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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

8 API Suppliers, 1 USDMF, 7 Listed Suppliers, $ API Reference Price

8 API Suppliers
1 USDMF
7 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

13 FDF Dossiers, 10 Europe, 3 Listed Dossiers

13 FDF Dossiers
10 Europe
3 Listed Dossiers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

8 Finished Drug Prices

globalSalesInformation
8 Finished Drug Prices

MARKET PLACE

16 APIs, 9 FDF Dossiers

marketPlace
16 APIs
9 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

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1 USP
1 Others

Zhejiang Hengkang Ademetionine

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 353

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: S-adenosylmethionine, Ademetionine, Adomet, 485-80-3, Donamet, S-adenosyl methionine

Molecular Formula

C₁₅H₂₃N₆O₅S+

Molecular Weight

399.4 g/mol

InChI Key

MEFKEPWMEQBLKI-AIRLBKTGSA-O

Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

1 2D Structure

Ademetionine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(3S)-3-amino-3-carboxypropyl]-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium

2.1.2 InChI

InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1

2.1.3 InChI Key

MEFKEPWMEQBLKI-AIRLBKTGSA-O

2.1.4 Canonical SMILES

C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O

2.1.5 Isomeric SMILES

C[S+](CC[C@@H](C(=O)O)N)C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Ademetionine

2. Adomet

3. Fo 1561

4. Fo-1561

5. Fo1561

6. Gumbaral

7. S Adenosyl L Methionine

8. S Adenosylmethionine

9. S Adenosylmethionine Sulfate Tosylate

10. S Amet

11. S-adenosylmethionine

12. S-adenosylmethionine Sulfate Tosylate

13. Sam-e

14. Samyr

2.2.2 Depositor-Supplied Synonyms

1. S-adenosylmethionine

2. Ademetionine

3. Adomet

4. 485-80-3

5. Donamet

6. S-adenosyl Methionine

7. Adenosylmethionine

8. Chebi:15414

9. Active Methionine

10. Chembl224120

11. Methionine, S-adenosyl-

12. (r)-s-adenosyl-l-methionine

13. (s)-s-adenosyl-l-methionine

14. S-(5'-deoxyadenosin-5'-yl)-l-methionine

15. Adenosine, 5'-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-

16. S-adenosyl-methionine

17. (s,s)-adomet

18. [(3s)-3-amino-3-carboxypropyl]-[[(2s,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium

19. S-(5'-adenosyl)-l-methionine

20. 2-s-adenosyl-l-methionine

21. Sam

22. Ncgc00167546-02

23. S-adenosyl-l-methionine Disulphate Tosylate

24. Ademethionine

25. Adome

26. Adenosine, 5'-((l-3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxy-, Hydroxide, Inner Salt

27. Bmse000059

28. Schembl25177

29. Schembl59293

30. Schembl599664

31. Gtpl4786

32. Chebi:33440

33. Chebi:33442

34. Dtxsid20110014

35. S-(5'-adenosyl)methionine-s-ium

36. Zinc4214738

37. Zinc4228231

38. Bdbm50513996

39. Akos025310126

40. Am84912

41. Ncgc00167546-01

42. S-adenosylmethionine (protonated Carboxy Group)

43. Q27115647

44. Q27115649

45. Q56071634

46. 5'-deoxyadenosine-5'-l-methionine Disulfate Ditosylate

47. 5'-deoxyadenosine-5'-l-methionine Disulphate Ditosylate

48. (3s)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine

49. [(3s)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium

50. 5'-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine

51. (3s)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, Inner Salt

52. (r)-[(3s)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium

53. (s)-[(3s)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium

54. [(3r)-3-amino-3-carboxypropyl]({[(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium

55. [(3s)-3-amino-3-carboxypropyl]({[(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium

56. [1-(adenin-9-yl)-1,5-dideoxy-beta-d-ribofuranos-5-yl][(3s)-3-amino-3-carboxypropyl](methyl)sulfonium

57. 5 Inverted Exclamation Marka-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5 Inverted Exclamation Marka-deoxyadenosine

58. 5invertedexclamationmarka-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5invertedexclamationmarka-deoxyadenosine

2.3 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₃N₆O₅S+
Molecular Weight	399.4 g/mol
XLogP3	-3.5
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	399.14506403 g/mol
Monoisotopic Mass	399.14506403 g/mol
Topological Polar Surface Area	184 Å²
Heavy Atom Count	27
Formal Charge	1
Complexity	533
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 ATC Code

A - Alimentary tract and metabolism

A16 - Other alimentary tract and metabolism products

A16A - Other alimentary tract and metabolism products

A16AA - Amino acids and derivatives

A16AA02 - Ademetionine

API SUPPLIERS

01

Zhejiang Hengkang Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI China

Attending

Zhejiang Hengkang Pharm Group is a dynamic pharmaceutical entity, spanning drug research, large-scale production, and global marketing.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

02

Bioquim

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Bioquim: An European GMP-certified company manufacturing bulk APIs, specializing in sterile lyophilization and chemical synthesis.

Contact Supplier

Spain

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

03

OMNIABIOS

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Cosmoprof India

Not Confirmed

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

USDMF

01

Omniabios Srl

France

Antibody Engineering

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

01

Zhejiang Hengkang Pharmaceutical

China

CPhI China

Attending

Zhejiang Hengkang Pharm Group is a dynamic pharmaceutical entity, spanning drug research, large-scale production, and global marketing.

Contact Supplier

China

Virtual Booth

Digital Content

Ademetionine

About the Company : Established in 2004 and headquartered in Hangzhou, Hengkang established multiple factories, research and sales centers in Zhejiang, Shandong, and Henan. With facilities conforming ...

Established in 2004 and headquartered in Hangzhou, Hengkang established multiple factories, research and sales centers in Zhejiang, Shandong, and Henan. With facilities conforming to global API standards, along with professional R&D and marketing teams, Hengkang’s operations span major pharmaceutical markets such as China, Europe, the CIS region, Japan, and South Korea. Hengkang has established long-term and stable relationships with nearly 70 countries overseas and hundreds of domestic enterprises.

Product Web Link

02

Bioquim

Spain

Antibody Engineering

Not Confirmed

Bioquim: An European GMP-certified company manufacturing bulk APIs, specializing in sterile lyophilization and chemical synthesis.

Contact Supplier

Spain

Virtual Booth

Digital Content

S-Adenosyl Methionine

About the Company : Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, pep...

Bioquim is a European company specializing in bulk oral & sterile APIs for the pharmaceutical industry. With over 40 years of experience, we offer high-quality corticosteroids, peptides, amino acids, penicillin derivatives, non-penicillin antibiotics, and HPAPIs for human & veterinary markets. We adhere to stringent GMP and operate state-of-the-art facilities with advanced technology. Bioquim also provides Custom Synthesis & Contract Manufacturing services, delivering tailored solutions backed by our expertise in chemical synthesis & lyophilization of sterile APIs. Trust Bioquim for your API needs & experience our commitment to quality.

Portfolio PDF

Product Web Link

Virtual Booth

China

Antibody Engineering

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

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