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Chemistry

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Also known as: 60-31-1, Miochol, Acecoline, Ach chloride, Chloroacetylcholine, Arterocoline
Molecular Formula
C7H16ClNO2
Molecular Weight
181.66  g/mol
InChI Key
JUGOREOARAHOCO-UHFFFAOYSA-M
FDA UNII
AF73293C2R

 Acetylcholine Chloride
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
1 2D Structure

 Acetylcholine Chloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-acetyloxyethyl(trimethyl)azanium;chloride
2.1.2 InChI
InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
2.1.3 InChI Key
JUGOREOARAHOCO-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CC(=O)OCC[N+](C)(C)C.[Cl-]
2.2 Other Identifiers
2.2.1 UNII
AF73293C2R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(acetyloxy)-n,n,n-trimethylethanaminium

2. Acetilcolina Cusi

3. Acetylcholine

4. Acetylcholine Bromide

5. Acetylcholine Fluoride

6. Acetylcholine Hydroxide

7. Acetylcholine Iodide

8. Acetylcholine L Tartrate

9. Acetylcholine L-tartrate

10. Acetylcholine Perchlorate

11. Acetylcholine Picrate

12. Acetylcholine Picrate (1:1)

13. Acetylcholine Sulfate (1:1)

14. Bromide, Acetylcholine

15. Bromoacetylcholine

16. Chloroacetylcholine

17. Cusi, Acetilcolina

18. Fluoride, Acetylcholine

19. Hydroxide, Acetylcholine

20. Iodide, Acetylcholine

21. L-tartrate, Acetylcholine

22. Miochol

23. Perchlorate, Acetylcholine

2.3.2 Depositor-Supplied Synonyms

1. 60-31-1

2. Miochol

3. Acecoline

4. Ach Chloride

5. Chloroacetylcholine

6. Arterocoline

7. Acecholin

8. Ovisot

9. 2-(acetyloxy)-n,n,n-trimethylethanaminium Chloride

10. Azetylcholinchlorid

11. Acetylcholine (chloride)

12. Choline Acetate (ester) Chloride

13. Ethanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride

14. 2-acetoxyethyltrimethylammonium Chloride

15. Miochol-e

16. Acetylcholinium Chloride

17. O-acetylcholine Chloride

18. Choline, Chloride Acetate

19. Acetylcholine Hydrochloride

20. Acetylcholinechloride

21. Acetilcolina Cloruro [dcit]

22. (2-hydroxyethyl)trimethylammonium Chloride Acetate

23. Ach (chloride)

24. Acetylcholini Chloridum [inn-latin]

25. Chlorure D'acetylcholine [inn-french]

26. Cloruro De Acetilcolina [inn-spanish]

27. Tl 1505

28. Ai3-51676

29. Choline Acetate (ester), Chloride

30. Nsc-755845

31. 60-31-1 (chloride)

32. Ammonium, (2-hydroxyethyl)trimethyl-, Chloride, Acetate

33. Mls000028640

34. Chebi:2417

35. Af73293c2r

36. Acetylcholine Chloride For Injection

37. Smr000059182

38. (2-acetoxyethyl)trimethylammonium Chloride

39. 2-acetyloxy-n,n,n-trimethylethanaminium Chloride

40. Dsstox_cid_28904

41. Dsstox_rid_83172

42. Dsstox_gsid_48978

43. Acetylcholini Chloridum

44. Cas-60-31-1

45. Acetilcolina Cloruro

46. Cloruro De Acetilcolina

47. Chlorure D'acetylcholine

48. Ncgc00018123-05

49. Einecs 200-468-8

50. Vasil

51. Unii-af73293c2r

52. Ach;ach Chloride

53. Miochol (tn)

54. Mfcd00011698

55. Acetylcholine Chloride [ban:inn:jan]

56. 2-(trimethylamino)ethyl Acetate, Chloride

57. 2-acetyloxyethyl(trimethyl)azanium;chloride

58. Acetylcholine Chloride [usp:inn:ban:jan]

59. Opera_id_1682

60. Bmse000168

61. Chembl1184

62. Regid_for_cid_6060

63. Schembl40885

64. Spectrum1500104

65. Dtxsid5048978

66. Hms502c08

67. 2-(acetyloxy)-n,n,n-trimethylethanaminium Chloride (1:1)

