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Chemistry

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Also known as: 112529-15-4, Pioglitazone hcl, Actos, Piomed, 5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride, U-72107a
Molecular Formula
C19H21ClN2O3S
Molecular Weight
392.9  g/mol
InChI Key
GHUUBYQTCDQWRA-UHFFFAOYSA-N
FDA UNII
JQT35NPK6C

Pioglitazone Hydrochloride
A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
1 2D Structure

Pioglitazone Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride
2.1.2 InChI
InChI=1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H
2.1.3 InChI Key
GHUUBYQTCDQWRA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl
2.2 Other Identifiers
2.2.1 UNII
JQT35NPK6C
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione

2. Actos

3. Ad 4833

4. Ad-4833

5. Ad4833

6. Pioglitazone

7. U 72107a

8. U-72107a

9. U72,107a

10. U72107a

2.3.2 Depositor-Supplied Synonyms

1. 112529-15-4

2. Pioglitazone Hcl

3. Actos

4. Piomed

5. 5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione Hydrochloride

6. U-72107a

7. Pioglitazone (hydrochloride)

8. Ad 4833

9. U 72107a

10. Jqt35npk6c

11. U-72107e

12. Pioglitazone (as Hydrochloride)

13. Str-001

14. [5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] Thiazolidinedione Hydrochloride

15. Nsc-758876

16. Ncgc00095131-01

17. Pioditazone Hydrochloride

18. 5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione Hydrochloride

19. Actos (tn)

20. Dsstox_cid_24203

21. Dsstox_rid_80116

22. Dsstox_gsid_44203

23. 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrochloride

24. 2,4-thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-, Monohydrochloride

25. Smr000469167

26. Cas-112529-15-4

27. Pioglitazone Hydrochloride [usan]

28. Unii-jqt35npk6c

29. 5-(4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl)-thiazolidine-2,4-dione Hydrochloride

30. 5-[4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl]-thiazolidine-2,4-dione Hydrochloride

31. 5-{4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl}-thiazolidine-2,4-dione Hydrochloride

32. 2,4-thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-, Monohydrochloride

33. Mfcd04975446

34. Poze

35. Pioglitazone Hydrochloride [usan:usp]

36. Pioglitazone Cloridrato

37. Pioglitazonehydrochloride

38. Cloridrato De Pioglitazona

39. Pioglitazone, Hydrochloride

40. Clorhidrato De Pioglitazona

41. Chlorhydrate De Pioglitazone

42. (+-)-5-(p-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione Monohydrochloride

43. 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione Monohydrochloride

44. Chembl1715

45. Schembl21843

46. Mls001306462

47. Mls001401386

48. Spectrum1504401

49. Chebi:8229

50. Dtxsid3044203

51. Pioglitazone Hcl [vandf]

52. Pioglitazone Hydrochloride ,(s)

53. Pioglitazone Hydrochloride- Bio-x

54. Hms1922l05

55. Pioglitazone Hydrochloride (actos)

56. Act04238

57. Bcp22942

58. Tox21_111440

59. Tox21_300584

60. Ccg-39097

61. S2046

62. Akos015844016

63. Tox21_111440_1

64. Ac-1037

65. Ccg-100931

66. Ks-1186

67. Nc00181

68. Nsc 758876

69. Pioglitazone Hydrochloride (jp17/usp)

70. Pioglitazone Hydrochloride [mi]

71. Sb17324

72. Pioglitazone Hydrochloride [jan]

73. Ncgc00095131-02

74. Ncgc00163128-08

75. Ncgc00254492-01

76. 2,4-thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-, Monohydrochloride, (+-)-

