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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

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API

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

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FDF Dossiers

FDF Dossiers

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

DIGITAL CONTENT

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Data Compilation #PharmaFlow

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Stock Recap #PipelineProspector

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Weekly News Recap #Phispers

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News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

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Annual Reports

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Finished Drug Prices

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0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 42228-92-2, Antibiotic at 125, At-125, Acivicine, At 125, Acivicino
Molecular Formula
C5H7ClN2O3
Molecular Weight
178.57  g/mol
InChI Key
QAWIHIJWNYOLBE-OKKQSCSOSA-N
FDA UNII
O0X60K76I6

Acivicin
Acivicin is a modified amino acid and structural analog of glutamine. Acivicin inhibits glutamine amidotransferases in the purine and pyrimidine biosynthetic pathways, thereby inhibiting tumor growth in cell lines dependent on glutamine metabolism. (NCI04)
1 2D Structure

Acivicin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S)-2-amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
2.1.2 InChI
InChI=1S/C5H7ClN2O3/c6-3-1-2(11-8-3)4(7)5(9)10/h2,4H,1,7H2,(H,9,10)/t2-,4-/m0/s1
2.1.3 InChI Key
QAWIHIJWNYOLBE-OKKQSCSOSA-N
2.1.4 Canonical SMILES
C1C(ON=C1Cl)C(C(=O)O)N
2.1.5 Isomeric SMILES
C1[C@H](ON=C1Cl)[C@@H](C(=O)O)N
2.2 Other Identifiers
2.2.1 UNII
O0X60K76I6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid

2. Alpha-s,5s-alpha-amino-3-chloro-2-isoxazoline-5-acetic Acid

3. At 125

4. At-125

5. L-(alphas,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid

6. Nsc 163501

7. U 42,126

8. U-42,126

2.3.2 Depositor-Supplied Synonyms

1. 42228-92-2

2. Antibiotic At 125

3. At-125

4. Acivicine

5. At 125

6. Acivicino

7. Acivicinum

8. Nsc-163501

9. Acia

10. Nsc 163501

11. U 42126

12. U-42,126

13. Nsc163501

14. (2s)-2-amino-2-[(5s)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic Acid

15. U-42126

16. U 42,126

17. (alphas,5s)-alpha-amino-3-chloro-2-isoxazoline-5-acetic Acid

18. Chebi:74545

19. (s)-2-amino-2-((s)-3-chloro-4,5-dihydroisoxazol-5-yl)acetic Acid

20. O0x60k76i6

21. (alpha-s,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid

22. (2s)-amino[(5s)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]ethanoic Acid

23. Acivicin [usan:inn]

24. Acivicine [inn-french]

25. Acivicinum [inn-latin]

26. Acivicino [inn-spanish]

27. Unii-o0x60k76i6

28. Ncgc00095996-01

29. Brn 1074648

30. Spectrum_000343

31. Acivicin [usan]

32. Acivicin (usan/inn)

33. Acivicin [inn]

34. Spectrum3_001857

35. Spectrum4_000902

36. Spectrum5_001706

37. Acivicin [mart.]

38. Acivicin [who-dd]

39. Ncimech_000028

40. Schembl4159

41. Dsstox_cid_26010

42. Dsstox_rid_81286

43. Dsstox_gsid_46010

44. Bspbio_003274

45. Kbiogr_001364

46. Kbioss_000823

47. Divk1c_000672

48. Spectrum1502002

49. Acivicin, >=98% (hplc)

50. Chembl1231101

51. Dtxsid0046010

52. Gtpl11402

53. Hms502b14

54. Kbio1_000672

55. Kbio2_000823

56. Kbio2_003391

57. Kbio2_005959

58. Kbio3_002775

59. Ninds_000672

60. At125

61. Zinc3871381

62. Tox21_111545

63. (2s)-amino[(5s)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic Acid

64. (alphas,5s)-alpha-amino-3-chlor-4,5-dihydro-5-isoxazolylessigsaeure

65. (s-(r*,r*))-4,5-dihydro-alpha-amino-3-chloro-5-isoxazoleacetic Acid

66. Ccg-35436

67. Mfcd00866432

68. Akos027327575

69. Cs-w017302

70. Hy-w016586

71. Idi1_000672

72. Ncgc00178172-01

73. As-56028

74. Nci60_001241

75. Cas-42228-92-2

76. D02755

77. A825818

78. Q4674217

79. 5-isoxazoleacetic Acid,5-dihydro-, [s-(r*,r*)]-

80. Brd-k11632748-001-02-5

81. Alphas-amino-3-chloro-4,5s-dihydro-5-isoxazoleacetic Acid

82. (2s)-amino[(5s)-3-chloro-4,5-dihydroisoxazol-5-yl]ethanoic Acid

83. (s)-2-amino-2-((s)-3-chloro-4,5-dihydroisoxazol-5-yl)aceticacid

84. (.alpha.s,5s)-.alpha.-amino-3-chloro-2-isoxazoline-5-acetic Acid

85. (2s)-2-amino-2-[(5s)-3-chloro-4,5-dihydroisoxazol-5-yl]acetic Acid

86. (alphas,5s)-alpha-amino-3-chloro- 4,5-dihydro-5-isoxazol-acetic Acid

87. (alphas,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazol-acetic Acid

88. (alphas,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazole Acetic Acid

89. (alphas,5s)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid

90. .alpha.-amino-3-chloro-4,5-dihydro-[s-(r*,r*)]-5-isoxazoleacetatic Acid

91. 5-isoxazoleacetic Acid, Alpha-amino-3-chloro-4,5-dihydro-, (s-(r*,r*))-

92. 5-isoxazoleacetic Acid, .alpha.-amino-3-chloro-4,5-dihydro-, (s-(r*,r*))-

93. 5-isoxazoleacetic Acid, 4,5-dihydro-alpha-amino-3-chloro-, (s-(r*,r*))-

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 178.57 g/mol
Molecular Formula C5H7ClN2O3
XLogP3-2.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass178.0145198 g/mol
Monoisotopic Mass178.0145198 g/mol
Topological Polar Surface Area84.9 Ų
Heavy Atom Count11
Formal Charge0
Complexity206
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antimetabolites

Drugs that are chemically similar to naturally occurring metabolites, but differ enough to interfere with normal metabolic pathways. (From AMA Drug Evaluations Annual, 1994, p2033) (See all compounds classified as Antimetabolites.)


Antibiotics, Antineoplastic

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. (See all compounds classified as Antibiotics, Antineoplastic.)


Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


Antimetabolites, Antineoplastic

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)


ABOUT THIS PAGE

Acivicin Manufacturers

A Acivicin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Acivicin, including repackagers and relabelers. The FDA regulates Acivicin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Acivicin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Acivicin Suppliers

A Acivicin supplier is an individual or a company that provides Acivicin active pharmaceutical ingredient (API) or Acivicin finished formulations upon request. The Acivicin suppliers may include Acivicin API manufacturers, exporters, distributors and traders.

click here to find a list of Acivicin suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Acivicin USDMF

A Acivicin DMF (Drug Master File) is a document detailing the whole manufacturing process of Acivicin active pharmaceutical ingredient (API) in detail. Different forms of Acivicin DMFs exist exist since differing nations have different regulations, such as Acivicin USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Acivicin DMF submitted to regulatory agencies in the US is known as a USDMF. Acivicin USDMF includes data on Acivicin's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Acivicin USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Acivicin suppliers with USDMF on PharmaCompass.

Acivicin GMP

Acivicin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Acivicin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Acivicin GMP manufacturer or Acivicin GMP API supplier for your needs.

Acivicin CoA

A Acivicin CoA (Certificate of Analysis) is a formal document that attests to Acivicin's compliance with Acivicin specifications and serves as a tool for batch-level quality control.

Acivicin CoA mostly includes findings from lab analyses of a specific batch. For each Acivicin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Acivicin may be tested according to a variety of international standards, such as European Pharmacopoeia (Acivicin EP), Acivicin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Acivicin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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