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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 56287-74-2, Arofuto, 4(3h)-quinazolinone, 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-, Airomate, Hq-495, Co4u2c8orz
Molecular Formula
C16H14FN3O
Molecular Weight
283.30  g/mol
InChI Key
VDOSWXIDETXFET-UHFFFAOYSA-N
FDA UNII
CO4U2C8ORZ

Afloqualone
1 2D Structure

Afloqualone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
2.1.2 InChI
InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3
2.1.3 InChI Key
VDOSWXIDETXFET-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF
2.2 Other Identifiers
2.2.1 UNII
CO4U2C8ORZ
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 56287-74-2

2. Arofuto

3. 4(3h)-quinazolinone, 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-

4. Airomate

5. Hq-495

6. Co4u2c8orz

7. 6-amino-2-(fluoromethyl)-3-(o-tolyl)quinazolin-4(3h)-one

8. 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one

9. 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3h)-quinazolinone

10. 6-amino-2-(fluoromethyl)-3-o-tolyl-4(3h)-quinazolinone

11. Afloqualon

12. 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-quinazolin-4-one

13. 6-amino-2-(fluoromethyl)-3-o-tolylquinazolin-4(3h)-one

14. Afloqualona

15. Afloqualonum

16. Afloqualone [inn:jan]

17. Afloqualonum [inn-latin]

18. Afloqualona [inn-spanish]

19. Unii-co4u2c8orz

20. Hq 495

21. Brn 0819769

22. Airomate (tn)

23. 6-amino-2-(fluoromethyl)-3-o-tolyl-4(3h)-chinazolinon

24. Afloqualone [mi]

25. 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3h)-one

26. Afloqualone [inn]

27. Afloqualone [jan]

28. 6-amino-3,4-dihydro-2-fluoromethyl-3-(2-methylphenyl)-4-chinazolinon

29. Dsstox_cid_2562

30. Afloqualone (jp17/inn)

31. Afloqualone [mart.]

32. Dsstox_rid_76631

33. Dsstox_gsid_22562

34. Afloqualone [who-dd]

35. Mls006010086

36. Schembl400184

37. Chembl2105918

38. Dtxsid5022562

39. Chebi:31177

40. 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)-4-quinazolinone

41. Hms3885g19

42. Bcp13264

43. Hy-b1833

44. Tox21_112447

45. Mfcd00867693

46. S3663

47. Zinc13831145

48. Akos015842375

49. Ac-1608

50. Ccg-267278

51. Cs-5009

52. Ncgc00167443-02

53. As-11726

54. Smr004701231

55. Cas-56287-74-2

56. Ft-0653844

57. D01638

58. D95096

59. A830986

60. Q4689289

61. 2-fluoromethyl-3-(o-tolyl)-6-amino-4(3h)-quinazolinone

62. 6-azanyl-2-(fluoranylmethyl)-3-(2-methylphenyl)quinazolin-4-one

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 283.30 g/mol
Molecular Formula C16H14FN3O
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass283.11209024 g/mol
Monoisotopic Mass283.11209024 g/mol
Topological Polar Surface Area58.7 Ų
Heavy Atom Count21
Formal Charge0
Complexity439
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Muscle Relaxants, Central

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)


Photosensitizing Agents

Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. (See all compounds classified as Photosensitizing Agents.)


4.2 Metabolism/Metabolites

Afloqualone has known human metabolites that include Afloqualone N-glucuronide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


ABOUT THIS PAGE

Afloqualone Manufacturers

A Afloqualone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Afloqualone, including repackagers and relabelers. The FDA regulates Afloqualone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Afloqualone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Afloqualone manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Afloqualone Suppliers

A Afloqualone supplier is an individual or a company that provides Afloqualone active pharmaceutical ingredient (API) or Afloqualone finished formulations upon request. The Afloqualone suppliers may include Afloqualone API manufacturers, exporters, distributors and traders.

click here to find a list of Afloqualone suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Afloqualone KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Afloqualone Drug Master File in Korea (Afloqualone KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Afloqualone. The MFDS reviews the Afloqualone KDMF as part of the drug registration process and uses the information provided in the Afloqualone KDMF to evaluate the safety and efficacy of the drug.

After submitting a Afloqualone KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Afloqualone API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Afloqualone suppliers with KDMF on PharmaCompass.

Afloqualone GMP

Afloqualone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Afloqualone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Afloqualone GMP manufacturer or Afloqualone GMP API supplier for your needs.

Afloqualone CoA

A Afloqualone CoA (Certificate of Analysis) is a formal document that attests to Afloqualone's compliance with Afloqualone specifications and serves as a tool for batch-level quality control.

Afloqualone CoA mostly includes findings from lab analyses of a specific batch. For each Afloqualone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Afloqualone may be tested according to a variety of international standards, such as European Pharmacopoeia (Afloqualone EP), Afloqualone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Afloqualone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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