77. Aa-10090

78. Bp164272

79. Hy-14601

80. Pioglitazone Hydrochloride [mart.]

81. Pioglitazone Hydrochloride [vandf]

82. Bcp0726000151

83. Pioglitazone Hydrochloride [usp-rs]

84. Pioglitazone Hydrochloride [who-dd]

85. Pioglitazone Hydrochloride, >=98% (hplc)

86. Am20061770

87. Ft-0601607

88. P1901

89. Sw197561-4

90. D00945

91. Pioglitazone Hydrochloride [orange Book]

92. Oseni Component Pioglitazone Hydrochloride

93. Pioglitazone Hydrochloride [ep Monograph]

94. 025p468

95. A802593

96. Duetact Component Pioglitazone Hydrochloride

97. Pioglitazone Hydrochloride [usp Monograph]

98. Pioglitazone Hydrochloride Component Of Oseni

99. Q-201584

100. Pioglitazone Hydrochloride 100 Microg/ml In Methanol

101. Pioglitazone Hydrochloride Component Of Duetact

102. Q27281642

103. Actoplus Met Component Pioglitazone Hydrochloride

104. Pioglitazone Hydrochloride Component Of Actoplus Met

105. 5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione Hcl

106. Pioglitazone Hydrochloride, European Pharmacopoeia (ep) Reference Standard

107. 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione, Hcl

108. 5-(4-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-benzyl)-thiazolidine-2,4-dione Hcl

109. 5-[[4-[2-(5-ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride

110. 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, Hydrochloride

111. 5-[4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione Hydrochloride

112. 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione Hydrochloride

113. Pioglitazone For System Suitability, European Pharmacopoeia (ep) Reference Standard

114. Pioglitazone Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

115. Pioglitazone Hydrochloride, United States Pharmacopeia (usp) Reference Standard

116. (+/-)-5-(p-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione Monohydrochloride

117. 127676-30-6

118. 2,4-thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-, Hydrochloride (1:1)

119. 2,4-thiazolidinedione, 5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-, Monohydrochloride, (+/-)-

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 392.9 g/mol
Molecular Formula C19H21ClN2O3S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass392.0961414 g/mol
Monoisotopic Mass392.0961414 g/mol
Topological Polar Surface Area93.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity466
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NamePioglitazone hydrochloride
Drug LabelACTOS (pioglitazone hydrochloride) is an oral antidiabetic agent that acts primarily by decreasing insulin resistance. ACTOS is used in the management of type2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus [NIDDM] or adul...
Active IngredientPioglitazone hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 15mg base; eq 30mg base; eq 45mg base
Market StatusPrescription
CompanySynthon Pharms; Mylan Pharms; Accord Hlthcare; Aurobindo Pharma; Teva Pharms Usa; Torrent Pharms; Lupin; Sandoz; Watson Labs; Macleods Pharms; Zydus Pharms Usa; Dr Reddys Labs

2 of 2  
Drug NamePioglitazone hydrochloride
Drug LabelACTOS (pioglitazone hydrochloride) is an oral antidiabetic agent that acts primarily by decreasing insulin resistance. ACTOS is used in the management of type2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus [NIDDM] or adul...
Active IngredientPioglitazone hydrochloride
Dosage FormTablet
RouteOral
Strengtheq 15mg base; eq 30mg base; eq 45mg base
Market StatusPrescription
CompanySynthon Pharms; Mylan Pharms; Accord Hlthcare; Aurobindo Pharma; Teva Pharms Usa; Torrent Pharms; Lupin; Sandoz; Watson Labs; Macleods Pharms; Zydus Pharms Usa; Dr Reddys Labs

4.2 Drug Indication

Pioglitazone is indicated as second or third line treatment of type-2 diabetes mellitus as described below:

- as

* monotherapy: :

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance.

- as

* dual oral therapy: in combination with:

- metformin, in adult patients (particularly overweight patients) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin;

- a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea;

- as

* triple oral therapy: in combination with:

- metformin and a sulphonylurea, in adult patients (particularly overweight patients) with insufficient glycaemic control despite dual oral therapy.

Pioglitazone is also indicated for combination with insulin in type-2 diabetes mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance.

After initiation of therapy with pioglitazone, patients should be reviewed after three to six months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained.


Pioglitazone is indicated in the treatment of type-2 diabetes mellitus as

* monotherapy: :

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance.

Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance.

After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained.


Pioglitazone is indicated in the treatment of type-2 diabetes mellitus:

* as monotherapy:

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance.

After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained.


Pioglitazone is indicated as second or third line treatment of type 2 diabetes mellitus as described below:

* as monotherapy:

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance.

* as dual oral therapy in combination with:

- metformin, in adult patients (particularly overweight patients) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin.

- a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea.

* as triple oral therapy in combination with:

- metformin and a sulphonylurea, in adult patients (particularly overweight patients) with insufficient glycaemic control despite dual oral therapy.

Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance (see section 4. 4).

After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained (see section 4. 4).


