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    Chemistry

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    Also known as: Salbutamol sulfate, 51022-70-9, Salbutamol hemisulfate, Proventil, Venetlin, Loftan
    Molecular Formula
    C26H44N2O10S
    Molecular Weight
    576.7  g/mol
    InChI Key
    BNPSSFBOAGDEEL-UHFFFAOYSA-N
    FDA UNII
    021SEF3731
    Salbutamol Sulphate
    A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
    1 2D Structure

    Salbutamol Sulphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;sulfuric acid
    2.1.2 InChI
    InChI=1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
    2.1.3 InChI Key
    BNPSSFBOAGDEEL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.CC(C)(C)NCC(C1=CC(=C(C=C1)O)CO)O.OS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    021SEF3731
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-t-butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol

    2. Albuterol

    3. Proventil

    4. Salbutamol

    5. Sultanol

    6. Ventolin

    2.3.2 Depositor-Supplied Synonyms

    1. Salbutamol Sulfate

    2. 51022-70-9

    3. Salbutamol Hemisulfate

    4. Proventil

    5. Venetlin

    6. Loftan

    7. Albuterol Hemisulfate

    8. Bronchospray

    9. Ventolin

    10. Accuneb

    11. Proventil-hfa

    12. Salbutamol Sulphate

    13. Sch 13949w Sulfate

    14. Proair

    15. Ventolin Rotacaps

    16. Proair Respiclick

    17. Vospire Er

    18. Sultanol

    19. Ventilastin

    20. Ecovent

    21. Salbumol

    22. Vospire

    23. Albuterol Sulfate(2:1)

    24. Albuterol Sulphate

    25. 36519-31-0

    26. Buventol

    27. Salamol

    28. Salbutamol (as Sulfate)

    29. Sch 13949w Sulphate

    30. Sch-13949w Sulphate

    31. Sulbutamol (as Sulphate)

    32. Sch-13949w Sulfate

    33. 4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol;sulfuric Acid

    34. R03ac02

    35. R03cc02

    36. Aerolin

    37. Airomir

    38. 021sef3731

    39. Nsc-289928

    40. Aerotec

    41. Aloprol

    42. Amocasin

    43. Broncodil

    44. Dipulmin

    45. Fartolin

    46. Inspiryl

    47. Emican

    48. Proventil (tn)

    49. Epaq

    50. Broncho Inhalat

    51. Huma-salmol

    52. Ventolin Hfa

    53. Dl-salbutamol Sulfate

    54. (+-)-salbutamol Sulfate

    55. 2-(tert-butylamino)-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol Hemisulfate

    56. 5-[2-(tert-butylamino)-1-hydroxyethyl]-2-hydroxybenzyl Alcohol Hemisulfate

    57. Albuterol Sulfate [usan]

    58. Proair Hfa

    59. Ah-3365

    60. Einecs 256-916-8

    61. Salbutamol Hemisulfate Salt

    62. Nsc 289928

    63. Accuvent

    64. Pediavent

    65. Torpex

    66. Volare

    67. Albuterol Sulfate [usan:usp]

    68. Ventolin Nebules

    69. Ventolin Sulfate

    70. Unii-021sef3731

    71. Salbutamol Diskus

    72. Salbutamoli Sulfas

    73. Buventol Easyhaler

    74. Proventil Repetabs

    75. Pulvinal Salbutamol

    76. Sulbutamol Sulphate

    77. Proventil Repetabs, Solution, Syrup, And Tablets

    78. Ventolin (tn)

    79. Accuneb (tn)

    80. Salbutamol Easyhaler

    81. Ventolin Easy-breathe

    82. Albuterol Sulfate,(s)

    83. Albuterol Sulfate (usp)

    84. Albuterol Sulfate- Bio-x

    85. 1-(4-hydroxy-3-hydroxymethylphenyl)-2-(tert-butylamino)ethanol Sulfate

    86. Salbutamol Sulfate (jp17)

    87. Tbs-7

    88. Schembl33279

    89. Alpha(sup 1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol Sulfate (2:1) (salt)

    90. Albuterol Sulfate [mi]

    91. Chebi:2550

    92. (+-)-ysulfate(2:1)(salt)

    93. Chembl1441059

    94. Salbutamol Sulfate [jan]

    95. Albuterol Sulfate [vandf]

    96. Dtxsid10881180

    97. Hms3263k18

    98. Hms3266d17

    99. Torpex (albuterol Sulfate)

    100. Albuterol Sulfate [usp-rs]

    101. Salbutamol Sulfate [mart.]

    102. Bis((tert-butyl)(beta,3,4-trihydroxyphenethyl)ammonium) Sulphate

    103. Salbutamol Sulfate [who-dd]

    104. Salbutamol Sulfate [who-ip]

    105. Tox21_501098

    106. Mfcd00055200

    107. Salbutamol Hemisulfate Salt, >=98%

    108. Akos015994719

    109. Albuterol Sulfate [green Book]

    110. Albuterol Sulfate [orange Book]

    111. Ccg-222402

    112. Ks-5056

    113. Lp01098

    114. Tq-1016

    115. Albuterol Sulfate [usp Impurity]

    116. Salbutamol Sulfate [ep Impurity]

    117. Salbutamol Sulphate (albuterol Sulphate)

    118. Albuterol Sulfate [usp Monograph]

    119. Duoneb Component Albuterol Sulfate

    120. Ncgc00094370-01

    121. Ncgc00261783-01

    122. Salbutamol Sulfate [ep Monograph]

    123. 1,3-benzenedimethanol, Alpha(sup 1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

