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Chemistry

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Drugs in Development

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Details:

Fabrazyme (agalsidase beta) works by replacing a naturally occurring enzyme (alpha-galactosidase A) to help clear GL-3 build-up in cells, including those lining the blood vessels of the kidneys, heart and skin. It is the only FDA-approved therapy for Fabry disease.


Lead Product(s): Agalsidase Beta

Therapeutic Area: Genetic Disease Brand Name: Fabrazyme

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 12, 2020

Sanofi Company Banner

01

Sanofi

France
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BIO Partnering at JPM
Not Confirmed

Lead Product(s) : Agalsidase Beta

Therapeutic Area : Genetic Disease

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : Fabrazyme (agalsidase beta) works by replacing a naturally occurring enzyme (alpha-galactosidase A) to help clear GL-3 build-up in cells, including those lining the blood vessels of the kidneys, heart and skin. It is the only FDA-approved therapy for Fab...

Brand Name : Fabrazyme

Molecule Type : Large molecule

Upfront Cash : Not Applicable

March 12, 2020

Sanofi Company Banner

Details:

mAbxience will manufacture the biosimilar of Fabrazyme (agalsidase beta), developed by Biosidus, for Fabry disease treatment under the agreement.


Lead Product(s): Agalsidase Beta

Therapeutic Area: Genetic Disease Brand Name: Undisclosed

Study Phase: Phase IIIProduct Type: Large molecule

Sponsor: Biosidus

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement February 05, 2024

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Mabxience

Spain
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BIO Partnering at JPM
Not Confirmed

Mabxience

Spain
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BIO Partnering at JPM
Not Confirmed

Details : mAbxience will manufacture the biosimilar of Fabrazyme (agalsidase beta), developed by Biosidus, for Fabry disease treatment under the agreement.

Brand Name : Undisclosed

Molecule Type : Large molecule

Upfront Cash : Undisclosed

February 05, 2024

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Details:

Fabagal (agalsidase-beta) is a recombinant analogue of human alpha-galactosidase A and is produced by recombinant DNA technology. It is approved for the treatment of fabry disease in adults and children from 8 years old.


Lead Product(s): Agalsidase Beta

Therapeutic Area: Genetic Disease Brand Name: Fabagal

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: ISU ABXIS

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 02, 2023

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03

Petrovax

Russia
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BIO Partnering at JPM
Not Confirmed

Petrovax

Russia
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BIO Partnering at JPM
Not Confirmed

Details : Fabagal (agalsidase-beta) is a recombinant analogue of human alpha-galactosidase A and is produced by recombinant DNA technology. It is approved for the treatment of fabry disease in adults and children from 8 years old.

Brand Name : Fabagal

Molecule Type : Large molecule

Upfront Cash : Not Applicable

October 02, 2023

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Details:

The agreement includes the marketing alliance for JR-051 (agalsidase beta BS), a biosimilar of Fabrazyme, a therapeutic enzyme, being sold by JCR for the treatment of Fabry disease.


Lead Product(s): Agalsidase Beta

Therapeutic Area: Genetic Disease Brand Name: JR-051

Study Phase: ApprovedProduct Type: Cell and Gene therapy

Sponsor: Sumitomo Pharma

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Agreement March 01, 2022

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BIO Partnering at JPM
Not Confirmed
BIO Partnering at JPM
Not Confirmed

Details : The agreement includes the marketing alliance for JR-051 (agalsidase beta BS), a biosimilar of Fabrazyme, a therapeutic enzyme, being sold by JCR for the treatment of Fabry disease.

Brand Name : JR-051

Molecule Type : Cell and Gene therapy

Upfront Cash : Undisclosed

March 01, 2022

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Details:

Under the agreement, Petrovax gains access to Fabagal (agalsidase beta), indicated for long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease (α-galactosidase A deficiency).