Pioglitazone is indicated in the treatment of type 2 diabetes mellitus:

- as monotherapy

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance

- as dual oral therapy in combination with

- metformin, in adult patients (particularly overweight patients) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin

- a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea

- as triple oral therapy in combination with

- metformin and a sulphonylurea, in adult patients (particularly overweight patients) with insufficient glycaemic control despite dual oral therapy.

Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance.

After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained.


Pioglitazone is indicated as second or third line treatment of type-2 diabetes mellitus as described below:

- as monotherapy:

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance;

- as dual oral therapy in combination with:

- metformin, in adult patients (particularly overweight patients) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin;

- a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea;

- as triple oral therapy in combination with:

- metformin and a sulphonylurea, in adult patients (particularly overweight patients) with insufficient glycaemic control despite dual oral therapy.

Pioglitazone is also indicated for combination with insulin in type-2 diabetes mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance.

After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained.


Pioglitazone is indicated in the treatment of type-2 diabetes mellitus:

- as

* monotherapy: :

- in patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance;

- as

* dual oral therapy: in combination with:

- metformin, in patients (particularly overweight patients) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin;

- a sulphonylurea, only in patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea;

- as

* triple oral therapy: in combination with:

- metformin and a sulphonylurea, in patients (particularly overweight patients) with insufficient glycaemic control despite dual oral therapy.

Pioglitazone is also indicated for combination with insulin in type-2 diabetes mellitus patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance.


Pioglitazone is indicated as second or third line treatment of type 2 diabetes mellitus as described below:

* as monotherapy:

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance;

as

* dual oral therapy: in combination with

- metformin, in adult patients (particularly overweight patients) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin;

- a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea;

as

* triple oral therapy: in combination with

- metformin and a sulphonylurea, in adult patients (particularly overweight patients) with insufficient glycaemic control despite dual oral therapy.

Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus in adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance.

After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained.


Pioglitazone is indicated as second or third line treatment of type 2 diabetes mellitus as described below:

as monotherapy

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance;

as dual oral therapy in combination with

- a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea;

Pioglitazone is also indicated for combination with insulin in type 2 diabetes mellitus in adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance.

After initiation of therapy with pioglitazone, patients should be reviewed after 3 to 6 months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained.


Pioglitazone is indicated as second- or third-line treatment of type-2 diabetes mellitus as described below:

* as monotherapy: :

- in adult patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance;

* as dual oral therapy in combination with: :

- metformin, in adult patients (particularly overweight patients) with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin;

- a sulphonylurea, only in adult patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycaemic control despite maximal tolerated dose of monotherapy with a sulphonylurea;

* as triple oral therapy in combination with: :

- metformin and a sulphonylurea, in adult patients (particularly overweight patients) with insufficient glycaemic control despite dual oral therapy.

Pioglitazone is also indicated for combination with insulin in type-2-diabetes-mellitus adult patients with insufficient glycaemic control on insulin for whom metformin is inappropriate because of contraindications or intolerance (see section 4. 4).

After initiation of therapy with pioglitazone, patients should be reviewed after three to six months to assess adequacy of response to treatment (e. g. reduction in HbA1c). In patients who fail to show an adequate response, pioglitazone should be discontinued. In light of potential risks with prolonged therapy, prescribers should confirm at subsequent routine reviews that the benefit of pioglitazone is maintained (see section 4. 4).


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Hypoglycemic Agents

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
PPAR gamma [CS]; Peroxisome Proliferator Receptor alpha Agonist [EPC]; Peroxisome Proliferator Receptor gamma Agonist [EPC]; Peroxisome Proliferator-activated Receptor Activity [MoA]; Thiazolidinedione [EPC]; Thiazolidinediones [CS]; PPAR alpha [CS]
5.3 ATC Code

A10BG03


A10BG03


A10BG03


A10BG03


A10BG03


A10BG03


A10BG03


A10BG03


A10BG03


A10BG03


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USDMF

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  • EDQM
  • WHO-GMP

Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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GDUFA

DMF Review : Complete

Rev. Date : 2014-01-14

Pay. Date : 2013-12-31

DMF Number : 21295

Submission : 2008-01-31

Status : Active

Type : II

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02

BIO Partnering at JPM
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothUSV offers custom peptide synthesis ranging from gram to multi-gram to multi-kilogram quantities.