    124. 1,3-benzenedimethanol, Alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

    125. Ba164388

    126. Salbutamoli Sulfas [who-ip Latin]

    127. Combivent Component Albuterol Sulfate

    128. Albuterol Sulfate Component Of Duoneb

    129. Eu-0101098

    130. Ft-0650809

    131. S0531

    132. Salbutamol Sulfate 100 Microg/ml In Methanol

    133. A51088

    134. Albuterol Sulfate Component Of Combivent

    135. D00683

    136. S 5013

    137. 022s709

    138. A828402

    139. Q27231480

    140. Salbutamol Hemisulfate Salt, Vetranal(tm), Analytical Standard

    141. Salbutamol Sulfate, British Pharmacopoeia (bp) Reference Standard

    142. Salbutamol Sulfate, European Pharmacopoeia (ep) Reference Standard

    143. Albuterol Sulfate, United States Pharmacopeia (usp) Reference Standard

    144. Albuterol Sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

    145. Salbutamol Sulfate For System Suitability, European Pharmacopoeia (ep) Reference Standard

    146. Salbutamol Sulphate (albuterol Sulphate) 1.0 Mg/ml In Methanol (as Free Base)

    147. (+/-)-2-tert-butylamino-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol Sulfate Salt (2:1)

    148. .alpha.(sup 1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-.alpha.,.alpha.'-diol Sulfate (2:1) (salt)

    149. .alpha.(sup 1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-.alpha.,.alpha.'-diol Sulphate (2:1) (salt)

    150. 1,3-benzenedimethanol,.alpha.(sup 1)-(((1,1 Dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

    151. 1,3-benzenedimethanol,.alpha.(sup 1)-(((1,1 Dimethylethyl)amino)methyl)-4-hydroxy-, Sulphate (2:1) (salt)

    152. 1,3-benzenedimethanol,.alpha.1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Sulfate (2:1) (salt)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 576.7 g/mol
    Molecular Formula C26H44N2O10S
    Hydrogen Bond Donor Count10
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count10
    Exact Mass576.27166678 g/mol
    Monoisotopic Mass576.27166678 g/mol
    Topological Polar Surface Area228 Ų
    Heavy Atom Count39
    Formal Charge0
    Complexity309
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count2
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 12  
    Drug NameAccuneb
    PubMed HealthAlbuterol (By breathing)
    Drug ClassesBronchodilator
    Drug LabelAlbuterol Sulfate Inhalation Solution is a relatively selective beta2-adrenergic bronchodilator (see CLINICAL PHARMACOLOGY section below). Albuterol sulfate, the racemic form of albuterol, has the chemical name 1-[(tert-Butylamino)methyl]-4-hydroxy...
    Active IngredientAlbuterol sulfate
    Dosage FormSolution
    RouteInhalation
    Strengtheq 0.021% base; eq 0.042% base
    Market StatusPrescription
    CompanyMylan Speclt

    2 of 12  
    Drug NameAlbuterol sulfate
    PubMed HealthAlbuterol
    Drug ClassesBronchodilator, Cardiovascular Agent
    Drug LabelThe active component of VENTOLIN HFA is albuterol sulfate, USP, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator. Albuterol sulfate has the chemical name 1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-,...
    Active IngredientAlbuterol sulfate
    Dosage FormTablet, extended release; Tablet; Syrup; Solution
    RouteInhalation; Oral
    Strengtheq 4mg base; eq 0.083% base; eq 2mg base; eq 0.021% base; eq 0.5% base; eq 2mg base/5ml; eq 0.042% base; eq 8mg base
    Market StatusPrescription
    CompanyWatson Labs; Amneal Pharms; Vistapharm; Teva Pharms; Hi Tech Pharma; Ritedose; Actavis Mid Atlantic; Mutual Pharm; Teva; Vintage; Bausch And Lomb; Landela Pharm; Nephron; Mylan Speclt; Mylan

    3 of 12  
    Drug NameProair hfa
    Active IngredientAlbuterol sulfate
    Dosage FormAerosol, metered
    RouteInhalation
    Strengtheq 0.09mg base/inh
    Market StatusPrescription
    CompanyTeva Branded Pharm

    4 of 12  
    Drug NameProventil-hfa
    Active IngredientAlbuterol sulfate
    Dosage FormAerosol, metered
    RouteInhalation
    Strengtheq 0.09mg base/inh
    Market StatusPrescription
    Company3m

