1235

    99. Nsc-5073

    100. Str08084

    101. Zinc4658603

    102. Acetohydroxamic Acid [vandf]

    103. Tox21_111301

    104. Acetohydroxamic Acid [mart.]

    105. Bdbm50099857

    106. Ccg-38927

    107. Geo-00010

    108. Nsc176136

    109. Nsc755855

    110. S4602

    111. Acetohydroxamic Acid [usp-rs]

    112. Acetohydroxamic Acid [who-dd]

    113. Akos000172340

    114. Tox21_111301_1

    115. Ab01014

    116. Cs-4881

    117. Db00551

    118. Nsc-755855

    119. Idi1_000821

    120. Ncgc00094576-02

    121. Ncgc00094576-03

    122. Ncgc00094576-05

    123. Acetohydroxamic Acid [orange Book]

    124. Bp-13320

    125. Smr000499570

    126. Sbi-0051270.p003

    127. Acetohydroxamic Acid [usp Monograph]

    128. Db-052632

    129. A0051

    130. Am20100343

    131. Ft-0621796

    132. En300-36948

    133. 46a883

    134. C06808

    135. D00220

    136. Ab00051907_07

    137. A830321

    138. Q481822

    139. Sr-01000763642

    140. Sr-01000763642-2

    141. W-105609

    142. Acetohydroxamic Acid, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 75.07 g/mol
    Molecular Formula C2H5NO2
    XLogP3-1.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass75.032028402 g/mol
    Monoisotopic Mass75.032028402 g/mol
    Topological Polar Surface Area49.3 Ų
    Heavy Atom Count5
    Formal Charge0
    Complexity42.9
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameLithostat
    PubMed HealthAcetohydroxamic Acid (By mouth)
    Drug ClassesUrinary Stone Agent
    Drug LabelAcetohydroxamic acid (AHA) is a stable, synthetic compound derived from hydroxylamine and ethyl acetate. Its molecular structure is similar to urea:AHA is weakly acidic, highly soluble in water, and chelates metals - notably iron. The molecular weigh...
    Active IngredientAcetohydroxamic acid
    Dosage FormTablet
    RouteOral
    Strength250mg
    Market StatusPrescription
    CompanyMission Pharma

    2 of 2  
    Drug NameLithostat
    PubMed HealthAcetohydroxamic Acid (By mouth)
    Drug ClassesUrinary Stone Agent
    Drug LabelAcetohydroxamic acid (AHA) is a stable, synthetic compound derived from hydroxylamine and ethyl acetate. Its molecular structure is similar to urea:AHA is weakly acidic, highly soluble in water, and chelates metals - notably iron. The molecular weigh...
    Active IngredientAcetohydroxamic acid
    Dosage FormTablet
    RouteOral
    Strength250mg
    Market StatusPrescription
    CompanyMission Pharma

    4.2 Therapeutic Uses

    Enzyme Inhibitors

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Acetohydroxamic acid is indicated in the prophylaxis of struvite calculi formation that is promoted by urease-producing bacteria such as Proteus. Its use may enhance effectiveness of urinary antibacterials, especially following surgical removal of existing stones. Use of acetohydroxamic acid also improves the possibility of reducing the frequency and rate of new stone formation. /Included in US product labeling/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    Acetohydroxamic acid is indicated as an adjunct in the treatment of chronic, urea-splitting urinary tract infections caused by urease-producing bacteria. Its inhibition of urease activity decreases the urinary ammonia and alkalinity produced from the enzyme hydrolysis of urea. /Included in US product labeling/

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    4.3 Drug Warning

    Acetohydroxamic acid is not indicated for dissolution of existing calculi, replacement of indicated surgical treatment, urinary tract infections controllable by culture-specific oral antibacterials, or urinary tract infections caused by nonurease producing organisms.

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    Use of acetohydroxamic acid is contraindicated during pregnancy since studies in animals have shown it to cause leg deformities at doses of 750 mg/kg of body weight and above. At doses of 1500 mg/kg, exencephaly and encephalocele occurred. Also, cardiac, coccygeal, and abdominal-wall anomalies developed in pups of beagle dogs given 25 mg/kg a day during pregnancy.