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 19250

Submission : 2006-03-10

Status : Active

Type : II

USV Private Limited

03

BIO Partnering at JPM
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  • fda
  • EDQM
  • WHO-GMP

Virtual BoothUSV offers custom peptide synthesis ranging from gram to multi-gram to multi-kilogram quantities.

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 16684

Submission : 2003-07-08

Status : Active

Type : II

USV Private Limited

04

  • fda
  • EDQM
  • WHO-GMP

Virtual BoothTAPI offers customized CDMO Solutions for API development and manufacturing services.

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GDUFA

DMF Review : N/A

Rev. Date :

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DMF Number : 16688

Submission : 2003-07-08

Status : Active

Type : II

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05

Biocon Ltd

India

USDMF

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06

Cipla Ltd

India

USDMF

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06

Cipla Ltd

India
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 16672

Submission : 2003-06-30

Status : Active

Type : II

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07

BIO Partnering at JPM
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07

BIO Partnering at JPM
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 18379

Submission : 2005-05-21

Status : Active

Type : II

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08

BIO Partnering at JPM
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09

BIO Partnering at JPM
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09

10

Wockhardt Ltd

India

USDMF

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CEP/COS

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05

BIO Partnering at JPM
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Certificate Number : R1-CEP 2012-363 - Rev 00

Status : Withdrawn by Holder

Issue Date : 2019-07-17

Type : Chemical

Substance Number : 2601

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06

BIO Partnering at JPM
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BIO Partnering at JPM
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Certificate Number : R0-CEP 2017-013 - Rev 01

Status : Withdrawn by Holder

Issue Date : 2019-04-05

Type : Chemical

Substance Number : 2601

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07

BIO Partnering at JPM
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08

BIO Partnering at JPM
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BIO Partnering at JPM
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Certificate Number : CEP 2012-315 - Rev 01

Status : Valid

Issue Date : 2024-07-11

Type : Chemical

Substance Number : 2601

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DR. REDDY'S LABORATORIES LIMITED Hy...

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CEP 2013-077 - Rev 01
Valid
Chemical
2024-03-05
2601
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DR. REDDY'S LABORATORIES LIMITED Hy...

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BIO Partnering at JPM
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DR. REDDY'S LABORATORIES LIMITED Hy...

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Certificate Number : CEP 2013-077 - Rev 01

Status : Valid

Issue Date : 2024-03-05

Type : Chemical

Substance Number : 2601

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BIO Partnering at JPM
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API Reference Price

