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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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EU WC

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KDMF

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NDC API

NDC API

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REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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API REF. PRICE (USD/KG)

GLOBAL SALES INFORMATION

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Chemistry

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Also known as: 1401066-79-2, Bms 906024, Osugacestat, Osugacestat [usan], Al101, Drl23n424r
Molecular Formula
C26H26F6N4O3
Molecular Weight
556.5  g/mol
InChI Key
AYOUDDAETNMCBW-GSHUGGBRSA-N
FDA UNII
DRL23N424R

AL101
Osugacestat is a small-molecule gamma secretase (GS) and pan-Notch inhibitor, with potential antineoplastic activity. Upon intravenous administration, osugacestat binds to GS and blocks activation of Notch receptors, which may inhibit the proliferation of tumor cells with an overly-active Notch pathway. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains that lead to their activation. Overactivation of the Notch signaling pathway, often triggered by activating mutations, has been correlated with increased cellular proliferation and poor prognosis in certain tumor types.
1 2D Structure

AL101

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,3R)-N'-[(3S)-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide
2.1.2 InChI
InChI=1S/C26H26F6N4O3/c1-36-19-10-6-5-9-18(19)20(15-7-3-2-4-8-15)34-22(24(36)39)35-23(38)17(12-14-26(30,31)32)16(21(33)37)11-13-25(27,28)29/h2-10,16-17,22H,11-14H2,1H3,(H2,33,37)(H,35,38)/t16-,17+,22+/m0/s1
2.1.3 InChI Key
AYOUDDAETNMCBW-GSHUGGBRSA-N
2.1.4 Canonical SMILES
CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC=CC=C3
2.1.5 Isomeric SMILES
CN1C2=CC=CC=C2C(=N[C@@H](C1=O)NC(=O)[C@H](CCC(F)(F)F)[C@H](CCC(F)(F)F)C(=O)N)C3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
DRL23N424R
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1401066-79-2

2. Bms 906024

3. Osugacestat

4. Osugacestat [usan]

5. Al101

6. Drl23n424r

7. (2r,3s)-n1-((s)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

8. Al-101

9. Bm0018

10. Bm-0018

11. (2s,3r)-n'-[(3s)-1-methyl-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2,3-bis(3,3,3-trifluoropropyl)butanediamide

12. Unii-drl23n424r

13. Osugacestat [inn]

14. Chembl4297269

15. Schembl12543868

16. Dtxsid30161234

17. Chebi:131164

18. Mfcd24849414

19. Nsc780812

20. Who 11648

21. Bms 906024 [who-dd]

22. Zinc100285156

23. Db12006

24. Nsc-780812

25. Bb162475

26. Hy-15670

27. Cs-0008191

28. Bms-906024, >=98% (hplc)

29. Q15408421

30. (2r,3s)-n1 -((3s)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-1,4- Benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)butanediamide

31. Butanediamide, N1-((3s)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1h-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluorophenyl)-, (2r,3s)-

32. Butanediamide, N1-((3s)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1h-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)-, (2r,3s)-

2.4 Create Date
2012-10-30
3 Chemical and Physical Properties
Molecular Weight 556.5 g/mol
Molecular Formula C26H26F6N4O3
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass556.19090968 g/mol
Monoisotopic Mass556.19090968 g/mol
Topological Polar Surface Area105 Ų
Heavy Atom Count39
Formal Charge0
Complexity916
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1401066-79-2 / AL101 API manufacturers, exporters & distributors?

AL101 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of AL101 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right AL101 manufacturer or AL101 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred AL101 manufacturer or AL101 supplier.

PharmaCompass also assists you with knowing the AL101 API Price utilized in the formulation of products. AL101 API Price is not always fixed or binding as the AL101 Price is obtained through a variety of data sources. The AL101 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

AL101

Synonyms

1401066-79-2, Bms 906024, Osugacestat, Osugacestat [usan], Drl23n424r, (2r,3s)-n1-((s)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1h-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

Cas Number

1401066-79-2

Unique Ingredient Identifier (UNII)

DRL23N424R

About AL101

Osugacestat is a small-molecule gamma secretase (GS) and pan-Notch inhibitor, with potential antineoplastic activity. Upon intravenous administration, osugacestat binds to GS and blocks activation of Notch receptors, which may inhibit the proliferation of tumor cells with an overly-active Notch pathway. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains that lead to their activation. Overactivation of the Notch signaling pathway, often triggered by activating mutations, has been correlated with increased cellular proliferation and poor prognosis in certain tumor types.

AL101 Manufacturers

A AL101 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AL101, including repackagers and relabelers. The FDA regulates AL101 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AL101 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

AL101 Suppliers

A AL101 supplier is an individual or a company that provides AL101 active pharmaceutical ingredient (API) or AL101 finished formulations upon request. The AL101 suppliers may include AL101 API manufacturers, exporters, distributors and traders.

AL101 GMP

AL101 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of AL101 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AL101 GMP manufacturer or AL101 GMP API supplier for your needs.

AL101 CoA

A AL101 CoA (Certificate of Analysis) is a formal document that attests to AL101's compliance with AL101 specifications and serves as a tool for batch-level quality control.

AL101 CoA mostly includes findings from lab analyses of a specific batch. For each AL101 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

AL101 may be tested according to a variety of international standards, such as European Pharmacopoeia (AL101 EP), AL101 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AL101 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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