EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 NDC API

1 NDC API

DEVELOPMENTS

24 Drugs in Development

24 Drugs in Development

DIGITAL CONTENT

14 NEWS #PharmaBuzz

media
14 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

24DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Aficamten [inn], Aficamten [usan], 2364554-48-1, B1i77mh6k1, Chembl4847050, Ck-3773274

Molecular Formula

C₁₈H₁₉N₅O₂

Molecular Weight

337.4 g/mol

InChI Key

IOVAZWDIRCRMTM-OAHLLOKOSA-N

FDA UNII

B1I77MH6K1

1 2D Structure

Aficamten

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methylpyrazole-4-carboxamide

2.1.2 InChI

InChI=1S/C18H19N5O2/c1-3-16-21-17(22-25-16)12-4-6-14-11(8-12)5-7-15(14)20-18(24)13-9-19-23(2)10-13/h4,6,8-10,15H,3,5,7H2,1-2H3,(H,20,24)/t15-/m1/s1

2.1.3 InChI Key

IOVAZWDIRCRMTM-OAHLLOKOSA-N

2.1.4 Canonical SMILES

CCC1=NC(=NO1)C2=CC3=C(C=C2)C(CC3)NC(=O)C4=CN(N=C4)C

2.1.5 Isomeric SMILES

CCC1=NC(=NO1)C2=CC3=C(C=C2)[C@@H](CC3)NC(=O)C4=CN(N=C4)C

2.2 Other Identifiers

2.2.1 UNII

B1I77MH6K1

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Aficamten [inn]

2. Aficamten [usan]

3. 2364554-48-1

4. B1i77mh6k1

5. Chembl4847050

6. Ck-3773274

7. 1h-pyrazole-4-carboxamide, N-((1r)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-

8. N-((1r)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)- 1-methyl-1h-pyrazole-4-carboxamide

9. Unii-b1i77mh6k1

10. Schembl21179170

11. Gtpl11524

12. Ex-a5344

13. Bdbm50575173

14. Ck-274

15. Who 11544

16. Ck3773274

17. Hy-139465

18. Ck-3773274;ck-274

19. Cs-0202223

20. (r)-n-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-1-methyl-1h-pyrazole-4-carboxamide

21. N-[(1r)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl]-1-methylpyrazole-4-carboxamide

2.4 Create Date

2019-11-02

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₁₉N₅O₂
Molecular Weight	337.4 g/mol
XLogP3	2.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	337.15387487 g/mol
Monoisotopic Mass	337.15387487 g/mol
Topological Polar Surface Area	85.8 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	490
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1