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Chemistry

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Also known as: S-adenosylmethionine, Ademetionine, Adomet, 485-80-3, Donamet, S-adenosyl methionine
Molecular Formula
C15H23N6O5S+
Molecular Weight
399.4  g/mol
InChI Key
MEFKEPWMEQBLKI-AIRLBKTGSA-O

Ademetionine
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
1 2D Structure

Ademetionine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(3S)-3-amino-3-carboxypropyl]-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium
2.1.2 InChI
InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1
2.1.3 InChI Key
MEFKEPWMEQBLKI-AIRLBKTGSA-O
2.1.4 Canonical SMILES
C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
2.1.5 Isomeric SMILES
C[S+](CC[C@@H](C(=O)O)N)C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Ademetionine

2. Adomet

3. Fo 1561

4. Fo-1561

5. Fo1561

6. Gumbaral

7. S Adenosyl L Methionine

8. S Adenosylmethionine

9. S Adenosylmethionine Sulfate Tosylate

10. S Amet

11. S-adenosylmethionine

12. S-adenosylmethionine Sulfate Tosylate

13. Sam-e

14. Samyr

2.2.2 Depositor-Supplied Synonyms

1. S-adenosylmethionine

2. Ademetionine

3. Adomet

4. 485-80-3

5. Donamet

6. S-adenosyl Methionine

7. Adenosylmethionine

8. Chebi:15414

9. Active Methionine

10. Chembl224120

11. Methionine, S-adenosyl-

12. (r)-s-adenosyl-l-methionine

13. (s)-s-adenosyl-l-methionine

14. S-(5'-deoxyadenosin-5'-yl)-l-methionine

15. Adenosine, 5'-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-

16. S-adenosyl-methionine

17. (s,s)-adomet

18. [(3s)-3-amino-3-carboxypropyl]-[[(2s,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium

19. S-(5'-adenosyl)-l-methionine

20. 2-s-adenosyl-l-methionine

21. Sam

22. Ncgc00167546-02

23. S-adenosyl-l-methionine Disulphate Tosylate

24. Ademethionine

25. Adome

26. Adenosine, 5'-((l-3-amino-3-carboxypropyl)methylsulfonio)-5'-deoxy-, Hydroxide, Inner Salt

27. Bmse000059

28. Schembl25177

29. Schembl59293

30. Schembl599664

31. Gtpl4786

32. Chebi:33440

33. Chebi:33442

34. Dtxsid20110014

35. S-(5'-adenosyl)methionine-s-ium

36. Zinc4214738

37. Zinc4228231

38. Bdbm50513996

39. Akos025310126

40. Am84912

41. Ncgc00167546-01

42. S-adenosylmethionine (protonated Carboxy Group)

43. Q27115647

44. Q27115649

45. Q56071634

46. 5'-deoxyadenosine-5'-l-methionine Disulfate Ditosylate

47. 5'-deoxyadenosine-5'-l-methionine Disulphate Ditosylate

48. (3s)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine

49. [(3s)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium

50. 5'-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine

51. (3s)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, Inner Salt

52. (r)-[(3s)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium

53. (s)-[(3s)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium

54. [(3r)-3-amino-3-carboxypropyl]({[(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium

55. [(3s)-3-amino-3-carboxypropyl]({[(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium

56. [1-(adenin-9-yl)-1,5-dideoxy-beta-d-ribofuranos-5-yl][(3s)-3-amino-3-carboxypropyl](methyl)sulfonium

57. 5 Inverted Exclamation Marka-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5 Inverted Exclamation Marka-deoxyadenosine

58. 5invertedexclamationmarka-[[(3s)-3-amino-3-carboxypropyl]methylsulfonio]-5invertedexclamationmarka-deoxyadenosine

2.3 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 399.4 g/mol
Molecular Formula C15H23N6O5S+
XLogP3-3.5
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass399.14506403 g/mol
Monoisotopic Mass399.14506403 g/mol
Topological Polar Surface Area184 Ų
Heavy Atom Count27
Formal Charge1
Complexity533
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 ATC Code

A - Alimentary tract and metabolism

A16 - Other alimentary tract and metabolism products

A16A - Other alimentary tract and metabolism products

A16AA - Amino acids and derivatives

A16AA02 - Ademetionine


API Reference Price

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15-May-2021
30-Dec-2024
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ABOUT THIS PAGE

Looking for 485-80-3 / Ademetionine API manufacturers, exporters & distributors?

Ademetionine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Ademetionine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ademetionine manufacturer or Ademetionine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ademetionine manufacturer or Ademetionine supplier.

PharmaCompass also assists you with knowing the Ademetionine API Price utilized in the formulation of products. Ademetionine API Price is not always fixed or binding as the Ademetionine Price is obtained through a variety of data sources. The Ademetionine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Ademetionine

Synonyms

S-adenosylmethionine, Adomet, 485-80-3, Donamet, S-adenosyl methionine, Adenosylmethionine

Cas Number

485-80-3

About Ademetionine

Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

Ademetionine Manufacturers

A Ademetionine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ademetionine, including repackagers and relabelers. The FDA regulates Ademetionine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ademetionine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Ademetionine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Ademetionine Suppliers

A Ademetionine supplier is an individual or a company that provides Ademetionine active pharmaceutical ingredient (API) or Ademetionine finished formulations upon request. The Ademetionine suppliers may include Ademetionine API manufacturers, exporters, distributors and traders.

click here to find a list of Ademetionine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Ademetionine USDMF

A Ademetionine DMF (Drug Master File) is a document detailing the whole manufacturing process of Ademetionine active pharmaceutical ingredient (API) in detail. Different forms of Ademetionine DMFs exist exist since differing nations have different regulations, such as Ademetionine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Ademetionine DMF submitted to regulatory agencies in the US is known as a USDMF. Ademetionine USDMF includes data on Ademetionine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ademetionine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Ademetionine suppliers with USDMF on PharmaCompass.

Ademetionine GMP

Ademetionine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Ademetionine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ademetionine GMP manufacturer or Ademetionine GMP API supplier for your needs.

Ademetionine CoA

A Ademetionine CoA (Certificate of Analysis) is a formal document that attests to Ademetionine's compliance with Ademetionine specifications and serves as a tool for batch-level quality control.

Ademetionine CoA mostly includes findings from lab analyses of a specific batch. For each Ademetionine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Ademetionine may be tested according to a variety of international standards, such as European Pharmacopoeia (Ademetionine EP), Ademetionine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ademetionine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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