Lead Product(s): Agalsidase Beta

Therapeutic Area: Genetic Disease Brand Name: Fabagal

Study Phase: ApprovedProduct Type: Large molecule

Sponsor: Petrovax

Deal Size: Undisclosed Upfront Cash: Undisclosed

Deal Type: Licensing Agreement January 26, 2022

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ISU ABXIS

South Korea
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BIO Partnering at JPM
Not Confirmed

ISU ABXIS

South Korea
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BIO Partnering at JPM
Not Confirmed

Details : Under the agreement, Petrovax gains access to Fabagal (agalsidase beta), indicated for long-term enzyme replacement therapy in patients with a confirmed diagnosis of Fabry disease (α-galactosidase A deficiency).

Brand Name : Fabagal

Molecule Type : Large molecule

Upfront Cash : Undisclosed

January 26, 2022

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FDF Dossiers

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Sanofi

France
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BIO Partnering at JPM
Not Confirmed
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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Regulatory Info :

Registration Country : USA

AGALSIDASE BETA

Brand Name : FABRAZYME

Dosage Form : VIAL; INTRAVENOUS

Dosage Strength : 5MG/VIAL

Packaging :

Approval Date :

Application Number : 103979

Regulatory Info :

Registration Country : USA

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Sanofi

France
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BIO Partnering at JPM
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

Regulatory Info :

Registration Country : USA

AGALSIDASE BETA

Brand Name : FABRAZYME

Dosage Form : VIAL; INTRAVENOUS

Dosage Strength : 35MG/VIAL

Packaging :

Approval Date :

Application Number : 103979

Regulatory Info :

Registration Country : USA

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Sanofi

France
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BIO Partnering at JPM
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

agalsidase beta

Brand Name : Fabrazyme

Dosage Form : POWDER FOR CONCENTRATE FOR

Dosage Strength : -

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

Sanofi Company Banner

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Sanofi

France
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BIO Partnering at JPM
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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Digital Content Digital Content

Regulatory Info :

Registration Country : Canada

AGALSIDASE BETA

Brand Name : FABRAZYME

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 5MG/VIAL

Packaging : 1.1ML

Approval Date :

Application Number : 2248965

Regulatory Info :

Registration Country : Canada

Sanofi Company Banner

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Sanofi

France
arrow
BIO Partnering at JPM
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info :

Registration Country : Canada

AGALSIDASE BETA

Brand Name : FABRAZYME

Dosage Form : POWDER FOR SOLUTION

Dosage Strength : 35MG/VIAL

Packaging : 7.2ML

Approval Date :

Application Number : 2248966

Regulatory Info :

Registration Country : Canada

Sanofi Company Banner

06

Sanofi

France
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BIO Partnering at JPM
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info : Originator

Registration Country : South Africa

Agalsidase beta

Brand Name : Fabrazyme 35mg

Dosage Form : POI

Dosage Strength : 35mg/20ml

Packaging : 20X1mg/20ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

Sanofi Company Banner

07

Sanofi

France
arrow
BIO Partnering at JPM
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info : Originator

Registration Country : South Africa

Agalsidase beta

Brand Name : Fabrazyme 5mg

Dosage Form : POI

Dosage Strength : 5mg/5ml

Packaging : 5X1mg/5ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

Sanofi Company Banner

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BIO Partnering at JPM
Not Confirmed
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AGALSIDASE ALFA

Brand Name : REPLAGAL

Dosage Form : SOLUTION

Dosage Strength : 1MG/ML

Packaging :

Approval Date :

Application Number : 2249057

Regulatory Info :

Registration Country : Canada

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BIO Partnering at JPM
Not Confirmed
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Agalsidase Alfa

Brand Name : Replagal

Dosage Form : INF

Dosage Strength : 1mg/ml

Packaging : 3.5X1mg/ml

Approval Date :

Application Number :

Regulatory Info : Originator

Registration Country : South Africa

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Country
BIO Partnering at JPM
Not Confirmed
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Country
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agalsidas alfa