68. Hms1920a09

69. Hms2091g09

70. Hms2230b10

71. Hms3259j11

72. Hms3371l03

73. Hms3651k19

74. Pharmakon1600-01500104

75. Acetylcholine Chloride [mi]

76. Bcp31537

77. Hy-b0282

78. Acetylcholine Chloride [inn]

79. Tox21_113435

80. Ccg-39125

81. Nsc755845

82. Acetylcholine Chloride [vandf]

83. Acetylcholine Chloride [mart.]

84. Akos005111031

85. Tox21_113435_1

86. Acetylcholine Chloride [usp-rs]

87. Acetylcholine Chloride [who-dd]

88. Nc00643

89. Nsc 755845

90. Acetylcholine Chloride (jp17/usp/inn)

91. Ncgc00018123-07

92. Ncgc00094577-01

93. Ncgc00094577-02

94. Ncgc00094577-03

95. Ds-11397

96. Acetylcholine Chloride [orange Book]

97. A0084

98. Acetylcholine Chloride [ep Monograph]

99. Acetylcholine Chloride [usp Impurity]

100. Ft-0621824

101. Ft-0661194

102. Sw220071-1

103. Acetylcholine Chloride [usp Monograph]

104. 2-acetoxy-n,n,n-trimethylethanaminium Chloride

105. C08201

106. D00999

107. D81773

108. 2-acetoxy-n,n,n-trimethylethan-1-aminium Chloride

109. Acetylcholine Chloride For Injection [jan]

110. Sr-01000003011

111. J-519537

112. Sr-01000003011-3

113. Q27105659

114. Ovisot; Tl 1505; Tl-1505; Tl-1505; Ach Chloride

115. Ethanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride (1:1)

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 181.66 g/mol
Molecular Formula C7H16ClNO2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass181.0869564 g/mol
Monoisotopic Mass181.0869564 g/mol
Topological Polar Surface Area26.3 Ų
Heavy Atom Count11
Formal Charge0
Complexity115
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameMiochol-e
PubMed HealthAcetylcholine (Into the eye)
Drug ClassesDirect Acting Miotic
Active IngredientAcetylcholine chloride
Dosage FormFor solution
RouteOphthalmic
Strength20mg/vial
Market StatusPrescription
CompanyBausch And Lomb

2 of 2  
Drug NameMiochol-e
PubMed HealthAcetylcholine (Into the eye)
Drug ClassesDirect Acting Miotic
Active IngredientAcetylcholine chloride
Dosage FormFor solution
RouteOphthalmic
Strength20mg/vial
Market StatusPrescription
CompanyBausch And Lomb

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Cholinergic Agonists

Drugs that bind to and activate cholinergic receptors. (See all compounds classified as Cholinergic Agonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cholinergic Receptor Agonist [EPC]; Cholinergic Agonists [MoA]

API Reference Price

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18-Jan-2021
10-Jun-2024
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FDF Dossiers

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Adcock Ingram

South Africa
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Adcock Ingram

South Africa
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Acetylcholine

Brand Name : Covochol

Dosage Form : OPD

Dosage Strength : 40mg

Packaging : 2X1mg

Approval Date :

Application Number :

Regulatory Info : Generic

Registration Country : South Africa

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02

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ACETYLCHOLINE CHLORIDE

Brand Name : MIOCHOL-E

Dosage Form : FOR SOLUTION;OPHTHALMIC

Dosage Strength : 20MG/VIAL

Packaging :

