Find Afuresertib manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 1047644-62-1, Gsk-2110183, Gsk2110183c, Afuresertib [usan], Asb183, Asb-183
Molecular Formula
C18H17Cl2FN4OS
Molecular Weight
427.3  g/mol
InChI Key
AFJRDFWMXUECEW-LBPRGKRZSA-N
FDA UNII
8739X25QI3

Afuresertib
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
1 2D Structure

Afuresertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide
2.1.2 InChI
InChI=1S/C18H17Cl2FN4OS/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26)/t12-/m0/s1
2.1.3 InChI Key
AFJRDFWMXUECEW-LBPRGKRZSA-N
2.1.4 Canonical SMILES
CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl
2.1.5 Isomeric SMILES
CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)N[C@@H](CC3=CC(=CC=C3)F)CN)Cl
2.2 Other Identifiers
2.2.1 UNII
8739X25QI3
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1047644-62-1

2. Gsk-2110183

3. Gsk2110183c

4. Afuresertib [usan]

5. Asb183

6. Asb-183

7. Gsk 2110183c

8. Afuresertib (gsk2110183)

9. Afuresertib (usan)

10. 8739x25qi3

11. Gsk-2110183c

12. N-[(2s)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide

13. 2-thiophenecarboxamide, N-((1s)-2-amino-1-((3-fluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-

14. N-((1s)-1-(aminomethyl)-2-(3-fluorophenyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)thiophene-2-carboxamide

15. Afuresertib [usan:inn]

16. Unii-8739x25qi3

17. 2-thiophenecarboxamide, N-[(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-

18. N-((2s)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)thiophene-2-carboxamide

19. N-[(2s)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)thiophene-2-carboxamide

20. Afuresertib [inn]

21. Afuresertib [who-dd]

22. Schembl187686

23. Gtpl7890

24. Chembl2219422

25. Dtxsid60146711

26. Chebi:131168

27. Bcp08435

28. Ex-a1574

29. Bdbm50502477

30. Nsc778305

31. Nsc781255

32. Nsc800109

33. Nsc829868

34. S7521

35. Zinc43197674

36. Ccg-268972

37. Cs-3384

38. Db11648

39. Nsc-778305

40. Nsc-781255

41. Nsc-800109

42. Nsc-829868

43. Gsk 2110183

44. Ncgc00387879-03

45. Ac-35761

46. Ba166066

47. Bs-14212

48. Hy-15727

49. A16392

50. D10381

51. D71036

52. A853608

53. Afuresertib, Gsk-2110183, Gsk-2110183b

54. Q27224945

55. N-((s)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)thiophene-2-carboxamide

56. N-((s)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)thiophene-2-carboxamide;afuresertib

57. N-[(2s)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methyl-3-pyrazolyl)-2-thiophenecarboxamide

58. N-{(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide

2.4 Create Date
2010-08-16
3 Chemical and Physical Properties
Molecular Weight 427.3 g/mol
Molecular Formula C18H17Cl2FN4OS
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass426.0484159 g/mol
Monoisotopic Mass426.0484159 g/mol
Topological Polar Surface Area101 Ų
Heavy Atom Count27
Formal Charge0
Complexity520
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Looking for 1047644-62-1 / Afuresertib API manufacturers, exporters & distributors?

Afuresertib manufacturers, exporters & distributors 1

15

PharmaCompass offers a list of Afuresertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Afuresertib manufacturer or Afuresertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Afuresertib manufacturer or Afuresertib supplier.

PharmaCompass also assists you with knowing the Afuresertib API Price utilized in the formulation of products. Afuresertib API Price is not always fixed or binding as the Afuresertib Price is obtained through a variety of data sources. The Afuresertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Afuresertib

Synonyms

1047644-62-1, Gsk-2110183, Gsk2110183c, Afuresertib [usan], Asb183, Asb-183

Cas Number

1047644-62-1

Unique Ingredient Identifier (UNII)

8739X25QI3

About Afuresertib

Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Afuresertib Manufacturers

A Afuresertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Afuresertib, including repackagers and relabelers. The FDA regulates Afuresertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Afuresertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Afuresertib Suppliers

A Afuresertib supplier is an individual or a company that provides Afuresertib active pharmaceutical ingredient (API) or Afuresertib finished formulations upon request. The Afuresertib suppliers may include Afuresertib API manufacturers, exporters, distributors and traders.

Afuresertib GMP

Afuresertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Afuresertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Afuresertib GMP manufacturer or Afuresertib GMP API supplier for your needs.

Afuresertib CoA

A Afuresertib CoA (Certificate of Analysis) is a formal document that attests to Afuresertib's compliance with Afuresertib specifications and serves as a tool for batch-level quality control.

Afuresertib CoA mostly includes findings from lab analyses of a specific batch. For each Afuresertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Afuresertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Afuresertib EP), Afuresertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Afuresertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty