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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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EU WC

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4 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 60-31-1, Miochol, Acecoline, Ach chloride, Chloroacetylcholine, Arterocoline
Molecular Formula
C7H16ClNO2
Molecular Weight
181.66  g/mol
InChI Key
JUGOREOARAHOCO-UHFFFAOYSA-M
FDA UNII
AF73293C2R

 Acetylcholine Chloride
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
1 2D Structure

 Acetylcholine Chloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-acetyloxyethyl(trimethyl)azanium;chloride
2.1.2 InChI
InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
2.1.3 InChI Key
JUGOREOARAHOCO-UHFFFAOYSA-M
2.1.4 Canonical SMILES
CC(=O)OCC[N+](C)(C)C.[Cl-]
2.2 Other Identifiers
2.2.1 UNII
AF73293C2R
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-(acetyloxy)-n,n,n-trimethylethanaminium

2. Acetilcolina Cusi

3. Acetylcholine

4. Acetylcholine Bromide

5. Acetylcholine Fluoride

6. Acetylcholine Hydroxide

7. Acetylcholine Iodide

8. Acetylcholine L Tartrate

9. Acetylcholine L-tartrate

10. Acetylcholine Perchlorate

11. Acetylcholine Picrate

12. Acetylcholine Picrate (1:1)

13. Acetylcholine Sulfate (1:1)

14. Bromide, Acetylcholine

15. Bromoacetylcholine

16. Chloroacetylcholine

17. Cusi, Acetilcolina

18. Fluoride, Acetylcholine

19. Hydroxide, Acetylcholine

20. Iodide, Acetylcholine

21. L-tartrate, Acetylcholine

22. Miochol

23. Perchlorate, Acetylcholine

2.3.2 Depositor-Supplied Synonyms

1. 60-31-1

2. Miochol

3. Acecoline

4. Ach Chloride

5. Chloroacetylcholine

6. Arterocoline

7. Acecholin

8. Ovisot

9. 2-(acetyloxy)-n,n,n-trimethylethanaminium Chloride

10. Azetylcholinchlorid

11. Acetylcholine (chloride)

12. Choline Acetate (ester) Chloride

13. Ethanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride

14. 2-acetoxyethyltrimethylammonium Chloride

15. Miochol-e

16. Acetylcholinium Chloride

17. O-acetylcholine Chloride

18. Choline, Chloride Acetate

19. Acetylcholine Hydrochloride

20. Acetylcholinechloride

21. Acetilcolina Cloruro [dcit]

22. (2-hydroxyethyl)trimethylammonium Chloride Acetate

23. Ach (chloride)

24. Acetylcholini Chloridum [inn-latin]

25. Chlorure D'acetylcholine [inn-french]

26. Cloruro De Acetilcolina [inn-spanish]

27. Tl 1505

28. Ai3-51676

29. Choline Acetate (ester), Chloride

30. Nsc-755845

31. 60-31-1 (chloride)

32. Ammonium, (2-hydroxyethyl)trimethyl-, Chloride, Acetate

33. Mls000028640

34. Chebi:2417

35. Af73293c2r

36. Acetylcholine Chloride For Injection

37. Smr000059182

38. (2-acetoxyethyl)trimethylammonium Chloride

39. 2-acetyloxy-n,n,n-trimethylethanaminium Chloride

40. Dsstox_cid_28904

41. Dsstox_rid_83172

42. Dsstox_gsid_48978

43. Acetylcholini Chloridum

44. Cas-60-31-1

45. Acetilcolina Cloruro

46. Cloruro De Acetilcolina

47. Chlorure D'acetylcholine

48. Ncgc00018123-05

49. Einecs 200-468-8

50. Vasil

51. Unii-af73293c2r

52. Ach;ach Chloride

53. Miochol (tn)

54. Mfcd00011698

55. Acetylcholine Chloride [ban:inn:jan]

56. 2-(trimethylamino)ethyl Acetate, Chloride

57. 2-acetyloxyethyl(trimethyl)azanium;chloride

58. Acetylcholine Chloride [usp:inn:ban:jan]

59. Opera_id_1682

60. Bmse000168

61. Chembl1184

62. Regid_for_cid_6060

63. Schembl40885

64. Spectrum1500104

65. Dtxsid5048978

66. Hms502c08

67. 2-(acetyloxy)-n,n,n-trimethylethanaminium Chloride (1:1)