Approval Date : 1993-09-22

Application Number : 20213

Regulatory Info : RX

Registration Country : USA

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03

Pharma, Lab & Chemical Expo
Not Confirmed
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ACETYLCHOLINE CHLORIDE

Brand Name : MIOCHOL-E

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 20MG/VIAL

Packaging : 2ML

Approval Date :

Application Number : 2133326

Regulatory Info :

Registration Country : Canada

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Acetylcholine chloride

Brand Name : MIOCHOL-E

Dosage Form : OPI

Dosage Strength : 20mg/2ml

Packaging : 12X1mg/2ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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05

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Not Confirmed
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ACETYLCHOLINE CHLORIDE

Brand Name : MIOCHOL

Dosage Form : FOR SOLUTION;OPHTHALMIC

Dosage Strength : 20MG/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Packaging :

Approval Date : 1982-01-01

Application Number : 16211

Regulatory Info : DISCN

Registration Country : USA

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06

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acetylkolinklorid

Brand Name : Miochol-E

Dosage Form : PULVER OCH VÄTSKA TILL

Dosage Strength : 10 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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ABOUT THIS PAGE

Acetylcholine (chloride) Manufacturers

A Acetylcholine (chloride) manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acetylcholine (chloride), including repackagers and relabelers. The FDA regulates Acetylcholine (chloride) manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acetylcholine (chloride) API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Acetylcholine (chloride) manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Acetylcholine (chloride) Suppliers

A Acetylcholine (chloride) supplier is an individual or a company that provides Acetylcholine (chloride) active pharmaceutical ingredient (API) or Acetylcholine (chloride) finished formulations upon request. The Acetylcholine (chloride) suppliers may include Acetylcholine (chloride) API manufacturers, exporters, distributors and traders.

click here to find a list of Acetylcholine (chloride) suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Acetylcholine (chloride) USDMF

A Acetylcholine (chloride) DMF (Drug Master File) is a document detailing the whole manufacturing process of Acetylcholine (chloride) active pharmaceutical ingredient (API) in detail. Different forms of Acetylcholine (chloride) DMFs exist exist since differing nations have different regulations, such as Acetylcholine (chloride) USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Acetylcholine (chloride) DMF submitted to regulatory agencies in the US is known as a USDMF. Acetylcholine (chloride) USDMF includes data on Acetylcholine (chloride)'s chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Acetylcholine (chloride) USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Acetylcholine (chloride) suppliers with USDMF on PharmaCompass.

Acetylcholine (chloride) JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Acetylcholine (chloride) Drug Master File in Japan (Acetylcholine (chloride) JDMF) empowers Acetylcholine (chloride) API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Acetylcholine (chloride) JDMF during the approval evaluation for pharmaceutical products. At the time of Acetylcholine (chloride) JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Acetylcholine (chloride) suppliers with JDMF on PharmaCompass.

Acetylcholine (chloride) NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Acetylcholine (chloride) as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Acetylcholine (chloride) API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Acetylcholine (chloride) as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Acetylcholine (chloride) and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Acetylcholine (chloride) NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Acetylcholine (chloride) suppliers with NDC on PharmaCompass.

Acetylcholine (chloride) GMP

Acetylcholine (chloride) Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Acetylcholine (chloride) GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Acetylcholine (chloride) GMP manufacturer or Acetylcholine (chloride) GMP API supplier for your needs.

Acetylcholine (chloride) CoA

A Acetylcholine (chloride) CoA (Certificate of Analysis) is a formal document that attests to Acetylcholine (chloride)'s compliance with Acetylcholine (chloride) specifications and serves as a tool for batch-level quality control.

Acetylcholine (chloride) CoA mostly includes findings from lab analyses of a specific batch. For each Acetylcholine (chloride) CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Acetylcholine (chloride) may be tested according to a variety of international standards, such as European Pharmacopoeia (Acetylcholine (chloride) EP), Acetylcholine (chloride) JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acetylcholine (chloride) USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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