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    It is not known if acetohydroxamic acid is distributed into breast milk. Although problems in humans have not been documented, its use is not recommended in breast-feeding mothers because of the potential for serious adverse effects in the nursing infant.

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    Headache, appearing during the first 48 hours of treatment, reportedly occurs in approximately 30% of patients receiving acetohydroxamic acid; however, several clinicians reported that mild, transient headache occurred in 70-75% of patients during initiation of therapy. Headache is generally mild, responsive to oral salicylate analgesics, and usually disappears spontaneously. Headache has not been associated with vertigo, tinnitus, or visual or auditory disturbances. Malaise occurs in about 20-25% of patients receiving the drug.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 97. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1997 (Plus Supplements)., p. 1980

    For more Drug Warnings (Complete) data for ACETOHYDROXAMIC ACID (12 total), please visit the HSDB record page.

    4.4 Drug Indication

    Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.

    5.2 MeSH Pharmacological Classification

    Enzyme Inhibitors

    Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    ACETOHYDROXAMIC ACID
    5.3.2 FDA UNII
    4RZ82L2GY5
    5.3.3 Pharmacological Classes
    Urease Inhibitors [MoA]; Urease Inhibitor [EPC]
    5.4 ATC Code

    G - Genito urinary system and sex hormones

    G04 - Urologicals

    G04B - Urologicals

    G04BX - Other urologicals

    G04BX03 - Acetohydroxamic acid

    5.5 Absorption, Distribution and Excretion

    Absorption

    Well absorbed from the GI tract following oral administration.

    Well absorbed from gastrointestinal tract.

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    Well distributed throughout body fluids.

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    Elimination: Renal- Unchanged, 36 to 65%; as acetamide, 9 to 14%. Respiratory - As carbon dioxide, 20 to 40%.

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    In rodents, about 55% of an intraperitoneal dose is excreted in urine as unchanged drug, 15% as acetamide, and 10% as acetate within 24 hours; approximately 7% of the dose is excreted by the lungs as carbon dioxide and less than 1% is excreted in feces within 24 hours.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 97. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1997 (Plus Supplements)., p. 1979

    In mice, highest concentrations of the drug occur in the liver and kidney, while the lowest concentrations occur in the brain.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 97. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1997 (Plus Supplements)., p. 1978

    5.6 Metabolism/Metabolites

    35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).

    ...is metabolized to acetamide.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 97. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1997 (Plus Supplements)., p. 1979

    5.7 Biological Half-Life

    5-10 hours in patients with normal renal function

    ...increases with increasing dose and reportedly ranges from about 3.5-10 hours in patients with normal renal function.

    McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 97. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1997 (Plus Supplements)., p. 1979

    5.8 Mechanism of Action

    Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate.

    Inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting bacteria, by reversible inhibition of the bacterial enzyme urease, and by the chelation of nickel, an essential component of urease enzymes. Such enzyme inhibition results in reduction of both urine alkalinity and ammonia concentration. The effectiveness of antibacterial medication is then enhanced and the formation of urinary calculi reduced.

    USP Convention. USPDI - Drug Information for the Health Care Professional. 17th ed. Volume I. Rockville, MD: Convention, Inc., 1997. (Plus Updates)., p. 14

