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Chemistry

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Also known as: 51037-30-0, Olbetam, 5-carboxy-2-methylpyrazine 1-oxide, Olbemox, 5-methylpyrazine-2-carboxylic acid 4-oxide, 5-methylpyrazinecarboxylic acid 4-oxide
Molecular Formula
C6H6N2O3
Molecular Weight
154.12  g/mol
InChI Key
DJQOOSBJCLSSEY-UHFFFAOYSA-N
FDA UNII
K9AY9IR2SD

Acipimox
Acipimox is a niacin derivative and nicotinic acid analog with activity as a hypolipidemic agent. Acipimox has special application for the treatment of hyperlipidemia in non-insulin-dependent diabetic patients.
1 2D Structure

Acipimox

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-methyl-4-oxidopyrazin-4-ium-2-carboxylic acid
2.1.2 InChI
InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
2.1.3 InChI Key
DJQOOSBJCLSSEY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CN=C(C=[N+]1[O-])C(=O)O
2.2 Other Identifiers
2.2.1 UNII
K9AY9IR2SD
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-methylpyrazine-2-carboxylic Acid 4-oxide

2. 5-methylpyrazinecarboxylic Acid 4-oxide

3. Nedios

4. Olbemox

5. Olbetam

2.3.2 Depositor-Supplied Synonyms

1. 51037-30-0

2. Olbetam

3. 5-carboxy-2-methylpyrazine 1-oxide

4. Olbemox

5. 5-methylpyrazine-2-carboxylic Acid 4-oxide

6. 5-methylpyrazinecarboxylic Acid 4-oxide

7. 5-methyl-4-oxidopyrazin-4-ium-2-carboxylic Acid

8. 2-carboxy-5-methylpyrazine 4-oxide

9. K-9321

10. Nsc-759818

11. Chembl345714

12. Ncgc00160519-01

13. Dsstox_cid_26202

14. Dsstox_rid_81433

15. 5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic Acid

16. Dsstox_gsid_46202

17. Cas-51037-30-0

18. Sr-05000001505

19. 5-methyl-2-pyrazinecarboxylic Acid 4-oxide

20. Acipimox-[d4]

21. Mfcd00865757

22. Acipimox (inn/ban)

23. Acipimox [inn]

24. Acipimox [mi]

25. Pyrazinecarboxylic Acid, 5-methyl-, 4-oxide

26. Acipimox [mart.]

27. K9ay9ir2sd

28. Acipimox [who-dd]

29. Schembl48922

30. Gtpl1596

31. Dtxsid2046202

32. Chebi:94688

33. Hms2090g05

34. Hms3655a14

35. Hms3713l18

36. Pharmakon1600-01504831

37. 5-carboxy-2-methylpyrazine1-oxide

38. Bcp28412

39. Hy-b0283

40. Zinc1481960

41. Tox21_111868

42. Tox21_112498

43. Tox21_112805

44. Ac-009

45. Bbl009924

46. Bdbm50208130

47. Nsc759818

48. S1806

49. Stk711089

50. 2-carboxy-5-methyl-pyrazine-4-oxide

51. Akos005530658

52. Ccg-213957

53. Db09055

54. Mb01535

55. 4-oxo-5-methyl-2-pyrazinecarboxylicacid

56. Ncgc00160519-02

57. Ncgc00160519-03

58. As-15565

59. Ba166874

60. 5-methyl-4-oxy-pyrazine-2-carboxylic Acid

61. Ft-0601589

62. M2053

63. Sw199084-2

64. D07190

65. Ab01274727-01

66. Ab01274727-02

67. Ab01274727_03

68. Ab01274727_04

69. K-9321;olbemox;olbetam; K9321; K 9321

70. A828409

71. 5-methyl-4-oxide-2-pyrazinecarboxylic Acid

72. 5-methylpyrazine-2-carboxylic Acid-4-oxide

73. Q2342544

74. Sr-05000001505-1

75. Sr-05000001505-2

76. W-105921

77. Brd-k63736853-001-01-4

2.4 Create Date
2005-12-16
3 Chemical and Physical Properties
Molecular Weight 154.12 g/mol
Molecular Formula C6H6N2O3
XLogP3-1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass154.03784206 g/mol
Monoisotopic Mass154.03784206 g/mol
Topological Polar Surface Area75.6 Ų
Heavy Atom Count11
Formal Charge0
Complexity162
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Used in the treatment of hyperlipidemias (abnormally elevated levels of any or all lipids and/or lipoproteins in the blood).


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Hypolipidemic Agents

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)


5.2 ATC Code

C10AD06

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


C - Cardiovascular system

C10 - Lipid modifying agents

C10A - Lipid modifying agents, plain

C10AD - Nicotinic acid and derivatives

C10AD06 - Acipimox


5.3 Mechanism of Action

Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL.


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ABOUT THIS PAGE

Acipimox Manufacturers

A Acipimox manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acipimox, including repackagers and relabelers. The FDA regulates Acipimox manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acipimox API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Acipimox manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Acipimox Suppliers

A Acipimox supplier is an individual or a company that provides Acipimox active pharmaceutical ingredient (API) or Acipimox finished formulations upon request. The Acipimox suppliers may include Acipimox API manufacturers, exporters, distributors and traders.

click here to find a list of Acipimox suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Acipimox GMP

Acipimox Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Acipimox GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Acipimox GMP manufacturer or Acipimox GMP API supplier for your needs.

Acipimox CoA

A Acipimox CoA (Certificate of Analysis) is a formal document that attests to Acipimox's compliance with Acipimox specifications and serves as a tool for batch-level quality control.

Acipimox CoA mostly includes findings from lab analyses of a specific batch. For each Acipimox CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Acipimox may be tested according to a variety of international standards, such as European Pharmacopoeia (Acipimox EP), Acipimox JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acipimox USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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