68. Hms1920a09

69. Hms2091g09

70. Hms2230b10

71. Hms3259j11

72. Hms3371l03

73. Hms3651k19

74. Pharmakon1600-01500104

75. Acetylcholine Chloride [mi]

76. Bcp31537

77. Hy-b0282

78. Acetylcholine Chloride [inn]

79. Tox21_113435

80. Ccg-39125

81. Nsc755845

82. Acetylcholine Chloride [vandf]

83. Acetylcholine Chloride [mart.]

84. Akos005111031

85. Tox21_113435_1

86. Acetylcholine Chloride [usp-rs]

87. Acetylcholine Chloride [who-dd]

88. Nc00643

89. Nsc 755845

90. Acetylcholine Chloride (jp17/usp/inn)

91. Ncgc00018123-07

92. Ncgc00094577-01

93. Ncgc00094577-02

94. Ncgc00094577-03

95. Ds-11397

96. Acetylcholine Chloride [orange Book]

97. A0084

98. Acetylcholine Chloride [ep Monograph]

99. Acetylcholine Chloride [usp Impurity]

100. Ft-0621824

101. Ft-0661194

102. Sw220071-1

103. Acetylcholine Chloride [usp Monograph]

104. 2-acetoxy-n,n,n-trimethylethanaminium Chloride

105. C08201

106. D00999

107. D81773

108. 2-acetoxy-n,n,n-trimethylethan-1-aminium Chloride

109. Acetylcholine Chloride For Injection [jan]

110. Sr-01000003011

111. J-519537

112. Sr-01000003011-3

113. Q27105659

114. Ovisot; Tl 1505; Tl-1505; Tl-1505; Ach Chloride

115. Ethanaminium, 2-(acetyloxy)-n,n,n-trimethyl-, Chloride (1:1)

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 181.66 g/mol
Molecular Formula C7H16ClNO2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass181.0869564 g/mol
Monoisotopic Mass181.0869564 g/mol
Topological Polar Surface Area26.3 Ų
Heavy Atom Count11
Formal Charge0
Complexity115
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameMiochol-e
PubMed HealthAcetylcholine (Into the eye)
Drug ClassesDirect Acting Miotic
Active IngredientAcetylcholine chloride
Dosage FormFor solution
RouteOphthalmic
Strength20mg/vial
Market StatusPrescription
CompanyBausch And Lomb

2 of 2  
Drug NameMiochol-e
PubMed HealthAcetylcholine (Into the eye)
Drug ClassesDirect Acting Miotic
Active IngredientAcetylcholine chloride
Dosage FormFor solution
RouteOphthalmic
Strength20mg/vial
Market StatusPrescription
CompanyBausch And Lomb

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Cholinergic Agonists

Drugs that bind to and activate cholinergic receptors. (See all compounds classified as Cholinergic Agonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Cholinergic Receptor Agonist [EPC]; Cholinergic Agonists [MoA]

API SUPPLIERS

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Siegfried AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east
Not Confirmed
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Siegfried AG

Switzerland

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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CPHI Middle east
Not Confirmed
USDMF Inactive-api CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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02

SIGMA TAU

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east
Not Confirmed
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SIGMA TAU

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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CPHI Middle east
Not Confirmed
USDMF Inactive-api CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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03

Tokyo Chemical Industry

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east
Not Confirmed
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Tokyo Chemical Industry

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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CPHI Middle east
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USDMF CEP/COS JDMF arrow-down EU-WC NDC KDMF VMF Others AUDIT
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Loba chemie

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPHI Middle east
Not Confirmed
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Loba chemie

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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CPHI Middle east
Not Confirmed
USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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USDMF

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Siegfried Ltd

Switzerland

USDMF

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Medlab Asia & Asia Health
Not Confirmed

01

Siegfried Ltd

Switzerland
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Medlab Asia & Asia Health
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 6095

Submission : 1985-11-01

Status : Inactive

Type : II

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02

Sigma F And D Div Ltd

U.S.A

USDMF

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Medlab Asia & Asia Health
Not Confirmed

02

Medlab Asia & Asia Health
Not Confirmed

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 7221

Submission : 1987-10-13

Status : Inactive

Type : II

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JDMF

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CPHI Middle east
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CPHI Middle east
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Acetylcholine chloride

Registration Number : 217MF11159

Registrant's Address : 6-15-9 Toshima, Kita-ku, Tokyo

Initial Date of Registration : 2005-12-12

Latest Date of Registration : 2006-10-20

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API Reference Price

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[{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1673548200,"product":"ACETYLCHOLINE CHLORIDE (QTY: 2 X 200 MG, VALUE: USD 265\/EACH)(FOC)","address":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,","city":"TURKAPALLY-V SHAMIRPET HYDERABAD,TE","supplier":"USP","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.0004","unit":"KGS","unitRateFc":"1325000","totalValueFC":"657.2","currency":"USD","unitRateINR":"134330650","date":"13-Jan-2023","totalValueINR":"53732.26","totalValueInUsd":"657.2","indian_port":"HYDERABAD AIR","hs_no":"29239000","bill_no":"4175934","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"P.NO. D6 & D8, SY.NO. 234\/2,234\/3, ,235\/2 & 542\/2, IKP KNOWLEDGE PARK,"}]
13-Jan-2023
13-Jan-2023
KGS
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Quantity (KGS) & Unit rate (USD/KGS) over time

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FDA Orange Book

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01

CPHI Middle east
Not Confirmed
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CPHI Middle east
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ACETYLCHOLINE CHLORIDE

Brand Name : MIOCHOL-E

Dosage Form : FOR SOLUTION;OPHTHALMIC

Dosage Strength : 20MG/VIAL

Approval Date : 1993-09-22

Application Number : 20213

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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02

NOVARTIS

Switzerland
CPHI Middle east
Not Confirmed
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NOVARTIS

Switzerland
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CPHI Middle east
Not Confirmed

ACETYLCHOLINE CHLORIDE

Brand Name : MIOCHOL

Dosage Form : FOR SOLUTION;OPHTHALMIC

Dosage Strength : 20MG/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

Approval Date : 1982-01-01

Application Number : 16211

RX/OTC/DISCN : DISCN

RLD : Yes

TE Code :

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Europe

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Dr Gerhard Mann, Chem-Pharm

Country
CPHI Middle east
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Dr Gerhard Mann, Chem-Pharm

Country
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CPHI Middle east
Not Confirmed

acetylkolinklorid

Brand Name : Miochol-E

Dosage Form : PULVER OCH VÄTSKA TILL

Dosage Strength : 10 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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