Brand Name : Replagal

Dosage Form : KONCENTRAT TILL INFUSIONSVÄTSKA, LÖSNING

Dosage Strength : 1 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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FDA Orange Book

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GENZYME

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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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RLD :

TE Code :

AGALSIDASE BETA

Brand Name : FABRAZYME

Dosage Form : VIAL; INTRAVENOUS

Dosage Strength : 5MG/VIAL

Approval Date :

Application Number : 103979

RX/OTC/DISCN :

RLD :

TE Code :

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GENZYME

France
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Biotech Showcase
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

RLD :

TE Code :

AGALSIDASE BETA

Brand Name : FABRAZYME

Dosage Form : VIAL; INTRAVENOUS

Dosage Strength : 35MG/VIAL

Approval Date :

Application Number : 103979

RX/OTC/DISCN :

RLD :

TE Code :

Sanofi Company Banner
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Europe

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BIO Partnering at JPM
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  • fda
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Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Flag France
Digital Content Digital Content

Regulatory Info :

Registration Country : Sweden

agalsidase beta

Brand Name : Fabrazyme

Dosage Form : POWDER FOR CONCENTRATE FOR

Dosage Strength : -

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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Shire Human Genetic Therapies AB

Country
BIO Partnering at JPM
Not Confirmed
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Shire Human Genetic Therapies AB

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BIO Partnering at JPM
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agalsidas alfa

Brand Name : Replagal

Dosage Form : KONCENTRAT TILL INFUSIONSVÄTSKA, LÖSNING

Dosage Strength : 1 MG/ML

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Sweden

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01

Brand Name : Fabrazyme

France
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Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase Beta

Main Therapeutic Indication : Rare Disorders

Currency : USD

2019 Revenue in Millions : 886

2018 Revenue in Millions : 823

Growth (%) : 8

Sanofi Company Banner

02

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase Beta

Main Therapeutic Indication : Rare Disorders

Currency : USD

2020 Revenue in Millions : 988

2019 Revenue in Millions : 983

Growth (%) : 0

Sanofi Company Banner

03

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase Beta

Main Therapeutic Indication : Rare Disorders

Currency : USD

2021 Revenue in Millions : 929

2020 Revenue in Millions : 891

Growth (%) : 3

Sanofi Company Banner

04

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase beta

Main Therapeutic Indication : Rare Diseases

Currency : USD

2022 Revenue in Millions : 1,029

2021 Revenue in Millions : 929

Growth (%) : 11

Sanofi Company Banner

05

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase Beta

Main Therapeutic Indication : Rare Diseases

Currency : USD

2023 Revenue in Millions : 1,070

2022 Revenue in Millions : 1,029

Growth (%) : 6

Sanofi Company Banner

06

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase beta

Main Therapeutic Indication : Rare Disease

Currency : USD

2014 Revenue in Millions : 20.10%

2013 Revenue in Millions :

Growth (%) :

Sanofi Company Banner

07

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase beta

Main Therapeutic Indication : Rare Disease

Currency : USD

2015 Revenue in Millions : 506

2014 Revenue in Millions : 651

Growth (%) : 29%

Sanofi Company Banner

08

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase Beta

Main Therapeutic Indication : Rare Diseases

Currency : USD

2016 Revenue in Millions : 714

2015 Revenue in Millions : 628

Growth (%) : 14

Sanofi Company Banner

09

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase Beta

Main Therapeutic Indication : Rare Diseases

Currency : USD

2017 Revenue in Millions : 895

2016 Revenue in Millions : 836

Growth (%) : 7

Sanofi Company Banner

10

Brand Name : Fabrazyme

France
arrow
Biotech Showcase
Not Confirmed
Flag France
Digital Content Digital Content
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

Agalsidase Beta

Main Therapeutic Indication : Rare Diseases

Currency : USD

2018 Revenue in Millions : 853

2017 Revenue in Millions : 816

Growth (%) : 5%

Sanofi Company Banner
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