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Chemistry

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Also known as: 9002-18-0, (2r,3s,4s,5r)-2-(hydroxymethyl)-6-[[(4r,5s)-4-hydroxy-3-methyl-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-methoxyoxane-3,5-diol, Mfcd00081288, Agar (bacteriological), Gum-agar, Agar, plant cell culture tested
Molecular Formula
C14H24O9
Molecular Weight
336.33  g/mol
InChI Key
GYYDPBCUIJTIBM-DYOGSRDZSA-N

Agar
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
1 2D Structure

Agar

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,3S,4S,5R)-2-(hydroxymethyl)-6-[[(4R,5S)-4-hydroxy-3-methyl-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-methoxyoxane-3,5-diol
2.1.2 InChI
InChI=1S/C14H24O9/c1-5-8(16)13-11(7(21-5)4-20-13)23-14-10(18)12(19-2)9(17)6(3-15)22-14/h5-18H,3-4H2,1-2H3/t5?,6-,7?,8-,9+,10-,11?,12+,13+,14?/m1/s1
2.1.3 InChI Key
GYYDPBCUIJTIBM-DYOGSRDZSA-N
2.1.4 Canonical SMILES
CC1C(C2C(C(O1)CO2)OC3C(C(C(C(O3)CO)O)OC)O)O
2.1.5 Isomeric SMILES
CC1[C@H]([C@H]2C(C(O1)CO2)OC3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)OC)O)O
2.2 Synonyms
2.2.1 Depositor-Supplied Synonyms

1. 9002-18-0

2. (2r,3s,4s,5r)-2-(hydroxymethyl)-6-[[(4r,5s)-4-hydroxy-3-methyl-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-methoxyoxane-3,5-diol

3. Mfcd00081288

4. Agar (bacteriological)

5. Gum-agar

6. Agar, Plant Cell Culture Tested

7. Agar, Pure, Powder Bacteriology And Molecular Biology Grade

2.3 Create Date
2013-06-21
3 Chemical and Physical Properties
Molecular Weight 336.33 g/mol
Molecular Formula C14H24O9
XLogP3-2.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass336.14203234 g/mol
Monoisotopic Mass336.14203234 g/mol
Topological Polar Surface Area127 Ų
Heavy Atom Count23
Formal Charge0
Complexity408
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count4
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

IT MAY BE EATEN AS A CEREAL SUBSTITUTE OR ADDED TO OTHER FOODS, OR IT MAY BE DISSOLVED IN HOT WATER & ALLOWED TO GEL BEFORE BEING TAKEN. HOWEVER, AGAR IS A RELATIVELY INEFFECTIVE BULK-FORMING AGENT IN THE USUAL DOSE OF 4 TO 16 G.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 979


...ALSO EMPLOYED AS AN EMULSIFYING AGENT IN A VARIETY OF PROPRIETARY NOSTRUMS COMBINED WITH MINERAL OIL & OTHER CATHARTICS, BUT THE DOSE OF AGAR IN THESE PREPARATIONS IS TOO SMALL TO CONTRIBUTE TO THEIR LAXATIVE EFFECT.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 979


MEDICATION (VET): LAXATIVE...USED IN CONSTIPATION.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 6


MECHANISTIC STUDIES REVEALED ANTIPEPTIC EFFECT OF AGAR WAS DUE TO A SUBSTRATE-INHIBITOR INTERACTION WITH HEMOGLOBIN. POSSIBLE SIGNIFICANCE IN THE INHIBITORY EFFECT OF AGAR IN ULCER THERAPY.

GOUDA MW; JODHKA G; INHIBITORY EFFECT OF AGAR ON PEPSIN ACTIVITY; CAN J PHARM SCI 12 (1): 4 (1977)


For more Therapeutic Uses (Complete) data for AGAR-AGAR (6 total), please visit the HSDB record page.


4.2 Minimum/Potential Fatal Human Dose

1(?)= PRACTICALLY NON-TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QUART FOR 70 KG PERSON (150 LB). /GUMS, VEGETABLE/

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-6


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Culture Media

Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. (See all compounds classified as Culture Media.)


5.2 Absorption, Distribution and Excretion

It passes through the intestinal tract mostly unabsorbed.

Leung, A.Y., Foster, S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York, NY. John Wiley & Sons, Inc. 1996., p. 10


5.3 Mechanism of Action

THESE SUBSTANCES DISSOLVE OR SWELL IN WATER TO FORM AN EMOLLIENT GEL OR VISCOUS SOLN THAT SERVES TO MAINTAIN THE FECES SOFT & HYDRATED. THE RESULTING BULK PROMOTES PERISTALSIS, & TRANSIT TIME IS REDUCED. /BULK-FORMING LAXATIVES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 978


API Reference Price

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15-Jan-2021
26-Nov-2024
KGS
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ABOUT THIS PAGE

Agar Manufacturers

A Agar manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Agar, including repackagers and relabelers. The FDA regulates Agar manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Agar API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Agar Suppliers

A Agar supplier is an individual or a company that provides Agar active pharmaceutical ingredient (API) or Agar finished formulations upon request. The Agar suppliers may include Agar API manufacturers, exporters, distributors and traders.

click here to find a list of Agar suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Agar CEP

A Agar CEP of the European Pharmacopoeia monograph is often referred to as a Agar Certificate of Suitability (COS). The purpose of a Agar CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Agar EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Agar to their clients by showing that a Agar CEP has been issued for it. The manufacturer submits a Agar CEP (COS) as part of the market authorization procedure, and it takes on the role of a Agar CEP holder for the record. Additionally, the data presented in the Agar CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Agar DMF.

A Agar CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Agar CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Agar suppliers with CEP (COS) on PharmaCompass.

Agar GMP

Agar Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Agar GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Agar GMP manufacturer or Agar GMP API supplier for your needs.

Agar CoA

A Agar CoA (Certificate of Analysis) is a formal document that attests to Agar's compliance with Agar specifications and serves as a tool for batch-level quality control.

Agar CoA mostly includes findings from lab analyses of a specific batch. For each Agar CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Agar may be tested according to a variety of international standards, such as European Pharmacopoeia (Agar EP), Agar JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Agar USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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