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    Also known as: Ephedrine sulphate, Isofedrol, Akovaz, 134-72-5, Corphedra, Ephedrine sulfate [usp]
    Molecular Formula
    C20H32N2O6S
    Molecular Weight
    428.5  g/mol
    InChI Key
    CAVQBDOACNULDN-KHFUBBAMSA-N
    FDA UNII
    U6X61U5ZEG
    Ephedrine Sulfate
    A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
    1 2D Structure

    Ephedrine Sulfate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric acid
    2.1.2 InChI
    InChI=1S/2C10H15NO.H2O4S/c2*1-8(11-2)10(12)9-6-4-3-5-7-9;1-5(2,3)4/h2*3-8,10-12H,1-2H3;(H2,1,2,3,4)/t2*8-,10-;/m00./s1
    2.1.3 InChI Key
    CAVQBDOACNULDN-KHFUBBAMSA-N
    2.1.4 Canonical SMILES
    CC(C(C1=CC=CC=C1)O)NC.CC(C(C1=CC=CC=C1)O)NC.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.OS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    U6X61U5ZEG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ephedrine

    2. Ephedrine Erythro Isomer

    3. Ephedrine Hydrochloride

    4. Ephedrine Renaudin

    5. Erythro Isomer Of Ephedrine

    6. Hydrochloride, Ephedrine

    7. Renaudin, Ephedrine

    8. Sal Phedrine

    9. Sal-phedrine

    10. Salphedrine

    11. Sulfate, Ephedrine

    2.3.2 Depositor-Supplied Synonyms

    1. Ephedrine Sulphate

    2. Isofedrol

    3. Akovaz

    4. 134-72-5

    5. Corphedra

    6. Ephedrine Sulfate [usp]

    7. U6x61u5zeg

    8. (-)-ephedrine Sulfate (2:1) (salt)

    9. 134-72-5 (sulfate)

    10. (-)-ephedrine Hemisulfate

    11. Nci-c55652

    12. Ephedrine Sulfate (usp)

    13. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alphar)-, Sulfate (2:1) (salt)

    14. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric Acid

    15. L-ephedrine Sulfate

    16. Unii-u6x61u5zeg

    17. Expansyl

    18. Ccris 1351

    19. Ephedrini Sulfas

    20. Pazo Ointment

    21. Franol Plus

    22. Franol-plus

    23. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol Sulfate (2:1) (salt)

    24. Pazo Suppositories

    25. Corphedra (tn)

    26. Emerphed (tn)

    27. Einecs 205-154-4

    28. Akovaz (tn)

    29. Emerphed

    30. Ephedrine L- Sulfate

    31. 1-phenyl-2-methylamine-propanol-1-sulfate

    32. Ec 205-154-4

    33. Schembl41262

    34. (1r,2s)-1-phenyl-2-methylaminopropanol-1 Sulfate

    35. Ephedrine Sulfate [mi]

    36. 1-alpha-(1-(methylamino)ethyl)benzyl Alcohol Sulfate

    37. Chembl1523964

    38. Dtxsid6020565

    39. Ephedrine Sulfate [vandf]

    40. Ephedrine Sulfate [mart.]

    41. Ephedrine Sulfate [usp-rs]

    42. Ephedrine Sulfate [who-dd]

    43. Ephedrine Sulfate [who-ip]

    44. (-)-erythro-1-hydroxy-2-(methylamino)-1-phenylpropane Sulfate

    45. Bdbm50480314

    46. Akos015901652

    47. Ephedrine Sulfate [orange Book]

    48. Ephedrini Sulfas [who-ip Latin]

    49. Ephedrine Sulfate [usp Monograph]

    50. Ncgc00093901-01

    51. Ephedrine Sulfate (2:1) (salt), (-)-

    52. Eu-0100501

    53. D04018

    54. E 3250

    55. Q27290771

    56. Ephedrine Sulphate 1.0 Mg/ml In Methanol (as Free Base)

    57. Bis((r-(r*,s*))-beta-hydroxy-alpha-methylphenethyl)methylammonium Sulphate

    58. Bis((r-(r*,s*))-beta-hydroxy-alpha-methylphenethyl)methylammonium) Sulphate

    59. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alphar)-, Sulfate (2:1)

    60. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (r-(r*,s*))-, Sulfate (2:1) (salt)

    61. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (theta-(theta,s))-, Sulfate (2:1) (salt)