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REDDY\\'S LABORATORIES","supplierCountry":"INDIA","foreign_port":"BANGKOK","customer":"BERLIN PHARMACEUTICAL INDUSTRY ","customerCountry":"THAILAND","quantity":"309.68","actualQuantity":"309.68","unit":"KGS","unitRateFc":"203.9","totalValueFC":"63931.1","currency":"USD","unitRateINR":15098.553991216741,"date":"07-Jan-2021","totalValueINR":"4675720.2","totalValueInUsd":"63931.1","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"7757182","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"THAILAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"7-1-27, AMEERPET, HYDERABAD, ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1610389800,"product":"PIOGLITAZONE HYDROCHLORIDE JP BATCH.NO K","address":"SCO.850, SHIVALIK ENCLAVE, NAC,MANIMAJRA,","city":"CHANDIGARH.","supplier":"IND SWIFT LABORATORIES LIMITED","supplierCountry":"INDIA","foreign_port":"LJUBLJANA - BRNIK","customer":"SANDOZ B2B","customerCountry":"SLOVENIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"2325","totalValueFC":"171855.9","currency":"USD","unitRateINR":167586.66666666666,"date":"12-Jan-2021","totalValueINR":"12569000","totalValueInUsd":"171855.9","indian_port":"DELHI AIR","hs_no":"29333919","bill_no":"7841525","productDescription":"API","marketType":"REGULATED MARKET","country":"SLOVENIA","selfForZScoreResived":"Pharma Grade","supplierPort":"DELHI AIR","supplierAddress":"SCO.850, SHIVALIK ENCLAVE, NAC,MANIMAJRA,, CHANDIGARH.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1611081000,"product":"PIOGLITAZONE HYDROCHLORIDE USP 42 BATCH NO: PZ044\/20 MFG DATE : DECEIMBER. 2020 EXPIRY DATE : NOVEMBER 2025","address":"MANI MAHAL, GROUND FLOOR, OFFICENO. 5\/6, 353, KALBADEVI ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"BIOCARE IMPEX","supplierCountry":"INDIA","foreign_port":"MEXICO CITY","customer":"AGENCIAS ADUANALES ALIANZAS ","customerCountry":"MEXICO","quantity":"250.00","actualQuantity":"250","unit":"KGS","unitRateFc":"111.6","totalValueFC":"28235.7","currency":"USD","unitRateINR":8260.2836800000005,"date":"20-Jan-2021","totalValueINR":"2065070.92","totalValueInUsd":"28235.7","indian_port":"AHMEDABAD AIR","hs_no":"29420090","bill_no":"8029227","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MEXICO","selfForZScoreResived":"Pharma Grade","supplierPort":"AHMEDABAD AIR","supplierAddress":"MANI MAHAL, GROUND FLOOR, OFFICENO. 5\/6, 353, KALBADEVI ROAD,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1611685800,"product":"PIOGLITAZONE HYDROCHLORIDE (GROUP-A)(TAX INVOICE NO:4900205225 DT:30.11.2020","address":"115\/2RT, 2ND FLOOR,SANJEEVA REDDY NAGAR,","city":"HYDERABAD. 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AP.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1612722600,"product":"PIOGLITAZONE HYDROCHLORIDE USP","address":"MUMBAI CENTRAL,","city":"MUMBAI, MAHARASHTRA.","supplier":"CIPLA","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"CELLTRION","customerCountry":"KOREA, REPUBLIC OF","quantity":"154.40","actualQuantity":"154.4","unit":"KGS","unitRateFc":"620","totalValueFC":"94757.8","currency":"USD","unitRateINR":44682.642487046629,"date":"08-Feb-2021","totalValueINR":"6899000","totalValueInUsd":"94757.8","indian_port":"BOMBAY AIR","hs_no":"29341000","bill_no":"8498848","productDescription":"API","marketType":"REGULATED MARKET","country":"KOREA,REPUBLIC OF","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"MUMBAI CENTRAL,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1612895400,"product":"PIOGLITAZONE HYDROCHLORIDE","address":"7-1-27, AMEERPET","city":"HYDERABAD, ANDHRA PRADESH","supplier":"DR. REDDY\\'S LABORATORIES","supplierCountry":"INDIA","foreign_port":"BANGKOK","customer":"BERLIN PHARMACEUTICAL INDUSTRY ","customerCountry":"THAILAND","quantity":"121.56","actualQuantity":"121.56","unit":"KGS","unitRateFc":"207.2","totalValueFC":"24921.5","currency":"USD","unitRateINR":14926.420039486675,"date":"10-Feb-2021","totalValueINR":"1814455.62","totalValueInUsd":"24921.5","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"8532942","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"THAILAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"7-1-27, AMEERPET, HYDERABAD, ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1616092200,"product":"PIOGLITAZONE HYDROCHLORIDE","address":"7-1-27, AMEERPET","city":"HYDERABAD, ANDHRA PRADESH","supplier":"DR. REDDY\\'S LABORATORIES","supplierCountry":"INDIA","foreign_port":"BANGKOK","customer":"BERLIN PHARMACEUTICAL INDUSTRY ","customerCountry":"THAILAND","quantity":"453.75","actualQuantity":"453.75","unit":"KGS","unitRateFc":"205.1","totalValueFC":"92101.4","currency":"USD","unitRateINR":14777.097564738291,"date":"19-Mar-2021","totalValueINR":"6705108.02","totalValueInUsd":"92101.4","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"9481878","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"THAILAND","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"7-1-27, AMEERPET, HYDERABAD, ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1616697000,"product":"PIOGLITAZONE HYDROCHLORIDE (TAX INVOICE NO:4900205311 DT:22.03.2021","address":"115\/2RT, 2ND FLOOR,SANJEEVA REDDY NAGAR,","city":"HYDERABAD. 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REDDY\\'S LABORATORIES","supplierCountry":"INDIA","foreign_port":"ISTANBUL","customer":"BILIM PHARMACEUTICALS","customerCountry":"TURKEY","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"213.3","totalValueFC":"42218","currency":"USD","unitRateINR":15367.633300000001,"date":"27-Mar-2021","totalValueINR":"3073526.66","totalValueInUsd":"42218","indian_port":"HYDERABAD AIR","hs_no":"29349990","bill_no":"9695475","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"TURKEY","selfForZScoreResived":"Pharma Grade","supplierPort":"HYDERABAD AIR","supplierAddress":"7-1-27, AMEERPET, HYDERABAD, ANDHRA PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"PIOGLITAZONE HYDROCHLORIDE","year":"2021","qtr":"Q1","strtotime":1616783400,"product":"PIOGLITAZONE HYDROCHLORIDE","address":"7-1-27, AMEERPET","city":"HYDERABAD, ANDHRA PRADESH","supplier":"DR. 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07-Jan-2021
15-Nov-2024
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - EQ 15MG BASE

USFDA APPLICATION NUMBER - 21073

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DOSAGE - TABLET;ORAL - EQ 30MG BASE

USFDA APPLICATION NUMBER - 21073

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DOSAGE - TABLET;ORAL - EQ 45MG BASE

USFDA APPLICATION NUMBER - 21073

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DOSAGE - TABLET;ORAL - 500MG;EQ 15MG BASE **F...DOSAGE - TABLET;ORAL - 500MG;EQ 15MG BASE **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 21842

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DOSAGE - TABLET;ORAL - 850MG;EQ 15MG BASE

USFDA APPLICATION NUMBER - 21842

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 1GM;...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 15MG BASE

USFDA APPLICATION NUMBER - 22024

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 1GM;...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 1GM;EQ 30MG BASE

USFDA APPLICATION NUMBER - 22024

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ABOUT THIS PAGE

Actos Manufacturers

A Actos manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Actos, including repackagers and relabelers. The FDA regulates Actos manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Actos API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Actos manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Actos Suppliers

A Actos supplier is an individual or a company that provides Actos active pharmaceutical ingredient (API) or Actos finished formulations upon request. The Actos suppliers may include Actos API manufacturers, exporters, distributors and traders.

click here to find a list of Actos suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Actos USDMF

A Actos DMF (Drug Master File) is a document detailing the whole manufacturing process of Actos active pharmaceutical ingredient (API) in detail. Different forms of Actos DMFs exist exist since differing nations have different regulations, such as Actos USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Actos DMF submitted to regulatory agencies in the US is known as a USDMF. Actos USDMF includes data on Actos's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Actos USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Actos suppliers with USDMF on PharmaCompass.

Actos JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Actos Drug Master File in Japan (Actos JDMF) empowers Actos API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Actos JDMF during the approval evaluation for pharmaceutical products. At the time of Actos JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Actos suppliers with JDMF on PharmaCompass.

Actos KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Actos Drug Master File in Korea (Actos KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Actos. The MFDS reviews the Actos KDMF as part of the drug registration process and uses the information provided in the Actos KDMF to evaluate the safety and efficacy of the drug.

After submitting a Actos KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Actos API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Actos suppliers with KDMF on PharmaCompass.

Actos CEP

A Actos CEP of the European Pharmacopoeia monograph is often referred to as a Actos Certificate of Suitability (COS). The purpose of a Actos CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Actos EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Actos to their clients by showing that a Actos CEP has been issued for it. The manufacturer submits a Actos CEP (COS) as part of the market authorization procedure, and it takes on the role of a Actos CEP holder for the record. Additionally, the data presented in the Actos CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Actos DMF.

A Actos CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Actos CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Actos suppliers with CEP (COS) on PharmaCompass.

Actos WC

A Actos written confirmation (Actos WC) is an official document issued by a regulatory agency to a Actos manufacturer, verifying that the manufacturing facility of a Actos active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Actos APIs or Actos finished pharmaceutical products to another nation, regulatory agencies frequently require a Actos WC (written confirmation) as part of the regulatory process.

click here to find a list of Actos suppliers with Written Confirmation (WC) on PharmaCompass.

Actos NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Actos as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Actos API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Actos as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Actos and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Actos NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Actos suppliers with NDC on PharmaCompass.

Actos GMP

Actos Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Actos GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Actos GMP manufacturer or Actos GMP API supplier for your needs.

Actos CoA

A Actos CoA (Certificate of Analysis) is a formal document that attests to Actos's compliance with Actos specifications and serves as a tool for batch-level quality control.

Actos CoA mostly includes findings from lab analyses of a specific batch. For each Actos CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Actos may be tested according to a variety of international standards, such as European Pharmacopoeia (Actos EP), Actos JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Actos USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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