    5 of 12  
    Drug NameVentolin hfa
    Drug LabelAlbuterol extended-release tablets contain albuterol sulfate, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator, in an extended-release formulation. Albuterol sulfate has the chemical name () 1-[(tert-butyla...
    Active IngredientAlbuterol sulfate
    Dosage FormAerosol, metered
    RouteInhalation
    Strengtheq 0.09mg base/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    6 of 12  
    Drug NameVospire er
    Drug LabelThe active ingredient of PROAIR HFA (albuterol sulfate) Inhalation Aerosol is albuterol sulfate, a racemic salt, of albuterol. Albuterol sulfate has the chemical name 1-[(tert-butylamino) methyl]-4-hydroxy-m-xylene-,'-diol sulfate (2:1) (salt),...
    Active IngredientAlbuterol sulfate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 4mg base; eq 8mg base
    Market StatusPrescription
    CompanyDava Pharms

    7 of 12  
    Drug NameAccuneb
    PubMed HealthAlbuterol (By breathing)
    Drug ClassesBronchodilator
    Drug LabelAlbuterol Sulfate Inhalation Solution is a relatively selective beta2-adrenergic bronchodilator (see CLINICAL PHARMACOLOGY section below). Albuterol sulfate, the racemic form of albuterol, has the chemical name 1-[(tert-Butylamino)methyl]-4-hydroxy...
    Active IngredientAlbuterol sulfate
    Dosage FormSolution
    RouteInhalation
    Strengtheq 0.021% base; eq 0.042% base
    Market StatusPrescription
    CompanyMylan Speclt

    8 of 12  
    Drug NameAlbuterol sulfate
    PubMed HealthAlbuterol
    Drug ClassesBronchodilator, Cardiovascular Agent
    Drug LabelThe active component of VENTOLIN HFA is albuterol sulfate, USP, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator. Albuterol sulfate has the chemical name 1-[(tert-butylamino)methyl]-4-hydroxy-m-xylene-,...
    Active IngredientAlbuterol sulfate
    Dosage FormTablet, extended release; Tablet; Syrup; Solution
    RouteInhalation; Oral
    Strengtheq 4mg base; eq 0.083% base; eq 2mg base; eq 0.021% base; eq 0.5% base; eq 2mg base/5ml; eq 0.042% base; eq 8mg base
    Market StatusPrescription
    CompanyWatson Labs; Amneal Pharms; Vistapharm; Teva Pharms; Hi Tech Pharma; Ritedose; Actavis Mid Atlantic; Mutual Pharm; Teva; Vintage; Bausch And Lomb; Landela Pharm; Nephron; Mylan Speclt; Mylan

    9 of 12  
    Drug NameProair hfa
    Active IngredientAlbuterol sulfate
    Dosage FormAerosol, metered
    RouteInhalation
    Strengtheq 0.09mg base/inh
    Market StatusPrescription
    CompanyTeva Branded Pharm

    10 of 12  
    Drug NameProventil-hfa
    Active IngredientAlbuterol sulfate
    Dosage FormAerosol, metered
    RouteInhalation
    Strengtheq 0.09mg base/inh
    Market StatusPrescription
    Company3m

    11 of 12  
    Drug NameVentolin hfa
    Drug LabelAlbuterol extended-release tablets contain albuterol sulfate, the racemic form of albuterol and a relatively selective beta2-adrenergic bronchodilator, in an extended-release formulation. Albuterol sulfate has the chemical name () 1-[(tert-butyla...
    Active IngredientAlbuterol sulfate
    Dosage FormAerosol, metered
    RouteInhalation
    Strengtheq 0.09mg base/inh
    Market StatusPrescription
    CompanyGlaxo Grp

    12 of 12  
    Drug NameVospire er
    Drug LabelThe active ingredient of PROAIR HFA (albuterol sulfate) Inhalation Aerosol is albuterol sulfate, a racemic salt, of albuterol. Albuterol sulfate has the chemical name 1-[(tert-butylamino) methyl]-4-hydroxy-m-xylene-,'-diol sulfate (2:1) (salt),...
    Active IngredientAlbuterol sulfate
    Dosage FormTablet, extended release
    RouteOral
    Strengtheq 4mg base; eq 8mg base
    Market StatusPrescription
    CompanyDava Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic beta-2 Receptor Agonists

    Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS. (See all compounds classified as Adrenergic beta-2 Receptor Agonists.)

    Tocolytic Agents

    Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    beta2-Adrenergic Agonist [EPC]; Adrenergic beta2-Agonists [MoA]

    API Reference Price

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    02-Jan-2021
    30-Sep-2024
    KGS
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    DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.0...DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.09MG BASE/INH

    USFDA APPLICATION NUMBER - 20503

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    DOSAGE - SOLUTION;INHALATION - EQ 0.083% BASE...DOSAGE - SOLUTION;INHALATION - EQ 0.083% BASE;0.017% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20950

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    DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.0...DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.09MG BASE/INH

    USFDA APPLICATION NUMBER - 20983

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    DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.0...DOSAGE - AEROSOL, METERED;INHALATION - EQ 0.09MG BASE/INH

    USFDA APPLICATION NUMBER - 21457

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