    62. (r-(r*,s*))-.alpha.-(1-(methylamino)ethyl)benzenemethanol Sulfate (2:1) (salt) [who-ip]

    63. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, (r-(r*,s*))-, Sulfate (2:1) (salt)

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 428.5 g/mol
    Molecular Formula C20H32N2O6S
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count6
    Exact Mass428.19810792 g/mol
    Monoisotopic Mass428.19810792 g/mol
    Topological Polar Surface Area148 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity202
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic Agents

    Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    Central Nervous System Stimulants

    A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Adrenergic beta-Agonists [MoA]; Increased Norepinephrine Activity [PE]; Norepinephrine Releasing Agent [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]

    API Reference Price

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    05-Jan-2021
    19-Mar-2025
    KGS
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    DOSAGE - SOLUTION;INTRAVENOUS - 25MG/5ML (5MG...DOSAGE - SOLUTION;INTRAVENOUS - 25MG/5ML (5MG/ML)

    USFDA APPLICATION NUMBER - 208289

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    Looking for 134-72-5 / Ephedrine Sulfate API manufacturers, exporters & distributors?

    Ephedrine Sulfate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Ephedrine Sulfate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ephedrine Sulfate manufacturer or Ephedrine Sulfate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ephedrine Sulfate manufacturer or Ephedrine Sulfate supplier.

    PharmaCompass also assists you with knowing the Ephedrine Sulfate API Price utilized in the formulation of products. Ephedrine Sulfate API Price is not always fixed or binding as the Ephedrine Sulfate Price is obtained through a variety of data sources. The Ephedrine Sulfate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ephedrine Sulfate

    Synonyms

    Ephedrine sulphate, Isofedrol, Akovaz, 134-72-5, Corphedra, Ephedrine sulfate [usp]

    Cas Number

    134-72-5

    Unique Ingredient Identifier (UNII)

    U6X61U5ZEG

    About Ephedrine Sulfate

    A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.

    AKOVAZ Manufacturers

    A AKOVAZ manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AKOVAZ, including repackagers and relabelers. The FDA regulates AKOVAZ manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AKOVAZ API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of AKOVAZ manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    AKOVAZ Suppliers

    A AKOVAZ supplier is an individual or a company that provides AKOVAZ active pharmaceutical ingredient (API) or AKOVAZ finished formulations upon request. The AKOVAZ suppliers may include AKOVAZ API manufacturers, exporters, distributors and traders.

    click here to find a list of AKOVAZ suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    AKOVAZ USDMF

    A AKOVAZ DMF (Drug Master File) is a document detailing the whole manufacturing process of AKOVAZ active pharmaceutical ingredient (API) in detail. Different forms of AKOVAZ DMFs exist exist since differing nations have different regulations, such as AKOVAZ USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A AKOVAZ DMF submitted to regulatory agencies in the US is known as a USDMF. AKOVAZ USDMF includes data on AKOVAZ's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The AKOVAZ USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of AKOVAZ suppliers with USDMF on PharmaCompass.

    AKOVAZ WC

    A AKOVAZ written confirmation (AKOVAZ WC) is an official document issued by a regulatory agency to a AKOVAZ manufacturer, verifying that the manufacturing facility of a AKOVAZ active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting AKOVAZ APIs or AKOVAZ finished pharmaceutical products to another nation, regulatory agencies frequently require a AKOVAZ WC (written confirmation) as part of the regulatory process.

    click here to find a list of AKOVAZ suppliers with Written Confirmation (WC) on PharmaCompass.

    AKOVAZ NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing AKOVAZ as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for AKOVAZ API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture AKOVAZ as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain AKOVAZ and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a AKOVAZ NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of AKOVAZ suppliers with NDC on PharmaCompass.

    AKOVAZ GMP

    AKOVAZ Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of AKOVAZ GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AKOVAZ GMP manufacturer or AKOVAZ GMP API supplier for your needs.

    AKOVAZ CoA

    A AKOVAZ CoA (Certificate of Analysis) is a formal document that attests to AKOVAZ's compliance with AKOVAZ specifications and serves as a tool for batch-level quality control.

    AKOVAZ CoA mostly includes findings from lab analyses of a specific batch. For each AKOVAZ CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    AKOVAZ may be tested according to a variety of international standards, such as European Pharmacopoeia (AKOVAZ EP), AKOVAZ JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AKOVAZ USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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