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1. 4'-hydroxytamoxifen
2. 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
3. 4-hydroxy-tamoxifen
4. 4-hydroxytamoxifen, (e)-isomer
5. 4-hydroxytamoxifen, (z)-isomer
6. 4-monohydroxytamoxifen
7. 4-oht Hydrotamoxifen
8. 4oh-tamoxifen
9. Afimoxifene
10. Hydroxytamoxifen
11. Ici 79280
12. Monohydroxytamoxifen
13. Para-hydroxytamoxifen
14. Phenol, 4-((1z)-1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-buten-1-yl)-
15. Phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-
16. Phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,
17. Tamoxifen Metabolite B
1. (z)-4-hydroxytamoxifen
2. Afimoxifene
3. 68047-06-3
4. Hydroxytamoxifen
5. Trans-4-hydroxytamoxifen
6. 4-monohydroxytamoxifen
7. Tamogel
8. (z)-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol
9. 68392-35-8
10. Ici 79280
11. 65213-48-1
12. (z)-4-hydroxy Tamoxifen
13. (e/z)-4-hydroxy Tamoxifen
14. Z-4-hydroxytamoxifen
15. C26h29no2
16. Chembl489
17. R-lipoic Acid Potassium Compund
18. Tamoxifen, 4-hydroxy-, (z)-
19. Mls000069742
20. 1077-29-8
21. Chebi:44616
22. (e/z)-4-hydroxytamoxifen
23. 95k54647bz
24. 4-hydroxy Tamoxifen
25. Smr000058939
26. 4-[(1z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol
27. 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
28. 4-hydroxy Tamoxifen-d5
29. 4-oh-tam
30. [3h]4-oht
31. 4-[(1z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
32. Cis-4-hydroxytamoxifen
33. Sr-01000759243
34. Afimoxifene [usan:inn]
35. Ici 79,280
36. Brn 4910749
37. Unii-17197f0kym
38. Ccris 8580
39. Unii-95k54647bz
40. (z)-4-oht
41. 4-[(1z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenyl-1-buten-1-yl]phenol
42. 4-oh Tamoxifen
43. Tamogel (tn)
44. 2bj4
45. Opera_id_600
46. Afimoxifene (usan/inn)
47. Dsstox_cid_2384
48. 4-((1z)-1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)phenol
49. Phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-,
50. Trans-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)phenol
51. Schembl9189
52. Dsstox_rid_76567
53. Bidd:pxr0104
54. Dsstox_gsid_22384
55. Afimoxifene, Z-isomer
56. Mls001077346
57. Bidd:er0193
58. Cid_449459
59. Dtxsid7022384
60. Bdbm20608
61. 17197f0kym
62. Hms2231f20
63. Zinc902197
64. Ex-a4661
65. Tox21_200943
66. 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
67. Hsci1_000353
68. Hy-16950a
69. Ici-79280
70. Mfcd00278780
71. Mfcd00468090
72. S8956
73. (z)-4-hydroxytamoxifen (z-4-oht)
74. 4-{1-[4-(2-dimethylamino-ethoxy)-phenyl]-2-phenyl-but-1-enyl}-phenol
75. Akos016010361
76. Db04468
77. Phenol, 4-((1z)-1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-
78. Phenol, 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)-, (z)-
79. Ncgc00164399-01
80. Ncgc00164399-02
81. Ncgc00258497-01
82. (z)-4-hydroxytamoxifen, >=98% Z Isomer
83. Cas-68047-06-3
84. Cs-0003592
85. C05011
86. D06551
87. 392h358
88. A904472
89. Q4689254
90. Sr-01000759243-3
91. Sr-01000759243-5
92. Brd-k04210847-001-01-1
93. 4-(1-[4-(dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol
94. (z)-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol
95. 4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol
96. 4-hydroxytamoxifen ??(1/2)70% Z Isomer (remainder Primarily E-isomer)
97. 4-[(1z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
98. 4-{(1z)-1-[4-(2-dimethylamino-ethoxy)-phenyl]-2-phenyl-but-1-enyl}-phenol
| Molecular Weight | 387.5 g/mol |
|---|---|
| Molecular Formula | C26H29NO2 |
| XLogP3 | 6.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 8 |
| Exact Mass | 387.219829168 g/mol |
| Monoisotopic Mass | 387.219829168 g/mol |
| Topological Polar Surface Area | 32.7 Ų |
| Heavy Atom Count | 29 |
| Formal Charge | 0 |
| Complexity | 493 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)
Selective Estrogen Receptor Modulators
A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63) (See all compounds classified as Selective Estrogen Receptor Modulators.)
Estrogen Antagonists
Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds. (See all compounds classified as Estrogen Antagonists.)
Absorption
Absorbed following topical application.
4-Hydroxytamoxifen has known human metabolites that include 3,4-Dihydroxy-Tamoxifen, Endoxifen, Tamoxifen 4-O-glucuronide, and Tamoxifen 4-O-sulfate.
4-Hydroxytamoxifen is a known human metabolite of tamoxifen.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
Afimoxifene binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes.
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PharmaCompass offers a list of Afimoxifene API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Afimoxifene manufacturer or Afimoxifene supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Afimoxifene manufacturer or Afimoxifene supplier.
PharmaCompass also assists you with knowing the Afimoxifene API Price utilized in the formulation of products. Afimoxifene API Price is not always fixed or binding as the Afimoxifene Price is obtained through a variety of data sources. The Afimoxifene Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Afimoxifene manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Afimoxifene, including repackagers and relabelers. The FDA regulates Afimoxifene manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Afimoxifene API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Afimoxifene supplier is an individual or a company that provides Afimoxifene active pharmaceutical ingredient (API) or Afimoxifene finished formulations upon request. The Afimoxifene suppliers may include Afimoxifene API manufacturers, exporters, distributors and traders.
Afimoxifene Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Afimoxifene GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Afimoxifene GMP manufacturer or Afimoxifene GMP API supplier for your needs.
A Afimoxifene CoA (Certificate of Analysis) is a formal document that attests to Afimoxifene's compliance with Afimoxifene specifications and serves as a tool for batch-level quality control.
Afimoxifene CoA mostly includes findings from lab analyses of a specific batch. For each Afimoxifene CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Afimoxifene may be tested according to a variety of international standards, such as European Pharmacopoeia (Afimoxifene EP), Afimoxifene JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Afimoxifene USP).
