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12 API Suppliers, 4 USDMF, 1 JDMF, 1 EU WC, 1 KDMF, 2 NDC API, 10 Listed Suppliers

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2 FDA Orange Book
12 Europe
2 Canada
1 Australia

DRUG PRODUCT COMPOSITIONS

POWDER, METERED;INHALATION - 0.4MG/INH, POWDER, METERED;INHALATION - 0.4MG/INH;0.012MG/INH

drugProductComposition
POWDER, METERED;INHALATION - 0.4MG/INH
POWDER, METERED;INHALATION - 0.4MG/INH;0.012MG/INH

RELATED EXCIPIENT COMPANIES

1 Faran Shimi Pharmaceutical, 3 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 2 DFE Pharma, 14 Kerry, 2 Microlex e.U, 1 Pluviaendo, 2 Sigachi Industries

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1 Faran Shimi Pharmaceutical
3 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
2 DFE Pharma
14 Kerry
2 Microlex e.U
1 Pluviaendo
2 Sigachi Industries

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7 Direct Compression
4 Co-Processed Excipients
4 Granulation
1 Parenteral

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 10 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
10 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 10 Finished Drug Prices, 10 Annual Reports

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1 US Medicaid Prescriptions
10 Finished Drug Prices
10 Annual Reports

MARKET PLACE

2 APIs

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2 APIs

PATENTS & EXCLUSIVITIES

8 US Patents, 3 Health Canada Patents

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8 US Patents
3 Health Canada Patents

Inke Aclidinium Bromide

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

$ 0

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API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

14,524,862

Annual Reports (USD Million)

744

Finished Drug Prices

26 RELATED EXCIPIENT COMPANIES

36EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 320345-99-1, Genuair, Tudorza pressair, Aclidinium (bromide), Las 34273, Las-w-330

Molecular Formula

C₂₆H₃₀BrNO₄S₂

Molecular Weight

564.6 g/mol

InChI Key

XLAKJQPTOJHYDR-QTQXQZBYSA-M

FDA UNII

UQW7UF9N91

1 2D Structure

Aclidinium Bromide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(3R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide

2.1.2 InChI

InChI=1S/C26H30NO4S2.BrH/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21;/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2;1H/q+1;/p-1/t20?,22-,27?;/m0./s1

2.1.3 InChI Key

XLAKJQPTOJHYDR-QTQXQZBYSA-M

2.1.4 Canonical SMILES

C1C[N+]2(CCC1C(C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-]

2.1.5 Isomeric SMILES

C1C[N+]2(CCC1[C@H](C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5.[Br-]

2.2 Other Identifiers

2.2.1 UNII

UQW7UF9N91

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (3r)-3-((hydroxy(di-2-thienyl)acetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane Bromide

2.3.2 Depositor-Supplied Synonyms

1. 320345-99-1

2. Genuair

3. Tudorza Pressair

4. Aclidinium (bromide)

5. Las 34273

6. Las-w-330

7. Las-34273

8. Las W-330

9. Las-34273 Micronized

10. Uqw7uf9n91

11. Chebi:65344

12. (3r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

13. (3r)-3-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium Bromide

14. (r)-3-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium Bromide

15. Bretaris

16. Eklira

17. Chembl551466

18. (3r)-3-((hydroxydi(thiophen-2-yl)acetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane Bromide

19. [(8r)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-8-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate Bromide

20. 1-azoniabicyclo(2.2.2)octane, 3-((hydroxydi-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-, Bromide, (3r)-

21. Unii-uqw7uf9n91

22. Aclidinium Bromide [usan]

23. Aclidinium Bromide [usan:inn]

24. Eklira Genuair (tn)

25. Tudorza Pressair (tn)

26. (3r)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

27. Schembl72694

28. Krp-ab1102

29. Aclidinium Bromide [mi]

30. Aclidinium Bromide [inn]

31. Aclidinium Bromide [jan]

32. Las 34273 Micronized

33. Las-w 330

34. Dtxsid30185854

35. Aclidinium Bromide [vandf]

36. Hms3885c20

37. Aclidinium Bromide [mart.]

38. Aclidinium Bromide [who-dd]

39. Aclidinium Bromide (jan/usan/inn)

40. Mfcd09954105

41. S4031

42. Akos016010522

43. Ccg-270072

44. Cs-0896

45. Aclidinium Bromide [orange Book]

46. Ac-23963

47. Bs-16987

48. Hy-14144

49. Sw219176-1

50. D08837

51. D81774

52. Duaklir Pressair Component Aclidinium Bromide

53. J-018606

54. Q27888207

55. Aclidinium Bromide Component Of Duaklir Pressair

56. (3r)-3-((2-hydroxy-2,2-di-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-1-azoniabicyclo(2.2.2)octane Bromide (1:1)

57. (3r)-3-[2-hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

58. [(3r)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-3-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate;bromide

59. 1-azoniabicyclo(2.2.2)octane, 3-((2-hydroxy-2,2-di-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-, Bromide (1:1), (3r)-

60. 3(r)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide

2.4 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₃₀BrNO₄S₂
Molecular Weight	564.6 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	10
Exact Mass	563.07996 g/mol
Monoisotopic Mass	563.07996 g/mol
Topological Polar Surface Area	112 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	647
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Tudorza pressair
PubMed Health	Aclidinium (By breathing)
Drug Classes	Bronchodilator, Respiratory Agent
Drug Label	TUDORZA PRESSAIR consists of a dry powder formulation of aclidinium bromide for oral inhalation only.Aclidinium bromide, the active component of TUDORZA PRESSAIR is an anticholinergic with specificity for muscarinic receptors. Aclidinium bromide is a...
Active Ingredient	Aclidinium bromide
Dosage Form	Powder, metered
Route	Inhalation
Strength	0.375mg/inh
Market Status	Prescription
Company	Forest Labs

2 of 2
Drug Name	Tudorza pressair
PubMed Health	Aclidinium (By breathing)
Drug Classes	Bronchodilator, Respiratory Agent
Drug Label	TUDORZA PRESSAIR consists of a dry powder formulation of aclidinium bromide for oral inhalation only.Aclidinium bromide, the active component of TUDORZA PRESSAIR is an anticholinergic with specificity for muscarinic receptors. Aclidinium bromide is a...
Active Ingredient	Aclidinium bromide
Dosage Form	Powder, metered
Route	Inhalation
Strength	0.375mg/inh
Market Status	Prescription
Company	Forest Labs

4.2 Drug Indication

Eklira Genuair is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).

Bretaris Genuair is indicated as a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD).

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

Cholinergic Antagonists [MoA]; Anticholinergic [EPC]

5.2 ATC Code

R03BB

R03AL05

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

R - Respiratory system

R03 - Drugs for obstructive airway diseases

R03B - Other drugs for obstructive airway diseases, inhalants

R03BB - Anticholinergics

R03BB05 - Aclidinium bromide

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