    API Reference Price

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INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"50","unit":"GMS","unitRateFc":"2.1","totalValueFC":"106.9","currency":"USD","unitRateINR":"166.8","date":"13-Jun-2022","totalValueINR":"8342","totalValueInUsd":"106.9","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1008454","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1660933800,"product":"BD21376-100G ACETOHYDROXAMIC ACID (ORGANIC COMPOUNDS) 300G","address":"39 40 P KIADB INDUSTRIAL AREA ELECTRONICS CITY PHASE II HOSUR ROA","city":"BANGALORE","supplier":"BLD PHARMATECH LTD.","supplierCountry":"CHINA","foreign_port":"NA","customer":"AURIGENE","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"0.3","unit":"KGS","unitRateFc":"588","totalValueFC":"178.5","currency":"USD","unitRateINR":"47334","date":"20-Aug-2022","totalValueINR":"14200.2","totalValueInUsd":"178.5","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"2080466","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"39 40 P KIADB INDUSTRIAL AREA ELECTRONICS CITY PHASE II HOSUR ROA"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1665685800,"product":"ACETOHYDROXAMIC ACID","address":"28\/A, IDA, NACHARAM, Contact No: 919989112452","city":"HYDERABAD","supplier":"COMBI BLOCKS INC.","supplierCountry":"CHINA","foreign_port":"NA","customer":"ARAGEN LIFE SCIENCES","customerCountry":"INDIA","quantity":"0.20","actualQuantity":"200","unit":"GMS","unitRateFc":"0.8","totalValueFC":"156.5","currency":"USD","unitRateINR":"64.4","date":"14-Oct-2022","totalValueINR":"12878.74","totalValueInUsd":"156.5","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"2878873","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"28\/A, IDA, NACHARAM, Contact No: 919989112452"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1666981800,"product":"ACETOHYDROXAMIC ACID","address":"28\/A, IDA, NACHARAM, Contact No: 919989112452","city":"HYDERABAD","supplier":"COMBI BLOCKS INC.","supplierCountry":"CHINA","foreign_port":"NA","customer":"ARAGEN LIFE SCIENCES","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1000","unit":"GMS","unitRateFc":"0.6","totalValueFC":"634.2","currency":"USD","unitRateINR":"52.2","date":"29-Oct-2022","totalValueINR":"52188.49","totalValueInUsd":"634.2","indian_port":"BANGALORE AIR","hs_no":"29339990","bill_no":"3088161","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"28\/A, IDA, NACHARAM, Contact No: 919989112452"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683484200,"product":"ACETOHYDROXAMIC ACID","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"OAKWOOD PRODUCTS INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"100","unit":"GMS","unitRateFc":"1","totalValueFC":"96","currency":"USD","unitRateINR":"79","date":"08-May-2023","totalValueINR":"7902","totalValueInUsd":"96","indian_port":"Biocon-SEZ","hs_no":"29280090","bill_no":"1006146","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"730 COLUMBIA HWY NORTH ESTILL SC 29918 US","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1686853800,"product":"ACETOHYDROXAMIC ACID","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"LOCKWOOD PRODUCTS INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.20","actualQuantity":"200","unit":"GMS","unitRateFc":"1","totalValueFC":"209.7","currency":"USD","unitRateINR":"86.2","date":"16-Jun-2023","totalValueINR":"17233","totalValueInUsd":"209.7","indian_port":"Biocon-SEZ","hs_no":"29280090","bill_no":"1008200","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"P.O. BOX 1546 LAKE OSWEGO OR 97035SDNFSDNF United States","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695061800,"product":"ACETOHYDROXAMIC ACID CAS 546-88-3 (A168949-100G) (FOR R & DPURPOSE)","address":"39-40 KIADB INDUSTRIAL AREA,ELECTR","city":"BANGALORE,KARNATAKA","supplier":"AMBEED INC","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"AURIGENE PHARMACEUTICAL SERVICES","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"100","unit":"GMS","unitRateFc":"0.6","totalValueFC":"75.5","currency":"USD","unitRateINR":"62.7","date":"19-Sep-2023","totalValueINR":"6265.8","totalValueInUsd":"75.5","indian_port":"Bangalore Air","hs_no":"29147990","bill_no":"7899586","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"3205 N WILKE RD STE 3205-125 ARLINGTON HTS, ILSDNF US","customerAddress":"39-40 KIADB INDUSTRIAL AREA,ELECTR"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1704393000,"product":"ACETOHYDROXAMIC ACID","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"OAKWOOD PRODUCTS INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"300","unit":"GMS","unitRateFc":"1.1","totalValueFC":"327.6","currency":"USD","unitRateINR":"90.8","date":"05-Jan-2024","totalValueINR":"27231","totalValueInUsd":"327.6","indian_port":"Biocon-SEZ","hs_no":"29280090","bill_no":"1000183","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709490600,"product":"ACETOHYDROXAMIC ACID","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"AMBEED INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"500","unit":"GMS","unitRateFc":"0.4","totalValueFC":"216.5","currency":"USD","unitRateINR":"36","date":"04-Mar-2024","totalValueINR":"17975","totalValueInUsd":"216.5","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1002694","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709577000,"product":"ACETOHYDROXAMIC ACID-VALUE FOR CUSTOM PURPOSES ONLY","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"OAKWOOD PRODUCT INC.","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"0.30","actualQuantity":"300","unit":"GMS","unitRateFc":"1.1","totalValueFC":"332.4","currency":"USD","unitRateINR":"92","date":"05-Mar-2024","totalValueINR":"27600","totalValueInUsd":"332.4","indian_port":"Biocon-SEZ","hs_no":"29280090","bill_no":"1002745","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730658600,"product":"ACETOHYDROXAMIC ACID-VALUE FOR CUSTOMS PURPOSES (FOC)","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"BLD PHARMATECH CO. ","supplierCountry":"UNITED STATES","foreign_port":"CINCINNATI","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"1.50","actualQuantity":"1500","unit":"GMS","unitRateFc":"0.3","totalValueFC":"444.5","currency":"USD","unitRateINR":"25","date":"04-Nov-2024","totalValueINR":"37509.05","totalValueInUsd":"444.5","indian_port":"Biocon-SEZ","hs_no":"29339990","bill_no":"6487621","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"CINCINNATI","supplierAddress":"10999 REED HARTMAN HWY 304B CINCINNATI OH SDNF UNITED STATES","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"}]
    07-Apr-2021
    04-Nov-2024
    KGS
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    ABOUT THIS PAGE

