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Chemistry

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Also known as: Aconiazide, Ncgc00160674-01, {2-[(e)-(isonicotinoylhydrazono)methyl]phenoxy}acetic acid, Aconiazide [inn], 8okq9ns8mo, 13410-86-1
Molecular Formula
C15H13N3O4
Molecular Weight
299.28  g/mol
InChI Key
MDFXJBQEWLCGHP-RQZCQDPDSA-N
FDA UNII
8OKQ9NS8MO

Aconiazide
Aconiazide is a hydrazone derivative of isoniazid, used in the treatment and prophylaxis of tuberculosis.
1 2D Structure

Aconiazide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[2-[(E)-(pyridine-4-carbonylhydrazinylidene)methyl]phenoxy]acetic acid
2.1.2 InChI
InChI=1S/C15H13N3O4/c19-14(20)10-22-13-4-2-1-3-12(13)9-17-18-15(21)11-5-7-16-8-6-11/h1-9H,10H2,(H,18,21)(H,19,20)/b17-9+
2.1.3 InChI Key
MDFXJBQEWLCGHP-RQZCQDPDSA-N
2.1.4 Canonical SMILES
C1=CC=C(C(=C1)C=NNC(=O)C2=CC=NC=C2)OCC(=O)O
2.1.5 Isomeric SMILES
C1=CC=C(C(=C1)/C=N/NC(=O)C2=CC=NC=C2)OCC(=O)O
2.2 Other Identifiers
2.2.1 UNII
8OKQ9NS8MO
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-formylphenoxyacetic Acid Isonicotinylhydrazone

2. Aconiazide

2.3.2 Depositor-Supplied Synonyms

1. Aconiazide

2. Ncgc00160674-01

3. {2-[(e)-(isonicotinoylhydrazono)methyl]phenoxy}acetic Acid

4. Aconiazide [inn]

5. 8okq9ns8mo

6. 13410-86-1

7. Aconiazide [mart.]

8. Dsstox_cid_26292

9. Dsstox_rid_81518

10. Dsstox_gsid_46292

11. Schembl635283

12. Chembl1590674

13. Dtxsid8046292

14. Tox21_111977

15. Stk181710

16. Akos001031966

17. Cas-13410-86-1

18. Sr-01000872617

19. Sr-01000872617-2

20. Isonicotinic Acid (2-(carboxymethoxy)benzylidene)hydrazide

21. 2-(2-{[2-(4-pyridylcarbonyl)hydrazinylidene]methyl}phenoxy)acetic Acid

22. (2-{(e)-[2-(pyridin-4-ylcarbonyl)hydrazinylidene]methyl}phenoxy)acetic Acid

2.4 Create Date
2006-04-28
3 Chemical and Physical Properties
Molecular Weight 299.28 g/mol
Molecular Formula C15H13N3O4
XLogP31.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass299.09060590 g/mol
Monoisotopic Mass299.09060590 g/mol
Topological Polar Surface Area101 Ų
Heavy Atom Count22
Formal Charge0
Complexity408
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antitubercular Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)


ABOUT THIS PAGE

Aconiazide Manufacturers

A Aconiazide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Aconiazide, including repackagers and relabelers. The FDA regulates Aconiazide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Aconiazide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Aconiazide Suppliers

A Aconiazide supplier is an individual or a company that provides Aconiazide active pharmaceutical ingredient (API) or Aconiazide finished formulations upon request. The Aconiazide suppliers may include Aconiazide API manufacturers, exporters, distributors and traders.

click here to find a list of Aconiazide suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Aconiazide USDMF

A Aconiazide DMF (Drug Master File) is a document detailing the whole manufacturing process of Aconiazide active pharmaceutical ingredient (API) in detail. Different forms of Aconiazide DMFs exist exist since differing nations have different regulations, such as Aconiazide USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Aconiazide DMF submitted to regulatory agencies in the US is known as a USDMF. Aconiazide USDMF includes data on Aconiazide's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Aconiazide USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Aconiazide suppliers with USDMF on PharmaCompass.

Aconiazide GMP

Aconiazide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Aconiazide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Aconiazide GMP manufacturer or Aconiazide GMP API supplier for your needs.

Aconiazide CoA

A Aconiazide CoA (Certificate of Analysis) is a formal document that attests to Aconiazide's compliance with Aconiazide specifications and serves as a tool for batch-level quality control.

Aconiazide CoA mostly includes findings from lab analyses of a specific batch. For each Aconiazide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Aconiazide may be tested according to a variety of international standards, such as European Pharmacopoeia (Aconiazide EP), Aconiazide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Aconiazide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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