    Acetohydroxamic Acid Manufacturers

    A Acetohydroxamic Acid manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acetohydroxamic Acid, including repackagers and relabelers. The FDA regulates Acetohydroxamic Acid manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acetohydroxamic Acid API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Acetohydroxamic Acid manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Acetohydroxamic Acid Suppliers

    A Acetohydroxamic Acid supplier is an individual or a company that provides Acetohydroxamic Acid active pharmaceutical ingredient (API) or Acetohydroxamic Acid finished formulations upon request. The Acetohydroxamic Acid suppliers may include Acetohydroxamic Acid API manufacturers, exporters, distributors and traders.

    click here to find a list of Acetohydroxamic Acid suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Acetohydroxamic Acid USDMF

    A Acetohydroxamic Acid DMF (Drug Master File) is a document detailing the whole manufacturing process of Acetohydroxamic Acid active pharmaceutical ingredient (API) in detail. Different forms of Acetohydroxamic Acid DMFs exist exist since differing nations have different regulations, such as Acetohydroxamic Acid USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Acetohydroxamic Acid DMF submitted to regulatory agencies in the US is known as a USDMF. Acetohydroxamic Acid USDMF includes data on Acetohydroxamic Acid's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Acetohydroxamic Acid USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Acetohydroxamic Acid suppliers with USDMF on PharmaCompass.

    Acetohydroxamic Acid NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Acetohydroxamic Acid as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Acetohydroxamic Acid API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Acetohydroxamic Acid as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Acetohydroxamic Acid and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Acetohydroxamic Acid NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Acetohydroxamic Acid suppliers with NDC on PharmaCompass.

    Acetohydroxamic Acid GMP

    Acetohydroxamic Acid Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Acetohydroxamic Acid GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Acetohydroxamic Acid GMP manufacturer or Acetohydroxamic Acid GMP API supplier for your needs.

    Acetohydroxamic Acid CoA

    A Acetohydroxamic Acid CoA (Certificate of Analysis) is a formal document that attests to Acetohydroxamic Acid's compliance with Acetohydroxamic Acid specifications and serves as a tool for batch-level quality control.

    Acetohydroxamic Acid CoA mostly includes findings from lab analyses of a specific batch. For each Acetohydroxamic Acid CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Acetohydroxamic Acid may be tested according to a variety of international standards, such as European Pharmacopoeia (Acetohydroxamic Acid EP), Acetohydroxamic Acid JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acetohydroxamic Acid USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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